Category Archives: Pharmacogenetics

Goldman/Dannemann: CYP450 Mediated Metabolism: From SIDS to Suicide

This paper is the opening salvo to a robust version that is in progress. It will contain supporting scientific studies and additional references to enhance reliability, interpretative  depth, clinical relevance, and up-to-date status. It will enable readers to see which variants matter and why, how much evidence there is, and additional, detailed, mechanistic background.

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_GOLDMAN_DANNEMANN SIDS to Suicide

What common thread links Shaken Baby Syndrome, Sudden Infant Death Syndrome, Autism Spectrum Disorders, Neurological Developmental Disorders, and outcomes such as suicide or homicide?

STUDY: Biochemistry, Cytochrome P450: The Common Thread Behind SIDS to Suicide

Cytochrome p450 is a superfamily of membrane-bound hemoprotein isozymes with distinct classifications. While present in most body tissues, CYP enzymes predominantly occupy the liver, intestines, and kidneys, with their highest concentration in the liver. Of the total 57 isozymes discovered to date, 6 of these are responsible for  90% of drug metabolism.

Due to their role in detoxifying potentially toxigenic xenobiotics and widespread nature throughout numerous organ systems, CYP enzymes are subject to a myriad of potential reactions and serve as a backbone in clinical research.

VLA Comment:  Toxigenic xenobiotics included in vaccines, in trace amounts, given to neonates, infants and children for the first 3 years of their lives have not been studied for their elimination and detoxification.  Research is widely established on the fact that Cyp 450 is immature in  neonates, infants and children under 3.  Cyp 450 doesn’t reach adult level until after 3 years old and some at 5 and 10 years old. If you add up a typical scenario (no delays, standard brands) by age ~2-3 years, the number of shots/doses is likely in the 20–30 injections range (counting multiple doses of each series)…that is an accumulation of 20-30 times of Trace amounts of toxigenic xenobiotics like Polysorbate 80, formaldehyde, glycerol, See vaccine excipient chart highlight for xenobiotics:    Vaccine-excipients-HIGHLIGHTED-3

Suicides/Homicides: A STUDY BY DR. YOLANDE LUCIRE

VERY COMPELLING: List of suicides and homicides with psyche drugs (2011 then censored or stopped collecting data)

 

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Drugs containing Tylenol

All drugs containing acetaminophen:

OTC
1. Tylenol: The most well-known brand for acetaminophen.

2. Excedrin: Often used for headaches, it combines acetaminophen with aspirin and caffeine.

3. NyQuil: A cold and flu medication that includes acetaminophen for pain relief.

4. DayQuil: Similar to NyQuil but formulated for daytime use.

5. Advil Dual Action: Combines ibuprofen and acetaminophen for enhanced pain relief.

6. Alka-Seltzer Plus: Some formulations include acetaminophen for cold and flu relief.

7. Midol: Often used for menstrual pain, some versions contain acetaminophen.

8. Aspirin-Free Excedrin: Contains acetaminophen, caffeine, and other ingredients for headache relief.

9. Bayer Back & Body: Combines acetaminophen with aspirin for back pain relief.

10. Aleve-D: Some formulations may include acetaminophen for added pain relief.

11. Tylenol Extra Strength: A higher dose formulation of acetaminophen for more severe pain.

12. Advil PM: Some formulations may include acetaminophen along with diphenhydramine.

Cold and Allergy Medications

1. Zyrtec-D: Some formulations may include acetaminophen for allergy relief.

2. Sudafed PE: Certain combinations may contain acetaminophen for cold symptoms.

3. Robitussin Cough + Chest Congestion DM: Some versions include acetaminophen for pain relief.

4. Vicks DayQuil: A daytime cold and flu relief option that contains acetaminophen.

5. Benadryl Allergy Plus Congestion: Certain formulations may contain acetaminophen for added relief.

6. Claritin-D: Some versions may include acetaminophen for allergy relief.

RX

1. Percocet: A combination of oxycodone and acetaminophen used for pain relief.

2. Tylenol with Codeine: Combines acetaminophen with codeine for more severe pain.

3. Fioricet: Contains acetaminophen, butalbital, and caffeine, often prescribed for migraines.

4. Vicodin: A combination of hydrocodone and acetaminophen, used for moderate to severe pain.

5. Lortab: Another combination of hydrocodone and acetaminophen.

6. Norco: Similar to Vicodin, it combines hydrocodone with acetaminophen.

7. Roxicet: A combination of oxycodone and acetaminophen, used for pain management.

8. Cocet: Combines acetaminophen with oxycodone for pain relief.

9. Fentanyl Combination Products: Some formulations may combine fentanyl with acetaminophen for pain management.

10. Lorcet: A combination of hydrocodone and acetaminophen.

11. Percodan: Combines oxycodone with acetaminophen for pain management.

12. Tylenol with Tramadol: A combination of acetaminophen and tramadol for moderate to severe pain.

Combination Products

1. Cold and Flu Formulations: Many products for cold and flu symptoms contain acetaminophen, such as Theraflu and Robitussin.

2. Pain Relievers: Some multi-symptom pain relievers may include acetaminophen along with other active ingredients.

3. Robitussin Multi-Symptom: Contains acetaminophen along with other ingredients for cough and cold relief.

4. Theraflu: Various formulations include acetaminophen for symptom relief.

5. Excedrin Tension Headache: Specifically formulated for tension headaches, containing acetaminophen.

6. Mucinex: Some formulations include acetaminophen for cold and flu symptom relief.

7. Coricidin HBP: Certain versions contain acetaminophen for cold symptoms, designed for those with high blood pressure.

8. Sominex: Some formulations may include acetaminophen for sleep aid with pain relief.

Pediatric

1. Children’s Tylenol: Liquid formulations specifically designed for children.

2. Infants’ Tylenol: Liquid acetaminophen specifically designed for infants.

3. Children’s Motrin: Some formulations may include acetaminophen alongside ibuprofen.

4. Children’s Advil: Some formulations may include acetaminophen alongside ibuprofen.

5. Pediatric Fever Reducers: Various brands offer liquid acetaminophen specifically for children.

Who Killed Alex Spourdalakis (Documentary by Dr.Andy Wakefield)

Watch Documentary

VLA Comment: The most riveting documentary I have ever seen.  Childhood vaccines that cause injury and behavior problems.Then psych drugs and medications that he could not metabolize. A real life horror story!  If we had his DNA we could attempt to prove that the vaccines and wrong medications tortured and killed him.

 

STUDY confirms mRNA Vaccines cross the placenta and reach the fetus

ABSTRACTIn this study, mRNA-1273 intramuscularly given to pregnant mice rapidly circulated in maternal blood and crossed the placenta within one hour to spread in fetal circulation. Although spike mRNA in fetal circulation faded away within 4-6 hours, it could accumulate in fetal tissues, mainly the liver and get translated into spike protein. Transplacental mRNA-1273 proved immunogenic in the fetuses, as postnatally equipped with anti-spike IgM, paternal allotypic anti-spike IgG2a and heightened anti-spike cellular immunity. Gestationally administered, mRNA-1273 had a dose-dependent effect on its transplacental transfer and immunogenicity in the fetuses, with higher mRNA-1273 doses leading to increased transplacental mRNA-1273 passage and greater serum titers of endogenous anti-spike IgM/IgG generated by the fetuses. Thus, gestationally maternal mRNA-1273 vaccination might endow the newborns with not only passive but also active anti-spike immunity.

READ STUDY

VLA Comment:  Although it is enlightening to expose the fact that the mRNA vaccines cross the placenta barrier, This study is crazy–stating that the transplacental inoculation of the fetus “endows” it with protection!

WHO KILLED ALEX SPOURADALAKIS? (The Cause of Autism)

OPEN LETTER by Founder VLA: Have you ever seen Andy Wakefield’s first documentary..WHO KILLED ALEX SPOURADALAKIS. It is exactly what is happening to those who were given poisons via vaccination and then further poisoned by psyche drug medication having the genetic inability to metabolize. It is the most amazing documentary I have ever seen.

To Whom It May Concern”

I am again…explaining this is common terms as the field of Pharmacogenetics is difficult to understand…so difficult that people in our vaccine/autism orbit have not yet grocked.  Just a few…but it hasn’t taken off yet. (Andy Wakefield, Dr. Goldman, Dr. Pulyiyel, Dr. Lucire and the late Dr. Bark).  It has been 20 years now that I have done the research, had the personal experience, and have tried to push this out into the open…lots of resistance due to the difficulty to understand it…but it answers the question of why some people are injured significantly and others not.It depends on the persistence of poisoning and the liver enzymes ability to methylate  the poison out of the body.

Yes, they poison us from birth to death.  The liver, which is actually a system of  a Super Family of Detox Enzymes, is…

#1 not mature in neonates and children under three.  Therefore ALL babies are harmed to more or less extent.  Moreover,
#2 Although there is a general commonality of Liver Enzymes in all human beings that rise up and detox the various poisons (and are very specific to each poison), the effectiveness of this natural intelligent design process depends on the “normal, rapid or slow metabolism” of the individual… established by family genetics and ethnicity.
#3 In my case, my family is “polymorphic” Cytochrome P450 2D6 which means there is no activity of that specific enzyme which metabolizes much of the hallucinogens and modern pharma drugs.
I found this out when my son, in college, started to take Adderall for studying and dabbling with Cannabis,  LSD and magic mushrooms, all of which need the liver enzyme Cytochrome P450 2D6 to get the poison out of the body via the liver.  He went psychotic, got labeled,  and was locked up in various psyche ward on and off for years.  There they gave him Haldol and Respirdol  which also needs to be metabolized by 2D6 which, as I point out,  he doesn’t have.  So, he became more and more crazy the more they poisoned him with drugs he could not metabolize. He spent many years being homeless.

#4  I was able to save him because a psychiatrist from Australia who was in my VaccineLiberationArmy.com orbit told me about Pharmacogenetics and the super family of Cytochrome P450 enzymes.  She did a study of homicide prisoners, tested them for the condition of their liver enzymes…found they were taking medication that they could not metabolize.  So some people commit suicide and some homicides depending on if they blame themselves or others. David tried suicide, but fortunately I was aware enough to save him,  (BTW he is doing great since he has stopped poisoning himself).  He was never vaccinated so I had a leg up on the situation.  If he were vaccinated he probably would have been Autistic or worse.

David restored (and me)

#5 This field of Pharmacogenetics is difficult to understand but it all comes down to the fact that the babies, children, youth, adults are being poisoned and can’t get it out of their system if they don’t have the right complement of enzymes as they are being poisoned by the same excipients and adjuvants at every well baby visit.  And because of this relentless medical mafia mandated, illegal protocol they are damaged irreversibly in so many cases.

As Dr. Haider says…all disease is either due to lack of nutrition or due to toxicity!

Have you ever seen Andy Wakefield’s first documentary..WHO KILLED ALEX SPOURADALAKIS.  It is exactly what is happening to those who were given poisons via vaccination and then further poisoned by psyche drug medication having the genetic inability to metabolize.  It is the most amazing documentary I have ever seen.

BTW…there is a DNA swab test to check the slow, normal, rapid and absent enzymes.  I did that and then compared that to the drugs David was given and found out that between the hallucinogens and the pharma psyche drugs he was constantly being poisoned, acting bizarre and then being picked up and sent to various psyche wards.  …. like Alex  whose mother had to killed him…he was in unbearable distress. (but fortunately for me David had a running chance…no vaccines and the Psychiatrist from Australia who educated me in time).
If you have the time and inclination…here is the link to my White Paper” on the homicides and suicides due to this.  Dr. Lucire’s paper is in that link also.

Here is my Final to Siri &Aug.24 Pharmacogeneticsfor another whack at La Pinada

Mayo Study: Vaccines and Pharmacogenetics

Abstract
The field of pharmacogenomics and pharmacogenetics provides a promising science base for vaccineresearch and development. A broad range of phenotype/genotype data combined with high through put genetic sequencing and bioinformatics are increasingly being integrated into this emerging field of vaccinomics. This paper discusses the hypothesis of the ‘immune response gene network’ and genetic (and bioinformatic) strategies to study associations between immune response gene polymorphisms and variations in humoral and cellular immune responses to prophylactic viral vaccines, such as measles–mumps–rubella, influenza, HIV, hepatitis B and smallpox. Immunogenetic studies reveal promising new vaccine targets by providing a better understanding of the mechanisms by which gene polymorphisms may influence innate and adaptive immune responses to vaccines, including vaccine failure and vaccine-associated adverse events. Additional benefits from vaccinomic studies include the development of personalized vaccines, the development of novel vaccines and the development of novel vaccine adjuvants.

pharmacogenomics_to_vacci-1 MAYO CLINIC STUDY

School shooting/Automatism Defense

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Suicides and Homicides: SSRI Stories

“Suicidal ideations, homicidal ideations, mental health issues,” Trey Gowdy said on Fox News. “The overwhelming majority of mass killers suffer from that.

VLA Comment:  Unfortunately,  he mistakenly thinks that the solution is red flag gun laws.  the solution has been discovered by organizations and hospitals like the Mayo Clinic, St. Jude’s, Sloan Kettering.  “No one should be given medications unless they take the Pharmacogenetic test (genesight labs)”  Homicides and suicides are caused by Doctors giving these young adults medications for ADHD, BiPolar,etc that they are lacking the liver enzyme (Cytochrome P450 super group) that would metabolize it out of the body.  Instead, without the corresponding enzyme that body accumulates the drug and poisons the patient to a point of hallucinations, homicidal ideations and suicidal ideations and events.  Read the Automatism Defense