Cannibas: Cytochrome p450 and Marijuana Addiction
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Genetic Polymorphism Of Cytochrome P450 -2d6*4 In Cannabis Smokers
Genetic variation in genes involved in drug metabolism may account for variations in responses to these drugs and may affect receptor adaptation, toxicity, altered drug effects and cross tolerance. Most drugs are metabolized by cytochrome P450 (CYP 450) system with metabolizing enzyme, CYP 2D6, responsible for the largest contribution. there is significant correlation between the genetic configuration and the cannabis dependency pattern as presented by the starting age of cannabis use, the regularity of its use and the personal and family norms about its use. It is concluded that there may be some genetic factors that determine the body response to cannabis dependence that need to be more specifically studied. This can be a marker for the risk of becoming dependent and / or the prediction of suitable effective treatment of dependence and also, prevention of relapse after withdrawal. Read more on Cannibas…
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