Category Archives: Pregnancy and birth

Pediatric Study: Pharmacogenomics – Adverse Reaction in Children

1 Reply

Drug-Metabolizing Enzyme Genotypes
and Aggressive Behavior Treatment Response
in Hospitalized Pediatric Psychiatric Patients

TracyGlauser Pharma study

Objective: The aim of this study was to examine the association between the CYP2D6 and CYP2C19 genotypepredicted combined phenotypes and short-term measures of psychotropic efficacy and toxicity.
Methods: A rater-blinded, retrospective genotype association design examined a cohort of hospitalized pediatric psychiatric patients genotyped for CYP2D6 and CYP2C19 as part of clinical care. These combined genotypes were used to predict a combined phenotype. The primary efficacy outcome measure was the behavior intervention score (BIS), a function of the number of recorded timeouts=seclusions, therapeutic holds, and physical restraints.

Patient response to commonly used psychotropic medications demonstrates significant variability; only 30–75% of patients experience efficacy, whereas 65–75% encounter ad-
verse events (Kirchheiner et al. 2004; Emslie et al. 2006; Kratochvil et al. 2006; Hetrick et al. 2007). Many psychotropic medications are metabolized by cytochrome P450 (CYP) en-
zymes coded for by the polymorphic genes CYP2D6(þ124030) and CYP2C19 (*124020).
The relationships between the distinct CYP2D6 or CYP2C19 genotypes and the pharmacokinetics of psychotropic medications are the basis for genotype-based dosing recommendations for some medications (Kirchheiner et al. 2001).Despite the prevalence of the problem, the contribution of drug-metabolizing enzyme genotypes to the variability in aggressive behavior treatment response in hospitalized pediatric psychiatric patients is unknown. The purpose of this study was to examine the association between CYP2D6 and CYP2C19 genotype-predicted metabolizing phenotypes and short-term measures of drug efficacy (incidence of behavioral interventions for aggressive behavior) and toxicity (adverse drug reaction)

Drug tolerability was defined as the total number of recorded adverse drug reactions.

 

Conclusion
Identifying factors underlying the variability in drug efficacy
or tolerability is a key component for optimizing the patient’s
response to therapy. This is the first study to demonstrate that,
for children hospitalized for psychiatric conditions,
CYP2D6 and CYP2C19 genetic variation contributes to psychotropic…
Consideration of a patient’s genotype at the onset of a psychiatric hospitalization could play a significant role in personalizing and improving subsequent therapy.
Prospective longitudinal studies are necessary to better inform
how to optimally incorporate this genetic information into the
medical management of patients with aggression. In summary,
this study indicates that CYP2D6 and CYP2C19genotypes are
 important in the clinical care of children with psychiatric diagnoses requiring medications that are metabolized throughthese two enzyme pathways.

Find out about pharmacogenomic: Cytochrome P450, homicide, suicide and school violence

Pharmacogentics, Suicide, Homicide and school violence

INFANT VACCINES/Cytochrome P450 and failure of infants to metabolize vaccine excipients  READ

Accounts of thousand of Suicides and Homicides: www.SSRIStories.net

Goldman: Chicken Pox/ SHINGLES? (story of CDC obstruction and denial)

Leave a reply

Review of the United States universal varicella vaccination program: Herpes
zoster incidence rates, cost-effectiveness, and vaccine efficacy based primarily on the Antelope Valley Varicella Active Surveillance Project data

In a cooperative agreement starting January 1995, prior to the FDA’s licensure of the varicella vaccine on March 17, the Centers for Disease Control and Prevention (CDC) funded the Los Angeles Department of Health Services’ Antelope Valley Varicella Active Surveillance Project (AV-VASP). Since only varicella case reports were gathered, baseline incidence data for herpes zoster (HZ) or shingles was lacking.

Goldman VaricellaAntelopeValley

VLA COMMENT:  The near eradication of the early childhood Chicken Pox has resulted in people who have had natural wild chickenpox as children are not getting their”subtle” exongenous boosters from the subsequent generation of our children or our grandchildren who unfortunately  are prevented from getting  wild chicken pox, They  are getting vaccinated with a different strain that can’t boost us. So, in essence, the CDC has simply brought another chicken pox strain into existence.  Now we have two. However, the wild typeis not prevelant enough to give us the necessary booster so we don’t get shingles.

Dr. Gary Goldman:  The reason why we are getting SHINGLES

The only reason that “children who get the chickenpox vaccine APPEAR to have a much lower risk of shingles” is that the live vaccine has provided these children with a recent boost to their immunity. However, the vaccine-strain of varicella zoster virus (VZV)–also known as the Oka strain–is genetically different from the wild-type U.S. strain. When a vaccinated child is exposed to an adult with shingles or a child with wild-type varicella, if the strains are sufficiently heterologous, the vaccinated child will break out in chickenpox. It is also possible for the weakened vaccine-strain to revert to a more virulent strain that manifests wild-type pathology. This means when children are exposed to the wild-type strain, even though they may not have a breakthrough infection with chickenpox, they now harbor two heterologous (genetically different) strains of VZV–both of which are at a later time subject to reactivation as shingles. Thus, as they age, they will be even more likely to reactivate with shingles (unless periodically administered booster vaccine doses for life in order to maintain the immunity)–especially if they do not receive exogenous (outside) boosts to their cell-mediated immunity which, in the pre-vaccine era, came from expostures to other children infected with wild-type varicella which provided the adult with a subclinical boost that helped to suppress or postpone reactivattion of shingles.

I would also like to clear up the point that shingles has always been increasing–even prior to the licensing of the varicella vaccine. This statement is true; however, the increases were on the order of 2 to 4% per year (which were likely due to an aging population, or greater access to healthcare). Once a community had widespread distribution of varicella vaccine, increases in herpes zoster were on the order of 20% per year. For example, this source [Yih WK, Brooks DR, Lett SM, et al. The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a period of increasing varicella vaccine coverage, 1998-2003. BMC Public Health 2005; 5:68.
32. Schmid DS, Jumaan AO. Impact of varicella vaccine on varicella-zoster virus dynamics. Clin Microbiol Rev 2010; 23(1):202–217] found a 90% increase in shingles over 5 years (1999-2003).

Pharmacogenetics/Cytochrome P450/Suicides & Homicides/school violence

Leave a reply

Brandon Turbervile comprehensive article:  Psychiatric Drugs, School Violence, and the Big Pharma Cover-up

Excerpts:

the CYP450 enzymes are the primary catalysts for detoxification reactions that render water-insoluble molecules sufficiently water soluble to be excreted in the urine. . . . Drugs, hormones, toxins, carcinogens, mutagens, environmental pollutants, and other xenobiotics are metabolized by CYP450 enzymes.

Of the CYP450 enzyme family, there are other more specific enzymes such as CYP2C9, CYP2C19, and CYP2D6, etc. These three enzymes specifically are responsible for approximately 40% of all CYP450-mediated drug metabolism. The CYP2D6 enzyme itself is responsible for the bulk of drug metabolism at around 20% to 30% of drug metabolism in the CYP450 family.

In relation to the CYP2D6 enzyme, there are four classifications – Extensive Metabolizers (EM), Poor Metabolizers (PM), Intermediate Metabolizers (IM), and Ultrarapid Metabolizers (UM).
EM (Extensive Metabolizers) are considered the “normal genotype,” “which is free of inactivating polymorphisms, deletions, or duplications.”  PM (Poor Metabolizers) are individuals who have “deficient” enzyme function in terms of CYP450 metabolic processes and, subsequently, have difficulty clearing certain medications. IM (Intermediate Metabolizers) are those who have some functioning CYP450 enzymes but are subject to loss of the function of these enzymes after the “second hit” of medication, thus turning them into PM. UM (Ultrarapid Metabolizers) are those who metabolize the drug so rapidly that it clears so quickly that there is little or none of the desired effect.  In medications that required metabolism to activate, however, UM individuals the metabolite may be produced too quickly, resulting in toxicity and the realization of side effects.
While there are potentially adverse health effects with any one of the four classifications, the focus of this article is on those who are generally PM (Poor Metabolizers). This is because these individuals have a higher chance of experiencing adverse health effects of pharmaceuticals than those with “normal” functioning EMCYP2D6 enzymes.
Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity.
SPECIAL PHARMACOKINETICS AND PHARMACODYNAMIC CONSIDERATION IN CHILDREN

Mayo Clinic Conference on Pharmackinetics Sept. 2018

Journal publication: Human Exposure to Aluminum (Exley)

Leave a reply

Environmental Science Processes & Impacts

Human Exposure to Aluminium Exley

 

Pharmacogenomics: Suppressive effect of accumulated aluminum trichloride on the hepatic microsomal cytochrome P450 enzyme system in rats.

https://www.ncbi.nlm.nih.gov/pubmed/23059508

NEW YORK STATE-TIME SENSITIVE BILL RELIGIOUS WAIVERS FOR VACCINES

Leave a reply

NY, MAKE 9 PHONE CALLS TODAY TO MOVE BILL A8123B, the bil that protects the religious waiver to vaccines. We have to light a fire under the Education Committee Assemblymembers who have NOT made a decision on the bill. While they may not be your rep, they make decisions that affects 20 million NYers. YOU are one of them.
They are:

  1. Catherine Nolan- 518-455-4851
  2. Earlene Hooper- 518-455-5861
  3. Alicia Hyndman- 518-455-4451
  4. Michael Miller- 518-455-4621
  5. Daniel O’Donnell- 518-455-5603
  6. Steven Otis- 518-455-4897
  7. Phil Ramos- 518-455-5185
  1. Sean Ryan- 518-455-4886
  2. Michelle Titus- 518-455-5668

Ask them, politely and respectfully, to support the bill that keeps kids in public school and respects existing law. Need more to say? See below:

  1. Children of families who do not have the resources/ money to hire attorneys or who do not have the ability to articulate in English are being barred from school and denied their right to an education. This translates to minorities, single parents, parents of color being disproportionately adversely affected.
  2. 46 states use such a accepted form, along with most schools in NY. There is no correlation between a high refusal rate and a standard accepted form.
  3. ‘Religious sincerity interviews’ are WRONG, a waste of money and profoundly offensive.

Please post your  responses!

SHARE THIS POST

VLA COMMENT: (paraphrased from Ageless Wisdom):

Religion is the name given to the recognition by the “part” of its relationship to the “Whole”.  It is observed that there is a constantly growing demand by the part (individual) for an increased awareness of that Relation (God). Religion is the experience of the “seeking” aspirant to the “sought-for” Divinity. This archetypical drive towards wholeness (God) is natural to mankind, inherent in all individuals. Therefore,  Religion is natural and personalized foremost to the individual and out of that comes human systems, not the other way around!

“Every Church claims that ‘we are the true Church’ and that they have some ultimate authority. We have the infallible Pope;  the inerrant Bible.

The idea that the Truth of God can be bound in any human system; by any human creed; by any human book is almost beyond imagination. God is not a Christian. God is not a Jew or a Muslim, a Hindu or a Buddhist. All of those are human systems which Human being have created only to help walk us through the mystery of God. We honor tradition. We walk through the tradition. But the tradition does not define God. It only points to God.

. -Bishop John Shelby Spong

“No one church, its representative or the government has the authority to define religion, to authorize, or substantiate an individual’s religious beliefs”

.…Eileen Dannemann, Director. National Coalition of Organized Women

Mass Shootings

1 Reply

Pharmaceutical Murder – Mass Shootings Caused by Drugs!

Twenty-seven drug regulatory agency warnings cite psychiatric drug side effects of mania, psychosis, violence and homicidal ideation; 1,531 cases of psychiatric drug induced homicide/homicidal ideation have been reported to the US FDA; 65 high profile cases of mass shootings/murder have been committed by individuals under the influence of these drugs, yet there has never been a federal investigation into the link between seemingly senseless acts of violence and the use of mind-altering psychotropic drugs.

READ MORE….

From Prozac to Parkland: Are Psychiatric Drugs Causing Mass Shootings?

While mass killers generally have guns in their hands, another commonality is that they often have psychiatric drugs in their blood. The difference, though, is that it isn’t guns that have the side effect of “homicidal ideation.”

New American article

VLA COMMENT:  There is “science” on this.  It is in the field of pharmacogenetic.pharmacokinetics.  These drugs show in their package insert that they are metabolized through the super family of liver enzymes called Cytochrome P450. 10% of Caucasians, for example, cannot metabolize upwards of 50% of today’s common psyche drugs.  These people are called “non-metabolizers”.  The pharmacuetical industry has blocked the movement to “test” each patient for their metabolizm prior to prescribing drugs.  The have also blocked education in pharmacokinetics aimed at the nation’s medical students.  Considering every doctor including pediatricians who prescribe psyche drugs to children as young as one year old and considering the extensive use to all demographics, we must include pharmacogenetics as a required continuing education course.  See: www.SSRIStories.net for the lists of suicides and homicides associated with prescription drugs.

We don’t understand why the activists that are exposing the association of pharmacueticals to the homicides and suicides are not explaining the science.   Put Cytochrome P450 into our search engine for more information.

Furthermore, Cytochrome P450 is not “mature” until a child is at least 3 years old.  All infants have immature liver enzyme function. Yet they are injected at birth and during their early years with excipients that need a fully functioning Cytochrome P450.  In other words, we are poisoning all incoming generations of humanity, as they are not able to detoxify the excipients found in early childhood vaccines.  Put “Infants” in our search engine.  Put CDC excipentsin our search engine to see the CDC list of excipients in vaccines.

2nd Amendment WARNING:

Every child who is vaccinated are being injured by the excipients in the vaccines, including heavy metal aluminum and mercury which interfere in Cytochrome P450 metabolism.  The damage shows up an neurological problems, regressive autism and is being diagnosed as “mental illness”.  Without testing for metabolism these recipients of vaccines appear via the Diagnostic Statisical Manual as “mental illness”.  Those who seek to destroy the second amendment will do so by funded and required mental illness testing in school.

Already 25% of American children are on some form of psyche drugs. This translates into 25% of the future population being red flagged and dissallowed gun ownership.  However, rightfully so, as due to the vaccine schedule currently of 49 vaccine doses by the age of three, these kids are damaged.

Psychiatric drugs are now being given to infants and toddlers in unprecedented numbers.

An analysis of 2013 IMS Data, found that over 274,000 infants (0-1 year olds) and some 370,000 toddlers (1-3 years age) in the U.S. were on antianxiety (e.g. Xanax) and antidepressant (e.g. Prozac) drugs. This report also found over 1,400 infants were on ADHD drugs.

A 2014 Georgia Medicaid analyses led by Susanna Visser at the CDC (see a video of her fascinating talk) when extrapolated nationwide by the New York Times found that over 10,000 toddlers were put on ADHD treatments. (Dr. Visser is currently working on national estimates but believes that the estimate from the Georgia data is conservative.)

READ MORE… 

VLA COMMENT: What are the chances that the gun owners, politicians, Pres. Trump realize that the solution to the mass shooting is not to ban guns but to stop poisoning infants who are subsequently prescribed drugs that they cannot metabolize; have suicidal and homicidal ideations; commit heinous acts of mass shootings.

This is the “Science if Pharmacokinetics”

 

Canada Supreme Court Orders New Trial for Non-vaccinating Parents Accused of Son’s Death

Leave a reply

Canada Supreme Court Orders New Trial for Non-vaccinating Parents Accused of Son’s Death – New Evidence Points to Cover-up of Medical Malpractice

Almost from the beginning, the pro-vaccine lobby has seemed intent on blaming Ezekiel’s death on the lack of a vaccine. People involved on every level worked together to paint a false narrative of events.

The grieving parents were brutalized in the court of public opinion as wild distortions of the truth were propagated by the media. They were brutalized as well in the courtroom as witnesses lied, evidence was suppressed, and facts of the events were twisted to accuse the parents of harming their child.

There are parts of the story that the Stephans are only just now learning. Evidence is surfacing that support the parents’ version of events. Other evidence is coming out revealing that the corruption, malpractice, and wrongdoing go far deeper than anyone could have imagined.

READ MORE…

VLA COMMENT:  Go David and Colette! Today you can’t trust doctors or dentists.  You can’t even trust the bank which, in the day, we thought would never make a mistake

Monsanto: Glyphosate (known Cancer causing) found is most foods in the USA

Leave a reply

 

Internal FDA emails obtained by investigative journalist Carey Gillam7 through Freedom of Information Act (FOIA) requests reveal Roundup has been found in virtually all foods tested, including granola and crackers. Gillam writes:

“[T]he internal documents obtained by the Guardian show the FDA has had trouble finding any food that does not carry traces of the pesticide. ‘I have brought wheat crackers, granola cereal and corn meal from home and there’s a fair amount in all of them,’ FDA chemist Richard Thompson wrote to colleagues in an email last year regarding glyphosate … broccoli was the only food he had ‘on hand’ that he found to be glyphosate-free …
Separately, FDA chemist Narong Chamkasem found ‘over-the-tolerance’ levels of glyphosate in corn, detected at 6.5 parts per million [ppm], an FDA email states. The legal limit is 5.0 ppm. An illegal level would normally be reported to the Environmental Protection Agency (EPA), but an FDA supervisor wrote to an EPA official that the corn was not considered an ‘official sample.’”  READ MORE…