Category Archives: Personal stories psyche drugs

Anti-Depressant, Opioids-Induced Homicides-Diminishing metabolizing genes of the Cyp450 Family

STUDY: Cyp 450 Homicides Lucire

Published paper by Dr. Yolande Lucire,

Dr Yolande Lucire is a forensic psychiatrist who specialises in adverse drug reactions to psychiatric drugs. Truly compassionate, a pioneer in her field she has successfully taken people off of their medications.

VLA Recommendation:  RIVETING!!!  Make sure you view Table 3 STUDY: Cyp 450 Homicides Lucire Read below excerpts of personal experience from Dr. Lucire’s published paper… for example,  of subject #1.  Those people who are non or poor metabolizers of Cyp 450 do not just have ordinary suicidal or homicidal ideation but have heinous! ideations (see below).  Hence…school shootings by young men who are taking or withdrawing from prescription drugs or street drugs.  Every child vaccinated before the age of three years old is damaged because Cyp 450 is “maturing”.  This detox liver super family of enzymes is not mature enough to metabolize the excipients in vaccines including aluminum, mercury, ethanol, formaldyde, Poly sorbate 80, etc.  All children given vaccines before Cyp 450 is mature is damaged to some extent. Many of these vaccinated individuals , especially life long genetic non metabolizers (absent the activity of cyp 450 variable…10% of Caucasians, for example) are so damaged by early vaccines that they then get subsequently mis-diagnosed as mentally ill and put on counter indicated drugs which continue to make them psychotic, Homicidal, suicidal.

Study:  Information on subjects’ drug regimes, CYP450 genotypes, criminal acts, and outcomes for ten of those suffering violent akathisia.

Twenty-six were known to be taking illicit or herbal psychoactivesubstances metabolized by CYP450 and had beentreated with antidepressants, antipsychotics, atypicals, and enforced zuclopenthixol depot injections (all also metabolizedby CYP450) and remained under psychiatric careuntil they stopped medication or committed suicide. Their treating doctors are among the 30 unresponsive to genetic information. This attitude may be related to a popular butcontested belief that cannabis accelerates the onset of mental illness. It has not been possible to follow up the fates of 26 of them. Of the tested population, 86 seemed to have been fully functioningworkers or students experiencing various degrees of
psychosocial stress, who were being treated for compensable injuries and/or stressors. Four had been diagnosed with mentalillness before they used substances, medicinal or other: two
with schizophrenia and two with bipolar disorder. At least 26were given psychiatric medications following or during theuse of illicit substances such as cannabis, amphetamines,
and ecstasy (MDMA), three had taken hypericum beforetaking antidepressants and had developed similar adversity on that. Three had received attention for anorexia nervosa,
three for the effects of sexual abuse, two for brain injuries,one for organophosphate poisoning, and one for epilepsy. The expected array of human problems was disclosed, with
overlapping alcohol overuse (2), personality disorders (6), and bereavements (4). The premedication conditions of sixcould not be reliably assessed.

Out of the 129, eight had committed homicide, three had
committed suicide and one had sleepwalked to her death. The
first author restored 16 to their previously normal personalities
by supervising a very slow and safe withdrawal of medications
in the correct order.  READ More…Cyp 450 Homicides Lucire

Subject # 1 in her own words:

My husband was drinking. I took small doses of valerian
for a month and had weird dreams and premonitions. When
I took nortriptyline, I immediately wanted to kill myself,
talked myself out of it. I’d never had thoughts like that
before. My husband was angry, shouting. I walked outside
a lot, with palpitations, trouble breathing, and became more
depressed. My smoking went up to 25 a day, no alcohol.
I didn’t sleep for two nights, dreamt, then slept maybe three
hours, felt awful. I dreamt that my daughter had dark teeth
and I saw a black halo around her head, a spear hanging over
it. I felt like a zombie. I believed I had to help my daughter,
that a bad spirit possessed her. I picked up a knife and
stabbed her and woke up. I was not myself. I was looking
on from the outside, controlled by dark forces. She said:
“Mum, what are you doing here?” I realized what I’d done.
I asked my husband to kill me. He called the police. I felt
better in the police cells without the pills, but the pills started
again and thoughts of killing myself returned.

More SSRI Stories even of 7 year old children hanging themselves by their belts in their closets:

The relevance of cytochrome P450 polymorphism in forensic medicine and akathisia-related violence and suicide

Excerpts: A forensic investigation combined with medication history, reports from observers, clinical records and a blood sample or a non-invasive swab from the living or dead can help elucidate the proximate, pharmacogenetic cause of death, suicide or violence. This determination can absolve persons charged with homicide (or abort the investigation), affect insurance pay-outs for suicide, provide an absolute defence of involuntary intoxication for the perpetrator of violence, and should protect a living person from getting more drugs with the same metabolic pathways as those that caused the problem.

Forensic pharmacogenomics correlates genetic variations to response to drugs.29 DNA testing can provide forensic examiners with a tool to investigate death caused by medication.30 In 2000, forensic pharmacogenetics was first used to explain the death of a nine-year-old child treated with a combination of methylphenidate, codeine and fluoxetine where the medical examiner reported fluoxetine toxicity. Finding that the child was defective in CYP2D6 capability aborted a homicide investigation of the parents by explaining the toxic level.31 Lucire and Crotty reported ten akathisia homicides (and some attempts) committed by people taking antidepressants, not for mental illness, but for distress caused by their predicaments. These individuals also had diminishing mutations in the CYP450 family of metabolizing enzymes and all were taking medicines that further decreased metabolism by inhibition.32

3. Subject 1, USA

A 39-year-old woman, with no prior history of mental illness, suicidality or violence had a difficult marriage and was prescribed zolpidem 10 mg/night for insomnia and alprazolam for fear of flying. A year later, she had divorced, moved to a new house, a parent had died, and she felt overwhelmed. Sertraline, 50 mg/day, was superimposed on long-term zolpidem use. Her mental state deteriorated. She said she had no emotions and felt like a “zombie”. She was switched to venlafaxine 150 mg/day. Throughout her treatment, she had been restless and had slept only with zolpidem, waking after few hours in an agitated state. At some point, she began believing that killing her husband and herself was the right thing to do for her children. She stopped venlafaxine abruptly and, on the following day, she ambushed her husband with a baseball bat, then stabbed him many times. Intent on committing suicide, she overdosed on zolpidem, alprazolam and alcohol, but survived and was charged with murder. The metabolic pathways of the drugs in use are presented in Table 1. Her P450 genotypes for the relevant enzymes are presented in Table 2.

Partial Excerpt from another subject: A woman:

A couple of months later, the note, “this patient does not belong in psychiatric care,” was recorded, and she was discharged. Venlafaxine was reduced to 75 mg/day, and temazepam and quetiapine were ceased. After nine months, she stopped venlafaxine without tapering but, two weeks later, she resumed her prescribed dosage. Her behaviour was described as “erratic” and “chaotic”. Without warning, she suffocated her two-year-old son with a pillow, hanged him using the cord of her bathrobe, put him in a box, woke her 7-year-old-daughter and told her that they all, including herself, had to die. She drove a car, along with her daughter, into a canal. Her daughter escaped. Charged with murder and attempted murder, she had only patchy recall of these events. Drugs and enzymes for this subject are given in Table 3. A year later, the defence team requested genetic testing for CYP450 (Table 4). 


VLA Comment:  People who are on counter indicated drugs, prescription or street drugs,  based on deminished genetic metabolism commit these homicides as if driven by some inexplicable heinous force and barely recall the event. Some defense such as Automaton and Involuntary Intoxication are used as defenses.

Opioid Crisis & Cytochrome P450

This review will focus on the effect of the CYP450 enzyme system metabolism on opioid agents codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone, and oxymorphone, as well as the potential effect of these opioids on the metabolism of other medications and vice versa. READ Study…





PSYCHOTROPIC DRUGS-Stories of Suicides & Homicides

Lawyer Impulsively Jumps In Front of Train: Effexor, like All A/D’s, Can Cause Impulsivness
Suicide Med For Depression 2011-11-11 England Physician Kills Himself Shortly After Starting an A/D
Personality Drained Away/Huge Weight Gain Med For Depression 2011-11-10 England After Many Years on A/D’s, Man Felt Like His Personaity Was Drained Away & He Became Obese
Violence Med For Depression 2011-11-10 Canada Man Strikes an Ax at a Neighbor
Death Antidepressant 2011-11-10 England 23 Year Old Woman Dies of Cardio-Respiratory Arrest: High Level of A/D’s in Body: No Alcohol or Drug
Suicide Celexa Antidepressant 2011-11-10 England Woman, 73, Kills Herself While on Celexa
Murder-Suicide Prozac 2011-11-09 California Man Kills Two Police Officers & Himself
Heart Disease Med For Depression 2011-11-09 Global ++Depression Meds Are More Likely to Cause Heart Disease
Murder Attempt Med For Depression 2011-11-08 Malta/Mediterranean Man Attempts to Murder Uncle With Hammer: Confused & Agitated
Bizarre Behavior Lexapro & Desyrel Antidepressants 2011-11-08 California +Famous Actress Kim Richards Exhibits Bizarre Behavior on TV
Dulled Mind/Numbed Body Zoloft 2011-11-07 Georgia Woman Physician Quits Zoloft: Tells How She Recovered From Depression
Suicide Med For Depression 2011-11-07 Texas Woman Drives Her Car Into Lake
Suicide Antidepressants 2011-11-05 Ohio Soldier, 22, Kills Himself: Black Box Warning on Suicidality for This Age Group

Go to website…read more…

Jury Awards $11.9 Million in Paxil Suicide Malpractice Case


Largest malpractice award of its kind: $11.9 million malpractice verdict confirms that SSRI antidepressants can cause suicide. “The jury award confirms increasing judicial and public awareness that psychiatric drugs can cause violent and suicidal behaviors,” according to the psychiatric expert Peter Breggin, MD.

Read more…



It’s not Adderall or Oxy. It’s Klonopin. And doctors are doling it out like candy, causing a surge of hellish withdrawals, overdoses and deaths.

Clonazepam has wreaked such havoc on people partly because it is so highly addictive; anyone who takes it for more than a few weeks may well develop a dependence on it. As a result, you can be prescribed Klonopin as a short-term treatment for, say, insomnia, and wind up so hooked on it that you’ll begin frantically “doctor shopping” for new prescriptions if the first physician who gave it for you refuses to renew the prescription. As with all benzos, use of Klonopin for more than a month can lead to a dangerous condition known as “benzodiazepine withdrawal syndrome,” featuring elevation of a user’s heart rate and blood pressure along with insomnia, nightmares, hallucinations, anxiety, panic, weight loss, muscular spasms or cramps, and seizures.

The singer Stevie Nicks:  Nicks has described the drug as a “horrible, dangerous drug,” and said that her eventual 45-day hospital detox and rehab from the drug felt like “somebody opened up a door and pushed me into hell.” Others have described Klonopin’s effects as beginning with an energized sense of euphoria but ending up with horrifying sense of anxiety and paralysis, akin to  sticking your tongue into an electric outlet, or suddenly feeling that your brain is on fire.

Read more…

Psychiatric Drug Withdrawal

Towards a Ban on Psychiatrically Diagnosing and Drugging Children



By Peter Breggin, MD  – March 6, 2015

The video series has scientific support in Peter Breggin’s  book Psychiatric Drug Withdrawal, which cites and summarizes some of the most recent studies on how damaged “ADHD kids” become when reaching adulthood — including increased incarceration in jails and mental hospitals, increased suicide, increased drug addiction, increased dependence on multiple psychiatric drugs, obesity, shrinkage (atrophy) of the brain, shortened lifespan, and a general reduction in quality and length of life.

In addition, the  peer-reviewed article in the journal Children & Society presents a scientific and ethical overview of the harm done to children by stimulants and by antipsychotic drugs, such as Abilify, Seroquel, Risperdal, Invega, Zyprexa, Geodon, Latuda, Saphris, Fanapt, and Symbax.  It cites many scientific studies.  The antipsychotic drugs are often given to children when their behavior and mental state deteriorates as a result of being given stimulants. Website…

A GREAT STORY OF “Liberation”: Today’s Generation-Diagnosed with Bi Polar, schizophrenia:

VLA: She looks GREAT. I great light to show that liberation is possible after years and years of Depakote, Prozac, etc.

There has been some response that the two words..”complete” and “recovery” are misplaced…as in nothing is ever “complete”. It is an eternal journey. And recovery would mean to cover again. So, I have re-thunk it:::))) We shall use the world “liberation” (from an illusion).