The vitamin K administered by hospitals to newborns is the synthetic phytonadione.
Toxic ingredients accompanying the Vitamin K
- The vitamin K injections administered by hospitals and manufactured by Merck and Roche and Abbott contain benzyl alcohol as a preservative. The 1989 PDR states that, “there is no evidence to suggest that the small amount of benzyl alcohol contained in AquaMEPHYTON (Merck’s vitamin K injection product), when used as recommended, is associated with toxicity.” Interestingly, in November 1988, the French medical journal, Dev Pharmacol Ther, published a paper regarding benzyl alcohol metabolism and elimination in babies. The report stated that “…we cannot directly answer the issue of safety of ‘low doses’ of benzyl alcohol as found in some medications administered to neonates. This study confirms the immaturity of the benzoic acid detoxification process in premature newborns.”
- Roche’s vitamin K product KONAKION contains ingredients such as phenol (carbolic acid-a poisonous substance distilled from coal tar), propylene glycol (derived from petroleum and used as an antifreeze and in hydraulic brake fluid) and acetic acid (an astringent antimicrobial agent that may drastically reduce the amount of natural vitamin K that would have otherwise been produced in the digestive tract). As reported in the PDR and as published in the IM vitamin K packet inserts for Merck, Roche and Abbott, “Studies of carcinogenicity, mutagenesis or impairment of fertility have not been conducted with Vitamin K1 Injection (Phytonadione Injection, USP).”
- The Vitamin K injection can be in a base of polyethoxylated castor oil.
- Vitamin K injections also contain hydrochloric acid and lecithin.
WARNING — INTRAVENOUS AND INTRAMUSCULAR USE
Severe reactions, including fatalities, have occurred during and immediately after INTRAVENOUSinjection of phytonadione, even when precautions have been taken to dilute the phytonadione and to avoid rapid infusion. Severe reactions, including fatalities, have also been reported following INTRAMUSCULAR administration. Typically these severe reactions have resembled hypersensitivityor anaphylaxis, including shock and cardiac and/or respiratory arrest. Some patients have exhibited these severe reactions on receiving phytonadione for the first time. Therefore the INTRAVENOUS andINTRAMUSCULAR routes should be restricted to those situations where the subcutaneous route is notfeasible and the serious risk involved is considered justified.
WARNING: This product contains aluminum that may be toxic.
Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they required large amounts of calcium and phosphate solutions, which contain aluminum.
Research indicates that patients with impaired kidney function, including premature neonates,
who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur ateven lower rates of administration. PDF PACKAGE INSERT HOSPIRA
WARNING: PREMATURE NEONATES INTRAVENOUS NUTRITIONAL FORMULA CONTAINS ALUMINUM
A number of substances commonly administered intravenously, including calcium and phosphorus salts and albumin, have high levels of aluminum. Premature infants receiving intravenous fluid therapy may accumulate aluminum and show evidence of aluminum toxicity. Efforts are being made to reduce the levels of aluminum in products added to intravenous solutions; these efforts must continue.
Some infant formulas may contain relatively high concentrations of aluminum. The reported concentrations of aluminum in soy formulas and premature infant formulas are higher than those in other infant formulas. READ MORE…
Severe reactions, including fatalities, have also been reported following INTRAMUSCULAR administration. Typically these severe reactions have resembled hypersensitivity or anaphylaxis, including shock and cardiac and/or respiratory arrest.
“Warning” Benzyl alcohol as a preservative in Bacteriostatic Sodium Chloride Injection has been associated with toxicity in newborns. […] Benzyl alcohol has been reported to be associated with a fatal “Gasping Syndrome” in premature infants.
VLA COMMENT: Benzyl alcohol dose-dependently inhibits cytochrome P450 activities. Correlating
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