INFERTILITY UNEXPLAINED: Vaccines- Polysorbate 80 metabolized by Cytochrome P450, HPV vaccine

Are we sterilizing or genderbending the population between hormonal disrupting agricultural herbicides and vaccines and pharmacuetical drugs?

Research paper (Polysorbate 80)

Effects of non-ionic surfactants on cytochrome P450-mediated metabolism in vitro

Author links open overlay panelAnneChristiansenabThomasBackensfeldaKarstenDennercWernerWeitschiesb

 

Biotransformation XXXIX. Metabolism of testosterone, androstenedione, progesterone and testosterone derivatives in Absidia coerulea culture

Read study Abstract

FULL TEXT PDFsurfactants_suppress_CYP_enzymes_2011

VLA comment: Re: “Non-ionic surfactants like polysorbate 80 inhibit the CYP3A4 mediated hydroxylation of testosterone”.  I am wondering if Polysorbate 80 in vaccines considering it needs to be metabolized by Cyp 450 family of enzymes, involving hydroxylated testosterone, has a gender tweaking or has a precocious puberty effect that we find in Autism.

Polysorbate 80 in Vaccines:

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The U.S. Centers for Disease Control and Prevention (CDC) Vaccine Excipient and Media Summary lists 11 vaccines that contain polysorbate 80:

  • DTaP (Infanrix);
  • DTaP—IPV (Kinrix);
  • DTap-HepB-IPV (Pediarix);
  • DTaP-IPV-Hib (Pentacel);
  • Gardasil
  • Influenza (Agriflu);
  • Influenza (Fluarix);
  • Meningococcal (MenB-Trumenba);
  • Pneumococcal (PCV13—Prevnar13);
  • Rotavirus (RotaTeq);
  • Tdap (Boostrix)5
  • HPV

INFANTS INABILITY TO METABOLIZE VACCINE EXCIPIENTS

Studies: Cytochrome P450 and failure of infants to metabolize vaccine excipients

Top Medications with this excipient

Hypersensitivity reaction to human papillomavirus vaccine due to polysorbate 80.

Read study polysorbate_80_reaction_to_HPV_vaccine_2012

Abstract

A 17-year-old girl reported generalised urticaria, eyelid angioedema, rhino-conjunctivitis, dyspnoea and wheezing 1 h after third intramuscular administration of quadrivalent human papilloma virus vaccine (Gardasil). She was treated with antihistamine, and corticosteroids with prompt relief of rhinitis and dyspnoea, while urticaria and angioedema lasted 24 h. Intradermal test with Gardasil, which contains polysorbate 80 (PS80), resulted positive, while skin tests with the bivalent vaccine were negative. Prick test performed with PS80 resulted positive in the patient and negative in ten healthy controls. The CD203 basophil activation test result was negative for PS80 at all the tested dilutions and specific IgE was not found. As flu vaccine was recommended, the authors skin tested two flu vaccine, one containing PS80 (Fluarix, GSK), which resulted positive and another flu vaccine with no adjuvant or preservative (Vaxigrip, Sanofi Pasteur MSD), which gave negative results. The patient then received Vaxigrip without adverse reactions.

A lowered probability of pregnancy in females in the USA aged 25–29 who received a human papillomavirus vaccine injection

NEW STUDY (2017) LOWERED PREGNANCY RATES

Results suggest that females who received the HPV shot were less likely to have ever been pregnant than women in the same age group who did not receive the shot. If 100% of females in this study had received the HPV vaccine, data suggest the number of women having ever conceived would have fallen by 2 million. Further study into the influence of HPV vaccine on fertility is thus warranted.

VLA COMMENT: Lots of vaccines (see above) contain Polysorbate 80.  Does Polysorbate 80 considering its effect on testosterone have a negative hormonal effect on woman after years of being injected with the stuff.   Could the HPV vaccine with Polysorbate 80 providing the direct target to the reproductive system be the tipping point?  Or is there some other component  interfering? I believe in-vitro technology was rising prior to the Gardasil shot due to some interference in fertility.  January 1979 in Glasgow.[12] A team led by Ian Johnston and Alex Lopata were responsible for Australia’s first baby conceived by IVF, Candice Reed, born on 23 June 1980 in Melbourne.[13]   Hormanal disruption via agriculture chemicals came into being after WW II, (such as Atrazine, Alachlor and DDT).  See Peter Montague’s work such as Sperm in the News.

 

SPERM IN THE NEWS (1996)

This must be the year of the sperm. The NEW YORKER magazine ran a long story [1] January 15th called “Silent Sperm” –a wry reference to Rachel Carson’s SILENT SPRING, which made its debut in the NEW YORKER 35 years ago. “Silent Sperm” describes the 50% loss in sperm count that has occurred in men worldwide during the past 40 years. Furthermore, the January issue of ESQUIRE features an article on sperm loss, [2] titled “Downward Motility.” MOTHER JONES magazine [3] also began the new year with a sperm story, titled “Down for the Count.” And the nation’s newspaper of record, the NEW YORK TIMES, ran a 4-part, front-page series on increasing infertility in the U.S. January 7-10.

VLA Comment: The hormonal disrupting DDT was introduced in the 1940s (WWII era). In Vitro started gain steam in the 1980/90s. Study showed that Male sperm count was down 50% in 1996. How long before the study was there a consistently reduceing sperm count in males? How long have Vaccines contained polysorbate 80 that inhibits the CYP3A4 mediated hydroxylation of testosterone?.

 

 

 

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