Aluminum & Cytochrome P450

Suppressive effect of accumulated aluminum trichloride on the hepatic microsomal cytochrome P450 enzyme system in rats.

The results revealed that exposure to AlCl3 inhibited the microsomal CYP450 dependent enzyme system of liver. Our findings suggest that long term daily exposure of AlCl3 exerts the suppressive effects and thus may cause dysfunction of hepatic CYP450 dependent enzyme system of rat.

Highlights

► AlCl3 exposure through drinking water gets close with actual chronic oral Al exposure. ► Effects of Al exposure on the hepatic microsomal protein, AND and ERND were studied. ► Metabolism of Al affected the hepatic microsomal cytochrome P450 enzyme system.

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Aluminium compounds for use in vaccines | Immunology & Cell Biology

https://www.nature.com/articles/icb200476
by EB Lindblad – ‎2004 – ‎Cited by 397 – ‎Related articles

Oct 1, 2004 – Holt, shortly after, demonstrated that preformed aluminium phosphate, prepared from equimolar amounts of aluminium chloride and trisodium phosphate, acted as an adsorbant and was adjuvant active with diphtheria. Data on the use of alum-precipitated vaccines can be found in older literature, but in …

The mechanisms of action of vaccines containing aluminum adjuvants …

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406982/
by TR Ghimire – ‎2015 – ‎Cited by 20 – ‎Related articles

Apr 16, 2015 – Adjuvants such as the aluminum compounds (alum) have been dominantly used in many vaccines due to their immunopotentiation and safety records …. Aluminum compounds such as aluminum chloride, aluminum silicate, algammulin (gamma inulin plus AH), cesium alum (CA), Imject alum (IA) (AH plus ..

 

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