6.4. Modification of drug hepatic metabolism (cyp450)
Reports of patients developing phenytoin, warfarin or theophylline
toxicity, following acute infections [118,119] and anti-influenza vaccination,
have been published [119–128]. In one study, toxic elevations
in the levels of the concurrent medicines were reported to occur up to
28 days after vaccination . Other vaccines such as Bacillus Calmette
Guerin (BCG), and immunostimulators such as interferons and various
cytokines are able to produce the same effect [129–131]. The effect of
immunostimulation on drug metabolismwas demonstrated several decades
ago in laboratory animals, using several vaccines and adjuvants,
with the demonstration that cytochrome P450 hepatic enzyme inhibition
as a consequence immunostimulation is involved, leading to
reduced clearance of the concurrently administered medicines
[132–135]. Years later, Renton reported that the release of cytokines,
such as IL-1, IL-2, IL-6, TNF, TGF-β and IFNs, is involved in modulating
the expression of several P450 isoforms . Reversible changes in
the pharmacokinetic parameters of theophylline, and decreased expression
of CYP1A, 2B1/2, and 3A subfamily, have also been reported in rats
after intravenous injection of lipopolysaccharide (endotoxin) derived
from Klebsiella pneumoniae  and a similar effect was observed
after application of FCA to mice (used as a positive control), for comparison
with a non-toxic intranasal adjuvant called AFCo1 .
On the other hand, Prandota have shown the rapid decrease in the
total CYP450 liver content of FCA-treated rats and the selective downregulation
of specific CYP isoforms through a direct reduction in
mRNA levels (CYP2B, CYP2CI1, CYP3A1, and CYP2E1), protein content
(CYP2B, CYP2C11, and CYP2E1) and catalytic activity (CYP2C6,
CYP2C11, and CYP2E1). Thus, Prandota has highlighted that polymorphisms
of drug-metabolizing enzymes and cytokines may contribute
markedly to drug-induced hepatotoxicity and drug pharmacokinetic
disturbances, affecting genetically predisposed subjects .
Vaccines Excipients: PHARMACOGENETICS: Inability of infants and children to metabolize vaccine xenobiotic excipients (cyp 450)
MEDICAL HORROR: Genetic sequencing of common vaccine finds entire male human genome from aborted human baby… “a complete individual genome” with abnormal, modified genes… 560 genes linked to cancer
“What’s clear from this genetic sequencing is that the vaccine industry is inoculating children with engineered cancer. As CHD explains, the vaccines are deliberately formulated with cancer-causing genes which have been specifically modified to promote cancer tumors” (Mike Adams)
1- The fetal cell line was found to belong to a male fetus.
2- The cell line presents itself in such a way that it is likely to be very old, thus consistent with the declared line of the 1960s.
3- The fetal human DNA represented in this vaccine is a complete individual genome, that is, the genomic DNA of all the chromosomes of an individual is present in the vaccine.
4- The human genomic DNA contained in this vaccine is clearly, undoubtedly abnormal, presenting important inconsistencies with a typical human genome, that is, with that of a healthy individual.
5- 560 genes known to be associated with forms of cancer were tested and all underwent major modifications.
6- There are variations whose consequences are not even known, not yet appearing in the literature, but which still affect genes involved in the induction of human cancer.
7- What is also clearly abnormal is the genome excess showing changes in the number of copies and structural variants.
VLA Comment: Makes sensed that there is a probability that a fetus that has been aborted may have genes that are defective or faulty or disturbed due to the vaccine process.
Psychiatric drugs and some general medications
have effects that are not always the ones intended.
Reactions to different drugs and drug-drug combinations
are governed by individual metabolising rates. Phase 1
metabolism takes place via the cytochrome P450 enzymes
with 57 human genes identified that are genetically
variable i.e. polymorphic. The population are coded as
poor, extensive (known as normal), intermediate or ultra
Emerging evidence of an impending Parkinson’s disease pandemic identified
Neurological disorders are now the leading cause of disability globally, and the fastest growing neurological disorder in the world is PD, a slowly progressive disorder that affects movement, muscle control, and balance. In 1855, forty years after Dr. James Parkinson first described the condition, approximately 22 people of 15 million in England and Wales died of PD. In 2014, roughly 5,000 to 10,000 individuals of 65 million in the UK died of PD. From 1990 to 2015, the number of people with PD doubled worldwide to over six million. Driven principally by aging, this number is projected to double again to over 12 million by 2040, and additional factors, including increasing longevity, declining smoking rates, ….VLA Comment: How about mass vaccination for nearly every newborn, toddler, child and adolescent….that presents in the majority of the emerging generation neurological and physiological disorders and regressions.
Mike Adams (NATURAL NEWS/THE HEALTH RANGER) discusses terraforming the planet as to make earth inhabitable to an alien species. He will be live in Branson, Missouri, Sept 13-15 for the True Legend Conference with Steve Quayle of which I (VLA founder) intend to go.I am a fan of both Mike Adams and Steve Quayle.
I have also included herein the Lecture of Dr. Rudolf Steiner, Christian Clairvoyant and founder of Biodynamic Agriculture, the Waldorf education system and Anthroposophy called the 8th (demonic) sphere. Included in this link is the alert on 5G that appears to be part of plan.
Inflammation is associated with down regulations of hepatic and extrahepatic CYP enzymes drug metabolism.
The CYP represent a superfamily of enzymes with a key role in the activation or inactivation of a plethora of therapeutic agents. CYP enzymes are involved in the metabolism of xenobiotic substances. Cytochromes present intra- or interindividual and intra- or interethnic genetic polymorphisms. Variations in the pharmacokinetic drug profile are linked to the rising toxicity following a declining metabolism, reduced efficacy of the drug, adverse drug interaction, and increasing production of toxic metabolites. The high-metabolic rate of the intestinal microbiota is due to its many enzymes which catalyze reactions in phase I and II drug metabolism. In case of a compromised intestinal barrier, there may be an increase in paracellular passive absorption.
It is evident that high-microbial abundance following intestinal disturbances, environment, aging, or food-associated diseases promotes the microbial metabolism of a drug before absorption.
Above link Includes CDC Vaccine Excipient list of xenobiotics