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Vaccines Excipients: PHARMACOGENETICS: Inability of infants and children to metabolize vaccine xenobiotic excipients

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Clinical Pharmacogenetics in Pediatric Patients

Anwar Husain; Jennifer A. Loehle; David W. Hein Pharmacogenomics. 2007;8(10):1403-1411.

Newborns and infants rapidly undergo simultaneous stages of organ growth and demonstrate large variability in drug response and metabolizing capabilities.[1,2] The enzymes, transporters and targets important for pediatric drugs all have the potential to vary along developmental timelines in terms of affinity, functional capacity and expression. Drug-metabolizing enzymes can vary according to chronological age.[3,4]

As such, determining gene expression patterns at various ontological periods becomes of key importance in formulating treatment plans for pediatric patients. Exposure to toxins or pharmaceutical agents or lack of medical treatment of a particular illness at sensitive periods of development could irreversibly disrupt the normal maturation of an individual. Observable consequences of such disruption may not appear until much later in life.              READ MORE….

ASTHMA excerpt: Polymorphisms (lack of specific enzyme in individuals) have been identified within the molecular proteins and enzymes involved in the pathways by which such drugs (vaccine excipients) may bring about their effects that may influence inter-individual variation in patient response.

What is Cytochrome P450 and what does it have to do with drugs and vaccine metabolism and adverse reactions?

Cytochrome P-450 is the liver’s enzyme system and is responsible for most drug metabolism.  Numerous medications, nutrients, and herbal therapies are metabolized through the cytochrome P450 (CYP450) enzyme system. This system can be inhibited or induced by drugs including excipients in vaccines. It is to be noted that cytochrome P450 is maturing and is immature in infants who are regularly vaccinated with Hepatitis B as early as one hour and those who receive the Vitamin K injection.

There are more than 50 CYP450 enzymes, but the CYP1A2, CYP2C19, CYP2D6, CYP1A2, CYP3A4, and CYP3A5 enzymes are responsible for metabolizing 45% of drug metabolism. The CYP2D6 (20–30%), the CYP2C9 (10%) and the CYP2E1 and CYP1A2 (5%) complete this enzyme system. Many ingredients in vaccines inhibit Cytochrome P450, therefore the offending agent remains in the body of the infant and toddler and act as a poison damaging the mitachondria found in every cell in the body except for the blood.   If a medication is taken with an agent that inhibits its metabolism, then the toxin level can rise and result in a harmful or adverse effect.

But it is not only that “all” infants  have immature Cyp 450 enzymes.  For example, 10% of Caucasians are non-metabolizers (Cyp 450 2D6).  For their whole life long these poor (polymorphic) metabolizers cannot metabolize 20-30% of drugs.  7% of African Americans are poor/non metabolizers of drugs dependent on CYP2D6.  Due to hereditary genetic variations (not defects) they do not have the activity of Cyp 2D6. That means that children and teens given drugs such as Adderall, Haldol, Respiridal; street drugs like LSD, psilosybn, cocaine, codeine without adequate genetic pre-testing are likely to have “drug induced psychosis”; suicidal ideation, homicidal ideations by which “heinous” thoughts drive them to such violence as school shootings and mass attacks.

  *Ped cyp enzymes  (see graph)  (very important study of the immaturity of cyp 450 superfamilies in infants and children.

STUDY DOWNLOAD

Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity.:

Study #2:  Immaturity of Cyp 450 in Neonate boys (book)

Study #3 (2018) The Ontogeny of Cytochrome P450 Enzyme Activity and Protein Abundance in Conventional Pigs in Support of Preclinical Pediatric Drug Research

Joske Millecam1, Laura De Clerck2, Elisabeth Govaert2, Mathias Devreese1, Elke Gasthuys1, Wim Schelstraete1, Dieter Deforce2, Lies De Bock3, Jan Van Bocxlaer3, Stanislas Sys4 and Siska Croubels1*

Neonate maturation of Cyp 450 Enzymes (table)

Comprehensive Vaccine Ingredient Information- CDC VACCINE EXCIPIENTS LIST PER VACCINE  CDC Vaccine excipients-table-2 

DIRECT LIST OF THE XENOBIOTIC INGREDIENTS IN VACCINES

Medical treatments and drug protocols including vaccines should be  implemented within a framework of the patient’s heritage, race, and culture in order to provide effective management modalities. Infants as well as adults should be assessed for their ability to metabolize the ingredients in vaccines.

When in comes to diet,  CYP450 inducers and inhibitors are commonly ingested items such as grapefruit juice (inhibitor) and tobacco and herbs such as St. John’s Wort (inducers).  In the case of grapefruit juice, there are numerous medications known to interact with grapefruit juice including statins, antiarrhythmic agents, immunosuppressive agents, and calcium channel blockers. Furthermore, the inhibition of the enzyme system seems to be dose dependent; thus, the more a patient drinks, the more the inhibition that occurs. Additionally, the effects can last for several days if grapefruit juice is consumed on a regular basis. Luckily, the effect of this is not seen with other citrus juices.

Hopefully, this brief review has opened the door to your inquisitive nature on how the liver’s enzyme system is effected by numerous medications and vaccine excipients and why some patients experience clinically significant unanticipated adverse reactions or therapeutic failures.

The above was edited and altered to include vaccines excipients from Davis’ Drug Guide

Effects of Polysorbate 80, a widely used ingredient in vaccines

The results indicate that these non-ionic surfactants are in vitro inhibitors of CYP-mediated metabolism and might have the potential to modify the pharmacokinetics of co-administered drugs, which are substrates of CYP, and thereby enhance their bioavailability.

Read more…

More on Polysorbate 80 and Polysorbate 20

The vaccine ingredients effects on the human body, followed by links to substantiating documentation of causation

Comprehensive Vaccine Ingredient Information- CDC VACCINE EXCIPIENTS LIST PER VACCINE  CDC Vaccine excipients-table-2 

Vaccination ingredients according to the product insert:

MMR II: Measles, Mumps and Rubella

http://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf

The Ingredients: measles, mumps, rubella virus, neomycin, sorbitol, hydrolized gelatin, chick embryonic fluid, and human diploid cells from aborted fetal tissue.

Infanrix: Dipthetheria, Tetanus and Pertussis

http://us.gsk.com/products/assets/us_infanrix.pdf

The Ingredients: Diphtheria, Tetanus and Pertussis toxoids, 2-Phenoxyethanol, Aluminum hydroxide, and Formaldehyde.

IPOL: Polio

http://www.vaccineshoppe.com/US_PDF/IPOL_942420_11.06.pdf

The Ingredients: 3 types of polio viruses, neomycin, streptomycin, polymyxin B, formaldehyde, 2-phenoxyethenol, and a continuous line of monkey kidney cells.
Act-Hib: Haeomophilus Influenza type B

http://www.novaccine.com/pdffiles/Act_HIB_package_insert.pdf

The Ingredients: Haemophilus influenza Type B, polyribosylribitol phosphate, ammonium sulfate, formalin, and sucrose.
Menactra: Meningococcal

www.fda.gov/CbER/products/menactra.htm

The Ingredients: Neisseria meningitidis A, C, Y and W-135 strains, Mueller Hinton Agar, Watson Scherp Media, polysaccharide antigens, formaldehyde, diphtheria toxoid protein, ammonium sulfate.
Prevnar: Pneumococcal

http://www.wyeth.com/content/showlabeling.asp?id=134

The Ingredients: saccharides from capsular Streptococcus pneumoniae antigens (7 serotypes) individually conjugated to diphtheria CRM 197 protein, aluminum phosphate, ammonium sulfate, soy protein, and yeast.

Varivax: Varicella (chickenpox)

www.merck.com/product/usa/pi_circulars/v/varivax/varivaxpi.pdf

The Ingredients: varicella live virus, neomycin, phosphate, sucrose, and monosodium glutamate (MSG), processed gelatin, fetal bovine serum, guinea pig embryo cells, albumin from human blood, and human diploid cells from aborted fetal tissue.
Rotarix: Rotavirus

http://www.fda.gov/CbER/label/rotarixLB.pdf

The Ingredients: weakened human rotavirus, dextran, sorbitol, xanthan, Dulbecco’s Modified Eagle Medium (DMEM), which contains: sodium chloride, potassium chloride, magnesium sulphate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, L-glutamine, calcium chloride, sodium hydrogenocarbonate, and phenol red.
Gardasil:HPV
http://www.merck.com/product/usa/pi_circulars/g/gardasil/gardasil_pi.pdf
The Ingredients: HPV types 6, 11, 16 and 18, saccharomyces cerevisiae, “fermentation media”, aluminum, sodium chloride, polysorbate 80, sodium borate.
FluZone (or FluShield, same product): Influenza

www.fda.gov/CBER/label/fluzoneLB.pdf

The Ingredients: Trivalent influenza virus, gentamicin sulphate, formaldehyde, thimerosal, polysorbate 80 (Tween 80) and chick embryonic fluid

Havrix: Hepatitis A

http://us.gsk.com/products/assets/us_havrix.pdf

Ingredients: Hepatitis A virus/toxoids, formalin, aluminum hydroxide, 2-phenoxyethanol, polysorbate 20, and residual MRC5 proteins -human diploid cells from aborted fetal tissue.
Energix B: Hepatitis B

http://us.gsk.com/products/assets/us_engerixb.pdf

The Ingredients: genetic sequence of the hepatitis B virus that codes for the surface antigen (HbSAg), cloned into GMO yeast, aluminum hydroxide, and thimerosal.
———————————————————————–

What’s in the vaccine that needs Cyp450 to metabolize?

Comprehensive list of Xenobiotics in Vaccines: MUST SEE LIST

Vaccine Ingredients

Aluminum= Neurotoxin
http://informedcitizensagainstvaccination.blogspot.com/2009/11/aluminum-neurotoxic-vaccine-adjuvant.html

Formaldehyde= Carcinogen (cancer causer); linked causally to an assortment of cancers, most recently Leukemia. The International Agency for Research on Cancer (IARC) classified it as a known human carcinogen in 2004.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/formaldehyde-carcinogen-in-vaccinations.html

Thimerosal (mercury)= Neurotoxin; controversially linked to Autism in the media, but is well known and causally proven to cause many neurological disorders, cell death in the brain, mitochondrial damage, etcetera. Thimerosal is still being used in the Hepatitis B and Influenza vaccines as of 2009, and is also contained within several of the H1N1 vaccinations.

http://informedcitizensagainstvaccination.blogspot.com/2009/11/thimerosal-neurotoxic-in-plethora-of.html
2-Phenoxyethanol aka “Antifreeze” aka “ethylene glycol monomethyl ether”= neurotoxic, CNS toxicant.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/2-phenoxyethanol-antifreeze-neurotoxin.html

Phenol= nephrotoxic; CNS toxin, heart toxin, gastrointestinal, kidney, lung and blood vessel toxin… known to induce coma’s and death; by far one of the most toxic of all vaccine ingredients.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/phenol-cns-toxin-causes-comas-and-death.html

Sorbitol= cardiac toxin, causes neuropathy in and exacerbation of diabetes, CNS toxin, our own government states under no uncertain terms that this substance is NOT to be injected… then allows it to be used in childhood vaccinations.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/sorbitol-cardiac-toxin-causes.html

Neomycin, Streptomycin, Polyxmyxin B, Gentamicin Sulfate= Antibiotics. Immune suppressing, lead to the development of more virulent organisms and antibacterial resistance so people cannot combat them.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/antibiotics-in-vaccinations.html
Egg (chick embryonic fluid), soy, yeast, gelatin= Allergens, risk of anaphylaxis and the development of Asthma.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/allergens-in-vaccinations.html
Monosodium Glutamate= Excitotoxin; hazardous to your health in so many ways: read the full length article for further details.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/monosodium-glutmate-creating-dumb-obese.html

Polysorbate 80 or Tween 80= anaphylaxis risk, also permeates the BBB (blood brain barrier) which means vaccine toxins can enter the brain.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/polysorbate-80-aka-tween-80-allows.html
Chick embryonic fluid, fetal bovine serum, guinea pig embryo cells, monkey kidney cells= Animal products in vaccinations that are highly susceptible to contamination. There is a particularly elevated risk with bovine serum (bovine polyomavirus) and monkey kidney cells (SV40 contamination causing cancer).

What is in the “mediums“? https://vaccineliberationarmy.com/2019/01/15/dogs-cats-increasingly-receiving-psyche-drugs-as-in-humans-its-the-vaccines/

READ MORE FROM ORIGINAL LINK

Animal Products (Contaminants) in Vaccinations

 Animal products in vaccination: Monkey kidney cells, sheep red blood cells, chick embryonic fluid, fetal bovine serum, bovine gelatin, guinea pig embryo cells= risk and history of contamination.
Calf fetus, chick embryo, chick kidney, chicken egg, cow heart, dog kidney, duck egg, guinea pig embryo, horse blood, monkey kidney, monkey lung, mouse blood, pig blood, rabbit brain, sheep blood and others. These are used in various vaccine production lines. Residues are not completely purified out of the final packaged product. Contamination can introduce new pathogens.  READ MORE…
List of ingredients and levels of carcinogenicity,  for each, etc.
See also:

The dangerous impurities of vaccines by Janine Roberts

On the toxic ingredients of vaccinations: plays special emphasis to animal by-products and their production process in vaccinations.

http://www.foresight-preconception.org.uk/pdf/dangerous-impurities-of-vaccines.pdf

Study: Vaccine excipients, xenobiotics-Cause of Inflammation after vaccination?

Study: Vaccine excipients, xenobiotics-Cause of Inflammation after vaccination?

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CDC Excipient Chart

Inflammation is associated with down regulations of hepatic and extrahepatic CYP enzymes drug metabolism.

The CYP represent a superfamily of enzymes with a key role in the activation or inactivation of a plethora of therapeutic agents. CYP enzymes are involved in the metabolism of xenobiotic substances. Cytochromes present intra- or interindividual and intra- or interethnic genetic polymorphisms. Variations in the pharmacokinetic drug profile are linked to the rising toxicity following a declining metabolism, reduced efficacy of the drug, adverse drug interaction, and increasing production of toxic metabolites. The high-metabolic rate of the intestinal microbiota is due to its many enzymes which catalyze reactions in phase I and II drug metabolism. In case of a compromised intestinal barrier, there may be an increase in paracellular passive absorption.

It is evident that high-microbial abundance following intestinal disturbances, environment, aging, or food-associated diseases promotes the microbial metabolism of a drug before absorption.

READ STUDY…

INFANTS INABILITY TO METABOLIZE XENOBIOTICS IN VACCINES

Above link Includes CDC Vaccine Excipient list of xenobiotics

Activist Post: Cytochrome P450 and Vaccine Excipients-poisons that cannot be metabolized by children under 3yrs

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The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D(3) synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases. [2]

Question:  Are metabolism differences in CYP genes the cause of many vaccine adverse reactions, especially brain encephalopathy that precipitates Autism and other clinically relevant diseases in infants, toddlers and even adults?  Was that the reasoning why a Vaccine Court Master awarded Hannah Poling’s Autism claim $1.5 million plus ongoing $500,000 per year for life [4]?  READ MORE…

Cyp 450 superfamilies in infants and children.

STUDY DOWNLOAD

Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity.:

Study #2:  Immaturity of Cyp 450 in Neonate boys (book)

PHARMACOGENETIC TEST SIGNIFICANTLY INCREASE REMISSION OF MENTAL ILLNESS (DEPRESSION)

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GeneSight employs a proprietary algorithm to analyze 12 genes and assess how they impact patients’ ability to process dozens of psychotropic medications. The test report buckets depression treatments as red (significant gene-drug interaction), yellow (moderate gene-drug interaction), or green (use as directed.) When the test report shows that patients are on red or yellow medications, their doctors should consider changing the drug or dose, while patients on green medications don’t require a medication change.

Researchers further evaluated patients who entered the study on red medications and either remained on red medications or were switched to yellow or green drugs. Remission rates were 153 percent higher, response rates were 71 percent higher, and symptom improvement rates were 59 percent higher when patients were switched from red to yellow or green meds — all statistically significant changes.

This analysis “establishes a new standard of care” for physicians by demonstrating that patients on red medications must be identified and have their medications modified, said Dechairo. “This switching analysis has also been an important point in our payor discussions, as utilization management programs can focus on switching patients from red medications, which would deliver results even better than those in the GUIDED study,” he said.

One prior cost-effectiveness study using drug claims data showed that using GeneSight can increase treatment adherence and save an average of $1,036 per year per patient, while another study using commercial claims data showed GeneSight’s potential to save $1,556 per patient by reducing disability claims, medical utilization, workplace absence.

Currently, the more than 300,000 GeneSight tests Myriad sells per year are largely ordered by psychiatrists. Once there is greater reimbursement traction, Myriad is planning a significant marketing push into the primary care market, including direct-to-patient advertising for the test, according to Capone.

GeneSight, which is a lab-developed test (LDT) performed in a CLIA-certified lab, must be ordered by physicians.

Capone noted that the FDA has publicly stated that it will continue to practice enforcement discretion for LDTs, and leave it up to legislators to reform diagnostic regulations that may or may not bring LDTs under the agency’s oversight. In December, legislators in the House of Representatives and the Senate incorporated the FDA’s ideas for diagnostics regulatory reform into a draft bill that features a pre-certification program that labs could use to bring the majority of new diagnostics to market, while having to submit around 10 percent of tests for premarket review.  READ MORE…

ABSTRACT OF STUDY

 

Glyphosate , Psyche Drug and Vaccines: THE CONNECTION

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CCHR Newsletter: Overview of Cyp 450, Pharmacogenetics, Psyche Drugs, vaccines.

AGRICULTURE

Read Study glyphosate_rats_CYP_enzyme_suppression_2006

Syngenta Patent shows that the Genetic Engineering of our nations food supply is based on Cytochrome P450 technology whereby the genetically engineered seed is manipulated to be an ultra rapidmetabolizer while the “weeds” who are normal metabolizer dies in the presence of Glysophate.  Cytochrome P450 Gene Conferring herbicide resistance PATENT

MENTAL ILLNESS DIAGNOSIS –

PHARMA DRUGS, STREET DRUGS & MEDICATION AND METABOLIZING OPIOIDS

Plants and humans share the same detox mechanism involving Cytochrome P450.  In humans Cytocrome P450

90% of today’s modern drugs are metabolized by Cytochrome P450.

CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 enzymes metabolize 90 percent of drugs. these enzymes are predominantly expressed in the liver, but they also occur in the small intestine (reducing drug bioavailability), lungs, placenta, and kidneys.2

One out of every 15 white or black persons may have an exaggerated response to standard doses of beta blockers (e.g., metoprolol [Lopressor]), or no response to the analgesic tramadol (Ultram). This is because drug metabolism via CYP450 enzymes exhibits genetic variability (polymorphism) that influences a patient’s response to a particular drug.3

Every person inherits one genetic allele from each parent. Alleles are referred to as “wild type” or “variant,” with wild type occurring most commonly in the general population.

For example, 7 percent of white persons and 2 to 7 percent of black persons are poor metabolizers of drugs dependent on CYP2D6, which metabolizes many beta blockers, antidepressants, and opioids.7,8 One in five Asian persons is a poor metabolizer of drugs dependent on CYP2C19, which metabolizes phenytoin (Dilantin), phenobarbital, omeprazole (Prilosec), and other drugs.9 

The Effect of Cytochrome P450
Metabolism on Drug Response,
Interactions, and Adverse Effects READ STUDYCyp Study

VACCINES

Studies: Cytochrome P450 and failure of infants to metabolize vaccine excipients READ more…

Early Childhood Vaccines contain excipients that need Cytochrome P450 to metabolize.

VLA Comment: Cytochrome P450 is not mature in infants and children under the age of three years old yet we are giving vaccines with excipients that must be detoxed out of the body by Cytochrome P450 family of liver enzymes which infants do not have. These enzymes are predominantly expressed in the liver, but they also occur in the small intestine (reducing drug bioavailability), lungs, placenta, and kidneys.2 

Note in cases of Autism and vaccinating pregnant women:

Cyp 450 are found in the “Small intestines and placenta”

READ more…

Pediatric Study: Pharmacogenomics – Adverse Reaction in Children

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Drug-Metabolizing Enzyme Genotypes
and Aggressive Behavior Treatment Response
in Hospitalized Pediatric Psychiatric Patients

TracyGlauser Pharma study

Objective: The aim of this study was to examine the association between the CYP2D6 and CYP2C19 genotypepredicted combined phenotypes and short-term measures of psychotropic efficacy and toxicity.
Methods: A rater-blinded, retrospective genotype association design examined a cohort of hospitalized pediatric psychiatric patients genotyped for CYP2D6 and CYP2C19 as part of clinical care. These combined genotypes were used to predict a combined phenotype. The primary efficacy outcome measure was the behavior intervention score (BIS), a function of the number of recorded timeouts=seclusions, therapeutic holds, and physical restraints.

Patient response to commonly used psychotropic medications demonstrates significant variability; only 30–75% of patients experience efficacy, whereas 65–75% encounter ad-
verse events (Kirchheiner et al. 2004; Emslie et al. 2006; Kratochvil et al. 2006; Hetrick et al. 2007). Many psychotropic medications are metabolized by cytochrome P450 (CYP) en-
zymes coded for by the polymorphic genes CYP2D6(þ124030) and CYP2C19 (*124020).
The relationships between the distinct CYP2D6 or CYP2C19 genotypes and the pharmacokinetics of psychotropic medications are the basis for genotype-based dosing recommendations for some medications (Kirchheiner et al. 2001).Despite the prevalence of the problem, the contribution of drug-metabolizing enzyme genotypes to the variability in aggressive behavior treatment response in hospitalized pediatric psychiatric patients is unknown. The purpose of this study was to examine the association between CYP2D6 and CYP2C19 genotype-predicted metabolizing phenotypes and short-term measures of drug efficacy (incidence of behavioral interventions for aggressive behavior) and toxicity (adverse drug reaction)

Drug tolerability was defined as the total number of recorded adverse drug reactions.

 

Conclusion
Identifying factors underlying the variability in drug efficacy
or tolerability is a key component for optimizing the patient’s
response to therapy. This is the first study to demonstrate that,
for children hospitalized for psychiatric conditions,
CYP2D6 and CYP2C19 genetic variation contributes to psychotropic…
Consideration of a patient’s genotype at the onset of a psychiatric hospitalization could play a significant role in personalizing and improving subsequent therapy.
Prospective longitudinal studies are necessary to better inform
how to optimally incorporate this genetic information into the
medical management of patients with aggression. In summary,
this study indicates that CYP2D6 and CYP2C19genotypes are
 important in the clinical care of children with psychiatric diagnoses requiring medications that are metabolized throughthese two enzyme pathways.

Find out about pharmacogenomic: Cytochrome P450, homicide, suicide and school violence

Pharmacogentics, Suicide, Homicide and school violence

INFANT VACCINES/Cytochrome P450 and failure of infants to metabolize vaccine excipients  READ

Accounts of thousand of Suicides and Homicides: www.SSRIStories.net

Aluminum & Cytochrome P450

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Suppressive effect of accumulated aluminum trichloride on the hepatic microsomal cytochrome P450 enzyme system in rats.

Zhu Y1, Han Y, Zhao H, Li J, Hu C, Li Y, Zhang Z.

The results revealed that exposure to AlCl3 inhibited the microsomal CYP450 dependent enzyme system of liver. Our findings suggest that long term daily exposure of AlCl3 exerts the suppressive effects and thus may cause dysfunction of hepatic CYP450 dependent enzyme system of rat.

Highlights

► AlCl3 exposure through drinking water gets close with actual chronic oral Al exposure. ► Effects of Al exposure on the hepatic microsomal protein, AND and ERND were studied. ► Metabolism of Al affected the hepatic microsomal cytochrome P450 enzyme system.

Read Abstract

Aluminium compounds for use in vaccines | Immunology & Cell Biology

https://www.nature.com/articles/icb200476
by EB Lindblad – ‎2004 – ‎Cited by 397 – ‎Related articles

Oct 1, 2004 – Holt, shortly after, demonstrated that preformed aluminium phosphate, prepared from equimolar amounts of aluminium chloride and trisodium phosphate, acted as an adsorbant and was adjuvant active with diphtheria. Data on the use of alum-precipitated vaccines can be found in older literature, but in …

‎Introduction · ‎Analytical methods · ‎Mechanisms of adjuvant … · ‎Stimulation of IgE

The mechanisms of action of vaccines containing aluminum adjuvants …

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406982/
by TR Ghimire – ‎2015 – ‎Cited by 20 – ‎Related articles

Apr 16, 2015 – Adjuvants such as the aluminum compounds (alum) have been dominantly used in many vaccines due to their immunopotentiation and safety records …. Aluminum compounds such as aluminum chloride, aluminum silicate, algammulin (gamma inulin plus AH), cesium alum (CA), Imject alum (IA) (AH plus ..

 

Study: Developmental Pharmacokinetics in Pediatric Populations (Vaccines are drugs)

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Developmental Pharmacokinetics in Pediatric Populations
Hong Lu, PhD and Sara Rosenbaum, PhD
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island

Information on drug absorption and disposition in infants and children has increased considerably over the past 2 decades. However, the impact of specific age-related effects on pharmacokinetics, pharmacodynamics, and dose requirements remains poorly understood. Absorption can be affected by the differences in gastric pH and stomach emptying time that have been observed in the pediatric population. Low plasma protein
concentrations and a higher body water composition can change drug distribution. Metabolic processes are often immature at birth, which can lead to a reduced clearance and a prolonged half-life for those drugs for which metabolism is a significant mechanism for elimination. Renal excretion is also reduced in neonates due to immature glomerular filtration, tubular secretion, and reabsorption. Limited data are available on the pharmacodynamic behavior of drugs in the pediatric population.Pediatric Population study Cyp 450.

VLA Comment: Remember children under 3 years old have “immature” cytochrome P450 and 10% of Caucasians for example, are “non-metabolizers”…they cannot metablize many drugs all their lives and become psychotic when given drugs after being diagnosed as ADHD, Autism, etc which are vaccine injuries caused by inability to metabolize the ingredients in vaccines.

 

Hundreds of Thousands of Babies on Antidepressants & Psychotropic Drugs

FDA: Vaccine Cause Autism

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The FDA has published conclusive proof on their website that the DTap vaccine causes autism.

According to the FDA’s online Biologics Blood Vaccines document (between pages 6 to 11), a vaccine manufacturer admits on its package insert that their vaccination can cause autism as one of many adverse reactions.

READ MORE…

VLA COMMENT: Aside from excipients in vaccines such as phenol, formaldehyde, aluminum, polysorbate 80, mercury, ethanol, herein we list the ingredient in what is usually just listed as “the medium…Mueller and Miller medium and Stainer-Scholte medium. Such ingredients as listed above and within the mediums, as well, need a fully mature Cytochrome P450 (detox liver enzyme familiers) to rid the system of these toxins.  All children do not have mature Cytochrome P450 until at least 3 years old and 10% for example of Caucasian are non-metabolizer of the major detox pathway Cytochrome p450 2D6 and become damaged when vaccinated and psychotic when given many of today’s modern drugs.  There is an easy test for metabolism but it is not “standard of care” because the pharmacuetical company would loose billions of dollars if the public knew.  On the other hand medicaid, medicare and insurance companies would save billions of dollars if the test became standard of care.

Mueller and Miller medium, according to the information I found, contains:

glucose, sodium chloride, sodium phosphate dibasic, monopotassium, phosphate, magnesium sulfate hydrate, ferrous sulfate heptaphydrate, cystine hydrochloride, tyrosine hydrochloride, urasil hydrochloride, Ca-pantothenate in ethanol, thiamine in ethanol, pyridoxin-hydrochloride in ethanol, riboflavin in ethanol, biotin in ethanol, sodium hydroxide, beef heart infusion (de- fatted beef heart and distilled water), casein [milk protein] solution.

While Stainer-Scholte medium has the following ingredients:

Tris hydrochloride, tris base, glutamate (monosodium salt) [MSG], proline, salt, monopotassium phosphate, potassium chloride, magnesium chloride, calcium chloride, ferrous sulfate, asorbic acid, niacin, glutathione

The vaccine is formulated without preservatives, but contains a trace amount of thimerosal[(mercury derivative), (≤0.3 μg mercury/dose)] from the manufacturing process. Each 0.5 mL dose also contains, by assay, not more than 0.170 mg of aluminum and not more than 100 μg(0.02%) of residual formaldehyde. The vaccine contains gelatin and polysorbate 80 (Tween-80), which are used in the production of the pertussis concentrate.