Tag Archives: PHARMACOGENETICS

PSYCHOTROPIC DRUGS-Stories of Suicides & Homicides

Lawyer Impulsively Jumps In Front of Train: Effexor, like All A/D’s, Can Cause Impulsivness
Suicide Med For Depression 2011-11-11 England Physician Kills Himself Shortly After Starting an A/D
Personality Drained Away/Huge Weight Gain Med For Depression 2011-11-10 England After Many Years on A/D’s, Man Felt Like His Personaity Was Drained Away & He Became Obese
Violence Med For Depression 2011-11-10 Canada Man Strikes an Ax at a Neighbor
Death Antidepressant 2011-11-10 England 23 Year Old Woman Dies of Cardio-Respiratory Arrest: High Level of A/D’s in Body: No Alcohol or Drug
Suicide Celexa Antidepressant 2011-11-10 England Woman, 73, Kills Herself While on Celexa
Murder-Suicide Prozac 2011-11-09 California Man Kills Two Police Officers & Himself
Heart Disease Med For Depression 2011-11-09 Global ++Depression Meds Are More Likely to Cause Heart Disease
Murder Attempt Med For Depression 2011-11-08 Malta/Mediterranean Man Attempts to Murder Uncle With Hammer: Confused & Agitated
Bizarre Behavior Lexapro & Desyrel Antidepressants 2011-11-08 California +Famous Actress Kim Richards Exhibits Bizarre Behavior on TV
Dulled Mind/Numbed Body Zoloft 2011-11-07 Georgia Woman Physician Quits Zoloft: Tells How She Recovered From Depression
Suicide Med For Depression 2011-11-07 Texas Woman Drives Her Car Into Lake
Suicide Antidepressants 2011-11-05 Ohio Soldier, 22, Kills Himself: Black Box Warning on Suicidality for This Age Group

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Pharmacogenetics: Cytochrome P450 in Pediatric Population

The various factors that impact pharmacokinetics
and pharmacodynamics mature towards adult values at different rates, thus requiring continual modification of drug dose regimens in neonates, infants, and children.

Read Study Pediatric Population study Cyp 450.

The New Science of Vaccinomics: Pharmacogenetics and Vaccines

Abstract

The field of pharmacogenomics and pharmacogenetics provides a promising science base for vaccine research and development. A broad range of phenotype/genotype data combined with high-throughput genetic sequencing and bioinformatics are increasingly being integrated into this emerging field of vaccinomics. This paper discusses the hypothesis of the ‘immune response gene network’ and genetic (and bioinformatic) strategies to study associations between immune response gene polymorphisms and variations in humoral and cellular immune responses to prophylactic viral vaccines, such as measles–mumps–rubella, influenza, HIV, hepatitis B and smallpox. Immunogenetic studies reveal promising new vaccine targets by providing a better understanding of the mechanisms by which gene polymorphisms may influence innate and adaptive immune responses to vaccines, including vaccine failure and vaccine-associated adverse events. Additional benefits from vaccinomic studies include the development of personalized vaccines, the development of novel vaccines and the development of novel vaccine adjuvants.

As one clinician noted, ‘…vaccines licensed in the USA are safe and effective. However, not every vaccine is equally safe or equally effective in every person’ [].

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