Pharmacokinetics and Differential Regulation of Cytochrome P450 Enzymes in Type 1 Allergic Mice
“We investigated hepatic P450 metabolism and drug pharmacokinetics in type 1 allergic mice induced by ovalbumin (OVA) emulsified with aluminum and inactive Bordetella pertussis. To further propose a possible key factor in drug-allergic disease interactions, we examined the inhibitory effect of NO, a marker of allergic conditions on the activities of major P450 isoforms”.
Magic Mushrooms and some individual’s inability to metabolize-causing psychosis, albeit temporary
Magic Mushrooms: Some individuals are not able to metabolize-causing psychosis, albeit temporary and not to be confused with “mental illness”.
Indolealkylamines: Biotransformations and Potential Drug–Drug Interactions (STUDY)
Increased knowledge in this area may advance our understanding of individual vulnerability to and/or protection from illicit drugs of abuse (15). This review, therefore, aims to describe our current understanding of the metabolism READ STUDY…
The various factors that impact pharmacokinetics
and pharmacodynamics mature towards adult values at different rates, thus requiring continual modification of drug dose regimens in neonates, infants, and children.
Read Study Pediatric Population study Cyp 450.