Tag Archives: neonate

Studies: Cytochrome P450 and failure of infants to metabolize vaccine excipients

What is Cytochrome P450 and what does it have to do with drugs and vaccine metabolism and adverse reactions?

Cytochrome P-450 is the liver’s enzyme system and is responsible for most drug metabolism.  Numerous medications, nutrients, and herbal therapies are metabolized through the cytochrome P450 (CYP450) enzyme system. This system can be inhibited or induced by drugs including excipients in vaccines. It is to be noted that cytochrome P450 is maturing and is immature in infants who are regularly vaccinated as early as one hour and those who receive the Vitamin K injection.

There are more than 50 CYP450 enzymes, but the CYP1A2, CYP2C19, CYP2D6, CYP1A2, CYP3A4, and CYP3A5 enzymes are responsible for metabolizing 45% of drug metabolism. The CYP2D6 (20–30%), the CYP2C9 (10%) and the CYP2E1 and CYP1A2 (5%) complete this enzyme system. Many ingredients in vaccines inhibit Cytochrome P450, therefore the offending agent remains in the body of the infant and act as a poison.  If a medication is taken with an agent that inhibits its metabolism, then the toxin level can rise and result in a harmful or adverse effect.

But it is not only all infants that have immature Cyp 450 superfamiilies.  For example, 10% of Caucasians are Cytochrome P450 2D65 are non-metabolizers (Cyp2D6..the superfamily that metabolizes 20-30% of drugs) their whole life long. 7% of African Americans are poor metabolizers of drugs dependent on CYP2D6.  Due to hereditary genetic variations (not defects) they do not have the activity of Cyp 2D6.

Study #1:  *Ped cyp enzymes  (see graph)  (very important study of the immaturity of cyp 450 superfamilies in infants and children. Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity.:

Study #2:  Immaturity of Cyp 450 in Neonate boys (book)

 

Comprehensive Vaccine Ingredient Information- CDC VACCINE EXCIPIENTS LIST PER VACCINE  CDC Vaccine excipients-table-2 

Medical treatments and drug protocols including vaccines should be  implemented within a framework of the patient’s heritage, race, and culture in order to provide effective management modalities. Infants as well as adults should be assessed for their ability to metabolize the ingredients in vaccines.

When in comes to diet,  CYP450 inducers and inhibitors are commonly ingested items such as grapefruit juice (inhibitor) and tobacco and herbs such as St. John’s Wort (inducers).  In the case of grapefruit juice, there are numerous medications known to interact with grapefruit juice including statins, antiarrhythmic agents, immunosuppressive agents, and calcium channel blockers. Furthermore, the inhibition of the enzyme system seems to be dose dependent; thus, the more a patient drinks, the more the inhibition that occurs. Additionally, the effects can last for several days if grapefruit juice is consumed on a regular basis. Luckily, the effect of this is not seen with other citrus juices.

Hopefully, this brief review has opened the door to your inquisitive nature on how the liver’s enzyme system is effected by numerous medications and vaccine excipients and why some patients experience clinically significant unanticipated adverse reactions or therapeutic failures.

The above was edited and altered to include vaccines excipients from Davis’ Drug Guide

 

CDC VACCINE EXCIPIENTS LIST PER VACCINE  CDC Vaccine excipients-table-2

Effects of Polysorbate 80, a widely used ingredient in vaccines

The results indicate that these non-ionic surfactants are in vitro inhibitors of CYP-mediated metabolism and might have the potential to modify the pharmacokinetics of co-administered drugs, which are substrates of CYP, and thereby enhance their bioavailability.

Read more…

More on Polysorbate 80 and Polysorbate 20

The vaccine ingredients effects on the human body, followed by links to substantiating documentation of causation

Comprehensive Vaccine Ingredient Information- CDC VACCINE EXCIPIENTS LIST PER VACCINE  CDC Vaccine excipients-table-2 

Vaccination ingredients according to the product insert:

MMR II: Measles, Mumps and Rubella

http://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf

The Ingredients: measles, mumps, rubella virus, neomycin, sorbitol, hydrolized gelatin, chick embryonic fluid, and human diploid cells from aborted fetal tissue.

Infanrix: Dipthetheria, Tetanus and Pertussis

http://us.gsk.com/products/assets/us_infanrix.pdf

The Ingredients: Diphtheria, Tetanus and Pertussis toxoids, 2-Phenoxyethanol, Aluminum hydroxide, and Formaldehyde.

IPOL: Polio

http://www.vaccineshoppe.com/US_PDF/IPOL_942420_11.06.pdf

The Ingredients: 3 types of polio viruses, neomycin, streptomycin, polymyxin B, formaldehyde, 2-phenoxyethenol, and a continuous line of monkey kidney cells.
Act-Hib: Haeomophilus Influenza type B

http://www.novaccine.com/pdffiles/Act_HIB_package_insert.pdf

The Ingredients: Haemophilus influenza Type B, polyribosylribitol phosphate, ammonium sulfate, formalin, and sucrose.
Menactra: Meningococcal

www.fda.gov/CbER/products/menactra.htm

The Ingredients: Neisseria meningitidis A, C, Y and W-135 strains, Mueller Hinton Agar, Watson Scherp Media, polysaccharide antigens, formaldehyde, diphtheria toxoid protein, ammonium sulfate.
Prevnar: Pneumococcal

http://www.wyeth.com/content/showlabeling.asp?id=134

The Ingredients: saccharides from capsular Streptococcus pneumoniae antigens (7 serotypes) individually conjugated to diphtheria CRM 197 protein, aluminum phosphate, ammonium sulfate, soy protein, and yeast.

Varivax: Varicella (chickenpox)

www.merck.com/product/usa/pi_circulars/v/varivax/varivaxpi.pdf

The Ingredients: varicella live virus, neomycin, phosphate, sucrose, and monosodium glutamate (MSG), processed gelatin, fetal bovine serum, guinea pig embryo cells, albumin from human blood, and human diploid cells from aborted fetal tissue.
Rotarix: Rotavirus

http://www.fda.gov/CbER/label/rotarixLB.pdf

The Ingredients: weakened human rotavirus, dextran, sorbitol, xanthan, Dulbecco’s Modified Eagle Medium (DMEM), which contains: sodium chloride, potassium chloride, magnesium sulphate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, L-glutamine, calcium chloride, sodium hydrogenocarbonate, and phenol red.
Gardasil:HPV
http://www.merck.com/product/usa/pi_circulars/g/gardasil/gardasil_pi.pdf
The Ingredients: HPV types 6, 11, 16 and 18, saccharomyces cerevisiae, “fermentation media”, aluminum, sodium chloride, polysorbate 80, sodium borate.
FluZone (or FluShield, same product): Influenza

www.fda.gov/CBER/label/fluzoneLB.pdf

The Ingredients: Trivalent influenza virus, gentamicin sulphate, formaldehyde, thimerosal, polysorbate 80 (Tween 80) and chick embryonic fluid

Havrix: Hepatitis A

http://us.gsk.com/products/assets/us_havrix.pdf

Ingredients: Hepatitis A virus/toxoids, formalin, aluminum hydroxide, 2-phenoxyethanol, polysorbate 20, and residual MRC5 proteins -human diploid cells from aborted fetal tissue.
Energix B: Hepatitis B

http://us.gsk.com/products/assets/us_engerixb.pdf

The Ingredients: genetic sequence of the hepatitis B virus that codes for the surface antigen (HbSAg), cloned into GMO yeast, aluminum hydroxide, and thimerosal.
———————————————————————–

What’s in the vaccine that needs Cyp450 to metabolize?

Aluminum= Neurotoxin
http://informedcitizensagainstvaccination.blogspot.com/2009/11/aluminum-neurotoxic-vaccine-adjuvant.html

Formaldehyde= Carcinogen (cancer causer); linked causally to an assortment of cancers, most recently Leukemia. The International Agency for Research on Cancer (IARC) classified it as a known human carcinogen in 2004.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/formaldehyde-carcinogen-in-vaccinations.html

Thimerosal (mercury)= Neurotoxin; controversially linked to Autism in the media, but is well known and causally proven to cause many neurological disorders, cell death in the brain, mitochondrial damage, etcetera. Thimerosal is still being used in the Hepatitis B and Influenza vaccines as of 2009, and is also contained within several of the H1N1 vaccinations.

http://informedcitizensagainstvaccination.blogspot.com/2009/11/thimerosal-neurotoxic-in-plethora-of.html
2-Phenoxyethanol aka “Antifreeze” aka “ethylene glycol monomethyl ether”= neurotoxic, CNS toxicant.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/2-phenoxyethanol-antifreeze-neurotoxin.html

Phenol= nephrotoxic; CNS toxin, heart toxin, gastrointestinal, kidney, lung and blood vessel toxin… known to induce coma’s and death; by far one of the most toxic of all vaccine ingredients.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/phenol-cns-toxin-causes-comas-and-death.html

Sorbitol= cardiac toxin, causes neuropathy in and exacerbation of diabetes, CNS toxin, our own government states under no uncertain terms that this substance is NOT to be injected… then allows it to be used in childhood vaccinations.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/sorbitol-cardiac-toxin-causes.html

Neomycin, Streptomycin, Polyxmyxin B, Gentamicin Sulfate= Antibiotics. Immune suppressing, lead to the development of more virulent organisms and antibacterial resistance so people cannot combat them.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/antibiotics-in-vaccinations.html
Egg (chick embryonic fluid), soy, yeast, gelatin= Allergens, risk of anaphylaxis and the development of Asthma.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/allergens-in-vaccinations.html
Monosodium Glutamate= Excitotoxin; hazardous to your health in so many ways: read the full length article for further details.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/monosodium-glutmate-creating-dumb-obese.html

Polysorbate 80 or Tween 80= anaphylaxis risk, also permeates the BBB (blood brain barrier) which means vaccine toxins can enter the brain.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/polysorbate-80-aka-tween-80-allows.html
Chick embryonic fluid, fetal bovine serum, guinea pig embryo cells, monkey kidney cells= Animal products in vaccinations that are highly susceptible to contamination. There is a particularly elevated risk with bovine serum (bovine polyomavirus) and monkey kidney cells (SV40 contamination causing cancer).

What is in the “mediums“? http://vaccineliberationarmy.com/2019/01/15/dogs-cats-increasingly-receiving-psyche-drugs-as-in-humans-its-the-vaccines/

READ MORE FROM ORIGINAL LINK

Animal Products (Contaminants) in Vaccinations

 Animal products in vaccination: Monkey kidney cells, sheep red blood cells, chick embryonic fluid, fetal bovine serum, bovine gelatin, guinea pig embryo cells= risk and history of contamination.
Calf fetus, chick embryo, chick kidney, chicken egg, cow heart, dog kidney, duck egg, guinea pig embryo, horse blood, monkey kidney, monkey lung, mouse blood, pig blood, rabbit brain, sheep blood and others. These are used in various vaccine production lines. Residues are not completely purified out of the final packaged product. Contamination can introduce new pathogens.  READ MORE…
List of ingredients and levels of carcinogenicity,  for each, etc.
See also:

The dangerous impurities of vaccines by Janine Roberts

On the toxic ingredients of vaccinations: plays special emphasis to animal by-products and their production process in vaccinations.

http://www.foresight-preconception.org.uk/pdf/dangerous-impurities-of-vaccines.pdf

Pharmacogenetics: Inability of Infants to metabolize Vaccine Excipients – Cytochrome P450

Excipients in Vaccines & Cytochrome P450

Lets look more closely at the excipient ingredients in vaccines.   The following understanding that Infants cannot metabolize the multiple overload of the repetitive excipeint ingredients in multiple vaccines due to an inability of infants and children to metabolize these toxins due to the generally recognized fact that Cytochrome P450 is “immature” in infants and children.

CDC List of Exipients:  http://vaccineliberationarmy.com/2015/03/07/11935/


VACCINE Excipients and Cyp P450:  
Common excipients in Vaccines inhibit Cytochrome P450,the major detox mechanism in humans, plants and animals.   Considering Cyp 450 is immature in the infant and child,  the following excipients can’t be dealt with, released or detoxified in the infant and growing child.  It is to be noted that the inhibition of Cytochrome P450 and the inability to release the toxins from the body in cases of Adults cause serious psychotic events including suicide and “heinous” homicides.  Could these vaccine ingredients that are not metabolized by infants and children in various degrees appear like “mental illness”, hence the DSM misdiagnosis criteria?

The sample list of excipients below commonly injected MANY times into infants in many overlapping vaccines need Cyp 450 to metabolize yet some children, due to genetic variation,  are totally missing the activity of Cyp 450 and, in any case all children have immature Cyp 450 activity. This may give us one of the answers to the apparent range of vaccine injury in the general population.

Details on “the mediums” in vaccines

Re: Polysorbate 80, a common vaccine excipient:

The results indicate that these non-ionic surfactants are in vitro inhibitors of CYP-mediated metabolism
Study…
http://www.ncbi.nlm.nih.gov/pubmed/21220010

RE:  Ethanol and Formaldehyde, vaccine excipients: 
Study…
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.320.1093&rep=r…

Re:  Alcohol, a vaccine excipient

RE: Benzethonium Chloride, a vaccine excipient
Notice that in the latest drug commercials they advertiser warns against Grapefruit seed extract.  This is because GSE inhibits Cytochrome P450 and therefore inhibits detoxifcation of toxic elements
Study….
http://www.ncbi.nlm.nih.gov/pubmed/17468864
Some manufacturers of GSE have stated that their extract has compounds nearly identical to benzethonium chloride

Phenol, a benzene metabolite, a vaccine excipient
Study…
http://www.ncbi.nlm.nih.gov/pubmed/11701230

Asthma, Allergies, Inflammation & the role of Cyp 450
Study…
http://www.sciencedirect.com/science/article/pii/S0003986106003791

Re: Aluminum Hydroxide adjuvant
Is Aluminum Hydroxide inhibiting the already immature activity of Cyp 450 that apparently is important in  reducing inflammation?
Study…
http://www.sciencedirect.com/science/article/pii/S0003986106003791
Cyp 450 and lungs

Aluminum Phosphate, a vaccine excipient and SHAKING BABY SYNDROME

Shaking Baby Syndrome & bone breaking symptoms:

Aluminum accumulation in bone has become much less frequent with cessation of use of aluminum-containing phosphate binders. Unfortunately, the binders which have largely replaced aluminum have not proven completely satisfactory

Study…

http://www2.kidney.org/professionals/KDOQI/guidelines_bone/Guide13B.htm

Osteomalacia – Mayo Clinic http://www.mayoclinic.org/diseases-conditions/osteomalacia/basics/definitio…
Osteomalacia refers to a softening of your bones, often caused by a vitamin D deficiency. Soft bones are more likely to bow and fracture than are harder, healthy bones.  Note:  As per the SBS & bone breaking symptom in the above link Aluminum – containing phosphae binders cause Osteomalacia as well.

Neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson¹s disease patients Amandeep Manna,(5)

 

The Journal of Pediatric Pharmacology and Therapeutics

“Developmental Pharmacokinetics in Pediatric Populations”

Hong Lu, PhD and Sara Rosenbaum, PhD

*Ped cyp enzymes  (see graph)  (very important study of the immaturity of cyp 450 superfamilies in infants and children. Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity. DOWNLOAD STUDY

The graph in the above link  shows that infants and children have immature enyzmes and therefore an inability to metabolize toxins.  Although these and other studies are being done so that the pharmacuetical industry can adjust dosage of pharmacuetical drugs to infants, toddlers and children, we must look at it from the point of view that the excipients in the vaccines need mature enyzmes to metabolize.   This entire post  lists some studies involving the need for mature enzymes in order to metabolize such ingredients as aluminum, mercury, phenol, formaldahyde, ethanol, phenol, polysorbate 80, etc.  If these enzymes are not mature until the age of three years old, then by giving vaccines and moreover, multiple vaccines at one time, we are POISONING our infants and children.

Immaturity of Cytochrome P450 in Neonate boys (book)

 

 

Immaturity of Cyp 450 in infants (So why are we giving Hep B with
at one hour old?) Attached

Comment Hep B contains many of these excipient ingredients which an infant is unable to metabolize.  This is a point that can be made when writing a model Hep B bill.

SUPER CYP 450 DATA BANK:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808967/
SuperCYP (http://bioinformatics.charite.de/supercyp) is a comprehensive resource focused on CYPs and drug metabolism.

Layman’s talk on Cyp 450

Finally, it must be noted that non metabolism (polymorphism of cyp 450 aka lack of activity) runs in the family.
Parents and siblings will all be found to have the same polymorphism.

In addition to the MTHFR gene, there is a gene called the CYP450 pathway which is critical for effective detoxification. It is suppressed genetically in 43% of Africans. Unfortunately, CYP450 pathway affects the safety and efficacy of 90% of therapeutic drugs and other environmental chemicals.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868406/ http://www.ncbi.nlm.nih.gov/pubmed/23641907 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1390790/ http://www.biomedcentral.com/1471-2156/14/34
http://www.nature.com/tpj/journal/v13/n1/full/tpj201245a.html

Furthermore, Latinos have a suppressed CYP3A4*10 enzyme and CYP3A4*16A enzyme.

http://www.pharmacologyweekly.com/articles/genetic-polymorphisms-cytochrome-P450-CYP3A4-enzyme
http://www.sciencedirect.com/science/article/pii/S0163725813000065
http://www.aafp.org/afp/2007/0801/p391.html
http://www.ncbi.nlm.nih.gov/pubmed/15364537
http://www.medscape.com/viewarticle/744945_3
http://www.hoajonline.com/jdrcm/2050-0866/1/22

https://books.google.com/books?id=XAfUAgAAQBAJ&pg=PA335&lpg=PA335&dq=hispanic+cyp450+enzyme&source=bl&ots=Eyzy37i1gr&sig=W8VMcXeAucdMmbGRgKlV2uThWAs&hl=en&sa=X&ei=mdEmVePCOsuWsAXJqIHgBw&ved=0CF0Q6AEwCA#v=onepage&q=hispanic%20cyp450%20enzyme&f=false http://www.fda.gov/downloads/Drugs/ScienceResearch/…/UCM085502.pdf?hc_location=ufi