Category Archives: Psyche Ward

JAMA STUDY: Depression: An Adverse Effect of Prescription Medication

IMPORTANCE: Prescription medications are increasingly used among adults in the United
States and many have a potential for causing depression.
OBJECTIVES: To characterize use of prescription medications with depression as a potential
adverse effect and to assess associations between their use and concurrent depression.

Prescription medications are widely and increasingly
used in the United States, with approximately 15% of
adults estimated to have been using 5 or more concurrent
prescription medications in 2011 and 2012.1 Alongside evidence
that adverse drug events from prescription medications
are often implicated in emergency department visits and
hospitalizations,2 there is gaining recognition thatmany commonlyused
prescriptionmedications, includinghormonalcontraceptives
and β-blockers, are associated with an increased
risk of depression.

CONCLUSION: In this cross-sectional survey study, use of prescription
medications that have depression as a potential adverse effect was common. Use of multiple
medications was associated with greater likelihood of concurrent depression.

Read study:  JAMA_drugs_linked_to_depression(1)

The real cause is found in PHARMACOGENOMICS and drug metabolism

Must read:  Pharmacogentics, Suicide, Homicide and school violence

List of sucides and homicides on psychiatric drugs: www.SSRIStories.net

Pediatric Study: Pharmacogenomics – Adverse Reaction in Children

Drug-Metabolizing Enzyme Genotypes
and Aggressive Behavior Treatment Response
in Hospitalized Pediatric Psychiatric Patients

TracyGlauser Pharma study

Objective: The aim of this study was to examine the association between the CYP2D6 and CYP2C19 genotypepredicted combined phenotypes and short-term measures of psychotropic efficacy and toxicity.
Methods: A rater-blinded, retrospective genotype association design examined a cohort of hospitalized pediatric psychiatric patients genotyped for CYP2D6 and CYP2C19 as part of clinical care. These combined genotypes were used to predict a combined phenotype. The primary efficacy outcome measure was the behavior intervention score (BIS), a function of the number of recorded timeouts=seclusions, therapeutic holds, and physical restraints.

Patient response to commonly used psychotropic medications demonstrates significant variability; only 30–75% of patients experience efficacy, whereas 65–75% encounter ad-
verse events (Kirchheiner et al. 2004; Emslie et al. 2006; Kratochvil et al. 2006; Hetrick et al. 2007). Many psychotropic medications are metabolized by cytochrome P450 (CYP) en-
zymes coded for by the polymorphic genes CYP2D6(þ124030) and CYP2C19 (*124020).
The relationships between the distinct CYP2D6 or CYP2C19 genotypes and the pharmacokinetics of psychotropic medications are the basis for genotype-based dosing recommendations for some medications (Kirchheiner et al. 2001).Despite the prevalence of the problem, the contribution of drug-metabolizing enzyme genotypes to the variability in aggressive behavior treatment response in hospitalized pediatric psychiatric patients is unknown. The purpose of this study was to examine the association between CYP2D6 and CYP2C19 genotype-predicted metabolizing phenotypes and short-term measures of drug efficacy (incidence of behavioral interventions for aggressive behavior) and toxicity (adverse drug reaction)

Drug tolerability was defined as the total number of recorded adverse drug reactions.

 

Conclusion
Identifying factors underlying the variability in drug efficacy
or tolerability is a key component for optimizing the patient’s
response to therapy. This is the first study to demonstrate that,
for children hospitalized for psychiatric conditions,
CYP2D6 and CYP2C19 genetic variation contributes to psychotropic…
Consideration of a patient’s genotype at the onset of a psychiatric hospitalization could play a significant role in personalizing and improving subsequent therapy.
Prospective longitudinal studies are necessary to better inform
how to optimally incorporate this genetic information into the
medical management of patients with aggression. In summary,
this study indicates that CYP2D6 and CYP2C19genotypes are
 important in the clinical care of children with psychiatric diagnoses requiring medications that are metabolized throughthese two enzyme pathways.

Find out about pharmacogenomic: Cytochrome P450, homicide, suicide and school violence

Pharmacogentics, Suicide, Homicide and school violence

INFANT VACCINES/Cytochrome P450 and failure of infants to metabolize vaccine excipients  READ

Accounts of thousand of Suicides and Homicides: www.SSRIStories.net

Pharmacogenetics/Cytochrome P450/Suicides & Homicides/school violence

Brandon Turbervile comprehensive article:  Psychiatric Drugs, School Violence, and the Big Pharma Cover-up

Excerpts:

the CYP450 enzymes are the primary catalysts for detoxification reactions that render water-insoluble molecules sufficiently water soluble to be excreted in the urine. . . . Drugs, hormones, toxins, carcinogens, mutagens, environmental pollutants, and other xenobiotics are metabolized by CYP450 enzymes.

Of the CYP450 enzyme family, there are other more specific enzymes such as CYP2C9, CYP2C19, and CYP2D6, etc. These three enzymes specifically are responsible for approximately 40% of all CYP450-mediated drug metabolism. The CYP2D6 enzyme itself is responsible for the bulk of drug metabolism at around 20% to 30% of drug metabolism in the CYP450 family.

In relation to the CYP2D6 enzyme, there are four classifications – Extensive Metabolizers (EM), Poor Metabolizers (PM), Intermediate Metabolizers (IM), and Ultrarapid Metabolizers (UM).
EM (Extensive Metabolizers) are considered the “normal genotype,” “which is free of inactivating polymorphisms, deletions, or duplications.”  PM (Poor Metabolizers) are individuals who have “deficient” enzyme function in terms of CYP450 metabolic processes and, subsequently, have difficulty clearing certain medications. IM (Intermediate Metabolizers) are those who have some functioning CYP450 enzymes but are subject to loss of the function of these enzymes after the “second hit” of medication, thus turning them into PM. UM (Ultrarapid Metabolizers) are those who metabolize the drug so rapidly that it clears so quickly that there is little or none of the desired effect.  In medications that required metabolism to activate, however, UM individuals the metabolite may be produced too quickly, resulting in toxicity and the realization of side effects.
While there are potentially adverse health effects with any one of the four classifications, the focus of this article is on those who are generally PM (Poor Metabolizers). This is because these individuals have a higher chance of experiencing adverse health effects of pharmaceuticals than those with “normal” functioning EMCYP2D6 enzymes.
Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity.
SPECIAL PHARMACOKINETICS AND PHARMACODYNAMIC CONSIDERATION IN CHILDREN

Mayo Clinic Conference on Pharmackinetics Sept. 2018

Mass Shootings

Pharmaceutical Murder – Mass Shootings Caused by Drugs!

Twenty-seven drug regulatory agency warnings cite psychiatric drug side effects of mania, psychosis, violence and homicidal ideation; 1,531 cases of psychiatric drug induced homicide/homicidal ideation have been reported to the US FDA; 65 high profile cases of mass shootings/murder have been committed by individuals under the influence of these drugs, yet there has never been a federal investigation into the link between seemingly senseless acts of violence and the use of mind-altering psychotropic drugs.

READ MORE….

From Prozac to Parkland: Are Psychiatric Drugs Causing Mass Shootings?

While mass killers generally have guns in their hands, another commonality is that they often have psychiatric drugs in their blood. The difference, though, is that it isn’t guns that have the side effect of “homicidal ideation.”

New American article

VLA COMMENT:  There is “science” on this.  It is in the field of pharmacogenetic.pharmacokinetics.  These drugs show in their package insert that they are metabolized through the super family of liver enzymes called Cytochrome P450. 10% of Caucasians, for example, cannot metabolize upwards of 50% of today’s common psyche drugs.  These people are called “non-metabolizers”.  The pharmacuetical industry has blocked the movement to “test” each patient for their metabolizm prior to prescribing drugs.  The have also blocked education in pharmacokinetics aimed at the nation’s medical students.  Considering every doctor including pediatricians who prescribe psyche drugs to children as young as one year old and considering the extensive use to all demographics, we must include pharmacogenetics as a required continuing education course.  See: www.SSRIStories.net for the lists of suicides and homicides associated with prescription drugs.

We don’t understand why the activists that are exposing the association of pharmacueticals to the homicides and suicides are not explaining the science.   Put Cytochrome P450 into our search engine for more information.

Furthermore, Cytochrome P450 is not “mature” until a child is at least 3 years old.  All infants have immature liver enzyme function. Yet they are injected at birth and during their early years with excipients that need a fully functioning Cytochrome P450.  In other words, we are poisoning all incoming generations of humanity, as they are not able to detoxify the excipients found in early childhood vaccines.  Put “Infants” in our search engine.  Put CDC excipentsin our search engine to see the CDC list of excipients in vaccines.

2nd Amendment WARNING:

Every child who is vaccinated are being injured by the excipients in the vaccines, including heavy metal aluminum and mercury which interfere in Cytochrome P450 metabolism.  The damage shows up an neurological problems, regressive autism and is being diagnosed as “mental illness”.  Without testing for metabolism these recipients of vaccines appear via the Diagnostic Statisical Manual as “mental illness”.  Those who seek to destroy the second amendment will do so by funded and required mental illness testing in school.

Already 25% of American children are on some form of psyche drugs. This translates into 25% of the future population being red flagged and dissallowed gun ownership.  However, rightfully so, as due to the vaccine schedule currently of 49 vaccine doses by the age of three, these kids are damaged.

Psychiatric drugs are now being given to infants and toddlers in unprecedented numbers.

An analysis of 2013 IMS Data, found that over 274,000 infants (0-1 year olds) and some 370,000 toddlers (1-3 years age) in the U.S. were on antianxiety (e.g. Xanax) and antidepressant (e.g. Prozac) drugs. This report also found over 1,400 infants were on ADHD drugs.

A 2014 Georgia Medicaid analyses led by Susanna Visser at the CDC (see a video of her fascinating talk) when extrapolated nationwide by the New York Times found that over 10,000 toddlers were put on ADHD treatments. (Dr. Visser is currently working on national estimates but believes that the estimate from the Georgia data is conservative.)

READ MORE… 

VLA COMMENT: What are the chances that the gun owners, politicians, Pres. Trump realize that the solution to the mass shooting is not to ban guns but to stop poisoning infants who are subsequently prescribed drugs that they cannot metabolize; have suicidal and homicidal ideations; commit heinous acts of mass shootings.

This is the “Science if Pharmacokinetics”

 

Over one million children under age 6 are on psychiatric drugs

Overall, more than eight million kids in America are on some sort of psychotropic drug — and the medical establishment is hardly batting an eye.

Under 6 year-olds – 1,146,530 (yes, that’s well over a million!) and breaking down this figure 

Less than 1 year olds – 274,804

2-3 year olds – 370,778

4-5 year olds – 500,948

6-12 Year olds – 4,130,340

13-17 Year olds – 3,617,593

If parents refuse to get their child (vaccinated ) or medicated on a potentially life-destroying psychiatric drug then they could find themselves charged with “gross medical neglect” by the CPS (Child Protective Service)  READ MORE….

 

VLA Comment:  There are kids as young as three being diagnosed as ADHD.  Wake up folks, The cause is the 49 vaccine doses given to all American children by mandate in order to go to school.  The first one Hep B at birth with 400 mcgs of Aluminum and the Vitamin K shot with 100 mcgs of Aluminum…right after the cord gets cut!!!

The Violence Inducing Effects of Psychiatric Medication

Psychiatric medications have some dangerous, often-overlooked side effects, which could include suicide and homicide.

On May 17, 2017, we learned that Chris Cornell of Soundgarden had reportedly committed suicide by hanging. His family reports knowing a different Chris than one who would make this fatal decision, and suspect his anti-anxiety prescription in the altered state he was witnessed to be in the night he died. Perhaps an “addict turned psychiatric patient”, like so many, Chris Cornell seemed to have left the frying pan of substance abuse for the fire of psychiatric medication risks.

According to available data – 3 large meta-analyses – more psychiatric treatment means more suicide.[10] [11] [12]

READ More…

Magic Mushrooms and some individual’s inability to metabolize-causing psychosis

Magic Mushrooms and some individual’s inability to metabolize-causing psychosis, albeit temporary

Magic Mushrooms:  Some individuals are not able to metabolize-causing psychosis, albeit temporary and not to be confused with “mental illness”.

Indolealkylamines: Biotransformations and Potential Drug–Drug Interactions (STUDY)

Increased knowledge in this area may advance our understanding of individual vulnerability to and/or protection from illicit drugs of abuse (). This review, therefore, aims to describe our current understanding of the metabolism  READ STUDY…

 

Anti-Depressant, Opioids-Induced Homicides-Diminishing metabolizing genes of the Cyp450 Family

STUDY: Cyp 450 Homicides Lucire

STUDY #2 The relevance of cytochrome P450 polymorphism in forensic medicine
and akathisia-related violence and suicide Lucire#2

Published paper by Dr. Yolande Lucire,
PhD MBBS DPM FRANZCP
FORENSIC & MEDICO-LEGAL PSYCHIATRY

Dr Yolande Lucire is a forensic psychiatrist who specialises in adverse drug reactions to psychiatric drugs. Truly compassionate, a pioneer in her field, she has successfully taken people, who were considered “mentally ill”, off of their contraindicated medications.

VLA Recommendation:  RIVETING!!!  Make sure you view Table 3

STUDY: Cyp 450 Homicides Lucire

Read below excerpts of personal experience from Dr. Lucire’s published paper… for example,  of subject #1.  Those people who are non or poor metabolizers of Cyp 450 do not just have ordinary suicidal or homicidal ideation but have heinous! ideations (see below).  Hence…school shootings by young men who are taking or withdrawing from prescription drugs or street drugs.  Every child vaccinated before the age of three years old is damaged because Cyp 450 is “maturing”.  This detox liver super family of enzymes is not mature enough to metabolize the excipients in vaccines including aluminum, mercury, ethanol, formaldyde, Poly sorbate 80, etc.  All children given vaccines before Cyp 450 is mature is damaged to some extent. Many of these vaccinated individuals , especially life long genetic non metabolizers (absent the activity of cyp 450 variable…10% of Caucasians, for example) are so damaged by early vaccines that they then get subsequently mis-diagnosed as mentally ill and put on counter indicated drugs which continue to make them psychotic, Homicidal, suicidal.

http://vaccineliberationarmy.com/2015/10/17/studies-cytochrome-p450-and-failure-of-infants-to-metabolize-vaccine-excipients/

Study#1:  Information on subjects’ drug regimes, CYP450 genotypes, criminal acts, and outcomes for ten of those suffering violent akathisia.

Study #2: Lucire#2 The relevance of cytochrome P450 polymorphism in forensic medicine
and akathisia-related violence and suicide

Study #1 excerpts: Twenty-six were known to be taking illicit or herbal psychoactivesubstances metabolized by CYP450 and had beentreated with antidepressants, antipsychotics, atypicals, and enforced zuclopenthixol depot injections (all also metabolizedby CYP450) and remained under psychiatric careuntil they stopped medication or committed suicide. Their treating doctors are among the 30 unresponsive to genetic information. This attitude may be related to a popular butcontested belief that cannabis accelerates the onset of mental illness. It has not been possible to follow up the fates of 26 of them. Of the tested population, 86 seemed to have been fully functioningworkers or students experiencing various degrees of
psychosocial stress, who were being treated for compensable injuries and/or stressors. Four had been diagnosed with mentalillness before they used substances, medicinal or other: two
with schizophrenia and two with bipolar disorder. At least 26were given psychiatric medications following or during theuse of illicit substances such as cannabis, amphetamines,
and ecstasy (MDMA), three had taken hypericum beforetaking antidepressants and had developed similar adversity on that. Three had received attention for anorexia nervosa,
three for the effects of sexual abuse, two for brain injuries,one for organophosphate poisoning, and one for epilepsy. The expected array of human problems was disclosed, with
overlapping alcohol overuse (2), personality disorders (6), and bereavements (4). The premedication conditions of sixcould not be reliably assessed.

Out of the 129, eight had committed homicide, three had
committed suicide and one had sleepwalked to her death. The
first author restored 16 to their previously normal personalities
by supervising a very slow and safe withdrawal of medications
in the correct order.  READ More…Cyp 450 Homicides Lucire

Subject # 1 in her own words:

My husband was drinking. I took small doses of valerian
for a month and had weird dreams and premonitions. When
I took nortriptyline, I immediately wanted to kill myself,
talked myself out of it. I’d never had thoughts like that
before. My husband was angry, shouting. I walked outside
a lot, with palpitations, trouble breathing, and became more
depressed. My smoking went up to 25 a day, no alcohol.
I didn’t sleep for two nights, dreamt, then slept maybe three
hours, felt awful. I dreamt that my daughter had dark teeth
and I saw a black halo around her head, a spear hanging over
it. I felt like a zombie. I believed I had to help my daughter,
that a bad spirit possessed her. I picked up a knife and
stabbed her and woke up. I was not myself. I was looking
on from the outside, controlled by dark forces. She said:
“Mum, what are you doing here?” I realized what I’d done.
I asked my husband to kill me. He called the police. I felt
better in the police cells without the pills, but the pills started
again and thoughts of killing myself returned.

More SSRI Stories ie. 7 year old children hanging themselves by their belts in their closets.

SSRI Stories is a riveting website and collection of drug induced homicides and suicides

Study #2: Lucire#2 The relevance of cytochrome P450 polymorphism in forensic medicine and akathisia-related violence and suicide

Excerpts: A forensic investigation combined with medication history, reports from observers, clinical records and a blood sample or a non-invasive swab from the living or dead can help elucidate the proximate, pharmacogenetic cause of death, suicide or violence. This determination can absolve persons charged with homicide (or abort the investigation), affect insurance pay-outs for suicide, provide an absolute defence of involuntary intoxication for the perpetrator of violence, and should protect a living person from getting more drugs with the same metabolic pathways as those that caused the problem.

Forensic pharmacogenomics correlates genetic variations to response to drugs.29 DNA testing can provide forensic examiners with a tool to investigate death caused by medication.30 In 2000, forensic pharmacogenetics was first used to explain the death of a nine-year-old child treated with a combination of methylphenidate, codeine and fluoxetine where the medical examiner reported fluoxetine toxicity. Finding that the child was defective in CYP2D6 capability aborted a homicide investigation of the parents by explaining the toxic level.31 Lucire and Crotty reported ten akathisia homicides (and some attempts) committed by people taking antidepressants, not for mental illness, but for distress caused by their predicaments. These individuals also had diminishing mutations in the CYP450 family of metabolizing enzymes and all were taking medicines that further decreased metabolism by inhibition.32

3. Subject 1, USA

A 39-year-old woman, with no prior history of mental illness, suicidality or violence had a difficult marriage and was prescribed zolpidem 10 mg/night for insomnia and alprazolam for fear of flying. A year later, she had divorced, moved to a new house, a parent had died, and she felt overwhelmed. Sertraline, 50 mg/day, was superimposed on long-term zolpidem use. Her mental state deteriorated. She said she had no emotions and felt like a “zombie”. She was switched to venlafaxine 150 mg/day. Throughout her treatment, she had been restless and had slept only with zolpidem, waking after few hours in an agitated state. At some point, she began believing that killing her husband and herself was the right thing to do for her children. She stopped venlafaxine abruptly and, on the following day, she ambushed her husband with a baseball bat, then stabbed him many times. Intent on committing suicide, she overdosed on zolpidem, alprazolam and alcohol, but survived and was charged with murder. The metabolic pathways of the drugs in use are presented in Table 1. Her P450 genotypes for the relevant enzymes are presented in Table 2.

Partial Excerpt from another subject: A woman:

A couple of months later, the note, “this patient does not belong in psychiatric care,” was recorded, and she was discharged. Venlafaxine was reduced to 75 mg/day, and temazepam and quetiapine were ceased. After nine months, she stopped venlafaxine without tapering but, two weeks later, she resumed her prescribed dosage. Her behaviour was described as “erratic” and “chaotic”. Without warning, she suffocated her two-year-old son with a pillow, hanged him using the cord of her bathrobe, put him in a box, woke her 7-year-old-daughter and told her that they all, including herself, had to die. She drove a car, along with her daughter, into a canal. Her daughter escaped. Charged with murder and attempted murder, she had only patchy recall of these events. Drugs and enzymes for this subject are given in Table 3. A year later, the defence team requested genetic testing for CYP450 (Table 4). 

READ MORE….

VLA Comment:  People who are on counter indicated drugs, prescription or street drugs,  based on deminished genetic metabolism commit these homicides as if driven by some inexplicable heinous force and barely recall the event. Some defense such as Automaton and Involuntary Intoxication are used as defenses.

Opioid Crisis & Cytochrome P450

This review will focus on the effect of the CYP450 enzyme system metabolism on opioid agents codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone, and oxymorphone, as well as the potential effect of these opioids on the metabolism of other medications and vice versa. READ Study…