DIYers used a security flaw to bypass the $8.3 billion insulin delivery business with a cobbled-together artificial pancreas. Read more…
In February 2018, the FDA and CDC approved the recommendation for a new hepatitis B vaccine, Heplisav-B targeting adults over the age of 18. The U.S. Food and Drug Administration (FDA) had twice rejected the application for licensure for Heplisav-B in the past four years because of safety signals. Heplisav-B differs from other licensed hepatitis B vaccines in that it contains a new synthetic adjuvant known as cytosine phosphoguanine 1018 (CpG 1018) composed of short synthetic DNA molecules. In 2016, the FDA rejected an application for licensure for the Heplisav-B vaccine, because the agency was concerned about an increased rate of heart attacks and deaths in people who had been given the vaccine. During the trial, approximately 14 subjects had heart attacks. In July 2017, the FDA committee convened to re-evaluate the scientific evidence and make a decision on whether Heplisav B should or should not be approved for use in the U.S. This committee had only one cardiologist on the team, Milton Packer, MD, who is a distinguished scholar in cardiovascular science at the Baylor University Medical Center in Dallas, Texas. According to Dr. Packer, it was possible that the Heplisav B vaccine’s novel adjuvant was related to the higher number of heart attacks in study participants who received the experimental vaccine. He stated: “To know if the 7 -1 heart attack imbalance represented a real risk, we’d need comparative data in 50,000 people.” However, the only way to conduct such a large trial would be to approve the vaccine and see what happens in the public. With Dr. Packer abstaining in his vote to recommend the vaccine, the FDA committee approved it anyway. Dr. Packer stated: “Why did I abstain? Based on the available data, it was impossible for anyone to know if the increase in heart attack risk was real. There is a simple rule in life: if you don’t know, you should say you don’t know.” The vaccine is now available to the public, and all those who receive it are basically guinea pigs to find out if heart attacks will result from the experimental vaccine, and if it will continue to have FDA approval.
Study on combining Aluminum with 1018 (CPG1018 as above)
Cochrane, a non-profit organization whose research helps individuals make informed health decisions, published a review in May 2018 claiming that the HPV vaccine helps prevent cancer and precancerous changes in the cervix with no serious side effects. The review aimed to increase public confidence in the HPV vaccine – both its efficacy in cancer prevention and its long-term safety. This publication has the potential to affect the opinions of many people regarding the HPV vaccine, possibly reassuring some parents and convincing them to choose it
for their children. READ ARTICLE
VLA Comment: The article is interesting to read however, the link to the BMJ review of the HPV Cochrane study shows the poor and fallacious design of the study whose conclusion is that the HPV vaccine is safe. The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias
Abstract. There are unexplained links between human exposure to aluminium and the incidence, progression and aetiology of Alzheimer’s disease. The null hypothesis which underlies any link is that there would be no Alzheimer’s disease in the effective absence of a body burden of aluminium. To test this the latter would have to be reduced to and retained at a level that was commensurate with an Alzheimer’s disease-free population. In the absence of recent human interference in the biogeochemical cycle of aluminium the reaction of silicic acid with aluminium has acted as a geochemical control of the biological availability of aluminium. This same mechanism might now be applied to both the removal of aluminium from the body and the reduced entry of aluminium into the body while ensuring that essential metals, such as iron, are unaffected. Based upon the premisethat urinary aluminium is the best non-invasive estimate of body burden of aluminium patients with Alzheimer’s disease were asked to drink 1.5 L of a silicic acid-rich mineral water each day for five days and, by comparison of their urinary excretion of aluminium pre-and post this simple procedure, the influence upon their body burden of aluminium was determined. Drinking the mineral water increased significantly (P <0.001) their urinary excretion of silicic acid (34.3 ± 15.2 to 55.7 ± 14.2 μmol/mmol
creatinine) and concomitantly reduced significantly (P = 0.037) their urinary excretion of aluminium (86.0 ± 24.3 to 62.2 ± 23.2 nmol/mmol creatinine). The latter was achieved without any significant (P >0.05) influence upon the urinary excretion of iron (20.7 ± 9.5 to 21.7 ± 13.8 nmol/mmol creatinine). The reduction in urinary aluminium supported the future longer-term
use of silicic acid as non-invasive therapy for reducing the body burden of aluminium in Alzheimer’s disease.
Author links open overlay panelAnneChristiansenabThomasBackensfeldaKarstenDennercWernerWeitschiesb
FULL TEXT PDFsurfactants_suppress_CYP_enzymes_2011
The U.S. Centers for Disease Control and Prevention (CDC) Vaccine Excipient and Media Summary lists 11 vaccines that contain polysorbate 80:
INFANTS INABILITY TO METABOLIZE VACCINE EXCIPIENTS
Studies: Cytochrome P450 and failure of infants to metabolize vaccine excipients
A 17-year-old girl reported generalised urticaria, eyelid angioedema, rhino-conjunctivitis, dyspnoea and wheezing 1 h after third intramuscular administration of quadrivalent human papilloma virus vaccine (Gardasil). She was treated with antihistamine, and corticosteroids with prompt relief of rhinitis and dyspnoea, while urticaria and angioedema lasted 24 h. Intradermal test with Gardasil, which contains polysorbate 80 (PS80), resulted positive, while skin tests with the bivalent vaccine were negative. Prick test performed with PS80 resulted positive in the patient and negative in ten healthy controls. The CD203 basophil activation test result was negative for PS80 at all the tested dilutions and specific IgE was not found. As flu vaccine was recommended, the authors skin tested two flu vaccine, one containing PS80 (Fluarix, GSK), which resulted positive and another flu vaccine with no adjuvant or preservative (Vaxigrip, Sanofi Pasteur MSD), which gave negative results. The patient then received Vaxigrip without adverse reactions.
Results suggest that females who received the HPV shot were less likely to have ever been pregnant than women in the same age group who did not receive the shot. If 100% of females in this study had received the HPV vaccine, data suggest the number of women having ever conceived would have fallen by 2 million. Further study into the influence of HPV vaccine on fertility is thus warranted.
VLA COMMENT: Lots of vaccines (see above) contain Polysorbate 80. Does Polysorbate 80 considering its effect on testosterone have a negative hormonal effect on woman after years of being injected with the stuff. Could the HPV vaccine with Polysorbate 80 providing the direct target to the reproductive system be the tipping point? Or is there some other component interfering? I believe in-vitro technology was rising prior to the Gardasil shot due to some interference in fertility. January 1979 in Glasgow.[12] A team led by Ian Johnston and Alex Lopata were responsible for Australia’s first baby conceived by IVF, Candice Reed, born on 23 June 1980 in Melbourne.[13] Hormanal disruption via agriculture chemicals came into being after WW II, (such as Atrazine, Alachlor and DDT). See Peter Montague’s work such as Sperm in the News.
This must be the year of the sperm. The NEW YORKER magazine ran a long story [1] January 15th called “Silent Sperm” –a wry reference to Rachel Carson’s SILENT SPRING, which made its debut in the NEW YORKER 35 years ago. “Silent Sperm” describes the 50% loss in sperm count that has occurred in men worldwide during the past 40 years. Furthermore, the January issue of ESQUIRE features an article on sperm loss, [2] titled “Downward Motility.” MOTHER JONES magazine [3] also began the new year with a sperm story, titled “Down for the Count.” And the nation’s newspaper of record, the NEW YORK TIMES, ran a 4-part, front-page series on increasing infertility in the U.S. January 7-10.
VLA Comment: The hormonal disrupting DDT was introduced in the 1940s (WWII era). In Vitro started gain steam in the 1980/90s. Study showed that Male sperm count was down 50% in 1996. How long before the study was there a consistently reduceing sperm count in males? How long have Vaccines contained polysorbate 80 that inhibits the CYP3A4 mediated hydroxylation of testosterone?.
Summary:
As the Chair of the Department of Pharmacology with responsibility for training medical students in the use of drugs, he was fascinated by the kinetics of drug action. He and his wife Dody developed the plateau principle, which emerged from the recognition that the time to steady state for any drug administered continuously or repeatedly was dependent only on its rate of elimination. These developments drove his increasing desire to see the discipline of pharmacology, both in research and in medical and graduate education, as a science with a strong mechanistic and theoretical underpinning.
Avram was present in Moscow in 1961 when Marshall Nirenberg described his elucidation of the genetic code. With these seminal developments, Avram concluded that the time was ripe for the establishment of a journal devoted to mechanistic aspects of drug action at a molecular level.
Avram was able to persuade ASPET to publish the new journal, which would be called Molecular Pharmacology. “Suitable papers are those which describe applications of the methods of biochemistry, biophysics, genetics and molecular biology to pharmacologic or toxicologic problems…”
Avram, together with his Stanford faculty colleagues Lew Aronow and Sumner Kalman, were working on Principles of Drug Action (Goldstein et al., 1968), a pharmacology textbook that was new for its time in focusing only on basic principles underlying drug action and the longer-term responses of the body to the presence of drugs.
VLA Comment: The field of Pharmacogenomics, Pharmacogenetics, Pharmacogenomics has a 61 YEAR HISTORY well accepted research concerning drug metabolism. Education in this field of research has been actively suppressed by Pharma. Anonymous sources in the field of education for medical students tells us that this information is actively suppressed as the pharmacuetical industry would loose billions and billions of dollars if the public knew. Moreso medical students and hospital psychiatrists and doctors in general from Pediatricians ot Oconologists have virtually no knowledge or education of drug metabolism, yet they all provide prescriptions that are contraindicated, causing Medication (drug) induced psychosis. 90% of drugs need an active and mature liver system of Cytochrome P450 enzymes to metabolize and eliminate them from an individual’s body. A substantial percentage of Caucasians, Asians, Blacks have no activity to metabolize these modern drugs. The results – increased (apparent) psychosis.
The increase in psychosis diagnosis is actually the agressive poisoning of humanity by uneducated doctors from the cradle to the grave. The increase in (apparent) mental illness and special needs is due to the inability of many individuals to eliminate, from the body, modern drugs (and streets drugs) such as SSRIs vaccine excipients.
Vaccines contain excipients that need a mature superfamily of Cytochrome P450 in order to be metabolize and successfully eliminated from the body of infants and children. The damage done to the physiology of a one hour old infant, injected with Aluminum (which interferes in Cyp 450 metabolism in the Hep B and Vitamin K shots), and other vaccine excipients testifies to the basic underpinnings of the epidemic in Autism, ADHD, ADD, OCD, BiPolar,neurological, mitachondrial issues, depression, anxiety, panic attacks. The misdiagnosis of mental illness by uneducated medical professionals who extensively prescribe psychiatric drugs and the push to vaccinate, to eliminate parental choice, to eliminate vaccine waivers appears to be an organized effort to debilite the entire emerging generations of humanity through the suppression of this Pharmacogenomic knowedge. Note: There is no mandated continuing education in drug metabolism for practicing physicans; virtually no education for medical students; yet the prescrbing of medications and the push for vaccine compliance, school shootings, homicides and suicides, special needs education, is at an all time high.
Below, the American Society for Pharmacology and Experimental Therapeutics chronicled the discoveries and provided communications to advance the science of drug metabolism.
ABSTRACT (2008):
In 25 years, (now 35 years) drug metabolism research went from using subcellular
particles of undefined content to an understanding of metabolism
at the molecular level. The discoveries of cytochrome P450, en-
zyme induction, reactive intermediates, and genetic polymor-
phisms were milestones in the field. New publications from the
American Society for Pharmacology and Experimental Therapeu-
tics chronicled the discoveries and provided communications to
advance the science of drug metabolism.
THE DISCOVERY OF CYTOCHROME P450 (1957)
The discovery of P450 and its function evolved from observations by Ryan and Engel that C-21 hydroxylations of progesterone and hydroxylated progesterones were catalyzed by a CO inhibitable en-zyme in the adrenal cortex (Ryan and Engel, 1957). They character-ized the reaction as belonging to the class of enzymes categorized by
Mason as “mixed-function oxidases” (Mason, 1957) and by Hayaishias “oxygenases” (Hayaishi, 1962).
THE ROLE OF GLUTATHIONE (depleted in AUTISM?)
The role of glutathione as a precursor of mercapturic acids was confirmed in 1959 (Bray et al., 1959a,b), 80 years after the discovery of these important elimination products by Baumann and Preuss (1879). In the following 25 years, there were over 150 papers in the ASPET journals referring to aspects of glutathione in metabolism. The role of glutathione as a scavenger of reactive intermediates was ofprimary interest, as exemplified by the finding of the glutathione conjugate of acetaminophen by Hinson et al. (1982) or the formation of mercapturic acids from cyclohexene epoxide in the rat (van Bla-deren et al., 1981).
According to Mayo Clinic “generally, these antidepressants are an option during pregnancy:”
VLA comment: The list below are the recommended options that however come with risks. What is not listed are the rest of the pharma madness drugs given to women approaching child bearing age and therefore compelled to continue the regimen during pregancy. Other drugs are not listed because they are so risky for birth defects that they are not even considered. However, how many young women have been prescribed these medication since teenagers?
Electroshock is also known by the euphemism electroconvulsive therapy or ECT. Many electroshock patients receive the treatment against their will. Psychiatrists also claim that electroshock is safe during pregnancy and give the treatment to pregnant women.
VLA COMMENT: Suicidal ideations are a result of anti depressants and other drugs not being metabolized properly. These drugs need Cytochrome P450 to metabolize. If the patient does not have the activity of this family of liver enzymes and are prescribed drugs that are contra-indicated, as per the package inserts, adverse reactions such as “compelling” suicideal ideations (and heinous ideations of homicide) are likely to occur.
As the statement above refers to “acute treatment of suicidal ideation” it signals that the pregnant patient may be on medication that cannot be metabolized by his/her system of liver enzymes. Hence…the apparent solution to pregnant women who have been on anti depressants and psyche drugs for years and must continue during pregancy, is to top it all off with SHOCK TREATMENTS. This allows the women to remain on psyche drug medication during her pregnancy. However as noted in our posting Glyphosate, Drugs and Vaccines....the Cytochrome P450 metabolism is also found in the placenta.
According to the Citizen’s Commission on Human Rights (CCHR), Approximately 150,000 people get ECT every year in the US, with 2,000 shock treatments being done every year by WUSTL psychiatrists at Barnes-Jewish Hospital. Complications after treatment usually increase with the age of the patient; small surprise there. WUSTL psychiatrists say that, “ECT is considered a safe treatment modality in pregnant women in whom a number of medications may be associated with risk to the fetus.” READ MORE…
Article: ELECTRO SHOCK THERAPY WHILE PREGNANT
New Delhi 6 July 2018.
Two leading pediatricians in India have urged the World Health Organization (WHO) to urgently revise its manual on classification of “Adverse Events Following Immunization (AEFI),” warning that the new guidelines put children’s life at risk.
This needs to be done “urgently in the interest of child safety,” doctors Jacob Puliyel at St Stephen’s Hospital in Delhi, and Pathik Naik of Children Hospital in Surat, say in a report published in the prestigious journal ‘F1000Research’
The WHO has also changed the definition of “causal association,” the authors say. Under the revised guidelines, if there is an alternate explanation for the adverse event, or another factor is involved, causative association with vaccine should not be made. “In other words, if after vaccination, a child with an underlying congenital heart disease develops cardiac failure, it would not be considered causally related to the vaccine.”
The revised classification by WHO “is a major step backward for patient safety,” the authors say. “This could embolden vaccine manufacturers to be more reckless with regard to adverse reactions,” they warn.
Puliyel and Naik note that the Global Advisory Committee on Vaccine Safety has documented many deaths in children with pre-existing heart disease after they were administered the pentavalent vaccine (combined diphtheria, tetanus, pertussis, Hib, and hepatitis-B vaccine). “Under WHO’s ne
Both Sri Lanka and Vietnam governments withdrew the pentavalent vaccine following the deaths of five children in Sri Lanka and 12 in Vietnam soon after vaccination. But WHO investigating teams declared that the deaths were ‘unlikely’ to be related to vaccination, the report says. The authors point out that a new study in India, showed that the switch from DPT (diphtheria, tetanus, pertussis) to pentavalent vaccine almost doubled the deaths following vaccination. “A large number of these deaths could have been avoided had the AEFI manual not been revised.”
According to their report, the consequence of India adopting WHO’s new classification can be seen from the causality assessment of 132 serious AEFI cases uploaded on the website of the Ministry of Health and Family Welfare. Of the total AEFI cases, 54 babies died and 78 survived, “but not even one death was classified as vaccine-related. Nearly all the deaths were simply classified as unclassifiable or coincidental.”
Vaccines are drugs used as a preventive measure, given to healthy persons. . Adverse events following immunization must be monitored more carefully than other drugs, the authors note. “A credible immunization safety evaluation and monitoring system is essential for the success of immunization programmes.”
Adverse reaction and deaths may not show up as significantly increased in small safety studies. However, records of all deaths and serious adverse events following vaccinations should be maintained and periodically reviewed for safety signals.
According to the authors, WHO’s new AEFI classification scheme “that allows for an outright denial of any new causative association with vaccination” could fall foul of Article 2 of the European Convention on Human Rights. Adverse reaction and deaths may not show up as significantly increased in small safety studies. However, records of all deaths and serious adverse events following vaccinations should be maintained and periodically reviewed for safety signals.
“Paradoxically, the AEFI algorithm is said to be for vaccine safety,” says Puliyel. “Perhaps we need a scheme for public safety rather than vaccine safety.” (END)
Jacob Puliyel MD MRCP M Phil
Phone 0091 9868035091
The World Health Organisation (WHO) has recently revised how adverse events after immunization (AEFI) are classified. Only reactions that have previously been acknowledged in epidemiological studies to be caused by the vaccine are classified as a vaccine-product–related-
The definition of causal association has also been changed. It is now used only if there is ‘no other factor intervening in the processes’. Therefore, if a child with an underlying congenital heart disease (other factor), develops fever and cardiac decompensation after vaccination, the cardiac failure would not be considered causally related to the vaccine. The Global Advisory Committee on Vaccine Safety has documented many deaths in children with pre-existing heart disease after they were administered the pentavalent vaccine. The WHO now advises precautions when vaccinating such children. This has reduced the risk of death. Using the new definition of causal association, this relationship would not be acknowledged and lives would be put at risk. In view of the above, it is necessary that the AEFI manual be revaluated and revised urgently. AEFI reporting is said to be for vaccine safety. Child safety (safety of children) rather than vaccine safety (safety for vaccines) needs to be the emphasis.