Category Archives: Pharmacogenetics

Pharmacogenomics & the metabolism of drugs

pharmacogenetics

Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects.

Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. The convergence of pharmacogenetics and human genomics in recent years has dramatically accelerated the discovery of new genetic variations that potentially underlie variability in drug response, giving birth to pharmacogenomics. Read ABSRACT

VLA comment:  10 % of Caucasians, for example, are unable to metabolize these modern drugs.  Hence, the epidemic of suicides and homicides.  Early clinical examples of genetic influence on drug response involved variations in single genes (i.e., monogenic inheritance) in which polymorphisms (no metabolic ability) of a single gene encoding a drug-metabolizing enzyme responsible for the metabolism and disposition of a substrate drug caused aberrant response to the drug. The phenotypic variation can be dramatic, especially when no alternate pathway exists to perform the same function.

Involuntary Intoxication and Automatism Homicide Defense (prescription drugs)

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THE JOHN MARSHALL LAW REVIEW Read

VOL 48, ISSUE 3  THE LITTLE BLACK PILL (2015) LEGAL DEFENSE

Effexor and a multiple of other psyche drugs, can cause people to commit murder and proposes how an nontraditional but commonly recognized criminal defense should be applied to such people. Effexor is labeled for homicidal ideations.  The rest are black box warned for suicidal ideations.  But the reality is that there are two sides to the same coin.  Suicide is committed by those who blame themselves.  Homicide is committed by those who blame “others”.  If the pharmaceuticals put homicidal ideations on each drug, as Effexor did) the public would connect the heinous murders such as school shootings with the drug.  Suicides and the homicides are committed by those persons (10% of Causcasians and 7 % of African Americans) who are “non metabolizers”.  These demographics, simply by genetic variations, do not have the Cytochrome P450 2D6 physiological mechanics to metabolize today’s modern psyche drugs.  The drugs therefore accumulatesin the body in such a toxic manner that the distressed person either kills himself or another.  Today suicides in veterans who are given drugs for PST is at an epidemic proportion.

Part III analyzes two defenses,
involuntary intoxication and automatism, which a criminal
defendant taking antidepressants could raise to avoid being
unjustly convicted.

After a comparison of these two defenses –

Part IV proposes that courts accept automatism as a viable defense for criminal defendants who take Effexor and then commit homicide. Automatism could function as either a complete defense (absolute exoneration) or as a partial defense (sentence mitigation). In giving life to the automatism defense, courts should consider the latest scientific findings about the link between genetic mutations and one’s inability to process drugs and the resulting toxic effect.

Genetic testing for mutations on the CYP450 gene can prevent future homicides by identifying people who are predisposed to side effects from these drugs.

Read more…

INFANTS INABILITY TO METABOLIZE THE TOXIC EXCIPIENTS IN VACCINES

(click here for studies on infant metabolism of vaccine ingredients)

More and more  research in the area of pharmacogenetics is being funded by pharmacuetical companies in order to give physicians better guidelines for dosages.

Cytochrome P450, the major detox mechanism in the body (plants, animals and humans), varies among individuals.  Individuals can be rapid metabolizers, normal metabolizers and poor or non metabolizers.

Other than the fact that 10% of Caucasians and 7% of African Americans are straight out “non-metabolizers” and have the tendency to suicidal and/or homicidal ideations when given prescription drugs, cytochrome P450 is “maturing” and all infants do not have full mature activity this  important detox mechanism until the age of 3.

Ped cyp enzymes  (see graph)  (very important study of the immaturity of cyp 450 superfamilies in infants and children.

At birth and one hour old, all infants, except those whose parents have declined, will received a Vitamin K shot and Heb B vaccination.  With this they will be injected at birth with 450 mcgs. of aluminum and an amount of formaldehyde…we are talking an hour old.

According to Dr. Sherri Tenpenny:

Dr. Sherri J. Tenpenny’s Integrative Medical Center, by the time a child has reached 5 years of age, he or she has been injected with a total of 1,795 micrograms (mcg), or 1.795 milligrams of formaldehyde, as follows  Read more…

  • Hepatitis b – 3 doses x 15 mcg each
  • DTaP – 5 doses x 100 mcg each
  • Polio (IPV) – 5 doses x 200 mcg each
  • Influenza – 6 doses x 25 mcg each
  • Hepatitis A – 1 dose x 100 mcg each

              Total:  1,795 mcgs of fomaldehyde by age five

Included in the list of vaccine excipients is not only formaldehyde but ethanol, phenol, polysorbate 80, benzethonium chloride,  glutaraldehyde, acetone, thimerosal, aluminum. All needing mature cytochrome P450 enzymes to metabolize.

VLA Comment: Finally we have proof that our infants and children are being directly injected with poisons (toxins) that cannot be metabolized at such a young age.

 

 

 

Inability of Infants to metabolize Vaccine Excipients – Cytochrome P450

Excipients in Vaccines & Cytochrome P450

Lets look more closely at the excipient ingredients in vaccines.   The following understanding that Infants cannot metabolize the multiple overload of the repetitive excipeint ingredients in multiple vaccines due to an inability of infants and children to metabolize these toxins due to the generally recognized fact that Cytochrome P450 is “immature” in infants and children.

CDC List of Exipients:  http://vaccineliberationarmy.com/2015/03/07/11935/


VACCINE Excipients and Cyp P450:  
Common excipients in Vaccines inhibit Cytochrome P450,the major detox mechanism in humans, plants and animals.   Considering Cyp 450 is immature in the infant and child,  the following excipients can’t be dealt with, released or detoxified in the infant and growing child.  It is to be noted that the inhibition of Cytochrome P450 and the inability to release the toxins from the body in cases of Adults cause serious psychotic events including suicide and “heinous” homicides.  Could these vaccine ingredients that are not metabolized by infants and children in various degrees appear like “mental illness”, hence the DSM misdiagnosis criteria?

The sample list of excipients below commonly injected MANY times into infants in many overlapping vaccines need Cyp 450 to metabolize yet some children, due to genetic variation,  are totally missing the activity of Cyp 450 and, in any case all children have immature Cyp 450 activity. This may give us one of the answers to the apparent range of vaccine injury in the general population.

Re: Polysorbate 80, a common vaccine excipient:

The results indicate that these non-ionic surfactants are in vitro inhibitors of CYP-mediated metabolism
Study…
http://www.ncbi.nlm.nih.gov/pubmed/21220010

RE:  Ethanol and Formaldehyde, vaccine excipients: 
Study…
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.320.1093&rep=r…

Re:  Alcohol, a vaccine excipient

RE: Benzethonium Chloride, a vaccine excipient
Notice that in the latest drug commercials they advertiser warns against Grapefruit seed extract.  This is because GSE inhibits Cytochrome P450 and therefore inhibits detoxifcation of toxic elements
Study….
http://www.ncbi.nlm.nih.gov/pubmed/17468864
Some manufacturers of GSE have stated that their extract has compounds nearly identical to benzethonium chloride

Phenol, a benzene metabolite, a vaccine excipient
Study…
http://www.ncbi.nlm.nih.gov/pubmed/11701230

Asthma, Allergies, Inflammation & the role of Cyp 450
Study…
http://www.sciencedirect.com/science/article/pii/S0003986106003791

Re: Aluminum Hydroxide adjuvant
Is Aluminum Hydroxide inhibiting the already immature activity of Cyp 450 that apparently is important in  reducing inflammation?
Study…
http://www.sciencedirect.com/science/article/pii/S0003986106003791
Cyp 450 and lungs

Aluminum Phosphate, a vaccine excipient and SHAKING BABY SYNDROME

Shaking Baby Syndrome & bone breaking symptoms:

Aluminum accumulation in bone has become much less frequent with cessation of use of aluminum-containing phosphate binders. Unfortunately, the binders which have largely replaced aluminum have not proven completely satisfactory

Study…

http://www2.kidney.org/professionals/KDOQI/guidelines_bone/Guide13B.htm

Osteomalacia – Mayo Clinic http://www.mayoclinic.org/diseases-conditions/osteomalacia/basics/definitio…
Osteomalacia refers to a softening of your bones, often caused by a vitamin D deficiency. Soft bones are more likely to bow and fracture than are harder, healthy bones.  Note:  As per the SBS & bone breaking symptom in the above link Aluminum – containing phosphae binders cause Osteomalacia as well.

Neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson¹s disease patients Amandeep Manna,(5)

 

The Journal of Pediatric Pharmacology and Therapeutics

“Developmental Pharmacokinetics in Pediatric Populations”

Hong Lu, PhD and Sara Rosenbaum, PhD

*Ped cyp enzymes  (see graph)  (very important study of the immaturity of cyp 450 superfamilies in infants and children. Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity. DOWNLOAD STUDY

The graph in the above link  shows that infants and children have immature enyzmes and therefore an inability to metabolize toxins.  Although these and other studies are being done so that the pharmacuetical industry can adjust dosage of pharmacuetical drugs to infants, toddlers and children, we must look at it from the point of view that the excipients in the vaccines need mature enyzmes to metabolize.   This entire post  lists some studies involving the need for mature enzymes in order to metabolize such ingredients as aluminum, mercury, phenol, formaldahyde, ethanol, phenol, polysorbate 80, etc.  If these enzymes are not mature until the age of three years old, then by giving vaccines and moreover, multiple vaccines at one time, we are POISONING our infants and children.

 

 

Immaturity of Cyp 450 in infants (So why are we giving Hep B with
at one hour old?) Attached

Comment Hep B contains many of these excipient ingredients which an infant is unable to metabolize.  This is a point that can be made when writing a model Hep B bill.

Screen Shot 2015-05-27 at 12.04.03 PM

SUPER CYP 450 DATA BANK:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808967/
SuperCYP (http://bioinformatics.charite.de/supercyp) is a comprehensive resource focused on CYPs and drug metabolism.

Layman’s talk on Cyp 450

Finally, it must be noted that non metabolism (polymorphism of cyp 450 aka lack of activity) runs in the family.
Parents and siblings will all be found to have the same polymorphism.

In addition to the MTHFR gene, there is a gene called the CYP450 pathway which is critical for effective detoxification. It is suppressed genetically in 43% of Africans. Unfortunately, CYP450 pathway affects the safety and efficacy of 90% of therapeutic drugs and other environmental chemicals.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868406/ http://www.ncbi.nlm.nih.gov/pubmed/23641907 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1390790/ http://www.biomedcentral.com/1471-2156/14/34
http://www.nature.com/tpj/journal/v13/n1/full/tpj201245a.html

Furthermore, Latinos have a suppressed CYP3A4*10 enzyme and CYP3A4*16A enzyme.

http://www.pharmacologyweekly.com/articles/genetic-polymorphisms-cytochrome-P450-CYP3A4-enzyme
http://www.sciencedirect.com/science/article/pii/S0163725813000065
http://www.aafp.org/afp/2007/0801/p391.html
http://www.ncbi.nlm.nih.gov/pubmed/15364537
http://www.medscape.com/viewarticle/744945_3
http://www.hoajonline.com/jdrcm/2050-0866/1/22

https://books.google.com/books?id=XAfUAgAAQBAJ&pg=PA335&lpg=PA335&dq=hispanic+cyp450+enzyme&source=bl&ots=Eyzy37i1gr&sig=W8VMcXeAucdMmbGRgKlV2uThWAs&hl=en&sa=X&ei=mdEmVePCOsuWsAXJqIHgBw&ved=0CF0Q6AEwCA#v=onepage&q=hispanic%20cyp450%20enzyme&f=false http://www.fda.gov/downloads/Drugs/ScienceResearch/…/UCM085502.pdf?hc_location=ufi

 

WHY ARE SO MANY TODDLERS TAKING DRUGS

adhd-drug-child

Psychiatric drugs are now being given to infants and toddlers in unprecedented numbers.

An analysis of 2013 IMS Data, found that over 274,000 infants (0-1 year olds) and some 370,000 toddlers (1-3 years age) in the U.S. were on antianxiety (e.g. Xanax) and antidepressant (e.g. Prozac) drugs. This report also found over 1,400 infants were on ADHD drugs.

A 2014 Georgia Medicaid analyses led by Susanna Visser at the CDC (see a video of her fascinating talk) when extrapolated nationwide by the New York Times found that over 10,000 toddlers were put on ADHD treatments. (Dr. Visser is currently working on national estimates but believes that the estimate from the Georgia data is conservative.) READ MORE…

Pharmacogenetics: Explaining school/mass shootings, suicides & homicides

Letter to lawmakers from Eileen Dannemann  Why our kids are increasingly being diagnosed as mentally ill.

Dr. Renee Tocco Hunter Pharmacogenetic Testing.  Open letter on Antispsychotic Medication

New business opportunity in Pharmacogenetic Testing (Dec. 2015)  Get on board!

Pharma in Schools: $99 million govt. grants for psyche evaluations in schools

Psychiatric-Drugs

Mass media have blacked out the Obama administration’s program which transforms our nation’s public schools in to lucrative referral centers for big psychopharma.

On September 22, 2014 Department of Health and Human Services Secretary Sylvia M. Burwell announced $99 million in new grants “to train new mental health providers, help teachers and others recognize mental health issues in youth and connect them to help and increase access to mental health services for young people.”  Read more…

Obama’s mental health plan  Read more…

VLA comment:  Why are all our children mentally ill.  We can’t recognize normal any more.  It is the vaccines! 54 vaccine doses in order to enter school; 4 doses of which are given to pregnant women.  It is a travesty!  It is the vaccines!

​THERE WILL BE MORE MASS SHOOTINGS:

Due to ordinary genetic variation 10% of Caucasians, for example (and a percentage of Africans and Asians) are missing the activity of the major detox pathway, Cytochrome P450 2 D6.  When one of these persons are given the modern psyche drugs (and vaccines), they become psychotic (school mass shootings) because they can not rid their body of the drugs as they build up.Read more on why our kids and soldiers are becoming psychotic.

VLA comment: Citizen’s Commission on Human Rights (CCHR) has been fighting Teen Screen, Texas Algorithm project and other psyche evaluating programs in schools for ​years. And the establishment keeps f–king us over.

The same with the vaccine establishment.  The more we provide independent studies and anecdotal personal horror stories, the higher the rates of Autism, ADHD, Bi polar grow.  The establishment continues to disregard the people.  Special needs education is off the charts. Medicaid is strained over the top.  Expecting the establishment to listen to us is wasting energy.  Historically, they just f–k us more, despite the evidence of harm… with now 54 vaccine doses by the time a child is six years old…4 of which are given to pregnant women with no basis in science.

WE MUST RISE GRASSROOTS!  It is our only hope to educate people who still have the religious freedom to avoid vaccines.

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Cause of Autism & Psychosis: The Detox link between Round Up (GMO) Foods and Vaccines-Cytochrome P450

antifung_3

Read Eileen Dannemann’s layman’s article on Cytochrome P450, Vaccine Injury and Round Up ready crops.

Read recent study

Stephanie Seneff (MIT) published research on glysophate

 

Cytochrome P450 Immature In infants and Children

Another thing to consider is that cytochrome P450 is “maturing”. That is this major gene and detox pathway of the human body is not “mature” in the infant or child. Hence, every child that is vaccinated has a variation in their ability to clear out the toxins whether it is mercury, aluminum or other toxic elements of the vaccines.

Glutathione

Very interesting to note is that Cytochrome P450 also regulates glutathione – found depleted in Autism cases.

Mercury & Aluminum

Inhibits Cytochrome P450, the major detox pathway in human and plants

Glyphosate (Round Up & GMO foods)

Glyphosate (Round Up) interferes in Cytochrome P450 2D6 metabolism. Patents will show that the dual program of Round Up and GMO seeds has much to do with Cytochrome P450 in plants just like in humans.  Hence, the study’s implication that glyphosate is a contributor to Autism and psychosis in as much as it inhibits the functioning of Cytochrome P450 which is necessary to metabolize toxins such as vaccines ingredients and the subsequent psyche drugs that are being pushed on kids with ADHD, OCD, Autism etc.

VLA comment:  If you search Monsanto’s patents for Round up and GMO seeds and drugs like Respirdal you will see that they both implicate Cytochrome P450 as the detox pathway necessary to detoxify toxins out of the body.

School Shootings:

Without a functioning Cytochrome and its subsets our kids and soldiers are becoming psychotic.

Dr. Seneff estimates that 1 out of 2 children will be born on the autism spectrum in 2025.

 

CUTTING EDGE NEWS: Is Monsanto contributing to the rise in PSYCHE DRUG Mass Shootings???

1366750352_1320_a1monsantoskull_dees

Studies conducted over the last decade have clearly demonstrated the link between adverse reactions to Psycho-Pharmaceutical medications and underactive or underperforming CYP450 enzymes. This has caused some to wonder whether or not the recent uptick in mass shootings and the obvious link to many of the perpetrators and prescription drugs could be related to the performance of the CYP450 enzymes. Additional research, however, is now causing more questions to be asked in reference to the connections that chemicals like Glyphosate may have in the inhibition of proper CYP450 performance and, thus, in the uptick in mass shootings. Read more…

VLA COMMENT:  This cutting edge information.  Mass shootings, suicides, adverse reactions to vaccines, Autism, chronic illness, diabetes, obesity, asthma…are the results of the body not being able to detoxify toxins through its natural major detox channel – Cytochrome P450 .  This field of focus on drug interactions on the body is called Pharmacogenetics.  Education amongst the medical profession has been suppressed by the pharmacuetical industry. Yet all classifications physicians  today  are prescribing medications without understand the status of the individuals ability to metablolize these drugs and rid them from the body.  For example, Pediatricians have prescribed drugs such as paxil, prozac, etc  to over 275,000 children 0-1 year old.  10,000 toddlers are on psyche drugs. 25% of American children are on psyche drugs.  Ritalin and Adderall, amphetamine drugs saturate our schools.  Children have to line at camp in the morning to get their daily dosage.

A simple test to determine an individuals metabolic status has not been made standard of care although knowledge of this drug interaction causing suicidal and homicidal ideations is over 15 years old. More over, there are a variety of psyche drugs that are labeled as causing “suicidal ideations” (A self blame syndrome), but the “H” word is not mentioned ( homicide (an outer “blame” syndrome).

This labeling suggests that the manufacturers are aware of  the variance in the ability of individuals to metabolize their drugs. Respiridal, for example, now includes Cytochrome P450 channels of detox in their package inserts. But who reads them?

It is further interesting to note that the cytochrome is “maturing”.  This poses the question of how do infants one hour old, 2 months old, 6 months old metabolize toxins such as mercury and other ingredients in vaccines containing hormones, toxins;  have not been studied for carcinogenic or mutagenic effects;  are environmental pollutants, and other xenobiotics, all of  which are metabolized by CYP450 enzymes.  It is also worth mentioning that glutathione which is ultra depleted in children with Autism is also regulated by this Cytochrome.

As the author points out, as with human life, plant life also contains this mechanism of detoxification involving Cytochrome P450.  Monsanto patents reveal that Cytochrome P450 is  key to their Round Up (Glysophate) herbicide, the killing of natural plant life on behalf of  the survival of their patented genetically manipulated companion seeds.  VERY IMPORTANT ARTICLE BY BRANDON TURBEVILLE PUBLISHED BY ACTIVIST POST.