Category Archives: Pharmacogenetics

Pharmacogenetics: Man stabs wife 123 times after regularly taking over the counter cold medicine (Coricidin)

Read story:

VLA COMMENT: Although we contacted the Church to which the man and his wife attended we are unsure whether we were heard. We let them know that it appears that the man had a typical homicidal ideation after taking days of codeine (cough medicine). He should have been gene tested to see if he was polymorphic Cytochrome P450 2D6, of which 10% of Caucasians are .He received a life sentence and from the looks of him he is probably being treated with drugs for mental illness in prison.

The study below is of a young girl (9 years old) that died. She also was not tested to see if she was a “non metabolizer” (polymorphism) of Cyp 450 2D6. In the study you will see due to the autopsy they found out the she was a non metabolizer. They try to call it a GENETIC DEFECT so as to blame her for her own death.

It is not a genetic defect. It is simply a genetic variation depending on race, demographics, etc. The medical cabal and pharma tried to posture it as a genetic defect so as to “blame” the victim. A pharmacogenetic test should always be taken before prescribing drugs. See more in our room pharmacogentics.

There is a defense that is emerging as it regards pharmacogenetics called THE AUTOMATON DEFENSE. This defense should have been used, if and after the gene test. Automatism is a rarely used criminal defense. It is one of the mental condition defenses that relate to the mental state of the defendant. Automatism can be seen variously as lack of voluntariness, lack of culpability (unconsciousness) or excuse (Schopp).

Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.  READ STUDY Abstract

Review the list of thousands of suicide and homicide cases on www.SSRISTORIES.net

DAVID’S STORY

And we can’t find an medical negligent attorney in Iowa who has any knowledge of pharmacogenetics.

23 & Me (Genetic testing) signs $300 million deal with GSK

Popular DNA Testing Company Signs $300 Million Deal With Big Pharmaceutical Company

It might be time for people to reconsider before they spit in a tube. Online genetic testing services are wildly popular. Many people use services such as 23andMe and Ancestry.com to learn about their ancestral pasts. Many also use these services to gain more profound insights into their biological makeup, which is often used to assess risk for degenerative diseases, such as cancer. This information offers use for more trivial insights, such as a person’s rate of metabolism in concern with substances like caffeine.

Pharmaceutical companies with access to such genetic information would be able to develop new products in more efficient ways.

GlaxoSmithKline, seeking to take advantage of just that, has announced a four year deal with 23andMe that allows them access to everyone’s genetic information for precisely the purposes pertaining to drug research.

READ MORE…

 

Effects of Heavy Metals in Vaccines (pharmacogenetics)

Aside from the known DEPOPULATION trends such social programs to reduce births, abortion legislation, reduced male sperm count via toxic agriculture (50% reduction as early as 1945), the increasing need for in vitro derived pregnancies, iatrogenic deaths, etc, the worldwide establishment is actually “poisoning” all neonates and infants under 3 years old.

The Journal of Pediatric Pharmacology and Therapeutics

“Developmental Pharmacokinetics in Pediatric Populations”

Hong Lu, PhD and Sara Rosenbaum, PhD

*Ped cyp enzymes  (see graph)  (very important study of the immaturity of cyp 450 superfamilies in infants and children. Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity. DOWNLOAD STUDY

Detoxification mechanism (Fish Study/Liver)Effect Metals on Cyp 450PHD_Thesis_Eng(1)

CDC vaccine excipients

Failure of Infants to metabolize due to immature Liver Cyp450 system of enzymes until 3 years old.

The Effect Of Heavy Metal on Hepatic Chromosome P450

The results of our experiments have demonstrated that heavy metal ions react with cytochrome P450 dependent enzyme system of fish species leading to changes in confirmation of protein structure they resolve in inhibition of activity of enzymes involved in biotransformation, decrease in detoxifying enzymes. In conclusion the difference changes in enzyme activity and cytochrome P450 content induce by the various heavy metal treatments may also be explained by the living and feeding habits of individual fish species.

Like with all living organism, the body of the fish has a quite conserve protein systems providing molecular defense to insure metabolism and elimination of the foreign material. The main region of metabolism of pollutants entering into the fish body is the liver. Due to biotransformation processes these substances are converted to other compounds that can be eliminated from the body thereby becoming less toxic. The hepatic detoxifying enzymes, the cytochrome P450 dependent mixed function monooxygenases, have an important role in this process.  P450 enzyme activity in the body is not constant.  Foreign substances, Xenobiotic or some endogenous regulating molecules are able to increase (inducers) or decrease (inhibitors) the activity of cytochrome P450 enzymes.

Aluminum + Cytochrome P450 -Study: Suppressive effect of accumulated aluminum trichloride on the hepatic microsomal cytochrome P450 enzyme system in rats.

Vaccine Excipients

  • Which ones need a mature Cyp 450 to metabolize out of the body?

 

  • aluminum hydroxide
  • aluminum phosphate
  • ammonium sulfate
  • amphotericin B
  • animal tissues: pig blood, horse blood, rabbit brain,
  • dog kidney, monkey kidney,
  • chick embryo, chicken egg, duck egg
  • calf (bovine) serum
  • beta propiolactone
  • fetal bovine serum
  • formaldehyde
  • formalin
  • gelatin
  • glycerol
  • human diploid cells (originating from aborted human fetal tissue)
  • hydrolized gelatin
  • mercury thimerosal (thiomersal, Merthiolate®)
  • monosodium glutamate (MSG)
  • neomycin
  • neomycin sulfate
  • phenol red indicator
  • phenoxyethanol
  • potassium diphosphate
  • potassium monophosphate
  • polymyxin B
  • polysorbate 20
  • polysorbate 80
  • porcine (pig) pancreatic hydrolysate of casein
  • residual MRC5 proteins
  • sorbitol
  • squalene
  • sucrose
  • tri(n)butylphosphate,
  • VERO cells, a continuous line of monkey kidney cells, and
  • washed sheep red blood

 

VLA Conclusion:  Aside from the known DEPOPULATION trends such social programs to reduce births, abortion legislation, reduced male sperm count via toxic agriculture (50% reduction as early as 1945), the increasing need for in vitro derived pregnancies, iatrogenic deaths, etc, the worldwide establishment is actually “poisoning” all neonates and infants under 3 years old.

The Journal of Pediatric Pharmacology and Therapeutics“Developmental Pharmacokinetics in Pediatric Populations” Hong Lu, PhD and Sara Rosenbaum, PhD

*Ped cyp enzymes  (see graph)  (very important study of the immaturity of cyp 450 superfamilies in infants and children. Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity. DOWNLOAD STUDY

 

 

 

 

 

DAVID’S STORY: Psyche Drugs & Pharmacogenetics (A common story plaguing the World)

David’s Story- Psyche Drugs & Pharmacogenetics

 There is a field of research, Pharmacogenetics/Pharmacogenomics, that is rising to prominence, as we speak.  St. Jude’s Children Hospital, the Mayo Clinic are some of the institutions leading the charge. Turns out that one size doesn’t fit all, after all.  Vaccines contain excipients that must be metabolized by the liver’s superfamily of enzymes (Cytochrome P450).

Let’s take my family, for example.  We are a typical middle – upper class, educated Caucasian family.  We eat virtually only organic food. We meditate and are generally so healthy that we don’t have a family physician as we rarely have a need to go to a doctor. We are a combination of strong stock: Irish, Swedish, Polish, Danish. Our last child, a boy, was born in 1984.  During that time until 2001, 15 of the 39 or so vaccines contained a mercury compound known as Thimerosal. This “heavy metal” compound was removed from all the vaccines in and around 2001 with the exception of the multidose flu vaccine that was distributed in the general clinics, to Medicaid dependent children and pregnant women of all stripes. However, by that time I had educated myself about the risks and benefits of vaccines. So, I did not vaccinate David.

At the age of 18, David went to the University of Iowa, similar to most colleges where prescription drugs are ubiquitous.  Adderall was easily obtained, gladly shared by students who had been on Adderall in middle school and high school, some began as early as 5 years old. One day David, experimented in this revival ‘60s millennium drug culture with one dose of LSD.

 

Video Message to Dr. Yolande Lucire from David IMG_0044

PHARMACOGENETIC TEST SIGNIFICANTLY INCREASE REMISSION OF MENTAL ILLNESS (DEPRESSION)

GeneSight employs a proprietary algorithm to analyze 12 genes and assess how they impact patients’ ability to process dozens of psychotropic medications. The test report buckets depression treatments as red (significant gene-drug interaction), yellow (moderate gene-drug interaction), or green (use as directed.) When the test report shows that patients are on red or yellow medications, their doctors should consider changing the drug or dose, while patients on green medications don’t require a medication change.

Researchers further evaluated patients who entered the study on red medications and either remained on red medications or were switched to yellow or green drugs. Remission rates were 153 percent higher, response rates were 71 percent higher, and symptom improvement rates were 59 percent higher when patients were switched from red to yellow or green meds — all statistically significant changes.

This analysis “establishes a new standard of care” for physicians by demonstrating that patients on red medications must be identified and have their medications modified, said Dechairo. “This switching analysis has also been an important point in our payor discussions, as utilization management programs can focus on switching patients from red medications, which would deliver results even better than those in the GUIDED study,” he said.

One prior cost-effectiveness study using drug claims data showed that using GeneSight can increase treatment adherence and save an average of $1,036 per year per patient, while another study using commercial claims data showed GeneSight’s potential to save $1,556 per patient by reducing disability claims, medical utilization, workplace absence.

Currently, the more than 300,000 GeneSight tests Myriad sells per year are largely ordered by psychiatrists. Once there is greater reimbursement traction, Myriad is planning a significant marketing push into the primary care market, including direct-to-patient advertising for the test, according to Capone.

GeneSight, which is a lab-developed test (LDT) performed in a CLIA-certified lab, must be ordered by physicians.

Capone noted that the FDA has publicly stated that it will continue to practice enforcement discretion for LDTs, and leave it up to legislators to reform diagnostic regulations that may or may not bring LDTs under the agency’s oversight. In December, legislators in the House of Representatives and the Senate incorporated the FDA’s ideas for diagnostics regulatory reform into a draft bill that features a pre-certification program that labs could use to bring the majority of new diagnostics to market, while having to submit around 10 percent of tests for premarket review.  READ MORE…

ABSTRACT OF STUDY

 

New Study: Vaccines linked to Increase in mass school shootings and suicides

New Study: Vaccines Linked to Decline in Mental Health and Social Interaction – A Cause of Increase in Mass School Shootings?

CCHR NEWSLETTER:  CAN VACCINES CAUSE PSYCHIATRIC DISORDERS?

The authors statistically analyzed insurance claims data between 2002 and 2007 for thousands of children ages 6 to 15 for any relationships between various vaccinations (influenza, tetanus & diphtheria, hepatitis A, hepatitis B, meningitis, varicella) and various subsequent psychiatric diagnoses (obsessive-compulsive disorder, anorexia nervosa, tic disorders, attention deficit hyperactivity disorder, major depressive disorder, bipolar disorder).

The overall conclusion of this analysis implies that the onset of some psychiatric disorders may be related to some children having recently received a vaccination.

READ NEWSLETTER…

Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study

CCHR finds Study: Association of vaccines and psychiatric disorders in children and adolescents

Magic Mushrooms (Psilocybin) for Seniors

Psilocybin mushroom

Fungus

Description: A psilocybin mushroom is one of a polyphyletic group of fungi that contain any of various psychedelic compounds, including psilocybin, psilocin, and baeocystin. Common, colloquial terms for psilocybin mushrooms include psychedelic mushrooms, magic mushrooms, shrooms, and mush.

Johns Hopkins University studied psilocybin in particular and found that one-third of all participants reported that the experience was the single most spiritually significant moment of their lives and more than two-thirds reported it was among the top five most spiritually significant experiences. Two months after the study, 79% of the participants reported increased well-being or satisfaction; friends, relatives, and associates confirmed this. Read more…

VLA Comment and Warning:

10% of Caucasians and percentages of Asians and Blacks do not have the Liver enzyme, Cytochrome P450 2D6 necessary to metabolize psilocybin.  They become “psychotic”. 79% of the participants according to Hopkins Univ. experience increased well being.  What about the 21%?  Did they experience psychosis?  Every patient and every person in psychiatric drug testing should have their genetics tested prior to implementation.  A simple gene test is covered by medicare and medicaid.  See:

Foods and Medications to Avoid with MAOIs

Some specific pharmaceutical drugs that should not be combined with MAOIs (some are mild risks, others serious):

– Actifed
– Adderall
– Alaproclate
– Albuterol (Proventil, Ventolin)
– Amantadine hydrochloride (Symmetrel)
– Amiflamine
– Amineptine
– Amitriptaline
– Amoxapine (Asendin)
– Atomoxedine
– Bazinaprine
– Befloxetone’
– Befol
– Benadryl
– Benmoxinb (Nerusil, Neuralex)
– Benylin
– Benzedrine
– Benzphetamine (Didrex)
– Bicifadine
– Brasofensine
– Brofaromine (Consonar)
– Buprenorphine
– Bupropion (Wellbutrin)
– Buspirone (BuSpar)
– Butriptyline
– Carbamazepine (Tegretol, Epitol)
– Chlorpheniramine
– Chlor-Trimeton
– Cimoxetone
– Citalopram (Celexa)
– Clomipramine (Anafranil)
– Clorgyline
– Codeine
– Cyclobenzaprine (Flexeril)
– Cyclizine (Marezine)
– D-deprenyl
– Dapoxotine
– Desipramine (Pertofrane, Norpramin)
– Desvenlafaxine
– Dextroamphetamine (Dexedrine)
– Dextromethorphan (DXM)
– Dibenzepin
– Dienolide kavapyrone desmethoxyyangonin
– Diethylpropion
– Disopyramide (Norpace)
– Disulfiram (Antabuse)
– Dobutamine
– Dopamine (Intropin)
– Dosulepin
– Doxepin (Sinequan)
– Duloxetine (Cymbalta)
– Emsam
– Entacapone
– Ephedrine
– Epinephrine (Adrenalin)
– Escitalopram (Lexapro)
– Esuprone
– Etorphine
– Femoxitine
– Fenfluramine (Pondimin)
– Flavoxate Hydrochloride (Urispas)
– Fluoxetine (Prozac)
– Fluvoxamine
– Furazolidone (Furoxone)
– Gabapentin
– Guanethedine
– Guanadrel (Hylorel)
– Guanethidine (Ismelin)
– Hydralazine (Apresoline)
– Hydrazine
– 5-Hydroxytryptophan
– Imipramine (Tofranil)
– Iprindole
– Iproniazid (Marsilid, Iprozid, Ipronid, Rivivol, Propilniazida)
– Iproclozide (Sursum)
– Isocarboxazid (Marplan)
– Isoniazid (Laniazid, Nydrazid)
– Isoniazid rifampin (Rifamate, Rimactane)
– Isoproterenol (Isuprel)
– L-dopa (Sinemet)
– Ladostigil
– Lazabemide (Pakio, Tempium)
– Levodopa (Dopar, Larodopa)
– Linezolid (Zyvox, Zyvoxid)
– Lithium (Eskalith)
– Lofepramine
– Loratadine (Claritin)
– Maprotiline (Ludiomil)
– Mebanazine (Actomol)
– Medifoxamine
– Melitracen
– Meperidine (Demerol)
– Metaproterenol (Alupent, Metaprel)
– Metaraminol (Aramine)
– Metfendrazine (Inkazan)
– Methamphetamine (Desoxyn)
– Methyldopa (Aidomet)
– Methylphenidate (Ritalin)
– Metralindole
– Mianserin
– Milacimide
– Milnacipran
– Minaprine (Cantor)
– Mirtazapine (Remeron)
– Mofegeline
– Moclobemide (Aurorix, Manerix)
– Monomethylhydrazine
– Montelukast (Singulair)
– Nalbufrine
– Naloxone
– Naltrexone
– Nefazodone
– Nialamide (Niamid)
– Nisoxetine
– Nomifensine
– Norepinephrine (Levophed)
– Nortriptyline (Aventyl)
– Octamoxin (Ximaol, Nimaol)
– Oxybutynin chloride (Ditropan)
– Oxycodone
– Oxymetazoline (Afrin, Dimetapp)
– Oxymorphone
– Orphenadrine (Norflex)
– Pargyline (Eutonyl)
– Parnate
– Paroxetine (Paxil)
– Pemoline (Cylert)
– Percocet
– Pethedine (Demerol)
– Phendimetrazine (Plegiline)
– Phenelzine (Nardil)
– Phenergen
– Phenelzine (Nardil, Nardelzine)
– Pheniprazine (Catron)
– Phenmetrazine
– Phenoxypropazine (Drazine)
– Phentermine
– Phenylephrine (Dimetane, Dristan decongestant, Neo-Synephrine)
– Phenylhydrazine
– Phenylpropanolamine (found in many cold medicines)
– Phenelzine (Nardil)
– Pirlindole (Pirazidol)
– Procarbazine (Matulane)
– Procainamide (Pronestyl)
– Protriptyline (Vivactil)
– Pseudoephedrine
– Oxymetazoline (Afrin)
– Quinidine (Quinidex)
– Rasagiline (Azilect)
– Reboxetine
– Reserpine (Serpasil)
– Risperidone
– Salbutemol
– Salmeterol
– Selegiline (Eldepryl, Emsam, Zelapar)
– Sercloramine
– Sertraline (Zoloft)
– Sibutramine
– Sumatriptan (Imitrex)
– Terfenadine (Seldane-D)
– Tegretol
– Temaril
– Tesofensine
– Tetrindole
– Theophylline (Theo-Dur)
– Thesbutiaint
– Thioridazine (Mellaril)
– Tianeptine
– Tolcapone
– Toloxatone (Humoryl)
– Tramadol
– Tranylcypromine (Parnate)
– Trazodone
– Tricyclic antidepressants (Amitriptyline, Elavil)
– Trimipramine (Surmontil)
– Triptans
– Tyrima
– Vanoxerine
– Venlafaxine (Effexor)
– Viloxezine
– Yohimbine
– Zimelidine
– Ziprasidone (Geodon)

READ MORE…

The Causes Mental Illness: A 61 Year History of Pharmacogenetics suppressed by Pharma

Avram Goldstein: The Founder of Molecular Pharmacology
http://molpharm.aspetjournals.org/content/83/4/720

Summary:

As the Chair of the Department of Pharmacology with responsibility for training medical students in the use of drugs, he was fascinated by the kinetics of drug action. He and his wife Dody developed the plateau principle, which emerged from the recognition that the time to steady state for any drug administered continuously or repeatedly was dependent only on its rate of elimination. These developments drove his increasing desire to see the discipline of pharmacology, both in research and in medical and graduate education, as a science with a strong mechanistic and theoretical underpinning.

Avram was present in Moscow in 1961 when Marshall Nirenberg described his elucidation of the genetic code. With these seminal developments, Avram concluded that the time was ripe for the establishment of a journal devoted to mechanistic aspects of drug action at a molecular level.

Avram was able to persuade ASPET to publish the new journal, which would be called Molecular Pharmacology. “Suitable papers are those which describe applications of the methods of biochemistry, biophysics, genetics and molecular biology to pharmacologic or toxicologic problems…”

Avram, together with his Stanford faculty colleagues Lew Aronow and Sumner Kalman, were working on Principles of Drug Action (Goldstein et al., 1968), a pharmacology textbook that was new for its time in focusing only on basic principles underlying drug action and the longer-term responses of the body to the presence of drugs.

DRUG METABOLISM RESEARCH HAS A 61 YEAR HISTORY

VLA Comment: The field of Pharmacogenomics, Pharmacogenetics, Pharmacogenomics has a 61 YEAR HISTORY  well accepted research concerning drug metabolism.  Education in this field of research has been actively suppressed by Pharma. Anonymous sources in the field of education for medical students tells us that this information is actively suppressed as the pharmacuetical industry would loose billions and billions of dollars if the public knew.  Moreso  medical students and hospital psychiatrists and doctors in general from Pediatricians ot Oconologists  have virtually no knowledge or education of drug metabolism, yet they all provide prescriptions that are contraindicated, causing Medication (drug) induced psychosis.   90% of drugs need an active and mature liver system of Cytochrome P450 enzymes to metabolize and eliminate them from an individual’s body. A substantial percentage of Caucasians, Asians, Blacks have no activity to metabolize these modern drugs.  The results – increased (apparent) psychosis.

INCREASE IN PSYCHOSIS DIAGNOSES

The increase in psychosis diagnosis is actually the agressive poisoning of humanity by uneducated doctors from the cradle to the grave.  The increase in (apparent) mental illness and special needs is due to the inability of many individuals to eliminate, from the body, modern drugs (and streets drugs) such as SSRIs vaccine excipients.

VACCINES, THE BASIS OF MENTAL ILLNESS DIAGNOSES

Vaccines contain excipients that need a mature superfamily of Cytochrome P450 in order to be metabolize and successfully eliminated from the body of infants and children. The damage done to the physiology of a one hour old infant, injected with Aluminum (which interferes in Cyp 450 metabolism in the Hep B and Vitamin K shots),  and other vaccine excipients testifies to the basic underpinnings of the epidemic in Autism, ADHD, ADD, OCD, BiPolar,neurological, mitachondrial issues, depression, anxiety, panic attacks.   The misdiagnosis of mental illness by uneducated medical professionals who extensively prescribe psychiatric drugs and the push to vaccinate, to eliminate parental choice, to eliminate vaccine waivers appears to be an organized effort to debilite the entire emerging generations of humanity through the suppression of this Pharmacogenomic knowedge.  Note: There is no mandated continuing education in drug metabolism for practicing physicans; virtually no education for medical students; yet the prescrbing of medications and the push for vaccine compliance, school shootings, homicides and suicides, special needs education, is at an all time high.

CCHR Newsletter: Overview and layman understanding of Cyp 450, Pharmacogenetics, vaccines, psyche drugs,homicide, suicide.

Below, the American Society for Pharmacology and Experimental Therapeutics chronicled the discoveries and provided communications to advance the science of drug metabolism.

The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 2, 1959–1983
Patrick J. Murphy College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana Received February 18, 2008; accepted February 27, 2008

ABSTRACT (2008):
In 25 years, (now 35 years) drug metabolism research went from using subcellular
particles of undefined content to an understanding of metabolism
at the molecular level. The discoveries of cytochrome P450, en-
zyme induction, reactive intermediates, and genetic polymor-
phisms were milestones in the field. New publications from the
American Society for Pharmacology and Experimental Therapeu-
tics chronicled the discoveries and provided communications to
advance the science of drug metabolism.

THE DISCOVERY OF CYTOCHROME P450 (1957)
The discovery of P450 and its function evolved from observations by Ryan and Engel that C-21 hydroxylations of progesterone and hydroxylated progesterones were catalyzed by a CO inhibitable en-zyme in the adrenal cortex (Ryan and Engel, 1957). They character-ized the reaction as belonging to the class of enzymes categorized by
Mason as “mixed-function oxidases” (Mason, 1957) and by Hayaishias “oxygenases” (Hayaishi, 1962).

THE ROLE OF GLUTATHIONE (depleted in AUTISM?)

The role of glutathione as a precursor of mercapturic acids was confirmed in 1959 (Bray et al., 1959a,b), 80 years after the discovery of these important elimination products by Baumann and Preuss (1879). In the following 25 years, there were over 150 papers in the ASPET journals referring to aspects of glutathione in metabolism. The role of glutathione as a scavenger of reactive intermediates was ofprimary interest, as exemplified by the finding of the glutathione conjugate of acetaminophen by Hinson et al. (1982) or the formation of mercapturic acids from cyclohexene epoxide in the rat (van Bla-deren et al., 1981).