Cytochrome P450: Physiological and pharmacological role in Mental Illness, Cancer, Parkinson

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Suicides and homicides data

Images of School shooters

The cytochrome P450 isoenzymes are a superfamily of enzymes found in the Liver and in all cells except the blood.  These enzymes catalyse the metabolism of a large number of endogenous and exogenous compounds-prescription drugs and street drugs.

The vast individual variation of genetics vary greatly according to race and ethnicity.  It is the field of PHARMACOGENETICS that accounts for surge in “apparent” mental illness, suicides, drug addiction and homicides and disease susceptibility.

About 5–10% of Caucasians and 0.9% ofAsians metabolise debrisoquine and other substrates of CYP2D6 at a markedly decreased rate. In addition to thepoor and extensive metabolisers, a group called the ultrarapid metabolisers has been identified.

The CYP2C19 enzyme is also associated with genetic polymorphism. Slow metabolisers  are found in 2–5% of Caucasians, about20% of the Japanese population, 19% of African Americansand 8% of Africans [18].

Cytochrome P450: Physiological and pharmacological role READ THIS Study:

READ ALL OUR POSTS ON PHARMACOGENETICS

 

Killer Drugs? Homicide Risk Linked to Medications

Rudolf Steiner: Full Lecture on Traditional Childhood Illinesses and VACCINES

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VLA Comment:  This lecture is quite long and will be hard for most people to grasp.  But if you are interested in metaphysics, give it a try.  Here is a quote from his lecture on FALL OF THE SPIRITS OF DARKNESS: “I have told you that the spirits of darkness are going to inspire their human hosts, in whom they will be dwelling, to find a vaccine that will drive all inclination towards spirituality out of people’s souls when they are still very young, and this will happen in a roundabout way through the living body. Today, bodies are vaccinated against one thing and another; in future, children will be vaccinated with a substance which it will certainly be possible to produce, and this will make them immune, so that they do not develop foolish inclinations connected with spiritual life — ‘foolish’ here, of course, in the eyes of materialists.” 

READ LECTURE…ON TRADITIONAL CHILDHOOD ILLNESS AND VACCINES

Rudolf Steiner on Vaccination

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The whole trend goes in a direction where a way will finally be found to vaccinate bodies so that these bodies will not allow the inclination towards spiritual ideas to develop and all their lives people will believe only in the physical world they perceive with the senses. Out of impulses which the medical profession gained from presumption — oh, I beg your pardon, from the consumption they themselves suffered — people are now vaccinated against consumption, and in the same way they will be vaccinated against any inclination towards spirituality. This is merely to give you a particularly striking example of many things which will come in the near and more distant future in this field — the aim being to bring confusion into the impulses which want to stream down to earth after the victory of the spirits of light.

READ THE ORIGINAL LECTURE

Study: Vaccine excipients, xenobiotics-Cause of Inflammation after vaccination?

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Inflammation is associated with down regulations of hepatic and extrahepatic CYP enzymes drug metabolism.

The CYP represent a superfamily of enzymes with a key role in the activation or inactivation of a plethora of therapeutic agents. CYP enzymes are involved in the metabolism of xenobiotic substances. Cytochromes present intra- or interindividual and intra- or interethnic genetic polymorphisms. Variations in the pharmacokinetic drug profile are linked to the rising toxicity following a declining metabolism, reduced efficacy of the drug, adverse drug interaction, and increasing production of toxic metabolites. The high-metabolic rate of the intestinal microbiota is due to its many enzymes which catalyze reactions in phase I and II drug metabolism. In case of a compromised intestinal barrier, there may be an increase in paracellular passive absorption.

It is evident that high-microbial abundance following intestinal disturbances, environment, aging, or food-associated diseases promotes the microbial metabolism of a drug before absorption.

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INFANTS INABILITY TO METABOLIZE XENOBIOTICS IN VACCINES

Above link Includes CDC Vaccine Excipient list of xenobiotics

Pharmacogenetics (gene testing): Attorney’s are now stepping up!

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Medical DNA sequencing leads to lawsuits and legal questions

One of the biggest concerns is legal liability. Health care providers face a disconnect: Technology has outpaced their ability to interpret genetic results, such as a patient’s risk of breast cancer or heart attack from a particular mutation. Because of that, typical fallbacks including providing a rigorous standard of care—which can also act as a legal shield against malpractice claims—are becoming fuzzy. What is a doctor to do when a patient has results from a direct-to-consumer testing company like 23andMe and asks what implications they have for their health? Or when a lab notifies a doctor that a genetic variant their patient carries, thought meaningless 3 years ago, is now known to be harmful, but they can’t locate the patient? Can a testing lab be held liable for not regularly reviewing the scientific literature, to track science’s understanding of the gene variants it tests for?

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LawSeqSM: Building a Sound Legal Foundation for Translating Genomics into Clinical Application

This innovative 3-year project, based cooperatively at the University of Minnesota and Vanderbilt University, has convened a national Working Group of top legal and scientific experts to analyze current US federal and state law and regulation on translational genomics and to generate consensus guidance on what the law should be.

 

Thoughts from a Hipster Coffee Shop

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I’m sitting in a small coffee shop near Nokomis trying to think of what to write about. I scroll through my newsfeed on my phone looking at the latest headlines of Democratic candidates calling for policies to “fix” the so-called injustices of capitalism. I put my phone down and continue to look around. I see people talking freely, working on their MacBook’s, ordering food they get in an instant, seeing cars go by outside, and it dawned on me. We live in the most privileged time in the most prosperous nation and we’ve become completely blind to it.

Vehicles, food, technology, freedom to associate with whom we choose. These things are so ingrained in our American way of life we don’t give them a second thought. We are so well off here in the United States that our poverty line begins 31 times above the global average. Thirty. One. Times. Virtually no one in the United States is considered poor by global standards. Yet, in a time where we can order a product off Amazon with one click and have it at our doorstep the next day, we are unappreciative, unsatisfied, and ungrateful.

Our unappreciation is evident as the popularity of socialist policies among my generation continues to grow. Democratic Congresswoman Alexandria Ocasio-Cortez recently said to Newsweek talking about the millennial generation, “An entire generation, which is now becoming one of the largest electorates in America, came of age and never saw American prosperity.”

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VLA COMMENT:  Worth reading the rest::))

Vaccinology: An overall view!

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EXCERPTS

An attorney in the FDA Chief Counsel’s office regarding a court order to FDA made this really shocking statement, “Jonathan, the FDA will never abide by the Pearson decision.”2

Despite Jonathan’s noting it was a final and binding decision—an order of the court—the FDA attorney said, “That may be so, but I am telling you the FDA will never abide by that court decision, never, ever.”3   Emord tells us, “His words pierced to the very core of my being. Here was an agency’s legal officer telling me that the agency was, intentionally, lawless.”

While child mortality progressively declined across all countries, mortality in the US has been higher than in peer nations since the 1980s. From 2001 to 2010 the risk of death in the US was 76 percent greater for infants and 57 percent greater for children ages 1–19.

A rogue industry out of control due to the U.S. Congress in 1986 bailing out the pharmaceutical industry because of a ‘boatload’ of lawsuits against their vaccines. Big Pharma threatened not to make any more vaccines, if it didn’t get product liability legal exemptions for damages from their vaccines.

It’s rather interesting that Big Pharma wanted, threatened and obtained their vaccine exemptions, but humans, parents, children and pets cannot have exemptions!  What happened to a level playing field?

As a result, the pharmaceutical industry is falling all over itself in a rush to produce close to 300 new vaccines. Does that mean the CDC/FDA will mandate a vaccine a day for everyone in the USA?  That should be considered criminal: Injecting neurotoxins which have not been tested for safety when given in combinations of up to nine vaccines at one time, especially to 4 and 6 month old babies!

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Activist Post: Cytochrome P450 and Vaccine Excipients-poisons that cannot be metabolized by children under 3yrs

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The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D(3) synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases. [2]

Question:  Are metabolism differences in CYP genes the cause of many vaccine adverse reactions, especially brain encephalopathy that precipitates Autism and other clinically relevant diseases in infants, toddlers and even adults?  Was that the reasoning why a Vaccine Court Master awarded Hannah Poling’s Autism claim $1.5 million plus ongoing $500,000 per year for life [4]?  READ MORE…