Category Archives: Pharmacogenetics

Cytochrome P450: Physiological and pharmacological role in Mental Illness, Cancer, Parkinson

Suicides and homicides data

Images of School shooters

The cytochrome P450 isoenzymes are a superfamily of enzymes found in the Liver and in all cells except the blood.  These enzymes catalyse the metabolism of a large number of endogenous and exogenous compounds-prescription drugs and street drugs.

The vast individual variation of genetics vary greatly according to race and ethnicity.  It is the field of PHARMACOGENETICS that accounts for surge in “apparent” mental illness, suicides, drug addiction and homicides and disease susceptibility.

About 5–10% of Caucasians and 0.9% ofAsians metabolise debrisoquine and other substrates of CYP2D6 at a markedly decreased rate. In addition to thepoor and extensive metabolisers, a group called the ultrarapid metabolisers has been identified.

The CYP2C19 enzyme is also associated with genetic polymorphism. Slow metabolisers  are found in 2–5% of Caucasians, about20% of the Japanese population, 19% of African Americansand 8% of Africans [18].

Cytochrome P450: Physiological and pharmacological role READ THIS Study:

READ ALL OUR POSTS ON PHARMACOGENETICS

 

Killer Drugs? Homicide Risk Linked to Medications

Study: Vaccine excipients, xenobiotics-Cause of Inflammation after vaccination?

CDC Excipient Chart

Inflammation is associated with down regulations of hepatic and extrahepatic CYP enzymes drug metabolism.

The CYP represent a superfamily of enzymes with a key role in the activation or inactivation of a plethora of therapeutic agents. CYP enzymes are involved in the metabolism of xenobiotic substances. Cytochromes present intra- or interindividual and intra- or interethnic genetic polymorphisms. Variations in the pharmacokinetic drug profile are linked to the rising toxicity following a declining metabolism, reduced efficacy of the drug, adverse drug interaction, and increasing production of toxic metabolites. The high-metabolic rate of the intestinal microbiota is due to its many enzymes which catalyze reactions in phase I and II drug metabolism. In case of a compromised intestinal barrier, there may be an increase in paracellular passive absorption.

It is evident that high-microbial abundance following intestinal disturbances, environment, aging, or food-associated diseases promotes the microbial metabolism of a drug before absorption.

READ STUDY…

INFANTS INABILITY TO METABOLIZE XENOBIOTICS IN VACCINES

Above link Includes CDC Vaccine Excipient list of xenobiotics

Pharmacogenetics (gene testing): Attorney’s are now stepping up!

Medical DNA sequencing leads to lawsuits and legal questions

One of the biggest concerns is legal liability. Health care providers face a disconnect: Technology has outpaced their ability to interpret genetic results, such as a patient’s risk of breast cancer or heart attack from a particular mutation. Because of that, typical fallbacks including providing a rigorous standard of care—which can also act as a legal shield against malpractice claims—are becoming fuzzy. What is a doctor to do when a patient has results from a direct-to-consumer testing company like 23andMe and asks what implications they have for their health? Or when a lab notifies a doctor that a genetic variant their patient carries, thought meaningless 3 years ago, is now known to be harmful, but they can’t locate the patient? Can a testing lab be held liable for not regularly reviewing the scientific literature, to track science’s understanding of the gene variants it tests for?

Read more…

 

LawSeqSM: Building a Sound Legal Foundation for Translating Genomics into Clinical Application

This innovative 3-year project, based cooperatively at the University of Minnesota and Vanderbilt University, has convened a national Working Group of top legal and scientific experts to analyze current US federal and state law and regulation on translational genomics and to generate consensus guidance on what the law should be.

 

Activist Post: Cytochrome P450 and Vaccine Excipients-poisons that cannot be metabolized by children under 3yrs

The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D(3) synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases. [2]

Question:  Are metabolism differences in CYP genes the cause of many vaccine adverse reactions, especially brain encephalopathy that precipitates Autism and other clinically relevant diseases in infants, toddlers and even adults?  Was that the reasoning why a Vaccine Court Master awarded Hannah Poling’s Autism claim $1.5 million plus ongoing $500,000 per year for life [4]?  READ MORE…

Cyp 450 superfamilies in infants and children.

STUDY DOWNLOAD

Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity.:

Study #2:  Immaturity of Cyp 450 in Neonate boys (book)

Pharmacogenetics: Man stabs wife 123 times after regularly taking over the counter cold medicine (Coricidin)

Read story:

VLA COMMENT: Although we contacted the Church to which the man and his wife attended we are unsure whether we were heard. We let them know that it appears that the man had a typical homicidal ideation after taking days of codeine (cough medicine). He should have been gene tested to see if he was polymorphic Cytochrome P450 2D6, of which 10% of Caucasians are .He received a life sentence and from the looks of him he is probably being treated with drugs for mental illness in prison.

The study below is of a young girl (9 years old) that died. She also was not tested to see if she was a “non metabolizer” (polymorphism) of Cyp 450 2D6. In the study you will see due to the autopsy they found out the she was a non metabolizer. They try to call it a GENETIC DEFECT so as to blame her for her own death.

It is not a genetic defect. It is simply a genetic variation depending on race, demographics, etc. The medical cabal and pharma tried to posture it as a genetic defect so as to “blame” the victim. A pharmacogenetic test should always be taken before prescribing drugs. See more in our room pharmacogentics.

There is a defense that is emerging as it regards pharmacogenetics called THE AUTOMATON DEFENSE. This defense should have been used, if and after the gene test. Automatism is a rarely used criminal defense. It is one of the mental condition defenses that relate to the mental state of the defendant. Automatism can be seen variously as lack of voluntariness, lack of culpability (unconsciousness) or excuse (Schopp).

Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.  READ STUDY Abstract

Review the list of thousands of suicide and homicide cases on www.SSRISTORIES.net

DAVID’S STORY

And we can’t find an medical negligent attorney in Iowa who has any knowledge of pharmacogenetics.

23 & Me (Genetic testing) signs $300 million deal with GSK

Popular DNA Testing Company Signs $300 Million Deal With Big Pharmaceutical Company

It might be time for people to reconsider before they spit in a tube. Online genetic testing services are wildly popular. Many people use services such as 23andMe and Ancestry.com to learn about their ancestral pasts. Many also use these services to gain more profound insights into their biological makeup, which is often used to assess risk for degenerative diseases, such as cancer. This information offers use for more trivial insights, such as a person’s rate of metabolism in concern with substances like caffeine.

Pharmaceutical companies with access to such genetic information would be able to develop new products in more efficient ways.

GlaxoSmithKline, seeking to take advantage of just that, has announced a four year deal with 23andMe that allows them access to everyone’s genetic information for precisely the purposes pertaining to drug research.

READ MORE…

 

Effects of Heavy Metals in Vaccines (pharmacogenetics)

Aside from the known DEPOPULATION trends such social programs to reduce births, abortion legislation, reduced male sperm count via toxic agriculture (50% reduction as early as 1945), the increasing need for in vitro derived pregnancies, iatrogenic deaths, etc, the worldwide establishment is actually “poisoning” all neonates and infants under 3 years old.

The Journal of Pediatric Pharmacology and Therapeutics

“Developmental Pharmacokinetics in Pediatric Populations”

Hong Lu, PhD and Sara Rosenbaum, PhD

*Ped cyp enzymes  (see graph)  (very important study of the immaturity of cyp 450 superfamilies in infants and children. Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity. DOWNLOAD STUDY

Detoxification mechanism (Fish Study/Liver)Effect Metals on Cyp 450PHD_Thesis_Eng(1)

CDC vaccine excipients

Failure of Infants to metabolize due to immature Liver Cyp450 system of enzymes until 3 years old.

The Effect Of Heavy Metal on Hepatic Chromosome P450

The results of our experiments have demonstrated that heavy metal ions react with cytochrome P450 dependent enzyme system of fish species leading to changes in confirmation of protein structure they resolve in inhibition of activity of enzymes involved in biotransformation, decrease in detoxifying enzymes. In conclusion the difference changes in enzyme activity and cytochrome P450 content induce by the various heavy metal treatments may also be explained by the living and feeding habits of individual fish species.

Like with all living organism, the body of the fish has a quite conserve protein systems providing molecular defense to insure metabolism and elimination of the foreign material. The main region of metabolism of pollutants entering into the fish body is the liver. Due to biotransformation processes these substances are converted to other compounds that can be eliminated from the body thereby becoming less toxic. The hepatic detoxifying enzymes, the cytochrome P450 dependent mixed function monooxygenases, have an important role in this process.  P450 enzyme activity in the body is not constant.  Foreign substances, Xenobiotic or some endogenous regulating molecules are able to increase (inducers) or decrease (inhibitors) the activity of cytochrome P450 enzymes.

Aluminum + Cytochrome P450 -Study: Suppressive effect of accumulated aluminum trichloride on the hepatic microsomal cytochrome P450 enzyme system in rats.

Vaccine Excipientsf/CDC Vaccine Excipient Chart

  • Which ones need a mature Cyp 450 to metabolize out of the body?

 

  • aluminum hydroxide
  • aluminum phosphate
  • ammonium sulfate
  • amphotericin B
  • animal tissues: pig blood, horse blood, rabbit brain,
  • dog kidney, monkey kidney,
  • chick embryo, chicken egg, duck egg
  • calf (bovine) serum
  • beta propiolactone
  • fetal bovine serum
  • formaldehyde
  • formalin
  • gelatin
  • glycerol
  • human diploid cells (originating from aborted human fetal tissue)
  • hydrolized gelatin
  • mercury thimerosal (thiomersal, Merthiolate®)
  • monosodium glutamate (MSG)
  • neomycin
  • neomycin sulfate
  • phenol red indicator
  • phenoxyethanol
  • potassium diphosphate
  • potassium monophosphate
  • polymyxin B
  • polysorbate 20
  • polysorbate 80
  • porcine (pig) pancreatic hydrolysate of casein
  • residual MRC5 proteins
  • sorbitol
  • squalene
  • sucrose
  • tri(n)butylphosphate,
  • VERO cells, a continuous line of monkey kidney cells, and
  • washed sheep red blood

 

VLA Conclusion:  Aside from the known DEPOPULATION trends such social programs to reduce births, abortion legislation, reduced male sperm count via toxic agriculture (50% reduction as early as 1945), the increasing need for in vitro derived pregnancies, iatrogenic deaths, etc, the worldwide establishment is actually “poisoning” all neonates and infants under 3 years old.

The Journal of Pediatric Pharmacology and Therapeutics“Developmental Pharmacokinetics in Pediatric Populations” Hong Lu, PhD and Sara Rosenbaum, PhD

*Ped cyp enzymes  (see graph)  (very important study of the immaturity of cyp 450 superfamilies in infants and children. Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity. DOWNLOAD STUDY

 

 

 

 

 

DAVID’S STORY: Psyche Drugs & Pharmacogenetics (A common story plaguing the World)

David’s Story- Psyche Drugs & Pharmacogenetics

 There is a field of research, Pharmacogenetics/Pharmacogenomics, that is rising to prominence, as we speak.  St. Jude’s Children Hospital, the Mayo Clinic are some of the institutions leading the charge. Turns out that one size doesn’t fit all, after all.  Vaccines contain excipients that must be metabolized by the liver’s superfamily of enzymes (Cytochrome P450).

Let’s take my family, for example.  We are a typical middle – upper class, educated Caucasian family.  We eat virtually only organic food. We meditate and are generally so healthy that we don’t have a family physician as we rarely have a need to go to a doctor. We are a combination of strong stock: Irish, Swedish, Polish, Danish. Our last child, a boy, was born in 1984.  During that time until 2001, 15 of the 39 or so vaccines contained a mercury compound known as Thimerosal. This “heavy metal” compound was removed from all the vaccines in and around 2001 with the exception of the multidose flu vaccine that was distributed in the general clinics, to Medicaid dependent children and pregnant women of all stripes. However, by that time I had educated myself about the risks and benefits of vaccines. So, I did not vaccinate David.

At the age of 18, David went to the University of Iowa, similar to most colleges where prescription drugs are ubiquitous.  Adderall was easily obtained, gladly shared by students who had been on Adderall in middle school and high school, some began as early as 5 years old. One day David, experimented in this revival ‘60s millennium drug culture with one dose of LSD.

 

Video Message to Dr. Yolande Lucire from David IMG_0044

PHARMACOGENETIC TEST SIGNIFICANTLY INCREASE REMISSION OF MENTAL ILLNESS (DEPRESSION)

GeneSight employs a proprietary algorithm to analyze 12 genes and assess how they impact patients’ ability to process dozens of psychotropic medications. The test report buckets depression treatments as red (significant gene-drug interaction), yellow (moderate gene-drug interaction), or green (use as directed.) When the test report shows that patients are on red or yellow medications, their doctors should consider changing the drug or dose, while patients on green medications don’t require a medication change.

Researchers further evaluated patients who entered the study on red medications and either remained on red medications or were switched to yellow or green drugs. Remission rates were 153 percent higher, response rates were 71 percent higher, and symptom improvement rates were 59 percent higher when patients were switched from red to yellow or green meds — all statistically significant changes.

This analysis “establishes a new standard of care” for physicians by demonstrating that patients on red medications must be identified and have their medications modified, said Dechairo. “This switching analysis has also been an important point in our payor discussions, as utilization management programs can focus on switching patients from red medications, which would deliver results even better than those in the GUIDED study,” he said.

One prior cost-effectiveness study using drug claims data showed that using GeneSight can increase treatment adherence and save an average of $1,036 per year per patient, while another study using commercial claims data showed GeneSight’s potential to save $1,556 per patient by reducing disability claims, medical utilization, workplace absence.

Currently, the more than 300,000 GeneSight tests Myriad sells per year are largely ordered by psychiatrists. Once there is greater reimbursement traction, Myriad is planning a significant marketing push into the primary care market, including direct-to-patient advertising for the test, according to Capone.

GeneSight, which is a lab-developed test (LDT) performed in a CLIA-certified lab, must be ordered by physicians.

Capone noted that the FDA has publicly stated that it will continue to practice enforcement discretion for LDTs, and leave it up to legislators to reform diagnostic regulations that may or may not bring LDTs under the agency’s oversight. In December, legislators in the House of Representatives and the Senate incorporated the FDA’s ideas for diagnostics regulatory reform into a draft bill that features a pre-certification program that labs could use to bring the majority of new diagnostics to market, while having to submit around 10 percent of tests for premarket review.  READ MORE…

ABSTRACT OF STUDY