Zero Order Kinetics…when there is an polymorphism of Cytochrome P450 the drug accumulates in the liver, cannot be excreted by the kidneys and increases the potential for overdose. For polymorphism effect start at 4:44.
Suppressive effect of accumulated aluminum trichloride on the hepatic microsomal cytochrome P450 enzyme system in rats.
► AlCl3 exposure through drinking water gets close with actual chronic oral Al exposure. ► Effects of Al exposure on the hepatic microsomal protein, AND and ERND were studied. ► Metabolism of Al affected the hepatic microsomal cytochrome P450 enzyme system.
Oct 1, 2004 – Holt, shortly after, demonstrated that preformed aluminium phosphate, prepared from equimolar amounts of aluminium chloride and trisodium phosphate, acted as an adsorbant and was adjuvant active with diphtheria. Data on the use of alum
Apr 16, 2015 – Adjuvants such as the aluminum compounds (alum) have been dominantly used in many vaccines due to their immunopotentiation and safety records …. Aluminum compounds such as aluminum chloride, aluminum silicate, algammulin (gamma inulin plus AH), cesium alum (CA), Imject alum (IA) (AH plus
Developmental Pharmacokinetics in Pediatric Populations
Hong Lu, PhD and Sara Rosenbaum, PhD
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island
Information on drug absorption and disposition in infants and children has increased considerably over the past 2 decades. However, the impact of specific age-related effects on pharmacokinetics, pharmacodynamics, and dose requirements remains poorly understood. Absorption can be affected by the differences in gastric pH and stomach emptying time that have been observed in the pediatric population. Low plasma protein
concentrations and a higher body water composition can change drug distribution. Metabolic processes are often immature at birth, which can lead to a reduced clearance and a prolonged half-life for those drugs for which metabolism is a significant mechanism for elimination. Renal excretion is also reduced in neonates due to immature glomerular filtration, tubular secretion, and reabsorption. Limited data are available on the pharmacodynamic behavior of drugs in the pediatric population.Pediatric Population study Cyp 450.
VLA Comment: Remember children under 3 years old have “immature” cytochrome P450 and 10% of Caucasians for example, are “non-metabolizers”…they cannot metablize many drugs all their lives and become psychotic when given drugs after being diagnosed as ADHD, Autism, etc which are vaccine injuries caused by inability to metabolize the ingredients in vaccines.
The FDA has published conclusive proof on their website that the DTap vaccine causes autism.
According to the FDA’s online Biologics Blood Vaccines document (between pages 6 to 11), a vaccine manufacturer admits on its package insert that their vaccination can cause autism as one of many adverse reactions.
VLA COMMENT: Aside from excipients in vaccines such as phenol, formaldehyde, aluminum, polysorbate 80, mercury, ethanol, herein we list the ingredient in what is usually just listed as “the medium…Mueller and Miller medium and Stainer-Scholte medium. Such ingredients as listed above and within the mediums, as well, need a fully mature Cytochrome P450 (detox liver enzyme familiers) to rid the system of these toxins. All children do not have mature Cytochrome P450 until at least 3 years old and 10% for example of Caucasian are non-metabolizer of the major detox pathway Cytochrome p450 2D6 and become damaged when vaccinated and psychotic when given many of today’s modern drugs. There is an easy test for metabolism but it is not “standard of care” because the pharmacuetical company would loose billions of dollars if the public knew. On the other hand medicaid, medicare and insurance companies would save billions of dollars if the test became standard of care.
Mueller and Miller medium, according to the information I found, contains:
glucose, sodium chloride, sodium phosphate dibasic, monopotassium, phosphate, magnesium sulfate hydrate, ferrous sulfate heptaphydrate, cystine hydrochloride, tyrosine hydrochloride, urasil hydrochloride, Ca-pantothenate in ethanol, thiamine in ethanol, pyridoxin-hydrochloride in ethanol, riboflavin in ethanol, biotin in ethanol, sodium hydroxide, beef heart infusion (de- fatted beef heart and distilled water), casein [milk protein] solution.
While Stainer-Scholte medium has the following ingredients:
Tris hydrochloride, tris base, glutamate (monosodium salt) [MSG], proline, salt, monopotassium phosphate, potassium chloride, magnesium chloride, calcium chloride, ferrous sulfate, asorbic acid, niacin, glutathione
The vaccine is formulated without preservatives, but contains a trace amount of thimerosal[(mercury derivative), (≤0.3 μg mercury/dose)] from the manufacturing process. Each 0.5 mL dose also contains, by assay, not more than 0.170 mg of aluminum and not more than 100 μg(0.02%) of residual formaldehyde. The vaccine contains gelatin and polysorbate 80 (Tween-80), which are used in the production of the pertussis concentrate.
VLA COMMENT: LEARN WHY THERE IS AN EPIDEMIC OF PARTICULARLY HEINOUS MASS SHOOTINGS AND SUICIDES IN THE 21ST CENTURY.
In January, 2013, I wrote an article entitled, “Psychiatric Drugs, School Violence, And The Big Pharma Cover-up,” where I discussed the importance of the CYP450 enzymes on the metabolism of pharmaceutical drugs and the potential for adverse effects of those drugs if the CYP450 enzyme was not functioning properly.
Studies conducted over the last decade have clearly demonstrated the link between adverse reactions to Psycho-Pharmaceutical medications and underactive or underperforming CYP450 enzymes. This has caused some to wonder whether or not the recent uptick in mass shootings and the obvious link to many of the perpetrators and prescription drugs could be related to the performance of the CYP450 enzymes. Additional research, however, is now causing more questions to be asked in reference to the connections that chemicals like Glyphosate may have in the inhibition of proper CYP450 performance and, thus, in the uptick in mass shootings.
For those unfamiliar with the functions of the CYP450 enzymes, CYP450 stands for the Cytochrome P450 enzymes. Scientists understand these enzymes to be responsible for metabolizing almost half of all drugs currently on the market. P450 gene variants (polymorphisms) are implicated in the variability in drug response among a wide range of individuals. READ MORE…
What is Cytochrome P450 and what does it have to do with drugs and vaccine metabolism and adverse reactions?
Cytochrome P-450 is the liver’s enzyme system and is responsible for most drug metabolism. Numerous medications, nutrients, and herbal therapies are metabolized through the cytochrome P450 (CYP450) enzyme system. This system can be inhibited or induced by drugs including excipients in vaccines. It is to be noted that cytochrome P450 is maturing and is immature in infants who are regularly vaccinated as early as one hour and those who receive the Vitamin K injection.
There are more than 50 CYP450 enzymes, but the CYP1A2, CYP2C19, CYP2D6, CYP1A2, CYP3A4, and CYP3A5 enzymes are responsible for metabolizing 45% of drug metabolism. The CYP2D6 (20–30%), the CYP2C9 (10%) and the CYP2E1 and CYP1A2 (5%) complete this enzyme system. Many ingredients in vaccines inhibit Cytochrome P450, therefore the offending agent remains in the body of the infant and act as a poison. If a medication is taken with an agent that inhibits its metabolism, then the toxin level can rise and result in a harmful or adverse effect.
But it is not only all infants that have immature Cyp 450 superfamiilies. For example, 10% of Caucasians are Cytochrome P450 2D65 are non-metabolizers (Cyp2D6..the superfamily that metabolizes 20-30% of drugs) their whole life long. 7% of African Americans are poor metabolizers of drugs dependent on CYP2D6. Due to hereditary genetic variations (not defects) they do not have the activity of Cyp 2D6.
Here is the study: *Ped cyp enzymes (see graph) (very important study of the immaturity of cyp 450 superfamilies in infants and children. Synopsis: Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity.:
Comprehensive Vaccine Ingredient Information- CDC VACCINE EXCIPIENTS LIST PER VACCINE CDC Vaccine excipients-table-2
Medical treatments and drug protocols including vaccines should be implemented within a framework of the patient’s heritage, race, and culture in order to provide effective management modalities. Infants as well as adults should be assessed for their ability to metabolize the ingredients in vaccines.
When in comes to diet, CYP450 inducers and inhibitors are commonly ingested items such as grapefruit juice (inhibitor) and tobacco and herbs such as St. John’s Wort (inducers). In the case of grapefruit juice, there are numerous medications known to interact with grapefruit juice including statins, antiarrhythmic agents, immunosuppressive agents, and calcium channel blockers. Furthermore, the inhibition of the enzyme system seems to be dose dependent; thus, the more a patient drinks, the more the inhibition that occurs. Additionally, the effects can last for several days if grapefruit juice is consumed on a regular basis. Luckily, the effect of this is not seen with other citrus juices.
Hopefully, this brief review has opened the door to your inquisitive nature on how the liver’s enzyme system is effected by numerous medications and vaccine excipients and why some patients experience clinically significant unanticipated adverse reactions or therapeutic failures.
The above was edited and altered to include vaccines excipients from Davis’ Drug Guide
CDC VACCINE EXCIPIENTS LIST PER VACCINE CDC Vaccine excipients-table-2
Effects of Polysorbate 80, a widely used ingredient in vaccines
The results indicate that these non-ionic surfactants are in vitro inhibitors of CYP-mediated metabolism and might have the potential to modify the pharmacokinetics of co-administered drugs, which are substrates of CYP, and thereby enhance their bioavailability.
The vaccine ingredients effects on the human body, followed by links to substantiating documentation of causation
Comprehensive Vaccine Ingredient Information- CDC VACCINE EXCIPIENTS LIST PER VACCINE CDC Vaccine excipients-table-2
Vaccination ingredients according to the product insert:
MMR II: Measles, Mumps and Rubella
The Ingredients: measles, mumps, rubella virus, neomycin, sorbitol, hydrolized gelatin, chick embryonic fluid, and human diploid cells from aborted fetal tissue.
Infanrix: Dipthetheria, Tetanus and Pertussis
The Ingredients: Diphtheria, Tetanus and Pertussis toxoids, 2-Phenoxyethanol, Aluminum hydroxide, and Formaldehyde.
The Ingredients: 3 types of polio viruses, neomycin, streptomycin, polymyxin B, formaldehyde, 2-phenoxyethenol, and a continuous line of monkey kidney cells.
Act-Hib: Haeomophilus Influenza type B
The Ingredients: Haemophilus influenza Type B, polyribosylribitol phosphate, ammonium sulfate, formalin, and sucrose.
The Ingredients: Neisseria meningitidis A, C, Y and W-135 strains, Mueller Hinton Agar, Watson Scherp Media, polysaccharide antigens, formaldehyde, diphtheria toxoid protein, ammonium sulfate.
The Ingredients: saccharides from capsular Streptococcus pneumoniae antigens (7 serotypes) individually conjugated to diphtheria CRM 197 protein, aluminum phosphate, ammonium sulfate, soy protein, and yeast.
Varivax: Varicella (chickenpox)
The Ingredients: varicella live virus, neomycin, phosphate, sucrose, and monosodium glutamate (MSG), processed gelatin, fetal bovine serum, guinea pig embryo cells, albumin from human blood, and human diploid cells from aborted fetal tissue.
The Ingredients: weakened human rotavirus, dextran, sorbitol, xanthan, Dulbecco’s Modified Eagle Medium (DMEM), which contains: sodium chloride, potassium chloride, magnesium sulphate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, L-glutamine, calcium chloride, sodium hydrogenocarbonate, and phenol red.
The Ingredients: HPV types 6, 11, 16 and 18, saccharomyces cerevisiae, “fermentation media”, aluminum, sodium chloride, polysorbate 80, sodium borate.
FluZone (or FluShield, same product): Influenza
The Ingredients: Trivalent influenza virus, gentamicin sulphate, formaldehyde, thimerosal, polysorbate 80 (Tween 80) and chick embryonic fluid
Havrix: Hepatitis A
Ingredients: Hepatitis A virus/toxoids, formalin, aluminum hydroxide, 2-phenoxyethanol, polysorbate 20, and residual MRC5 proteins -human diploid cells from aborted fetal tissue.
Energix B: Hepatitis B
The Ingredients: genetic sequence of the hepatitis B virus that codes for the surface antigen (HbSAg), cloned into GMO yeast, aluminum hydroxide, and thimerosal.
Formaldehyde= Carcinogen (cancer causer); linked causally to an assortment of cancers, most recently Leukemia. The International Agency for Research on Cancer (IARC) classified it as a known human carcinogen in 2004.
Thimerosal (mercury)= Neurotoxin; controversially linked to Autism in the media, but is well known and causally proven to cause many neurological disorders, cell death in the brain, mitochondrial damage, etcetera. Thimerosal is still being used in the Hepatitis B and Influenza vaccines as of 2009, and is also contained within several of the H1N1 vaccinations.
2-Phenoxyethanol aka “Antifreeze” aka “ethylene glycol monomethyl ether”= neurotoxic, CNS toxicant.
Phenol= nephrotoxic; CNS toxin, heart toxin, gastrointestinal, kidney, lung and blood vessel toxin… known to induce coma’s and death; by far one of the most toxic of all vaccine ingredients.
Sorbitol= cardiac toxin, causes neuropathy in and exacerbation of diabetes, CNS toxin, our own government states under no uncertain terms that this substance is NOT to be injected… then allows it to be used in childhood vaccinations.
Neomycin, Streptomycin, Polyxmyxin B, Gentamicin Sulfate= Antibiotics. Immune suppressing, lead to the development of more virulent organisms and antibacterial resistance so people cannot combat them.
Egg (chick embryonic fluid), soy, yeast, gelatin= Allergens, risk of anaphylaxis and the development of Asthma.
Monosodium Glutamate= Excitotoxin; hazardous to your health in so many ways: read the full length article for further details.
Polysorbate 80 or Tween 80= anaphylaxis risk, also permeates the BBB (blood brain barrier) which means vaccine toxins can enter the brain.
Chick embryonic fluid, fetal bovine serum, guinea pig embryo cells, monkey kidney cells= Animal products in vaccinations that are highly susceptible to contamination. There is a particularly elevated risk with bovine serum (bovine polyomavirus) and monkey kidney cells (SV40 contamination causing cancer).
Animal Products (Contaminants) in Vaccinations
Animal products in vaccination: Monkey kidney cells, sheep red blood cells, chick embryonic fluid, fetal bovine serum, bovine gelatin, guinea pig embryo cells= risk and history of contamination.
Calf fetus, chick embryo, chick kidney, chicken egg, cow heart, dog kidney, duck egg, guinea pig embryo, horse blood, monkey kidney, monkey lung, mouse blood, pig blood, rabbit brain, sheep blood and others. These are used in various vaccine production lines. Residues are not completely purified out of the final packaged product. Contamination can introduce new pathogens. READ MORE…
List of ingredients and levels of carcinogenicity, for each, etc.
The dangerous impurities of vaccines by Janine Roberts
On the toxic ingredients of vaccinations: plays special emphasis to animal by-products and their production process in vaccinations.
10% of Caucasians are “non metabolizers”. This means that they cannot metabolize more than 50% of today’s drugs such as adderall, and other SSRIS. It is suspected that the heinous trend of school shootings and suicides are caused by non metabolizers who are given psychiatric drugs without first being tested for their ability to metabolize them. Because this test is not standard of care hospitals and doctors who destroy lives by giving counter indicated medication can not be successfully sued. There is a movement to make this test standard of care but it is being thwarted by the invested pharmacuetical companies who would stand to lose billions of dollars if the public knew.
The cytochrome p450 (CYP450) family is involved in the metabolism of a significant proportion of currently administered drugs, and genetic variants in cytochrome p450 are associated with altered metabolism of many drugs. It is proposed that genetic testing for cytochrome p450 variants may assist in selecting and dosing drugs that are impacted by these genetic variants.
Drug efficacy and toxicity vary substantially between individuals. Because drugs and doses are typically adjusted to meet individual requirements as needed by using trial and error, clinical consequences may include a prolonged time to optimal therapy and serious adverse events.
Various factors may influence the variability of drug effects, including age, liver function, concomitant diseases, nutrition, smoking, and drug-drug interactions. Inherited (germline) DNA sequence variation (polymorphisms) in genes coding for drug metabolizing enzymes, drug receptors, drug transporters, and molecules involved signal transduction pathways also may have major effects on the activity of those molecules and also on the efficacy and toxicity of the drug.
Pharmacogenomics is the study of how an individual’s genetic inheritance affects the body’s response to drugs. It may be possible to predict therapeutic failures or severe adverse drug reactions in individual patients by testing for important DNA polymorphisms (genotyping) in genes related to the metabolic pathway (pharmacokinetics) or single transduction pathway (pharmacodynamics) of the drug. Potentially, test results could be used to optimize drug choice and/or dose for more effective therapy, avoid serious adverse effects and decrease medical costs.
Some CYP450 enzyme genes are highly polymorphic, resulting in some enzyme variants that have variable metabolic capacities among individuals, and some with little to no impact on activity.
Individuals with a lack of function activity in these enzymes (CYP2C19, CYP2D6, CYP2C9, etc.) can be classified according to how fast they metabolize medications:
- Poor metabolizers (PMs): lack active enzyme gene alleles, they will process a certain drug more slowly than normal because of the missing enzyme(s), the medication can build up in their system which can increase the likelihood that it will cause side effects. The individual might still be able to benefit from the medication, but at lower dosages.
- Intermediate metabolizers (IMs): have one active and one inactive enzyme gene allele, these individuals have a reduced enzyme function in processing drugs, they may not process some medications as well as a normal metabolizer would. This can increase risk of side effects and drug interactions.
- Normal metabolizers (extensive metabolizers Ems): these individuals have 2 copies (alleles) of the most common (wild type) DNA sequence of a particular CYP450 enzyme gene resulting in an active molecule and are termed extensive metabolizers. Medications are processed normally, these individuals are more likely to benefit from treatment and have fewer side effects than people who don’t process the same medication(s) as well.
- Ultra-rapid metabolizers (UMs): individuals with more than 2 alleles of an active enzyme gene, which cause the medications to leave the body too quickly and often before they have had a chance to work properly. These individuals will likely need a higher than usual dose of medications.
Date: 05 Dec 2013
On the possible interaction between vaccines and drugs
Reduction in the hepatic cytochrome P450 system activity has been described after a vaccination in previous studies.
Moreover, it is unclear how the effects of vaccines on hepatic cytochrome P450 system activity affect patients who present risk factors such as age or genetic predisposition. Abstract
VLA Comment: The study was done regarding the effect of vaccination on patients taking drugs. Apparently, associated with vaccination, the vaccination interfered in Cytochrome P450 metabolism. Hence, after vaccination, the metabolism (detoxing the various drugs out of the body) slowed down resulting in the drug remaining in the body. The conclusion intimates that vaccination has a relationship to Cytochrome P450.