Background: Although the association of the measles, mumps, and rubella vaccine
with autism spectrum disorder has been convincingly disproven, the onset of certain
brain-related autoimmune and inflammatory disorders has been found to be temporally
associated with the antecedent administration of various vaccines. This study examines
whether antecedent vaccinations are associated with increased incidence of obsessive–
compulsive disorder (OCD), anorexia nervosa (AN), anxiety disorder, chronic tic disorder,
attention deficit hyperactivity disorder, major depressive disorder, and bipolar disorder ina national sample of privately insured children.