STUDY: Cyp 450 Homicides Lucire
STUDY #2 The relevance of cytochrome P450 polymorphism in forensic medicine
and akathisia-related violence and suicide Lucire#2
Published paper by Dr. Yolande Lucire,
PhD MBBS DPM FRANZCP
FORENSIC & MEDICO-LEGAL PSYCHIATRY
Dr Yolande Lucire is a forensic psychiatrist who specialises in adverse drug reactions to psychiatric drugs. Truly compassionate, a pioneer in her field, she has successfully taken people, who were considered “mentally ill”, off of their contraindicated medications.
VLA Recommendation: RIVETING!!! Make sure you view Table 3
STUDY: Cyp 450 Homicides Lucire
Read below excerpts of personal experience from Dr. Lucire’s published paper… for example, of subject #1. Those people who are non or poor metabolizers of Cyp 450 do not just have ordinary suicidal or homicidal ideation but have heinous! ideations (see below). Hence…school shootings by young men who are taking or withdrawing from prescription drugs or street drugs. Every child vaccinated before the age of three years old is damaged because Cyp 450 is “maturing”. This detox liver super family of enzymes is not mature enough to metabolize the excipients in vaccines including aluminum, mercury, ethanol, formaldyde, Poly sorbate 80, etc. All children given vaccines before Cyp 450 is mature is damaged to some extent. Many of these vaccinated individuals , especially life long genetic non metabolizers (absent the activity of cyp 450 variable…10% of Caucasians, for example) are so damaged by early vaccines that they then get subsequently mis-diagnosed as mentally ill and put on counter indicated drugs which continue to make them psychotic, Homicidal, suicidal.
Study#1: Information on subjects’ drug regimes, CYP450 genotypes, criminal acts, and outcomes for ten of those suffering violent akathisia.
Study #2: Lucire#2 The relevance of cytochrome P450 polymorphism in forensic medicine
and akathisia-related violence and suicide
Study #1 excerpts: Twenty-six were known to be taking illicit or herbal psychoactivesubstances metabolized by CYP450 and had beentreated with antidepressants, antipsychotics, atypicals, and enforced zuclopenthixol depot injections (all also metabolizedby CYP450) and remained under psychiatric careuntil they stopped medication or committed suicide. Their treating doctors are among the 30 unresponsive to genetic information. This attitude may be related to a popular butcontested belief that cannabis accelerates the onset of mental illness. It has not been possible to follow up the fates of 26 of them. Of the tested population, 86 seemed to have been fully functioningworkers or students experiencing various degrees of
psychosocial stress, who were being treated for compensable injuries and/or stressors. Four had been diagnosed with mentalillness before they used substances, medicinal or other: two
with schizophrenia and two with bipolar disorder. At least 26were given psychiatric medications following or during theuse of illicit substances such as cannabis, amphetamines,
and ecstasy (MDMA), three had taken hypericum beforetaking antidepressants and had developed similar adversity on that. Three had received attention for anorexia nervosa,
three for the effects of sexual abuse, two for brain injuries,one for organophosphate poisoning, and one for epilepsy. The expected array of human problems was disclosed, with
overlapping alcohol overuse (2), personality disorders (6), and bereavements (4). The premedication conditions of sixcould not be reliably assessed.
Out of the 129, eight had committed homicide, three had
committed suicide and one had sleepwalked to her death. The
first author restored 16 to their previously normal personalities
by supervising a very slow and safe withdrawal of medications
in the correct order. READ More…Cyp 450 Homicides Lucire
Subject # 1 in her own words:
My husband was drinking. I took small doses of valerian
for a month and had weird dreams and premonitions. When
I took nortriptyline, I immediately wanted to kill myself,
talked myself out of it. I’d never had thoughts like that
before. My husband was angry, shouting. I walked outside
a lot, with palpitations, trouble breathing, and became more
depressed. My smoking went up to 25 a day, no alcohol.
I didn’t sleep for two nights, dreamt, then slept maybe three
hours, felt awful. I dreamt that my daughter had dark teeth
and I saw a black halo around her head, a spear hanging over
it. I felt like a zombie. I believed I had to help my daughter,
that a bad spirit possessed her. I picked up a knife and
stabbed her and woke up. I was not myself. I was looking
on from the outside, controlled by dark forces. She said:
“Mum, what are you doing here?” I realized what I’d done.
I asked my husband to kill me. He called the police. I felt
better in the police cells without the pills, but the pills started
again and thoughts of killing myself returned.
More SSRI Stories ie. 7 year old children hanging themselves by their belts in their closets.
SSRI Stories is a riveting website and collection of drug induced homicides and suicides
Study #2: Lucire#2 The relevance of cytochrome P450 polymorphism in forensic medicine and akathisia-related violence and suicide
Excerpts: A forensic investigation combined with medication history, reports from observers, clinical records and a blood sample or a non-invasive swab from the living or dead can help elucidate the proximate, pharmacogenetic cause of death, suicide or violence. This determination can absolve persons charged with homicide (or abort the investigation), affect insurance pay-outs for suicide, provide an absolute defence of involuntary intoxication for the perpetrator of violence, and should protect a living person from getting more drugs with the same metabolic pathways as those that caused the problem.
Forensic pharmacogenomics correlates genetic variations to response to drugs.29 DNA testing can provide forensic examiners with a tool to investigate death caused by medication.30 In 2000, forensic pharmacogenetics was first used to explain the death of a nine-year-old child treated with a combination of methylphenidate, codeine and fluoxetine where the medical examiner reported fluoxetine toxicity. Finding that the child was defective in CYP2D6 capability aborted a homicide investigation of the parents by explaining the toxic level.31 Lucire and Crotty reported ten akathisia homicides (and some attempts) committed by people taking antidepressants, not for mental illness, but for distress caused by their predicaments. These individuals also had diminishing mutations in the CYP450 family of metabolizing enzymes and all were taking medicines that further decreased metabolism by inhibition.32
3. Subject 1, USA
A 39-year-old woman, with no prior history of mental illness, suicidality or violence had a difficult marriage and was prescribed zolpidem 10 mg/night for insomnia and alprazolam for fear of flying. A year later, she had divorced, moved to a new house, a parent had died, and she felt overwhelmed. Sertraline, 50 mg/day, was superimposed on long-term zolpidem use. Her mental state deteriorated. She said she had no emotions and felt like a “zombie”. She was switched to venlafaxine 150 mg/day. Throughout her treatment, she had been restless and had slept only with zolpidem, waking after few hours in an agitated state. At some point, she began believing that killing her husband and herself was the right thing to do for her children. She stopped venlafaxine abruptly and, on the following day, she ambushed her husband with a baseball bat, then stabbed him many times. Intent on committing suicide, she overdosed on zolpidem, alprazolam and alcohol, but survived and was charged with murder. The metabolic pathways of the drugs in use are presented in Table 1. Her P450 genotypes for the relevant enzymes are presented in Table 2.
Partial Excerpt from another subject: A woman:
A couple of months later, the note, “this patient does not belong in psychiatric care,” was recorded, and she was discharged. Venlafaxine was reduced to 75 mg/day, and temazepam and quetiapine were ceased. After nine months, she stopped venlafaxine without tapering but, two weeks later, she resumed her prescribed dosage. Her behaviour was described as “erratic” and “chaotic”. Without warning, she suffocated her two-year-old son with a pillow, hanged him using the cord of her bathrobe, put him in a box, woke her 7-year-old-daughter and told her that they all, including herself, had to die. She drove a car, along with her daughter, into a canal. Her daughter escaped. Charged with murder and attempted murder, she had only patchy recall of these events. Drugs and enzymes for this subject are given in Table 3. A year later, the defence team requested genetic testing for CYP450 (Table 4).
READ MORE….
VLA Comment: People who are on counter indicated drugs, prescription or street drugs, based on deminished genetic metabolism commit these homicides as if driven by some inexplicable heinous force and barely recall the event. Some defense such as Automaton and Involuntary Intoxication are used as defenses.
Opioid Crisis & Cytochrome P450
This review will focus on the effect of the CYP450 enzyme system metabolism on opioid agents codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone, and oxymorphone, as well as the potential effect of these opioids on the metabolism of other medications and vice versa. READ Study…
