Category Archives: Pharmacogenetics

Pharmacogenetics: Emergent Violence to Self and others: Oops, wrong medication causing suicide/ homicide

Findings:

Psychiatric drugs and some general medications
have effects that are not always the ones intended.
Reactions to different drugs and drug-drug combinations
are governed by individual metabolising rates. Phase 1
metabolism takes place via the cytochrome P450 enzymes
with 57 human genes identified that are genetically
variable i.e. polymorphic. The population are coded as
poor, extensive (known as normal), intermediate or ultra
rapid metabolisers.

STUDY: Brogan-Treatment Emergent Violence to Self and Others.

How the Establishment is going to take away our Guns

So far we can approximate, as of today (2019) that 25% of Americans (and growing) won’t be able to get guns because of their mental health record.

Overall, the researchers estimated that 16.7 percent of the 242 million adults in the United States filled at least one psychiatric drug in 2013, including:

  • 12 percent who reported filling one or more prescriptions for antidepressants;
  • 8.3 percent who reported filling one or more prescriptions for sedatives, hypnotics, and anxiolytics; and
  • 1.6 percent who reported filling one or more prescriptions for antipsychotics.

According to the research letter, the rates at which individuals reporting filling prescriptions for psychiatric drugs varied by race and ethnicity. The researchers found that:

  • 20.8 percent of white adults reported using psychiatric drugs;
  • 9.7 percent of black adults reported using psychiatric drugs;
  • 8.7 percent of Hispanic adults reported using psychiatric drugs; and
  • 4.8 percent of Asian adults reported using psychiatric drugs.

Further, the researchers found that the rate of psychiatric drug use increased by age. According to the study, 25.1 percent of adults ages 60 to 85 used at least one psychiatric drug, compared with 9 percent of those ages 18 to 39. The researchers also found that older adults were more likely to use antidepressants and anxiolytics, sedatives, and hypnotics, but not antipsychotics.

In addition, the researchers found that women were more likely than men to report using psychiatric drugs, at 21 and 12 percent, respectively.

According to the research letter, most individuals who reported using psychiatric drugs said they used the medications long-term. The researchers ound that 84.3 percent of adults filled three or more prescriptions for psychiatric drugs in 2013 or reported that they had started to take the drugs in 2011 or earlier. Long-term psychiatric drug users filled a mean of nearly 10 prescriptions for the drugs in 2013.  READ MORE…

(JAMA STUDY 2013 1 out of 6 adults are on psyche drugs)

These data show 1 of 6 US adults reported taking psychiatric drugs at least once during 2013, but with 2- to 3-fold differences by race/ethnicity, age, and sex. Moreover, use may have been underestimated because prescriptions were self-reported, and our estimates of long-term use were limited to a single survey year.

VLA comment:  That is 16.666% of US adults in 2013 that will not be able to get a gun permit.

How much has that increased six years later?  Say 20% of American Adults can’t get gun permits because they have been diagnosed with some form of mental illness and have been prescribed drugs.

Up to 23.5 percent of all children under age 18 take at least one prescription medication each month,1 including opioids, antidepressants, and other psychotropic medications.

We may already be at one quarter (1/4) of the population on psyche drugs.  Be careful with the legislation as this is the subtle alternative way to take away guns.  So far we can approximate that as of today (2019) 25% of Americans won’t be able to get guns because of their mental health record.

THE CAUSE OF MASS SHOOTINGS, SUICIDES CAN BE FOUND IN THE FIELD OF PHARMACOGENETICS (READ POSTS)

 

BMJ: Antidepressant increase the likihood of suicide and homicide

photo taken from this site…interesting comments

Antidepressants increase the risk of suicide, violence and homicide at all ages

“All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases. The following symptoms, anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia (psychomotor restlessness), hypomania, and mania, have been reported in adult and pediatric patients being treated with antidepressants” (1)  READ MORE….

see also www.SSRIStories.net (lists of suicides and homicides)

CAUSE: Pharmacogenetics

PHARMACOGENETICS: MASS SHOOTERS HAVE ONE THING IN COMMON

Nearly all mass shooters have one thing in common, and it isn’t guns

Mike Adams There’s a common thread that winds its way across nearly all mass shooters who carry out violence in America. It’s not guns, it’s psychiatric drugs

Multiple credible scientific studies going back more than a decade, as well as internal documents from certain pharmaceutical companies that suppressed the information show that SSRI drugs ( Selective Serotonin Re-Uptake Inhibitors ) have well known, but unreported side effects, including but not limited to suicide and other violent behavior. One need only Google relevant key words or phrases to see for themselves. www.ssristories.com is one popular site that has documented over 4500 ” Mainstream Media ” reported cases from around the World of aberrant or violent behavior by those taking these powerful drugs.

And what is the science behind this:  PHARMACOGENETICS

Neonate Maturation – Cytochrome P450

VLA Comment:  Clearly cyp 450 family of enzymes are “maturing”.  Many vaccine excipients given to neonates and children (such as formaldahyde (cyp4501A2), polysorbate 80 (cyp4503A4) cannot be metabolized, therefore poisoning the neonate, infant, child potentially at every 2 month well baby visit.

Some CYP450 enzymes are active in utero while others do not demonstrate activity until some time after birth. When corrected for weight the content of CYP enzymes in fetal livers is 30–60% of adult values. The link below has a table that indicates maturation times in some cyp 450 enzymes.

Neonatal maturation of Cyp 450 enzymes study*

Excerpt: Maturation rates are difficult to generalize and enzyme‐specific information needs to be determined for an accurate estimate of drug metabolism 7. Polymorphisms, diseases such as sepsis and complex surgery can all increase the variability of drug metabolism 32. A diet based on infant formula rather than breast milk 14 and antenatal exposure to cigarette smoke 33 can increase the rate of CYP enzyme development. Further, the routes of metabolism seen in adults may not be mirrored in neonates due to the activity or inactivity of particular CYP enzymes 3, summarized in Table 1. (click link above for table)

The Ontogeny of Cytochrome P450 Enzyme Activity and Protein Abundance in Conventional Pigs in Support of Preclinical Pediatric Drug Research

CYP450 enzymes are the most important phase I drug metabolizing enzymes, located on the smooth endoplasmic reticulum and highly expressed in liver compared to other tissues in pigs (Antonovic and Martinez, 2011; Nielsen et al., 2017). They metabolize between 70 and 80% of the human drugs used, most frequently by hydroxylation (Matalová et al., 2016). The ontogeny of the human CYP450 enzymes is rather well known. For example CYP2C9 enzyme activity increases rapidly after birth reaching adult values around 3 months of age, whereas CYP1A2 reaches adult values around 10 years of age (Alcorn and McNamara, 2002; Johnson et al., 2006; Matalová et al., 2016).

Click here for study

Drugs metabolized by 1A2  (as an example), such as formaldahyde in vaccines

CCHR: More About Psychiatric Drugs Causing Violence and Suicide

  “Antidepressant-induced akathisia-related homicides associated with diminishing mutations in metabolizing genes of the CYP450 family
  by Yolande Lucire and Christopher Crotty
  Pharmacogenomics and Personalized Medicine, 1 August 2011

This research paper details patients who had been referred to Dr. Lucire’s practice for expert opinion or treatment. More than 120 subjects were diagnosed with akathisia [a neurotoxic psychosis often characterized by a feeling of inner restlessness and inability to stay still] or serotonin toxicity [extremely high levels of serotonin causing toxic and potentially fatal effects] after taking psychiatric drugs that had been prescribed for psychosocial distress. Akathisia has been known to be associated with suicide since the 1950s and with homicide since 1985.

They were tested for variant alleles in cytochrome P450 (CYP450) genes, which play a major role in the metabolism of all antidepressant and many other drugs, indicating ultrarapid metabolism due to allele duplications. This seems to be strongly associated with a large number of deaths from intoxication and suicide. High or fast-changing levels of psychotropic substances can cause unpredictable toxicity leading to violent behavioral effects, including akathisia. [An allele is one of two or more alternative forms of a gene that arise by mutation and are found at the same place on a chromosome.]

 

Read more…

Medical/Legal: Pharmacogenetics-THE AUTOMATON DEFENSE

With the exception of liability without fault, which requires only actus reus, a crime requires two elements, actus reus and mens rea. While most criminal defenses attempt to excuse, justify or exculpate the defendant’s criminal guilt by addressing mens rea, the automatism defense is different in that it attempts to prove that the defendant did not actually commit actus reus. Automatism can therefor apply to both conventional cases and cases of strict liability & vicarious liability. If the defendant is found to have been acting as an automaton (“a machine that moves”) when the crime was committed, that is, totally unconsciously and involuntarily, then he cannot be said to have been “acting” at all, in a legal sense. And without actus reus, the defendant cannot be held criminally liable for his actions.

READ MORE…

VLA COMMENT:  The rise of information about pharmacogenetics (see room on right side list on this site) citing the inability of individuals to metabolize the popular pharmacueticals leading to mass shootings, suicides will give the legal professional plenty of business for those who have ears to hear!

We are at the cutting edge of its exposure right now in 2019/20.  Attorney’s get educated and open up several bank accounts in different  banks.

Suicides & homicides on pharma drugs

Dr. Lucire’s study:  Having gained access through many attorneys of clients who were convicted of homicide, Dr. Lucire, an Australian Psychiatrist and researcher into pharmacogenetics, shares her study of men and women, finally, taken off their prescription drugs, who relate heinous (emphasis added) homicidal ideations that led them to kill their loved ones.

Excerpt:

Subject 1, in her own words:

My husband was drinking. I took small doses of valerian for a month and had weird dreams and premonitions. When I took nortriptyline, I immediately wanted to kill myself, talked myself out of it. I’d never had thoughts like that before. My husband was angry, shouting. I walked outside a lot, with palpitations, trouble breathing, and became more depressed. My smoking went up to 25 a day, no alcohol. I didn’t sleep for two nights, dreamt, then slept maybe three hours, felt awful. I dreamt that my daughter had dark teeth and I saw a black halo around her head, a spear hanging over it. I felt like a zombie. I believed I had to help my daughter, that a bad spirit possessed her. I picked up a knife and stabbed her and woke up. I was not myself. I was looking on from the outside, controlled by dark forces. She said: “Mum, what are you doing here?” I realized what I’d done. I asked my husband to kill me. He called the police. I felt better in the police cells without the pills, but the pills started again and thoughts of killing myself returned.

 

Vaccines Excipients: PHARMACOGENETICS: Inability of infants and children to metabolize vaccine xenobiotic excipients

Clinical Pharmacogenetics in Pediatric Patients

Anwar Husain; Jennifer A. Loehle; David W. Hein Pharmacogenomics. 2007;8(10):1403-1411.

Newborns and infants rapidly undergo simultaneous stages of organ growth and demonstrate large variability in drug response and metabolizing capabilities.[1,2] The enzymes, transporters and targets important for pediatric drugs all have the potential to vary along developmental timelines in terms of affinity, functional capacity and expression. Drug-metabolizing enzymes can vary according to chronological age.[3,4]

As such, determining gene expression patterns at various ontological periods becomes of key importance in formulating treatment plans for pediatric patients. Exposure to toxins or pharmaceutical agents or lack of medical treatment of a particular illness at sensitive periods of development could irreversibly disrupt the normal maturation of an individual. Observable consequences of such disruption may not appear until much later in life.              READ MORE….

ASTHMA excerpt: Polymorphisms (lack of specific enzyme in individuals) have been identified within the molecular proteins and enzymes involved in the pathways by which such drugs (vaccine excipients) may bring about their effects that may influence inter-individual variation in patient response.

What is Cytochrome P450 and what does it have to do with drugs and vaccine metabolism and adverse reactions?

Cytochrome P-450 is the liver’s enzyme system and is responsible for most drug metabolism.  Numerous medications, nutrients, and herbal therapies are metabolized through the cytochrome P450 (CYP450) enzyme system. This system can be inhibited or induced by drugs including excipients in vaccines. It is to be noted that cytochrome P450 is maturing and is immature in infants who are regularly vaccinated with Hepatitis B as early as one hour and those who receive the Vitamin K injection.

There are more than 50 CYP450 enzymes, but the CYP1A2, CYP2C19, CYP2D6, CYP1A2, CYP3A4, and CYP3A5 enzymes are responsible for metabolizing 45% of drug metabolism. The CYP2D6 (20–30%), the CYP2C9 (10%) and the CYP2E1 and CYP1A2 (5%) complete this enzyme system. Many ingredients in vaccines inhibit Cytochrome P450, therefore the offending agent remains in the body of the infant and toddler and act as a poison damaging the mitachondria found in every cell in the body except for the blood.   If a medication is taken with an agent that inhibits its metabolism, then the toxin level can rise and result in a harmful or adverse effect.

But it is not only that “all” infants  have immature Cyp 450 enzymes.  For example, 10% of Caucasians are non-metabolizers (Cyp 450 2D6).  For their whole life long these poor (polymorphic) metabolizers cannot metabolize 20-30% of drugs.  7% of African Americans are poor/non metabolizers of drugs dependent on CYP2D6.  Due to hereditary genetic variations (not defects) they do not have the activity of Cyp 2D6. That means that children and teens given drugs such as Adderall, Haldol, Respiridal; street drugs like LSD, psilosybn, cocaine, codeine without adequate genetic pre-testing are likely to have “drug induced psychosis”; suicidal ideation, homicidal ideations by which “heinous” thoughts drive them to such violence as school shootings and mass attacks.

  *Ped cyp enzymes  (see graph)  (very important study of the immaturity of cyp 450 superfamilies in infants and children.

STUDY DOWNLOAD

Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity.:

Study #2:  Immaturity of Cyp 450 in Neonate boys (book)

Study #3 (2018) The Ontogeny of Cytochrome P450 Enzyme Activity and Protein Abundance in Conventional Pigs in Support of Preclinical Pediatric Drug Research

Joske Millecam1, Laura De Clerck2, Elisabeth Govaert2, Mathias Devreese1, Elke Gasthuys1, Wim Schelstraete1, Dieter Deforce2, Lies De Bock3, Jan Van Bocxlaer3, Stanislas Sys4 and Siska Croubels1*

Neonate maturation of Cyp 450 Enzymes (table)

Comprehensive Vaccine Ingredient Information- CDC VACCINE EXCIPIENTS LIST PER VACCINE  CDC Vaccine excipients-table-2 

DIRECT LIST OF THE XENOBIOTIC INGREDIENTS IN VACCINES

Medical treatments and drug protocols including vaccines should be  implemented within a framework of the patient’s heritage, race, and culture in order to provide effective management modalities. Infants as well as adults should be assessed for their ability to metabolize the ingredients in vaccines.

When in comes to diet,  CYP450 inducers and inhibitors are commonly ingested items such as grapefruit juice (inhibitor) and tobacco and herbs such as St. John’s Wort (inducers).  In the case of grapefruit juice, there are numerous medications known to interact with grapefruit juice including statins, antiarrhythmic agents, immunosuppressive agents, and calcium channel blockers. Furthermore, the inhibition of the enzyme system seems to be dose dependent; thus, the more a patient drinks, the more the inhibition that occurs. Additionally, the effects can last for several days if grapefruit juice is consumed on a regular basis. Luckily, the effect of this is not seen with other citrus juices.

Hopefully, this brief review has opened the door to your inquisitive nature on how the liver’s enzyme system is effected by numerous medications and vaccine excipients and why some patients experience clinically significant unanticipated adverse reactions or therapeutic failures.

The above was edited and altered to include vaccines excipients from Davis’ Drug Guide

Effects of Polysorbate 80, a widely used ingredient in vaccines

The results indicate that these non-ionic surfactants are in vitro inhibitors of CYP-mediated metabolism and might have the potential to modify the pharmacokinetics of co-administered drugs, which are substrates of CYP, and thereby enhance their bioavailability.

Read more…

More on Polysorbate 80 and Polysorbate 20

The vaccine ingredients effects on the human body, followed by links to substantiating documentation of causation

Comprehensive Vaccine Ingredient Information- CDC VACCINE EXCIPIENTS LIST PER VACCINE  CDC Vaccine excipients-table-2 

Vaccination ingredients according to the product insert:

MMR II: Measles, Mumps and Rubella

http://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf

The Ingredients: measles, mumps, rubella virus, neomycin, sorbitol, hydrolized gelatin, chick embryonic fluid, and human diploid cells from aborted fetal tissue.

Infanrix: Dipthetheria, Tetanus and Pertussis

http://us.gsk.com/products/assets/us_infanrix.pdf

The Ingredients: Diphtheria, Tetanus and Pertussis toxoids, 2-Phenoxyethanol, Aluminum hydroxide, and Formaldehyde.

IPOL: Polio

http://www.vaccineshoppe.com/US_PDF/IPOL_942420_11.06.pdf

The Ingredients: 3 types of polio viruses, neomycin, streptomycin, polymyxin B, formaldehyde, 2-phenoxyethenol, and a continuous line of monkey kidney cells.
Act-Hib: Haeomophilus Influenza type B

http://www.novaccine.com/pdffiles/Act_HIB_package_insert.pdf

The Ingredients: Haemophilus influenza Type B, polyribosylribitol phosphate, ammonium sulfate, formalin, and sucrose.
Menactra: Meningococcal

www.fda.gov/CbER/products/menactra.htm

The Ingredients: Neisseria meningitidis A, C, Y and W-135 strains, Mueller Hinton Agar, Watson Scherp Media, polysaccharide antigens, formaldehyde, diphtheria toxoid protein, ammonium sulfate.
Prevnar: Pneumococcal

http://www.wyeth.com/content/showlabeling.asp?id=134

The Ingredients: saccharides from capsular Streptococcus pneumoniae antigens (7 serotypes) individually conjugated to diphtheria CRM 197 protein, aluminum phosphate, ammonium sulfate, soy protein, and yeast.

Varivax: Varicella (chickenpox)

www.merck.com/product/usa/pi_circulars/v/varivax/varivaxpi.pdf

The Ingredients: varicella live virus, neomycin, phosphate, sucrose, and monosodium glutamate (MSG), processed gelatin, fetal bovine serum, guinea pig embryo cells, albumin from human blood, and human diploid cells from aborted fetal tissue.
Rotarix: Rotavirus

http://www.fda.gov/CbER/label/rotarixLB.pdf

The Ingredients: weakened human rotavirus, dextran, sorbitol, xanthan, Dulbecco’s Modified Eagle Medium (DMEM), which contains: sodium chloride, potassium chloride, magnesium sulphate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, L-glutamine, calcium chloride, sodium hydrogenocarbonate, and phenol red.
Gardasil:HPV
http://www.merck.com/product/usa/pi_circulars/g/gardasil/gardasil_pi.pdf
The Ingredients: HPV types 6, 11, 16 and 18, saccharomyces cerevisiae, “fermentation media”, aluminum, sodium chloride, polysorbate 80, sodium borate.
FluZone (or FluShield, same product): Influenza

www.fda.gov/CBER/label/fluzoneLB.pdf

The Ingredients: Trivalent influenza virus, gentamicin sulphate, formaldehyde, thimerosal, polysorbate 80 (Tween 80) and chick embryonic fluid

Havrix: Hepatitis A

http://us.gsk.com/products/assets/us_havrix.pdf

Ingredients: Hepatitis A virus/toxoids, formalin, aluminum hydroxide, 2-phenoxyethanol, polysorbate 20, and residual MRC5 proteins -human diploid cells from aborted fetal tissue.
Energix B: Hepatitis B

http://us.gsk.com/products/assets/us_engerixb.pdf

The Ingredients: genetic sequence of the hepatitis B virus that codes for the surface antigen (HbSAg), cloned into GMO yeast, aluminum hydroxide, and thimerosal.
———————————————————————–

What’s in the vaccine that needs Cyp450 to metabolize?

Comprehensive list of Xenobiotics in Vaccines: MUST SEE LIST

Vaccine Ingredients

Aluminum= Neurotoxin
http://informedcitizensagainstvaccination.blogspot.com/2009/11/aluminum-neurotoxic-vaccine-adjuvant.html

Formaldehyde= Carcinogen (cancer causer); linked causally to an assortment of cancers, most recently Leukemia. The International Agency for Research on Cancer (IARC) classified it as a known human carcinogen in 2004.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/formaldehyde-carcinogen-in-vaccinations.html

Thimerosal (mercury)= Neurotoxin; controversially linked to Autism in the media, but is well known and causally proven to cause many neurological disorders, cell death in the brain, mitochondrial damage, etcetera. Thimerosal is still being used in the Hepatitis B and Influenza vaccines as of 2009, and is also contained within several of the H1N1 vaccinations.

http://informedcitizensagainstvaccination.blogspot.com/2009/11/thimerosal-neurotoxic-in-plethora-of.html
2-Phenoxyethanol aka “Antifreeze” aka “ethylene glycol monomethyl ether”= neurotoxic, CNS toxicant.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/2-phenoxyethanol-antifreeze-neurotoxin.html

Phenol= nephrotoxic; CNS toxin, heart toxin, gastrointestinal, kidney, lung and blood vessel toxin… known to induce coma’s and death; by far one of the most toxic of all vaccine ingredients.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/phenol-cns-toxin-causes-comas-and-death.html

Sorbitol= cardiac toxin, causes neuropathy in and exacerbation of diabetes, CNS toxin, our own government states under no uncertain terms that this substance is NOT to be injected… then allows it to be used in childhood vaccinations.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/sorbitol-cardiac-toxin-causes.html

Neomycin, Streptomycin, Polyxmyxin B, Gentamicin Sulfate= Antibiotics. Immune suppressing, lead to the development of more virulent organisms and antibacterial resistance so people cannot combat them.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/antibiotics-in-vaccinations.html
Egg (chick embryonic fluid), soy, yeast, gelatin= Allergens, risk of anaphylaxis and the development of Asthma.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/allergens-in-vaccinations.html
Monosodium Glutamate= Excitotoxin; hazardous to your health in so many ways: read the full length article for further details.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/monosodium-glutmate-creating-dumb-obese.html

Polysorbate 80 or Tween 80= anaphylaxis risk, also permeates the BBB (blood brain barrier) which means vaccine toxins can enter the brain.
http://informedcitizensagainstvaccination.blogspot.com/2009/11/polysorbate-80-aka-tween-80-allows.html
Chick embryonic fluid, fetal bovine serum, guinea pig embryo cells, monkey kidney cells= Animal products in vaccinations that are highly susceptible to contamination. There is a particularly elevated risk with bovine serum (bovine polyomavirus) and monkey kidney cells (SV40 contamination causing cancer).

What is in the “mediums“? https://vaccineliberationarmy.com/2019/01/15/dogs-cats-increasingly-receiving-psyche-drugs-as-in-humans-its-the-vaccines/

READ MORE FROM ORIGINAL LINK

Animal Products (Contaminants) in Vaccinations

 Animal products in vaccination: Monkey kidney cells, sheep red blood cells, chick embryonic fluid, fetal bovine serum, bovine gelatin, guinea pig embryo cells= risk and history of contamination.
Calf fetus, chick embryo, chick kidney, chicken egg, cow heart, dog kidney, duck egg, guinea pig embryo, horse blood, monkey kidney, monkey lung, mouse blood, pig blood, rabbit brain, sheep blood and others. These are used in various vaccine production lines. Residues are not completely purified out of the final packaged product. Contamination can introduce new pathogens.  READ MORE…
List of ingredients and levels of carcinogenicity,  for each, etc.
See also:

The dangerous impurities of vaccines by Janine Roberts

On the toxic ingredients of vaccinations: plays special emphasis to animal by-products and their production process in vaccinations.

http://www.foresight-preconception.org.uk/pdf/dangerous-impurities-of-vaccines.pdf

Study: Vaccine excipients, xenobiotics-Cause of Inflammation after vaccination?

Cytochrome P450: Physiological and pharmacological role in Mental Illness, Cancer, Parkinson

Suicides and homicides data

Images of School shooters

The cytochrome P450 isoenzymes are a superfamily of enzymes found in the Liver and in all cells except the blood.  These enzymes catalyse the metabolism of a large number of endogenous and exogenous compounds-prescription drugs and street drugs.

The vast individual variation of genetics vary greatly according to race and ethnicity.  It is the field of PHARMACOGENETICS that accounts for surge in “apparent” mental illness, suicides, drug addiction and homicides and disease susceptibility.

About 5–10% of Caucasians and 0.9% ofAsians metabolise debrisoquine and other substrates of CYP2D6 at a markedly decreased rate. In addition to thepoor and extensive metabolisers, a group called the ultrarapid metabolisers has been identified.

The CYP2C19 enzyme is also associated with genetic polymorphism. Slow metabolisers  are found in 2–5% of Caucasians, about20% of the Japanese population, 19% of African Americansand 8% of Africans [18].

Cytochrome P450: Physiological and pharmacological role READ THIS Study:

READ ALL OUR POSTS ON PHARMACOGENETICS

 

Killer Drugs? Homicide Risk Linked to Medications

Study: Vaccine excipients, xenobiotics-Cause of Inflammation after vaccination?

CDC Excipient Chart

Inflammation is associated with down regulations of hepatic and extrahepatic CYP enzymes drug metabolism.

The CYP represent a superfamily of enzymes with a key role in the activation or inactivation of a plethora of therapeutic agents. CYP enzymes are involved in the metabolism of xenobiotic substances. Cytochromes present intra- or interindividual and intra- or interethnic genetic polymorphisms. Variations in the pharmacokinetic drug profile are linked to the rising toxicity following a declining metabolism, reduced efficacy of the drug, adverse drug interaction, and increasing production of toxic metabolites. The high-metabolic rate of the intestinal microbiota is due to its many enzymes which catalyze reactions in phase I and II drug metabolism. In case of a compromised intestinal barrier, there may be an increase in paracellular passive absorption.

It is evident that high-microbial abundance following intestinal disturbances, environment, aging, or food-associated diseases promotes the microbial metabolism of a drug before absorption.

READ STUDY…

INFANTS INABILITY TO METABOLIZE XENOBIOTICS IN VACCINES

Above link Includes CDC Vaccine Excipient list of xenobiotics