Adverse Events Following Smallpox Vaccination (genetic variations in individuals)



Necrotic skin reaction to traditional Vaccinia smallpox vaccination.

Background—Although vaccinia immunization is highly effective in preventing smallpox, postvaccinationreactions are common. Identifying genetic factors associated with AEs might allowscreening before vaccinia administration and provide a rational basis for the development of improved vaccine candidates. Methods—Two independent clinical trials in healthy, vaccinia-naïve adult volunteers were conducted with the Aventis Pasteur smallpox vaccine (APSV). Volunteers were assessed repeatedly for local and systemic AEs to vaccine and were genotyped using the same panel of 1442 singlenucleotide polymorphisms (SNPs).

FULL STUDY smallpox vaccination Adverse Reaction (genetics)

2 thoughts on “Adverse Events Following Smallpox Vaccination (genetic variations in individuals)

  1. Elaine

    I have a very large small pox scar on my left arm. As a child I asked my mom why & she would always say it was due to me jumping when the vaccine was administered. Obviously I guessed this to be untrue long ago but have wondered from time to time why it is so much larger than others. Could I have had a reaction as a child? It would have been in the 1950’s when I received the vaccine in Scotland. Thank you anyone with any ideas.

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