Category Archives: Pharmacogenetics

DR.MERCOLA: What Everyone Needs to Know About Antidepressants

STORY AT-A-GLANCE

  • SSRI antidepressants are one of the most harmful medications on the market, and because of just how many people they are given to (often for no good reason as only a minority of patients benefit from SSRIs) they have had a profound effect on the consciousness of our entire society
  • This article will review some of the more common side effects of SSRIs (and SNRIs), such as losing the ability to have sex, becoming numb to life, becoming severely agitated or imbalanced (sometimes to the point one becomes violently psychotic or commits suicide), losing your mind, and the development of birth defects
  • Like many other stimulant drugs (e.g., cocaine) SSRIs can be very difficult to quit. Because of this, patients frequently get severely ill when they attempt to stop them (withdrawals affect roughly half of SSRI users). Worse still, it is often extremely difficult to withdraw from them and very few doctors know how to safely facilitate this
  • Due to widespread denial in psychiatry about the issues with their drugs the common SSRI side effects (e.g., withdrawals) are often misinterpreted as a sign the individual had a pre-existing mental illness and needs more of the drug — which all too often then leads to catastrophic events for the over-medicated patient
  • This article will provide the critical information SSRI patients are rarely warned about and resources for patients already trapped in challenging mental health situations

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Goldman/Dannemann: CYP450 Mediated Metabolism: From SIDS to Suicide

This paper is the opening salvo to a robust version that is in progress. It will contain supporting scientific studies and additional references to enhance reliability, interpretative  depth, clinical relevance, and up-to-date status. It will enable readers to see which variants matter and why, how much evidence there is, and additional, detailed, mechanistic background.

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_GOLDMAN_DANNEMANN SIDS to Suicide

What common thread links Shaken Baby Syndrome, Sudden Infant Death Syndrome, Autism Spectrum Disorders, Neurological Developmental Disorders, and outcomes such as suicide or homicide?

STUDY: Biochemistry, Cytochrome P450: The Common Thread Behind SIDS to Suicide

Cytochrome p450 is a superfamily of membrane-bound hemoprotein isozymes with distinct classifications. While present in most body tissues, CYP enzymes predominantly occupy the liver, intestines, and kidneys, with their highest concentration in the liver. Of the total 57 isozymes discovered to date, 6 of these are responsible for  90% of drug metabolism.

Due to their role in detoxifying potentially toxigenic xenobiotics and widespread nature throughout numerous organ systems, CYP enzymes are subject to a myriad of potential reactions and serve as a backbone in clinical research.

VLA Comment:  Toxigenic xenobiotics included in vaccines, in trace amounts, given to neonates, infants and children for the first 3 years of their lives have not been studied for their elimination and detoxification.  Research is widely established on the fact that Cyp 450 is immature in  neonates, infants and children under 3.  Cyp 450 doesn’t reach adult level until after 3 years old and some at 5 and 10 years old. If you add up a typical scenario (no delays, standard brands) by age ~2-3 years, the number of shots/doses is likely in the 20–30 injections range (counting multiple doses of each series)…that is an accumulation of 20-30 times of Trace amounts of toxigenic xenobiotics like Polysorbate 80, formaldehyde, glycerol, See vaccine excipient chart highlight for xenobiotics:    Vaccine-excipients-HIGHLIGHTED-3

Suicides/Homicides: A STUDY BY DR. YOLANDE LUCIRE

VERY COMPELLING: List of suicides and homicides with psyche drugs (2011 then censored or stopped collecting data)

 

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Drugs containing Tylenol

All drugs containing acetaminophen:

OTC
1. Tylenol: The most well-known brand for acetaminophen.

2. Excedrin: Often used for headaches, it combines acetaminophen with aspirin and caffeine.

3. NyQuil: A cold and flu medication that includes acetaminophen for pain relief.

4. DayQuil: Similar to NyQuil but formulated for daytime use.

5. Advil Dual Action: Combines ibuprofen and acetaminophen for enhanced pain relief.

6. Alka-Seltzer Plus: Some formulations include acetaminophen for cold and flu relief.

7. Midol: Often used for menstrual pain, some versions contain acetaminophen.

8. Aspirin-Free Excedrin: Contains acetaminophen, caffeine, and other ingredients for headache relief.

9. Bayer Back & Body: Combines acetaminophen with aspirin for back pain relief.

10. Aleve-D: Some formulations may include acetaminophen for added pain relief.

11. Tylenol Extra Strength: A higher dose formulation of acetaminophen for more severe pain.

12. Advil PM: Some formulations may include acetaminophen along with diphenhydramine.

Cold and Allergy Medications

1. Zyrtec-D: Some formulations may include acetaminophen for allergy relief.

2. Sudafed PE: Certain combinations may contain acetaminophen for cold symptoms.

3. Robitussin Cough + Chest Congestion DM: Some versions include acetaminophen for pain relief.

4. Vicks DayQuil: A daytime cold and flu relief option that contains acetaminophen.

5. Benadryl Allergy Plus Congestion: Certain formulations may contain acetaminophen for added relief.

6. Claritin-D: Some versions may include acetaminophen for allergy relief.

RX

1. Percocet: A combination of oxycodone and acetaminophen used for pain relief.

2. Tylenol with Codeine: Combines acetaminophen with codeine for more severe pain.

3. Fioricet: Contains acetaminophen, butalbital, and caffeine, often prescribed for migraines.

4. Vicodin: A combination of hydrocodone and acetaminophen, used for moderate to severe pain.

5. Lortab: Another combination of hydrocodone and acetaminophen.

6. Norco: Similar to Vicodin, it combines hydrocodone with acetaminophen.

7. Roxicet: A combination of oxycodone and acetaminophen, used for pain management.

8. Cocet: Combines acetaminophen with oxycodone for pain relief.

9. Fentanyl Combination Products: Some formulations may combine fentanyl with acetaminophen for pain management.

10. Lorcet: A combination of hydrocodone and acetaminophen.

11. Percodan: Combines oxycodone with acetaminophen for pain management.

12. Tylenol with Tramadol: A combination of acetaminophen and tramadol for moderate to severe pain.

Combination Products

1. Cold and Flu Formulations: Many products for cold and flu symptoms contain acetaminophen, such as Theraflu and Robitussin.

2. Pain Relievers: Some multi-symptom pain relievers may include acetaminophen along with other active ingredients.

3. Robitussin Multi-Symptom: Contains acetaminophen along with other ingredients for cough and cold relief.

4. Theraflu: Various formulations include acetaminophen for symptom relief.

5. Excedrin Tension Headache: Specifically formulated for tension headaches, containing acetaminophen.

6. Mucinex: Some formulations include acetaminophen for cold and flu symptom relief.

7. Coricidin HBP: Certain versions contain acetaminophen for cold symptoms, designed for those with high blood pressure.

8. Sominex: Some formulations may include acetaminophen for sleep aid with pain relief.

Pediatric

1. Children’s Tylenol: Liquid formulations specifically designed for children.

2. Infants’ Tylenol: Liquid acetaminophen specifically designed for infants.

3. Children’s Motrin: Some formulations may include acetaminophen alongside ibuprofen.

4. Children’s Advil: Some formulations may include acetaminophen alongside ibuprofen.

5. Pediatric Fever Reducers: Various brands offer liquid acetaminophen specifically for children.

Who Killed Alex Spourdalakis (Documentary by Dr.Andy Wakefield)

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VLA Comment: The most riveting documentary I have ever seen.  Childhood vaccines that cause injury and behavior problems.Then psych drugs and medications that he could not metabolize. A real life horror story!  If we had his DNA we could attempt to prove that the vaccines and wrong medications tortured and killed him.

 

STUDY confirms mRNA Vaccines cross the placenta and reach the fetus

ABSTRACTIn this study, mRNA-1273 intramuscularly given to pregnant mice rapidly circulated in maternal blood and crossed the placenta within one hour to spread in fetal circulation. Although spike mRNA in fetal circulation faded away within 4-6 hours, it could accumulate in fetal tissues, mainly the liver and get translated into spike protein. Transplacental mRNA-1273 proved immunogenic in the fetuses, as postnatally equipped with anti-spike IgM, paternal allotypic anti-spike IgG2a and heightened anti-spike cellular immunity. Gestationally administered, mRNA-1273 had a dose-dependent effect on its transplacental transfer and immunogenicity in the fetuses, with higher mRNA-1273 doses leading to increased transplacental mRNA-1273 passage and greater serum titers of endogenous anti-spike IgM/IgG generated by the fetuses. Thus, gestationally maternal mRNA-1273 vaccination might endow the newborns with not only passive but also active anti-spike immunity.

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VLA Comment:  Although it is enlightening to expose the fact that the mRNA vaccines cross the placenta barrier, This study is crazy–stating that the transplacental inoculation of the fetus “endows” it with protection!