Tag Archives: cytochrome P450

Glyphosate , Psyche Drug and Vaccines: THE CONNECTION

CCHR Newsletter: Overview of Cyp 450, Pharmacogenetics, Psyche Drugs, vaccines.

AGRICULTURE

Read Study glyphosate_rats_CYP_enzyme_suppression_2006

Syngenta Patent shows that the Genetic Engineering of our nations food supply is based on Cytochrome P450 technology whereby the genetically engineered seed is manipulated to be an ultra rapidmetabolizer while the “weeds” who are normal metabolizer dies in the presence of Glysophate.  Cytochrome P450 Gene Conferring herbicide resistance PATENT

MENTAL ILLNESS DIAGNOSIS –

PHARMA DRUGS, STREET DRUGS & MEDICATION AND METABOLIZING OPIOIDS

Plants and humans share the same detox mechanism involving Cytochrome P450.  In humans Cytocrome P450

90% of today’s modern drugs are metabolized by Cytochrome P450.

CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 enzymes metabolize 90 percent of drugs. these enzymes are predominantly expressed in the liver, but they also occur in the small intestine (reducing drug bioavailability), lungs, placenta, and kidneys.2

One out of every 15 white or black persons may have an exaggerated response to standard doses of beta blockers (e.g., metoprolol [Lopressor]), or no response to the analgesic tramadol (Ultram). This is because drug metabolism via CYP450 enzymes exhibits genetic variability (polymorphism) that influences a patient’s response to a particular drug.3

Every person inherits one genetic allele from each parent. Alleles are referred to as “wild type” or “variant,” with wild type occurring most commonly in the general population.

For example, 7 percent of white persons and 2 to 7 percent of black persons are poor metabolizers of drugs dependent on CYP2D6, which metabolizes many beta blockers, antidepressants, and opioids.7,8 One in five Asian persons is a poor metabolizer of drugs dependent on CYP2C19, which metabolizes phenytoin (Dilantin), phenobarbital, omeprazole (Prilosec), and other drugs.

The Effect of Cytochrome P450
Metabolism on Drug Response,
Interactions, and Adverse Effects 
READ STUDYCyp Study

VACCINES

Studies: Cytochrome P450 and failure of infants to metabolize vaccine excipients READ more…

Early Childhood Vaccines contain excipients that need Cytochrome P450 to metabolize.

VLA Comment: Cytochrome P450 is not mature in infants and children under the age of three years old yet we are giving vaccines with excipients that must be detoxed out of the body by Cytochrome P450 family of liver enzymes which infants do not have. These enzymes are predominantly expressed in the liver, but they also occur in the small intestine (reducing drug bioavailability), lungs, placenta, and kidneys.

Note in cases of Autism and vaccinating pregnant women:

Cyp 450 are found in the “Small intestines and placenta”

READ more…

Pharmacogenetics/Cytochrome P450/Suicides & Homicides/school violence

Brandon Turbervile comprehensive article:  Psychiatric Drugs, School Violence, and the Big Pharma Cover-up

Excerpts:

the CYP450 enzymes are the primary catalysts for detoxification reactions that render water-insoluble molecules sufficiently water soluble to be excreted in the urine. . . . Drugs, hormones, toxins, carcinogens, mutagens, environmental pollutants, and other xenobiotics are metabolized by CYP450 enzymes.

Of the CYP450 enzyme family, there are other more specific enzymes such as CYP2C9, CYP2C19, and CYP2D6, etc. These three enzymes specifically are responsible for approximately 40% of all CYP450-mediated drug metabolism. The CYP2D6 enzyme itself is responsible for the bulk of drug metabolism at around 20% to 30% of drug metabolism in the CYP450 family.

In relation to the CYP2D6 enzyme, there are four classifications – Extensive Metabolizers (EM), Poor Metabolizers (PM), Intermediate Metabolizers (IM), and Ultrarapid Metabolizers (UM).
EM (Extensive Metabolizers) are considered the “normal genotype,” “which is free of inactivating polymorphisms, deletions, or duplications.”  PM (Poor Metabolizers) are individuals who have “deficient” enzyme function in terms of CYP450 metabolic processes and, subsequently, have difficulty clearing certain medications. IM (Intermediate Metabolizers) are those who have some functioning CYP450 enzymes but are subject to loss of the function of these enzymes after the “second hit” of medication, thus turning them into PM. UM (Ultrarapid Metabolizers) are those who metabolize the drug so rapidly that it clears so quickly that there is little or none of the desired effect.  In medications that required metabolism to activate, however, UM individuals the metabolite may be produced too quickly, resulting in toxicity and the realization of side effects.
While there are potentially adverse health effects with any one of the four classifications, the focus of this article is on those who are generally PM (Poor Metabolizers). This is because these individuals have a higher chance of experiencing adverse health effects of pharmaceuticals than those with “normal” functioning EMCYP2D6 enzymes.
Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity.
SPECIAL PHARMACOKINETICS AND PHARMACODYNAMIC CONSIDERATION IN CHILDREN

Mayo Clinic Conference on Pharmackinetics Sept. 2018

Study: (Cytochrome P450) Interaction between vaccines and drugs

Date: 05 Dec 2013

cyps2

On the possible interaction between vaccines and drugs

Reduction in the hepatic cytochrome P450 system activity has been described after a vaccination in previous studies.

Moreover, it is unclear how the effects of vaccines on hepatic cytochrome P450 system activity affect patients who present risk factors such as age or genetic predisposition.  Abstract

VLA Comment:  The study was done regarding the effect of vaccination on patients taking drugs.  Apparently, associated with vaccination, the vaccination interfered in Cytochrome P450 metabolism.  Hence, after vaccination, the metabolism (detoxing the various drugs out of the body) slowed down resulting in the drug remaining in the body. The conclusion intimates that vaccination has a relationship to Cytochrome P450.

Pharmagedon: Big Coverup: What is 2D6? Making our kids & soldiers psychotic!

The epidemic of  ADHD, ADD, OCD, Bipolar, Autism, encephalitis, narcolepsy is caused by the inordinate amount of vaccinations that are forced on children by our government in order to get into school.   To compensate or mitigate the effects of the vaccine injury, mis-nomered as “mental illness” psyche drugs are given out like candy.  25 % of all American children are on psyche drugs.

Suicide is the third leading cause of deaths for youths…Read more…

SSRIStories.org is a collection of over 5,000 stories that have appeared in the media (newspapers, TV, scientific journals) in which prescription drugs were mentioned and in which the drugs may be linked to a variety of adverse outcomes including violence.5000 Suicides & Murders. Access list

Bogus pharma establishment  Study studies 37,000 kids newly prescribed medication and suicide rates.  Clearly none of these kids were tested for Cytochrome P450 2D6 metabolic rates, although the opportunity is still there for the ones who did not complete the suicide attempt. Testing for Cytochrome P450 2D6 can be a little as $175.00 but it is not “standard of care”.

The National Coalition of Organized Women uncovered one of the most egregious Pharmacuetical cover-ups in modern psyche history. The information that would have averted the school shootings, the homicides, the overdoses, the bizarre epidemic of mentally ill in recent years has been available for circa 15 years since gene mapping.   Cytochrome P450 2D6 was discovered as the major metabolic pathway that detoxifies 50% of all psyche drugs and street drugs.  However, 7-10% of Caucasians, for example, due to genetic variation do not have sufficient activity of this gene to detoxify their bodies from these modern drugs. They are labeled poor or non-metabolizers due to a deletion or non-activity of the 2D6 pathway. There are a percentage of Asians, African Americans and Hispanics who are also poor metabolizers.  When certain drugs (list on link) are prescribed to these individuals, due to their inability to metabolize, these people become psychotic, homicidal, suicidal, a danger to themselves and society.

There are other pathways on Cytochrome P459 such as Cyt 3A4 implicated in the psychosis reports of soldiers on Larium, a malaria drug.  Another example:  Marijuana (Cannibals) is a powerful inhibitor of cytochrome P450 isozymes 3A4, 2C19, and 2D6. This is not a defect.  It is a genetic variation, that’s all.  Ethiopians and Tanzanian Afrikans who traditional have had poor soil to grow food have been consuming a lot of weeds (medicine weeds), they have evolved generational to multiply their Cytochrome 2D6.  These people are “rapid metabolizers”.

It is a very simple test: Swap the mouth, teeth and gums with 2 sterile swabs (looks like q-tips) and send to our lab contact in Australia.  Contact: Ncowmail@gmail.com for lab details. Price: $175.00.  Bottom line, perhaps these kids who are most affected by vaccines are poor metabolizers and can’t rid themselves of the toxins in vaccines.  Perhaps 45 shots by the time the kid is six years old is asking too much!  Contact us for cytochrome testing: Ncowmail@gmail.com

Links below:

You know those kids who are shooting each other and mothers who drown their kids in the bath tub? Check out this most egregious cover up in the history of modern psychiatry. Dr. Lucire elucidates –  Dr. Yolande Lucire’s recently published study. Her study  published in the summer of 2011 is not only a academic victory but the perpetrators speak of their experiences  on how they were moved to kill their loved ones while on or coming off of psyche drugs.

This information, now highlighted by Dr. Lucire has been heretofore suppressed by the stakeholder.  The justice system in the USA has not realized the implication in law. (See personalized Justice/Personalize Medicine).  These drugs force the patient who is a poor or non-metabolizer into heinous acts against themselves and society. And who and what  is really complicit when a crime is committed?  The manufacturer who “failed to warn”?; the physician who “failed to warn” and who did not do the simple genetic test?  Read Dr. Lucire’s study.  She removed her subjects from the drugs and they  regained their normal mental function.  It was the drugs. There is a test to prove it! However, the attorneys of several high profile cases such as Adam Lanza, Jerod Loughner, James Holmes were contacted and did not respond.

Dr. Yolande Lucire’s recently published study

list of the drugs that need 2D6 pathway to metabolize

Laymen’s Synopis

Mayo Clinic Report on 2D6

Psychosis reports of soldiers on Malaria Drugs

Comprehensive Article by Brandon Turberville

Dr. Mercola on Cytochrome P450 2D6

Autism is associated with precocious puberty.  Boys are 4X more likely to get Autism. Guess what else is regulated by Cytochrome P450 besides glutathione?

Personalized Justice/Personalize Medicine

Do you want the simple 2D6 gene test?  Contact us at NCOWmail@gmail.com