Scientists find cure for diabetes in animals

cats_dogs_03-300x225As reported in the February issue of the journal Diabetes1, researchers from the Center of Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona in Spain, used a single gene therapy session to treat dogs with type I diabetes. The dogs in the study regained their health and showed no further symptoms of disease. Some of the dogs were monitored for over four years with no recurrence of the condition. Read more…

Comment VLA editor: I hope we can consider this an animal study for humans with diabetes.

Abstract

“Diabetes is associated with severe secondary complications, caused largely by poor glycemic control. Treatment with exogenous insulin fails to prevent these complications completely, leading to significant morbidity and mortality. We previously demonstrated that it is possible to generate a “glucose sensor” in skeletal muscle through co-expression of glucokinase (Gck) and insulin (Ins), increasing glucose uptake and correcting hyperglycemia in diabetic mice. Here, we demonstrate long-term efficacy of this approach in a large animal model of diabetes. A one-time intramuscular administration of adenoassociated viral vectors of serotype 1 (AAV1) encoding for Gck and Ins in diabetic dogs resulted in normalization of fasting glycemia, accelerated disposal of glucose after oral challenge, and no episodes of hypoglycemia during exercise for >4 years after gene transfer. This was associated with recovery of body weight, reduced glycosylated plasma proteins levels, and long-term survival without secondary complications. Conversely, exogenous insulin or gene transfer for Ins or Gck alone failed to achieve complete correction of diabetes, indicating that the synergistic action of Ins and Gck are needed for full therapeutic effect. This study provides the first proof-of-concept in a large animal model for a gene transfer approach to treat diabetes.”

5 thoughts on “Scientists find cure for diabetes in animals

  1. Pingback: Scientists find cure for diabetes in animals | Piotr Bein's blog = blog Piotra Beina

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  3. Jim West

    Thank you for the article, however, if diabetes is a toxicological disease, there is no cure except abatement of toxic exposure and subsequent repair. The article may be an industrial press release designed to promote non-toxicological causation.

    Consider toxicological causation:

    “For identical twins, when one twin had type 1 diabetes, the other twin only had it 30%–50% of the time. Despite having exactly the same genome, one twin had the disease, where the other did not; this suggests environmental factors” http://en.wikipedia.org/wiki/Diabetes_mellitus_type_1#Environmental

  4. Editor Post author

    Jim: Regarding the twin who had diabetes 30% of the time and the other twin all the time. If mercury was injected in utero…like with Rhogam or the flu shot, the first baby that gets the food supply gets the heaviest dose of toxins and basically saves the other twin. Perhaps this is the case. Wonder if the mother got vaccines in utero.

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