Category Archives: Pharmacogenetics

STUDY-Vaccine Adjuvants: Systemic immunotoxicity reaction induced by adjuvanted vaccines

READ STUDY…

Adjuvants – Systemic_immunotoxicity_reactions_induced by adjuvanted vaccines

6.4. Modification of drug hepatic metabolism (cyp450)

Reports of patients developing phenytoin, warfarin or theophylline
toxicity, following acute infections [118,119] and anti-influenza vaccination,
have been published [119–128]. In one study, toxic elevations
in the levels of the concurrent medicines were reported to occur up to
28 days after vaccination [124]. Other vaccines such as Bacillus Calmette
Guerin (BCG), and immunostimulators such as interferons and various
cytokines are able to produce the same effect [129–131]. The effect of
immunostimulation on drug metabolismwas demonstrated several decades
ago in laboratory animals, using several vaccines and adjuvants,
with the demonstration that cytochrome P450 hepatic enzyme inhibition
as a consequence immunostimulation is involved, leading to
reduced clearance of the concurrently administered medicines
[132–135]. Years later, Renton reported that the release of cytokines,
such as IL-1, IL-2, IL-6, TNF, TGF-β and IFNs, is involved in modulating
the expression of several P450 isoforms [130]. Reversible changes in
the pharmacokinetic parameters of theophylline, and decreased expression
of CYP1A, 2B1/2, and 3A subfamily, have also been reported in rats
after intravenous injection of lipopolysaccharide (endotoxin) derived
from Klebsiella pneumoniae [136] and a similar effect was observed
after application of FCA to mice (used as a positive control), for comparison
with a non-toxic intranasal adjuvant called AFCo1 [97].
On the other hand, Prandota have shown the rapid decrease in the
total CYP450 liver content of FCA-treated rats and the selective downregulation
of specific CYP isoforms through a direct reduction in
mRNA levels (CYP2B, CYP2CI1, CYP3A1, and CYP2E1), protein content
(CYP2B, CYP2C11, and CYP2E1) and catalytic activity (CYP2C6,
CYP2C11, and CYP2E1). Thus, Prandota has highlighted that polymorphisms
of drug-metabolizing enzymes and cytokines may contribute
markedly to drug-induced hepatotoxicity and drug pharmacokinetic
disturbances, affecting genetically predisposed subjects [137].

Vaccines Excipients: PHARMACOGENETICS: Inability of infants and children to metabolize vaccine xenobiotic excipients (cyp 450)

FORBES: The Privacy Delusion of Gene Testing

ANNE WOJCICKI above sitting next to Facebook founder & CEO who now owns youtube.

Susan and Anne Wojcicki are sisters. Susan, 50, is the CEO of YouTube and has long worked for Google. Anne, 45, co-founded and serves as CEO of the genetic testing website 23andMe. Anne married Sergey Brin, a Google co founder, with whom she has kids. But the two split in 2013 (which means that, yes, her sister works under her ex).

Gene testing promises a revolution in healthcare. With just a few swabs of saliva, diagnostics can provide an unprecedented look into a person’s family history and potential health risks. Within a decade, global sales of genetic tests are expected to hit $10 billion. Direct-to-consumer companies such as 23andMe and Genos have proven particularly popular, with tens of thousands of people purchasing at-home testing kits every year.

But the industry’s rapid growth rests on a dangerous delusion: that genetic data is kept private. Most people assume this sensitive information simply sits in a secure database, protected from hacks and misuse.

Is your DNA genetic testing information SAFE?

Far from it. Genetic-testing companies cannot guarantee privacy. And many are actively selling user data to outside parties.

The problem starts with the Health Insurance Portability and Accountability Act (HIPAA), a 1996 federal law that allows medical companies to share and sell patient data if it has been “anonymized,” or scrubbed of any obvious identifying characteristics.

For instance, 23andMe has sold access to its database to at least 13 outside pharmaceutical firms. One buyer, Genentech, ponied up a cool $10 million for the genetic profiles of people suffering from Parkinson’s. AncestryDNA, another popular personal genetics company, recently announced a lucrative data-sharing partnership with the biotech company Calico.

Customers are wrong to think their information is safely locked away. It’s not; it’s getting sold far and wide.  READ MORE…

IS THE GOVERNMENT INVOLVED?

Is the government involved, as the relationship between DARPA and Facebook shows. The DARPA program, LifeLog, closed down on the very day that FaceBook began – February 4, 2004. Then there is the relationship to Internet collection sites, like Google and YouTube. They are not just business partners, they are family and marital partners! How close is close!

Apparently DARPA transferred its “LifeLog” project mission to collect DNA on everyone to Facebook in 2004

REGINA DUGAN 19th Director of DARPA

Worked for: Facebook, Google, RedXDefense, NASA

VLA COMMENT: It is very important to get a DNA test prior to be prescribed drugs.  Many individuals do not have the ability (via genetics) to metabolize specific drugs.  These individuals are, because they are not being tested, are commonly given contraindicated drugs which render them more and more psychotic, suicidal and homicidal with heinous ideations, beyond the comprehension of normal human beings. However, you might ask your doctor if the company that is doing the testing will keep you information safe including privacy of not redacting you name and selling the DNA.  Best it would be if, AS IT SHOULD BE, that genetic testing be covered by HIPPAA law.

PHARMACIDE: THE AUTOMATISM DEFENSE-virtual links to white paper by Eileen Dannemann

                                   PHARMACIDE

                             Automatism Defense

                Mental illness, Suicides, Homicides, Mass shootings

                          A white paper by Eileen Dannemann

                        Director, National Coalition of Organized Women

 

                                 1.  Outline compilation FINAL

                                  2. Discussion and Purpose

       photos shooters, suicides….THE EYES…

 

TOP-COCAINE, MIDDLE-KETAMINE, SPEED, BOTTOM-KETAMINE

                                      3. Mass Shooters Images and text

   Preface and Summary of homicidal/suicidal events

                                       4. SSRI STORIES #1 & SSRI STORIES #2

  Excerpts of 6,000 homicides/suicides on prescription drugs

                                       5. The Automatism Defense

                                       6. Case Series and Review#1..Dr. Lucire

Antidepressant-induced akathisia-related homicides associated with diminishing mutations in metabolizing genes of the CYP 450 family

                                       7. Review#2…Dr. Brogan

A literature Review of Neuropsychiatric Adverse Reaction for Antidepressant and Neuroleptic Psychiatric Drugs and General Medications

                                       8. SUICIDE AND MURDER…Dr. Mercola

                                       9. Cost Analysis#1

…of hospitalization and treatments: Psychiatry meets pharmacogenetics for the treatment of revolving door patients with psychiatric disorders

                                       10. Cost Analysis#2

Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost

 

Author, Eileen Dannemann, giving a “layman’s” talk on Pharmacogenetics.

Who KIlled Alex ? Mother who killed her autistic son released from prison

RIVER GROVE, Ill. (WLS) — Two women charged with killing a teenager with severe autism were released from prison on Wednesday afternoon.

Alex Spourdalakis, 16, was fatally stabbed in 2013 in a River Grove apartment by his mother, Dorothy Spourdalakis, and the boy’s godmother, Agatha Skrodzka.

An absolutely riveting documentary on Amazon.

Suicide and Murder — Side Effects of Medication

Suicide and Murder — Side Effects of Medication

Story at-a-glance

  • 1 in 6 Americans between the ages of 18 and 85 were on psychiatric drugs in 2013, most of them antidepressants. The highest rates of depression are reported among 18- to 25-year-olds. Suicide rates are at an all-time high as well, rising 31% between 2001 and 2017
  • While antidepressants are routinely used as a first-line treatment for depression, studies show their effectiveness is on par with placebo, while serious side effects are often ignored or hidden
  • Violence, including suicide and homicide, is a serious side effect of at least 25 different psychiatric drugs, some of which are now given to young children, toddlers and even babies
  • The proportion of adults taking at least one drug where suicide is a potential side effect hit 23.5% as of 2013; 38.4% of American adults were in 2014 on one or more medications that can cause depression as a side effect
  • Eli Lilly paid victims of Paxil-induced violence to shield damaging data about another drug that could have influenced the jury’s determination about Lilly’s responsibility in a 1989 mass-shooting

    Read more….

    Pharmacogenetics…oops wrong medication

  • Psychiatric drugs and some general medications
    have effects that are not always the ones intended.
    Reactions to different drugs and drug-drug combinations
    are governed by individual metabolising rates. Phase 1
    metabolism takes place via the cytochrome P450 enzymes
    with 57 human genes identified that are genetically
    variable i.e. polymorphic. The population are coded as
    poor, extensive (known as normal), intermediate or ultra
    rapid metabolisers.

    STUDY: Brogan-Treatment Emergent Violence to Self and Others.

  • VLA Comment:  Go to our PHARMACOGENETICS ROOM and see our studies

Pharmacogenetics: Emergent Violence to Self and others: Oops, wrong medication causing suicide/ homicide

Findings:

Psychiatric drugs and some general medications
have effects that are not always the ones intended.
Reactions to different drugs and drug-drug combinations
are governed by individual metabolising rates. Phase 1
metabolism takes place via the cytochrome P450 enzymes
with 57 human genes identified that are genetically
variable i.e. polymorphic. The population are coded as
poor, extensive (known as normal), intermediate or ultra
rapid metabolisers.

STUDY: Brogan-Treatment Emergent Violence to Self and Others.

How the Establishment is going to take away our Guns

So far we can approximate, as of today (2019) that 25% of Americans (and growing) won’t be able to get guns because of their mental health record.

Overall, the researchers estimated that 16.7 percent of the 242 million adults in the United States filled at least one psychiatric drug in 2013, including:

  • 12 percent who reported filling one or more prescriptions for antidepressants;
  • 8.3 percent who reported filling one or more prescriptions for sedatives, hypnotics, and anxiolytics; and
  • 1.6 percent who reported filling one or more prescriptions for antipsychotics.

According to the research letter, the rates at which individuals reporting filling prescriptions for psychiatric drugs varied by race and ethnicity. The researchers found that:

  • 20.8 percent of white adults reported using psychiatric drugs;
  • 9.7 percent of black adults reported using psychiatric drugs;
  • 8.7 percent of Hispanic adults reported using psychiatric drugs; and
  • 4.8 percent of Asian adults reported using psychiatric drugs.

Further, the researchers found that the rate of psychiatric drug use increased by age. According to the study, 25.1 percent of adults ages 60 to 85 used at least one psychiatric drug, compared with 9 percent of those ages 18 to 39. The researchers also found that older adults were more likely to use antidepressants and anxiolytics, sedatives, and hypnotics, but not antipsychotics.

In addition, the researchers found that women were more likely than men to report using psychiatric drugs, at 21 and 12 percent, respectively.

According to the research letter, most individuals who reported using psychiatric drugs said they used the medications long-term. The researchers ound that 84.3 percent of adults filled three or more prescriptions for psychiatric drugs in 2013 or reported that they had started to take the drugs in 2011 or earlier. Long-term psychiatric drug users filled a mean of nearly 10 prescriptions for the drugs in 2013.  READ MORE…

(JAMA STUDY 2013 1 out of 6 adults are on psyche drugs)

These data show 1 of 6 US adults reported taking psychiatric drugs at least once during 2013, but with 2- to 3-fold differences by race/ethnicity, age, and sex. Moreover, use may have been underestimated because prescriptions were self-reported, and our estimates of long-term use were limited to a single survey year.

VLA comment:  That is 16.666% of US adults in 2013 that will not be able to get a gun permit.

How much has that increased six years later?  Say 20% of American Adults can’t get gun permits because they have been diagnosed with some form of mental illness and have been prescribed drugs.

Up to 23.5 percent of all children under age 18 take at least one prescription medication each month,1 including opioids, antidepressants, and other psychotropic medications.

We may already be at one quarter (1/4) of the population on psyche drugs.  Be careful with the legislation as this is the subtle alternative way to take away guns.  So far we can approximate that as of today (2019) 25% of Americans won’t be able to get guns because of their mental health record.

THE CAUSE OF MASS SHOOTINGS, SUICIDES CAN BE FOUND IN THE FIELD OF PHARMACOGENETICS (READ POSTS)

 

BMJ: Antidepressant increase the likihood of suicide and homicide

photo taken from this site…interesting comments

Antidepressants increase the risk of suicide, violence and homicide at all ages

“All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases. The following symptoms, anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia (psychomotor restlessness), hypomania, and mania, have been reported in adult and pediatric patients being treated with antidepressants” (1)  READ MORE….

see also www.SSRIStories.net (lists of suicides and homicides)

CAUSE: Pharmacogenetics

PHARMACOGENETICS: MASS SHOOTERS HAVE ONE THING IN COMMON

Nearly all mass shooters have one thing in common, and it isn’t guns

Mike Adams There’s a common thread that winds its way across nearly all mass shooters who carry out violence in America. It’s not guns, it’s psychiatric drugs

Multiple credible scientific studies going back more than a decade, as well as internal documents from certain pharmaceutical companies that suppressed the information show that SSRI drugs ( Selective Serotonin Re-Uptake Inhibitors ) have well known, but unreported side effects, including but not limited to suicide and other violent behavior. One need only Google relevant key words or phrases to see for themselves. www.ssristories.com is one popular site that has documented over 4500 ” Mainstream Media ” reported cases from around the World of aberrant or violent behavior by those taking these powerful drugs.

And what is the science behind this:  PHARMACOGENETICS