Tag Archives: Brandon Turberville

Pharmacogenetics/Cytochrome P450/Suicides & Homicides/school violence

Brandon Turbervile comprehensive article:  Psychiatric Drugs, School Violence, and the Big Pharma Cover-up

Excerpts:

the CYP450 enzymes are the primary catalysts for detoxification reactions that render water-insoluble molecules sufficiently water soluble to be excreted in the urine. . . . Drugs, hormones, toxins, carcinogens, mutagens, environmental pollutants, and other xenobiotics are metabolized by CYP450 enzymes.

Of the CYP450 enzyme family, there are other more specific enzymes such as CYP2C9, CYP2C19, and CYP2D6, etc. These three enzymes specifically are responsible for approximately 40% of all CYP450-mediated drug metabolism. The CYP2D6 enzyme itself is responsible for the bulk of drug metabolism at around 20% to 30% of drug metabolism in the CYP450 family.

In relation to the CYP2D6 enzyme, there are four classifications – Extensive Metabolizers (EM), Poor Metabolizers (PM), Intermediate Metabolizers (IM), and Ultrarapid Metabolizers (UM).
EM (Extensive Metabolizers) are considered the “normal genotype,” “which is free of inactivating polymorphisms, deletions, or duplications.”  PM (Poor Metabolizers) are individuals who have “deficient” enzyme function in terms of CYP450 metabolic processes and, subsequently, have difficulty clearing certain medications. IM (Intermediate Metabolizers) are those who have some functioning CYP450 enzymes but are subject to loss of the function of these enzymes after the “second hit” of medication, thus turning them into PM. UM (Ultrarapid Metabolizers) are those who metabolize the drug so rapidly that it clears so quickly that there is little or none of the desired effect.  In medications that required metabolism to activate, however, UM individuals the metabolite may be produced too quickly, resulting in toxicity and the realization of side effects.
While there are potentially adverse health effects with any one of the four classifications, the focus of this article is on those who are generally PM (Poor Metabolizers). This is because these individuals have a higher chance of experiencing adverse health effects of pharmaceuticals than those with “normal” functioning EMCYP2D6 enzymes.
Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity.
SPECIAL PHARMACOKINETICS AND PHARMACODYNAMIC CONSIDERATION IN CHILDREN

Mayo Clinic Conference on Pharmackinetics Sept. 2018

Mass Shootings, homicides, suicides and Pharmacogenomics (WHAT’S THAT?)

VLA COMMENT:  LEARN WHY THERE IS AN EPIDEMIC OF PARTICULARLY HEINOUS MASS SHOOTINGS AND SUICIDES IN THE 21ST CENTURY.

MM+Pharmacogenomics

Posted on by Brandon Turbeville

In January, 2013, I wrote an article entitled, “Psychiatric Drugs, School Violence, And The Big Pharma Cover-up,” where I discussed the importance of the CYP450 enzymes on the metabolism of pharmaceutical drugs and the potential for adverse effects of those drugs if the CYP450 enzyme was not functioning properly. 

Studies conducted over the last decade have clearly demonstrated the link between adverse reactions to Psycho-Pharmaceutical medications and underactive or underperforming CYP450 enzymes. This has caused some to wonder whether or not the recent uptick in mass shootings and the obvious link to many of the perpetrators and prescription drugs could be related to the performance of the CYP450 enzymes. Additional research, however, is now causing more questions to be asked in reference to the connections that chemicals like Glyphosate may have in the inhibition of proper CYP450 performance and, thus, in the uptick in mass shootings.

For those unfamiliar with the functions of the CYP450 enzymes, CYP450 stands for the Cytochrome P450 enzymes. Scientists understand these enzymes to be responsible for metabolizing almost half of all drugs currently on the market. P450 gene variants (polymorphisms) are implicated in the variability in drug response among a wide range of individuals.  READ MORE…