Necrotic skin reaction to traditional Vaccinia smallpox vaccination.
Background—Although vaccinia immunization is highly effective in preventing smallpox, postvaccinationreactions are common. Identifying genetic factors associated with AEs might allowscreening before vaccinia administration and provide a rational basis for the development of improved vaccine candidates. Methods—Two independent clinical trials in healthy, vaccinia-naïve adult volunteers were conducted with the Aventis Pasteur smallpox vaccine (APSV). Volunteers were assessed repeatedly for local and systemic AEs to vaccine and were genotyped using the same panel of 1442 singlenucleotide polymorphisms (SNPs).