Clinical Pharmacogenetics in Pediatric Patients Anwar Husain; Jennifer A. Loehle; David W. Hein Pharmacogenomics. 2007;8(10):1403-1411. Newborns and infants rapidly undergo simultaneous stages of organ growth and demonstrate large variability in drug response and metabolizing capabilities.[1,2] The enzymes, transporters and targets important for pediatric drugs all have the potential to vary along developmental timelines in terms of … Continue reading Studies: Cytochrome P450 and failure of infants to metabolize vaccine excipients