Foods and Medications to Avoid with MAOIs

Some specific pharmaceutical drugs that should not be combined with MAOIs (some are mild risks, others serious):

– Actifed
– Adderall
– Alaproclate
– Albuterol (Proventil, Ventolin)
– Amantadine hydrochloride (Symmetrel)
– Amiflamine
– Amineptine
– Amitriptaline
– Amoxapine (Asendin)
– Atomoxedine
– Bazinaprine
– Befloxetone’
– Befol
– Benadryl
– Benmoxinb (Nerusil, Neuralex)
– Benylin
– Benzedrine
– Benzphetamine (Didrex)
– Bicifadine
– Brasofensine
– Brofaromine (Consonar)
– Buprenorphine
– Bupropion (Wellbutrin)
– Buspirone (BuSpar)
– Butriptyline
– Carbamazepine (Tegretol, Epitol)
– Chlorpheniramine
– Chlor-Trimeton
– Cimoxetone
– Citalopram (Celexa)
– Clomipramine (Anafranil)
– Clorgyline
– Codeine
– Cyclobenzaprine (Flexeril)
– Cyclizine (Marezine)
– D-deprenyl
– Dapoxotine
– Desipramine (Pertofrane, Norpramin)
– Desvenlafaxine
– Dextroamphetamine (Dexedrine)
– Dextromethorphan (DXM)
– Dibenzepin
– Dienolide kavapyrone desmethoxyyangonin
– Diethylpropion
– Disopyramide (Norpace)
– Disulfiram (Antabuse)
– Dobutamine
– Dopamine (Intropin)
– Dosulepin
– Doxepin (Sinequan)
– Duloxetine (Cymbalta)
– Emsam
– Entacapone
– Ephedrine
– Epinephrine (Adrenalin)
– Escitalopram (Lexapro)
– Esuprone
– Etorphine
– Femoxitine
– Fenfluramine (Pondimin)
– Flavoxate Hydrochloride (Urispas)
– Fluoxetine (Prozac)
– Fluvoxamine
– Furazolidone (Furoxone)
– Gabapentin
– Guanethedine
– Guanadrel (Hylorel)
– Guanethidine (Ismelin)
– Hydralazine (Apresoline)
– Hydrazine
– 5-Hydroxytryptophan
– Imipramine (Tofranil)
– Iprindole
– Iproniazid (Marsilid, Iprozid, Ipronid, Rivivol, Propilniazida)
– Iproclozide (Sursum)
– Isocarboxazid (Marplan)
– Isoniazid (Laniazid, Nydrazid)
– Isoniazid rifampin (Rifamate, Rimactane)
– Isoproterenol (Isuprel)
– L-dopa (Sinemet)
– Ladostigil
– Lazabemide (Pakio, Tempium)
– Levodopa (Dopar, Larodopa)
– Linezolid (Zyvox, Zyvoxid)
– Lithium (Eskalith)
– Lofepramine
– Loratadine (Claritin)
– Maprotiline (Ludiomil)
– Mebanazine (Actomol)
– Medifoxamine
– Melitracen
– Meperidine (Demerol)
– Metaproterenol (Alupent, Metaprel)
– Metaraminol (Aramine)
– Metfendrazine (Inkazan)
– Methamphetamine (Desoxyn)
– Methyldopa (Aidomet)
– Methylphenidate (Ritalin)
– Metralindole
– Mianserin
– Milacimide
– Milnacipran
– Minaprine (Cantor)
– Mirtazapine (Remeron)
– Mofegeline
– Moclobemide (Aurorix, Manerix)
– Monomethylhydrazine
– Montelukast (Singulair)
– Nalbufrine
– Naloxone
– Naltrexone
– Nefazodone
– Nialamide (Niamid)
– Nisoxetine
– Nomifensine
– Norepinephrine (Levophed)
– Nortriptyline (Aventyl)
– Octamoxin (Ximaol, Nimaol)
– Oxybutynin chloride (Ditropan)
– Oxycodone
– Oxymetazoline (Afrin, Dimetapp)
– Oxymorphone
– Orphenadrine (Norflex)
– Pargyline (Eutonyl)
– Parnate
– Paroxetine (Paxil)
– Pemoline (Cylert)
– Percocet
– Pethedine (Demerol)
– Phendimetrazine (Plegiline)
– Phenelzine (Nardil)
– Phenergen
– Phenelzine (Nardil, Nardelzine)
– Pheniprazine (Catron)
– Phenmetrazine
– Phenoxypropazine (Drazine)
– Phentermine
– Phenylephrine (Dimetane, Dristan decongestant, Neo-Synephrine)
– Phenylhydrazine
– Phenylpropanolamine (found in many cold medicines)
– Phenelzine (Nardil)
– Pirlindole (Pirazidol)
– Procarbazine (Matulane)
– Procainamide (Pronestyl)
– Protriptyline (Vivactil)
– Pseudoephedrine
– Oxymetazoline (Afrin)
– Quinidine (Quinidex)
– Rasagiline (Azilect)
– Reboxetine
– Reserpine (Serpasil)
– Risperidone
– Salbutemol
– Salmeterol
– Selegiline (Eldepryl, Emsam, Zelapar)
– Sercloramine
– Sertraline (Zoloft)
– Sibutramine
– Sumatriptan (Imitrex)
– Terfenadine (Seldane-D)
– Tegretol
– Temaril
– Tesofensine
– Tetrindole
– Theophylline (Theo-Dur)
– Thesbutiaint
– Thioridazine (Mellaril)
– Tianeptine
– Tolcapone
– Toloxatone (Humoryl)
– Tramadol
– Tranylcypromine (Parnate)
– Trazodone
– Tricyclic antidepressants (Amitriptyline, Elavil)
– Trimipramine (Surmontil)
– Triptans
– Tyrima
– Vanoxerine
– Venlafaxine (Effexor)
– Viloxezine
– Yohimbine
– Zimelidine
– Ziprasidone (Geodon)

READ MORE…

Samoa Seizes All MMR Vaccines After Two Infants Die Minutes After Receiving the Vaccine

TV1 in Samoa is reporting that two infants have died within minutes of receiving the measles, mumps, and rubella (MMR) vaccine.

Tala Fou brings you breaking news on the death of two young children both aged 1-year-old from the villages of Safotu and Sasina in Savaii. Both children died within minutes of being vaccinated with the MMR vacine at Safotu Hospital on Friday morning the 6th of July.

Our News Reporter Alisa Faamaoni met with both families in Savaii today. The parents of the first child Marietta and Samuelu Tuisuesue of Sasina explained in detail to Tala Fou that within three minutes of their 1-year-old daughter Lannacallystah Samuelu being injected with the MMR vacine by a nurse she was dead. (Source.)

What is so tragic, and has this island nation in such an uproar, is that the parents of the second child who died had reportedly already learned about the first infant’s death a couple hours earlier and declined to have their child receive the same vaccine. The mother reports that the nurse administered the MMR vaccine against her consent, leading to the child’s immediate death upon receiving the vaccine.  READ MORE..

INFERTILITY UNEXPLAINED: Vaccines- Polysorbate 80 metabolized by Cytochrome P450, HPV vaccine

Are we sterilizing or genderbending the population between hormonal disrupting agricultural herbicides and vaccines and pharmacuetical drugs?

Research paper (Polysorbate 80)

Effects of non-ionic surfactants on cytochrome P450-mediated metabolism in vitro

Author links open overlay panelAnneChristiansenabThomasBackensfeldaKarstenDennercWernerWeitschiesb

 

Biotransformation XXXIX. Metabolism of testosterone, androstenedione, progesterone and testosterone derivatives in Absidia coerulea culture

Read study Abstract

FULL TEXT PDFsurfactants_suppress_CYP_enzymes_2011

VLA comment: Re: “Non-ionic surfactants like polysorbate 80 inhibit the CYP3A4 mediated hydroxylation of testosterone”.  I am wondering if Polysorbate 80 in vaccines considering it needs to be metabolized by Cyp 450 family of enzymes, involving hydroxylated testosterone, has a gender tweaking or has a precocious puberty effect that we find in Autism.

Polysorbate 80 in Vaccines:

Read Article

The U.S. Centers for Disease Control and Prevention (CDC) Vaccine Excipient and Media Summary lists 11 vaccines that contain polysorbate 80:

  • DTaP (Infanrix);
  • DTaP—IPV (Kinrix);
  • DTap-HepB-IPV (Pediarix);
  • DTaP-IPV-Hib (Pentacel);
  • Gardasil
  • Influenza (Agriflu);
  • Influenza (Fluarix);
  • Meningococcal (MenB-Trumenba);
  • Pneumococcal (PCV13—Prevnar13);
  • Rotavirus (RotaTeq);
  • Tdap (Boostrix)5
  • HPV

INFANTS INABILITY TO METABOLIZE VACCINE EXCIPIENTS

Studies: Cytochrome P450 and failure of infants to metabolize vaccine excipients

Top Medications with this excipient

Hypersensitivity reaction to human papillomavirus vaccine due to polysorbate 80.

Read study polysorbate_80_reaction_to_HPV_vaccine_2012

Abstract

A 17-year-old girl reported generalised urticaria, eyelid angioedema, rhino-conjunctivitis, dyspnoea and wheezing 1 h after third intramuscular administration of quadrivalent human papilloma virus vaccine (Gardasil). She was treated with antihistamine, and corticosteroids with prompt relief of rhinitis and dyspnoea, while urticaria and angioedema lasted 24 h. Intradermal test with Gardasil, which contains polysorbate 80 (PS80), resulted positive, while skin tests with the bivalent vaccine were negative. Prick test performed with PS80 resulted positive in the patient and negative in ten healthy controls. The CD203 basophil activation test result was negative for PS80 at all the tested dilutions and specific IgE was not found. As flu vaccine was recommended, the authors skin tested two flu vaccine, one containing PS80 (Fluarix, GSK), which resulted positive and another flu vaccine with no adjuvant or preservative (Vaxigrip, Sanofi Pasteur MSD), which gave negative results. The patient then received Vaxigrip without adverse reactions.

A lowered probability of pregnancy in females in the USA aged 25–29 who received a human papillomavirus vaccine injection

NEW STUDY (2017) LOWERED PREGNANCY RATES

Results suggest that females who received the HPV shot were less likely to have ever been pregnant than women in the same age group who did not receive the shot. If 100% of females in this study had received the HPV vaccine, data suggest the number of women having ever conceived would have fallen by 2 million. Further study into the influence of HPV vaccine on fertility is thus warranted.

VLA COMMENT: Lots of vaccines (see above) contain Polysorbate 80.  Does Polysorbate 80 considering its effect on testosterone have a negative hormonal effect on woman after years of being injected with the stuff.   Could the HPV vaccine with Polysorbate 80 providing the direct target to the reproductive system be the tipping point?  Or is there some other component  interfering? I believe in-vitro technology was rising prior to the Gardasil shot due to some interference in fertility.  January 1979 in Glasgow.[12] A team led by Ian Johnston and Alex Lopata were responsible for Australia’s first baby conceived by IVF, Candice Reed, born on 23 June 1980 in Melbourne.[13]   Hormanal disruption via agriculture chemicals came into being after WW II, (such as Atrazine, Alachlor and DDT).  See Peter Montague’s work such as Sperm in the News.

 

SPERM IN THE NEWS (1996)

This must be the year of the sperm. The NEW YORKER magazine ran a long story [1] January 15th called “Silent Sperm” –a wry reference to Rachel Carson’s SILENT SPRING, which made its debut in the NEW YORKER 35 years ago. “Silent Sperm” describes the 50% loss in sperm count that has occurred in men worldwide during the past 40 years. Furthermore, the January issue of ESQUIRE features an article on sperm loss, [2] titled “Downward Motility.” MOTHER JONES magazine [3] also began the new year with a sperm story, titled “Down for the Count.” And the nation’s newspaper of record, the NEW YORK TIMES, ran a 4-part, front-page series on increasing infertility in the U.S. January 7-10.

VLA Comment: The hormonal disrupting DDT was introduced in the 1940s (WWII era). In Vitro started gain steam in the 1980/90s. Study showed that Male sperm count was down 50% in 1996. How long before the study was there a consistently reduceing sperm count in males? How long have Vaccines contained polysorbate 80 that inhibits the CYP3A4 mediated hydroxylation of testosterone?.

 

 

 

Glaxo Smith Kline (GSK) responds to Pandemrix and Narcolepsy

GlaxoSmithKline’s full statement to W5 on Pandemrix

1. A. Studies in Sweden, Finland, Ireland, Norway and Britain have also shown the risk of developing narcolepsy is between seven and 13 times higher in children who were immunized with Pandemrix than in those who were not – What is your response to these findings?

B. Can Pandemrix trigger narcolepsy in children?

Epidemiological data currently available to GSK suggest an increased risk of narcolepsy following vaccination with Pandemrix™ (H1N1). Due to the methodological limitations of the studies, which are retrospective observational studies, further research is needed to determine whether the observed risk is related to the vaccine, environmental effects, genetic factors, other factors or a combination of them. Further research also is needed to evaluate whether there are biologically plausible mechanisms by which vaccination with Pandemrix™ (H1N1) may have triggered narcolepsy in some individuals as no such mechanism has been demonstrated to date.

2. In some jurisdictions Pandemrix is no longer used in people under 20 – what do you think of that decision? Is it justified? Why? Why Not?

READ MORE…

 

The Causes Mental Illness: A 61 Year History of Pharmacogenetics suppressed by Pharma

Avram Goldstein: The Founder of Molecular Pharmacology
http://molpharm.aspetjournals.org/content/83/4/720

Summary:

As the Chair of the Department of Pharmacology with responsibility for training medical students in the use of drugs, he was fascinated by the kinetics of drug action. He and his wife Dody developed the plateau principle, which emerged from the recognition that the time to steady state for any drug administered continuously or repeatedly was dependent only on its rate of elimination. These developments drove his increasing desire to see the discipline of pharmacology, both in research and in medical and graduate education, as a science with a strong mechanistic and theoretical underpinning.

Avram was present in Moscow in 1961 when Marshall Nirenberg described his elucidation of the genetic code. With these seminal developments, Avram concluded that the time was ripe for the establishment of a journal devoted to mechanistic aspects of drug action at a molecular level.

Avram was able to persuade ASPET to publish the new journal, which would be called Molecular Pharmacology. “Suitable papers are those which describe applications of the methods of biochemistry, biophysics, genetics and molecular biology to pharmacologic or toxicologic problems…”

Avram, together with his Stanford faculty colleagues Lew Aronow and Sumner Kalman, were working on Principles of Drug Action (Goldstein et al., 1968), a pharmacology textbook that was new for its time in focusing only on basic principles underlying drug action and the longer-term responses of the body to the presence of drugs.

DRUG METABOLISM RESEARCH HAS A 61 YEAR HISTORY

VLA Comment: The field of Pharmacogenomics, Pharmacogenetics, Pharmacogenomics has a 61 YEAR HISTORY  well accepted research concerning drug metabolism.  Education in this field of research has been actively suppressed by Pharma. Anonymous sources in the field of education for medical students tells us that this information is actively suppressed as the pharmacuetical industry would loose billions and billions of dollars if the public knew.  Moreso  medical students and hospital psychiatrists and doctors in general from Pediatricians ot Oconologists  have virtually no knowledge or education of drug metabolism, yet they all provide prescriptions that are contraindicated, causing Medication (drug) induced psychosis.   90% of drugs need an active and mature liver system of Cytochrome P450 enzymes to metabolize and eliminate them from an individual’s body. A substantial percentage of Caucasians, Asians, Blacks have no activity to metabolize these modern drugs.  The results – increased (apparent) psychosis.

INCREASE IN PSYCHOSIS DIAGNOSES

The increase in psychosis diagnosis is actually the agressive poisoning of humanity by uneducated doctors from the cradle to the grave.  The increase in (apparent) mental illness and special needs is due to the inability of many individuals to eliminate, from the body, modern drugs (and streets drugs) such as SSRIs vaccine excipients.

VACCINES, THE BASIS OF MENTAL ILLNESS DIAGNOSES

Vaccines contain excipients that need a mature superfamily of Cytochrome P450 in order to be metabolize and successfully eliminated from the body of infants and children. The damage done to the physiology of a one hour old infant, injected with Aluminum (which interferes in Cyp 450 metabolism in the Hep B and Vitamin K shots),  and other vaccine excipients testifies to the basic underpinnings of the epidemic in Autism, ADHD, ADD, OCD, BiPolar,neurological, mitachondrial issues, depression, anxiety, panic attacks.   The misdiagnosis of mental illness by uneducated medical professionals who extensively prescribe psychiatric drugs and the push to vaccinate, to eliminate parental choice, to eliminate vaccine waivers appears to be an organized effort to debilite the entire emerging generations of humanity through the suppression of this Pharmacogenomic knowedge.  Note: There is no mandated continuing education in drug metabolism for practicing physicans; virtually no education for medical students; yet the prescrbing of medications and the push for vaccine compliance, school shootings, homicides and suicides, special needs education, is at an all time high.

CCHR Newsletter: Overview and layman understanding of Cyp 450, Pharmacogenetics, vaccines, psyche drugs,homicide, suicide.

Below, the American Society for Pharmacology and Experimental Therapeutics chronicled the discoveries and provided communications to advance the science of drug metabolism.

The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 2, 1959–1983
Patrick J. Murphy College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana Received February 18, 2008; accepted February 27, 2008

ABSTRACT (2008):
In 25 years, (now 35 years) drug metabolism research went from using subcellular
particles of undefined content to an understanding of metabolism
at the molecular level. The discoveries of cytochrome P450, en-
zyme induction, reactive intermediates, and genetic polymor-
phisms were milestones in the field. New publications from the
American Society for Pharmacology and Experimental Therapeu-
tics chronicled the discoveries and provided communications to
advance the science of drug metabolism.

THE DISCOVERY OF CYTOCHROME P450 (1957)
The discovery of P450 and its function evolved from observations by Ryan and Engel that C-21 hydroxylations of progesterone and hydroxylated progesterones were catalyzed by a CO inhibitable en-zyme in the adrenal cortex (Ryan and Engel, 1957). They character-ized the reaction as belonging to the class of enzymes categorized by
Mason as “mixed-function oxidases” (Mason, 1957) and by Hayaishias “oxygenases” (Hayaishi, 1962).

THE ROLE OF GLUTATHIONE (depleted in AUTISM?)

The role of glutathione as a precursor of mercapturic acids was confirmed in 1959 (Bray et al., 1959a,b), 80 years after the discovery of these important elimination products by Baumann and Preuss (1879). In the following 25 years, there were over 150 papers in the ASPET journals referring to aspects of glutathione in metabolism. The role of glutathione as a scavenger of reactive intermediates was ofprimary interest, as exemplified by the finding of the glutathione conjugate of acetaminophen by Hinson et al. (1982) or the formation of mercapturic acids from cyclohexene epoxide in the rat (van Bla-deren et al., 1981).

Billionaire Vaccine Entrepreneur Buys LA Times & San Diego Tribune

Big Pharma vaccine billionaire just bought the LA Times… yet another example of the media being run by pharma

(Natural News) The latest example of Big Pharma taking over the media is the purchase of the Los Angeles Times and the San Diego Tribune for $500 million by Big Pharma billionaire Dr. Patrick Soon-Shiong. Instead of paying for advertisements, pharma billionaires have decided to just buy the publications outright so they can control the entire publication. All the journalists here are now officially bought; these publications should officially be recognized as propaganda rags from now on.Big Pharma vaccine billionaire just bought the LA Times… yet another example of the media being run by pharma. READ MORE...

 

 

MAYO CLINIC: Anti-depressant and Pregnancy – and current protocol of Shock treatments

According to Mayo Clinic “generally, these antidepressants are an option during pregnancy:”

VLA comment: The list below are the recommended options that however come with risks.  What is not listed are the rest of the pharma madness drugs given to women approaching child bearing age and therefore compelled to continue the regimen during pregancy.  Other drugs are not listed because they are so risky for birth defects that they are not even considered.  However, how many young women have been prescribed these medication since teenagers?

  • Certain selective serotonin reuptake inhibitors (SSRIs). SSRIs are generally considered an option during pregnancy, including citalopram (Celexa), fluoxetine (Prozac) and sertraline (Zoloft). Potential complications include an increased risk of heavy bleeding after giving birth (postpartum hemorrhage), premature birth and low birth weight. Most studies show that SSRIs aren’t associated with birth defects. However, paroxetine (Paxil) appears to be associated with a small increased risk of a fetal heart defect.
  • Serotonin and norepinephrine reuptake inhibitors (SNRIs). SNRIs also are considered an option during pregnancy, including duloxetine (Cymbalta) and venlafaxine (Effexor XR). However, research suggests that taking SNRIs at the end of pregnancy is associated with postpartum hemorrhage.
  • Bupropion (Wellbutrin). This medication is used for both depression and smoking cessation. Although bupropion isn’t generally considered a first line treatment for depression during pregnancy, it might be an option for women who haven’t responded to other medications. Research suggests taking bupropion during pregnancy might be associated with heart defects.
  • Tricyclic antidepressants. This class of medications includes nortriptyline (Pamelor). Although tricyclic antidepressants aren’t generally considered a first line or second line treatment, they might be an option for women who haven’t responded to other medications. The tricyclic antidepressant clomipramine might be associated with fetal birth defects, including heart defects. Use of these medications during the second or third trimester might also be linked with postpartum hemorrhage.     READMore

SHOCK TREATMENTS

Electroshock is also known by the euphemism electroconvulsive therapy or ECT. Many electroshock patients receive the treatment against their will. Psychiatrists also claim that electroshock is safe during pregnancy and give the treatment to pregnant women.

Pregnancy and Electroconvulsive Therapy: A Multidisciplinary Approach  

STUDY: SHOCK TREATMENTS PREGNANCY 786178

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877273/
by SL Ray-Griffith – ‎2016 – ‎Cited by 7 – ‎Related articles

Electroconvulsive therapy is a safe and effective treatment during pregnancy and of particular benefit in the acute treatment of suicidal ideation.

VLA COMMENT: Suicidal ideations are a result of anti depressants and other drugs not being metabolized properly.  These drugs need Cytochrome P450 to metabolize.  If the patient does not have the activity of this family of liver enzymes and are prescribed drugs that are contra-indicated, as per the package inserts, adverse reactions such as “compelling” suicideal ideations (and heinous ideations of homicide) are likely to occur.

As the statement above refers to “acute treatment of suicidal ideation” it signals that the pregnant patient may be on medication that cannot be metabolized by his/her system of liver enzymes. Hence…the apparent solution to pregnant women who have been on anti depressants and psyche drugs for years and must continue during pregancy, is to top it all off with SHOCK TREATMENTS.  This allows the women to remain on psyche drug medication during her pregnancy.  However as noted in our posting Glyphosate, Drugs and Vaccines....the Cytochrome P450 metabolism is also found in the placenta.

Washington University in St. Louis Shocks Pregnant Women

According to the Citizen’s Commission on Human Rights (CCHR), Approximately 150,000 people get ECT every year in the US, with 2,000 shock treatments being done every year by WUSTL psychiatrists at Barnes-Jewish Hospital. Complications after treatment usually increase with the age of the patient; small surprise there. WUSTL psychiatrists say that, “ECT is considered a safe treatment modality in pregnant women in whom a number of medications may be associated with risk to the fetus.” READ MORE…

Article: ELECTRO SHOCK THERAPY WHILE PREGNANT

 

 

Glyphosate , Psyche Drug and Vaccines: THE CONNECTION

CCHR Newsletter: Overview of Cyp 450, Pharmacogenetics, Psyche Drugs, vaccines.

AGRICULTURE

Read Study glyphosate_rats_CYP_enzyme_suppression_2006

Syngenta Patent shows that the Genetic Engineering of our nations food supply is based on Cytochrome P450 technology whereby the genetically engineered seed is manipulated to be an ultra rapidmetabolizer while the “weeds” who are normal metabolizer dies in the presence of Glysophate.  Cytochrome P450 Gene Conferring herbicide resistance PATENT

MENTAL ILLNESS DIAGNOSIS –

PHARMA DRUGS, STREET DRUGS & MEDICATION AND METABOLIZING OPIOIDS

Plants and humans share the same detox mechanism involving Cytochrome P450.  In humans Cytocrome P450

90% of today’s modern drugs are metabolized by Cytochrome P450.

CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 enzymes metabolize 90 percent of drugs. these enzymes are predominantly expressed in the liver, but they also occur in the small intestine (reducing drug bioavailability), lungs, placenta, and kidneys.2

One out of every 15 white or black persons may have an exaggerated response to standard doses of beta blockers (e.g., metoprolol [Lopressor]), or no response to the analgesic tramadol (Ultram). This is because drug metabolism via CYP450 enzymes exhibits genetic variability (polymorphism) that influences a patient’s response to a particular drug.3

Every person inherits one genetic allele from each parent. Alleles are referred to as “wild type” or “variant,” with wild type occurring most commonly in the general population.

For example, 7 percent of white persons and 2 to 7 percent of black persons are poor metabolizers of drugs dependent on CYP2D6, which metabolizes many beta blockers, antidepressants, and opioids.7,8 One in five Asian persons is a poor metabolizer of drugs dependent on CYP2C19, which metabolizes phenytoin (Dilantin), phenobarbital, omeprazole (Prilosec), and other drugs.

The Effect of Cytochrome P450
Metabolism on Drug Response,
Interactions, and Adverse Effects 
READ STUDYCyp Study

VACCINES

Studies: Cytochrome P450 and failure of infants to metabolize vaccine excipients READ more…

Early Childhood Vaccines contain excipients that need Cytochrome P450 to metabolize.

VLA Comment: Cytochrome P450 is not mature in infants and children under the age of three years old yet we are giving vaccines with excipients that must be detoxed out of the body by Cytochrome P450 family of liver enzymes which infants do not have. These enzymes are predominantly expressed in the liver, but they also occur in the small intestine (reducing drug bioavailability), lungs, placenta, and kidneys.

Note in cases of Autism and vaccinating pregnant women:

Cyp 450 are found in the “Small intestines and placenta”

READ more…

WHO new Vaccine Adverse Reaction Guidelines (2018) Hides ADR’s post vaccination

 

New Delhi  6 July 2018.

Two leading pediatricians  in India have urged the   World Health Organization (WHO)  to urgently revise its manual on classification of “Adverse Events Following Immunization (AEFI),” warning that the new guidelines put children’s life at risk.

 This needs to be done “urgently in the interest of child safety,”  doctors Jacob Puliyel at St Stephen’s Hospital in Delhi, and Pathik Naik of  Children Hospital in Surat, say in a report published in the prestigious journal ‘F1000Research’

 Under  WHO’s revised   manual on AEFI,  only those adverse  reactions observed during  clinical trials of a vaccine,    should be  classified as   vaccine related.     All new serious adverse reactions including deaths  seen during post-marketing of the vaccine   should be considered  as ‘coincidental’  or ‘unclassifiable’, and the vaccine should not be blamed.

READ SOURCE ABSTRACT

 The WHO has also changed the  definition of  “causal association,” the authors say. Under the revised guidelines,  if there is an alternate explanation for the adverse event, or another factor is involved, causative association with vaccine should not be made.   “In other words,  if after vaccination,  a child with an underlying congenital heart disease  develops    cardiac failure, it would not be considered causally related to the vaccine.”

 The revised classification by WHO  “is a major step backward for patient safety,” the authors say.  “This could embolden vaccine manufacturers to be more reckless with regard to adverse reactions,” they warn.

 Puliyel and Naik note that the Global Advisory Committee on Vaccine Safety has documented many deaths in children with pre-existing heart disease after they were administered the pentavalent vaccine (combined diphtheria, tetanus, pertussis, Hib, and hepatitis-B vaccine).    “Under  WHO’s  new definition of causal association, these deaths would not be acknowledged as related to  vaccination.” 

 Both Sri Lanka and Vietnam governments withdrew  the pentavalent vaccine following the deaths of  five children in Sri Lanka and 12 in Vietnam soon  after vaccination.  But  WHO investigating teams declared that the deaths were ‘unlikely’ to be related to vaccination, the report says.   The authors point out that  a new study in India,    showed that the switch from DPT (diphtheria, tetanus, pertussis)  to pentavalent vaccine almost doubled the deaths following vaccination. “A large number of these deaths could have been avoided had the AEFI manual not been revised.”

 According to their  report, the consequence of India adopting WHO’s new classification   can be seen from the causality assessment of 132 serious AEFI cases uploaded on the website of the Ministry of Health and Family Welfare.  Of the total AEFI cases,  54   babies died and 78 survived,   “but not even one death was classified as vaccine-related. Nearly all the deaths were simply classified as unclassifiable or coincidental.”  

 Vaccines are drugs used as a preventive measure, given to   healthy persons.  . Adverse events following immunization   must be monitored more carefully than other drugs, the authors note. “A credible immunization safety evaluation and monitoring system is essential for the success of immunization programmes.”   

 Adverse reaction and deaths may not show up as significantly increased in small safety studies. However, records of all deaths and serious adverse events following vaccinations should be maintained and periodically reviewed for safety signals.     

According to the authors,  WHO’s  new AEFI classification scheme “that allows for an outright denial of any new causative association with vaccination” could fall foul of Article 2 of the  European Convention on Human Rights. Adverse reaction and deaths may not show up as significantly increased in small safety studies. However, records of all deaths and serious adverse events following vaccinations should be maintained and periodically reviewed for safety signals.     

 “Paradoxically, the AEFI algorithm is said to be for vaccine safety,” says Puliyel. “Perhaps we need a scheme for public safety rather than vaccine safety.” (END)

 Jacob Puliyel MD MRCP M Phil

puliyel@gmail.com

Phone 0091 9868035091

REVISED Revised World Health Organization (WHO)’s causality assessment of adverse events following immunization—a critique [version 2; referees: 2 approved]

OPEN PEER REVIEWREFEREE STATUS

The World Health Organisation (WHO) has recently revised how adverse events after immunization (AEFI) are classified. Only reactions that have previously been acknowledged in epidemiological studies to be caused by the vaccine are classified as a vaccine-product–related-reaction. Deaths observed during post-marketing surveillance are not considered as ‘consistent with causal association with vaccine’, if there was no statistically significant increase in deaths recorded during the small Phase 3 trials that preceded it. Of course, vaccines  noted to have caused a significant increase in deaths in the control-trials stage would probably not be licensed. After licensure, deaths and all new serious adverse reactions are labelled as ‘coincidental deaths/events’ or ‘unclassifiable’, and the association with vaccine is not acknowledged. The resulting paradox is evident. VLA Comment: INTERESTING POINT IN PINK
The definition of causal association has also been changed. It is now used only if there is ‘no other factor intervening in the processes’. Therefore, if a child with an underlying congenital heart disease (other factor), develops fever and cardiac decompensation after vaccination, the cardiac failure would not be considered causally related to the vaccine. The Global Advisory Committee on Vaccine Safety has documented many deaths in children with pre-existing heart disease after they were administered the pentavalent vaccine. The WHO now advises precautions when vaccinating such children. This has reduced the risk of death. Using the new definition of causal association, this relationship would not be acknowledged and lives would be put at risk. In view of the above, it is necessary that the AEFI manual be revaluated and revised urgently. AEFI reporting is said to be for vaccine safety. Child safety (safety of children) rather than vaccine safety (safety for vaccines) needs to be the emphasis.

 

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