The relevance of cytochrome P450 polymorphism in forensic medicine and akathisia-related violence and suicide Journal of Forensic and Legal Medicine
Three homicide studies elucidate how CYP450 enzymes interacted with drugs in use.
Adverse drug reactions and interactions are among the major causes of death in the United States. Antidepressants have been reported as causing suicide and homicide and share the class attribute of frequently producing akathisia, a state of severe restlessness associated with thoughts of death and violence. Medical examiners can now identify some pharmacogenetic interactions that cause drugs, deemed safe for most, to be lethal to others. READ STUDY