“We investigated hepatic P450 metabolism and drug pharmacokinetics in type 1 allergic mice induced by ovalbumin (OVA) emulsified with aluminum and inactive Bordetella pertussis. To further propose a possible key factor in drug-allergic disease interactions, we examined the inhibitory effect of NO, a marker of allergic conditions on the activities of major P450 isoforms”.
Magic Mushrooms: Some individuals are not able to metabolize-causing psychosis, albeit temporary and not to be confused with “mental illness”.
Increased knowledge in this area may advance our understanding of individual vulnerability to and/or protection from illicit drugs of abuse (15). This review, therefore, aims to describe our current understanding of the metabolism READ STUDY…
| Lawyer Impulsively Jumps In Front of Train: Effexor, like All A/D’s, Can Cause Impulsivness | ||||
| Suicide | Med For Depression | 2011-11-11 | England | Physician Kills Himself Shortly After Starting an A/D |
| Personality Drained Away/Huge Weight Gain | Med For Depression | 2011-11-10 | England | After Many Years on A/D’s, Man Felt Like His Personaity Was Drained Away & He Became Obese |
| Violence | Med For Depression | 2011-11-10 | Canada | Man Strikes an Ax at a Neighbor |
| Death | Antidepressant | 2011-11-10 | England | 23 Year Old Woman Dies of Cardio-Respiratory Arrest: High Level of A/D’s in Body: No Alcohol or Drug |
| Suicide | Celexa Antidepressant | 2011-11-10 | England | Woman, 73, Kills Herself While on Celexa |
| Murder-Suicide | Prozac | 2011-11-09 | California | Man Kills Two Police Officers & Himself |
| Heart Disease | Med For Depression | 2011-11-09 | Global | ++Depression Meds Are More Likely to Cause Heart Disease |
| Murder Attempt | Med For Depression | 2011-11-08 | Malta/Mediterranean | Man Attempts to Murder Uncle With Hammer: Confused & Agitated |
| Bizarre Behavior | Lexapro & Desyrel Antidepressants | 2011-11-08 | California | +Famous Actress Kim Richards Exhibits Bizarre Behavior on TV |
| Dulled Mind/Numbed Body | Zoloft | 2011-11-07 | Georgia | Woman Physician Quits Zoloft: Tells How She Recovered From Depression |
| Suicide | Med For Depression | 2011-11-07 | Texas | Woman Drives Her Car Into Lake |
| Suicide | Antidepressants | 2011-11-05 | Ohio | Soldier, 22, Kills Himself: Black Box Warning on Suicidality for This Age Group |
The various factors that impact pharmacokinetics
and pharmacodynamics mature towards adult values at different rates, thus requiring continual modification of drug dose regimens in neonates, infants, and children.
Read Study Pediatric Population study Cyp 450.
The results revealed that exposure to AlCl3 inhibited the microsomal CYP450 dependent enzyme system of liver. Our findings suggest that long term daily exposure of AlCl3 exerts the suppressive effects and thus may cause dysfunction of hepatic CYP450 dependent enzyme system of rat.
► AlCl3 exposure through drinking water gets close with actual chronic oral Al exposure. ► Effects of Al exposure on the hepatic microsomal protein, AND and ERND were studied. ► Metabolism of Al affected the hepatic microsomal cytochrome P450 enzyme system.
Oct 1, 2004 – Holt, shortly after, demonstrated that preformed aluminium phosphate, prepared from equimolar amounts of aluminium chloride and trisodium phosphate, acted as an adsorbant and was adjuvant active with diphtheria. Data on the use of alum
Apr 16, 2015 – Adjuvants such as the aluminum compounds (alum) have been dominantly used in many vaccines due to their immunopotentiation and safety records …. Aluminum compounds such as aluminum chloride, aluminum silicate, algammulin (gamma inulin plus AH), cesium alum (CA), Imject alum (IA) (AH plus
The field of pharmacogenomics and pharmacogenetics provides a promising science base for vaccine research and development. A broad range of phenotype/genotype data combined with high-throughput genetic sequencing and bioinformatics are increasingly being integrated into this emerging field of vaccinomics. This paper discusses the hypothesis of the ‘immune response gene network’ and genetic (and bioinformatic) strategies to study associations between immune response gene polymorphisms and variations in humoral and cellular immune responses to prophylactic viral vaccines, such as measles–mumps–rubella, influenza, HIV, hepatitis B and smallpox. Immunogenetic studies reveal promising new vaccine targets by providing a better understanding of the mechanisms by which gene polymorphisms may influence innate and adaptive immune responses to vaccines, including vaccine failure and vaccine-associated adverse events. Additional benefits from vaccinomic studies include the development of personalized vaccines, the development of novel vaccines and the development of novel vaccine adjuvants.
As one clinician noted, ‘…vaccines licensed in the USA are safe and effective. However, not every vaccine is equally safe or equally effective in every person’ [2].
Read…
Above chart click below for Cytochrome P450 maturation. Children do not have mature cytochrome P450 families and cannot metabolize the excipients in vaccines as neonates.Read…age of maturity of Cytochrome P450 For example:
Hep B (aluminum hydroxide, yeast protein, phosphate buffers, sodium dihydrogen phosphate dihydrate)
Vitamin K shot are given at birth
At 14:00 Ben Swan shows that black boys under “36 months” (3 years) had higher autism. This goes along with the new study that shows that children under 3 do not have a mature detox mechanism (Cytochrome P450) in order to detox the excipients in vaccines such such as phenol, alcohol, polysorbate 80, formaldahyde. Aluminum & mercury inhibit Cytochrome p450. See INABILITY OF INFANTS TO METABOLIZE VACCINE EXCIPIENTS
BEN SWAN OTHER VIDEOS
In January, 2013, I wrote an article entitled, “Psychiatric Drugs, School Violence, And The Big Pharma Cover-up,” where I discussed the importance of the CYP450 enzymes on the metabolism of pharmaceutical drugs and the potential for adverse effects of those drugs if the CYP450 enzyme was not functioning properly.
Studies conducted over the last decade have clearly demonstrated the link between adverse reactions to Psycho-Pharmaceutical medications and underactive or underperforming CYP450 enzymes. This has caused some to wonder whether or not the recent uptick in mass shootings and the obvious link to many of the perpetrators and prescription drugs could be related to the performance of the CYP450 enzymes. Additional research, however, is now causing more questions to be asked in reference to the connections that chemicals like Glyphosate may have in the inhibition of proper CYP450 performance and, thus, in the uptick in mass shootings.
For those unfamiliar with the functions of the CYP450 enzymes, CYP450 stands for the Cytochrome P450 enzymes. Scientists understand these enzymes to be responsible for metabolizing almost half of all drugs currently on the market. P450 gene variants (polymorphisms) are implicated in the variability in drug response among a wide range of individuals. READ MORE…
VLA comment: 10 % of Caucasians, for example, are unable to metabolize these modern drugs. Hence, the epidemic of suicides and homicides. Early clinical examples of genetic influence on drug response involved variations in single genes (i.e., monogenic inheritance) in which polymorphisms (no metabolic ability) of a single gene encoding a drug-metabolizing enzyme responsible for the metabolism and disposition of a substrate drug caused aberrant response to the drug. The phenotypic variation can be dramatic, especially when no alternate pathway exists to perform the same function.