Tag Archives: 2D6

Cytochrome P450 testing covered by Health policies


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10% of Caucasians are “non metabolizers”.  This means that they cannot metabolize more than 50% of today’s drugs such as adderall, and other SSRIS.  It is suspected that the heinous trend of school shootings and suicides are caused by non metabolizers who are given psychiatric drugs without first being tested for their ability to metabolize them.  Because this test is not standard of care hospitals and doctors who destroy lives by giving counter indicated medication can not be successfully sued.  There is a movement to make this test standard of care but it is being thwarted by the invested pharmacuetical companies who would stand to lose billions of dollars if the public knew.


The cytochrome p450 (CYP450) family is involved in the metabolism of a significant proportion of currently administered drugs, and genetic variants in cytochrome p450 are associated with altered metabolism of many drugs. It is proposed that genetic testing for cytochrome p450 variants may assist in selecting and dosing drugs that are impacted by these genetic variants.

Drug efficacy and toxicity vary substantially between individuals.  Because drugs and doses are typically adjusted to meet individual requirements as needed by using trial and error, clinical consequences may include a prolonged time to optimal therapy and serious adverse events.

Various factors may influence the variability of drug effects, including age, liver function, concomitant diseases, nutrition, smoking, and drug-drug interactions. Inherited (germline) DNA sequence variation (polymorphisms) in genes coding for drug metabolizing enzymes, drug receptors, drug transporters, and molecules involved signal transduction pathways also may have major effects on the activity of those molecules and also on the efficacy and toxicity of the drug.

Pharmacogenomics is the study of how an individual’s genetic inheritance affects the body’s response to drugs. It may be possible to predict therapeutic failures or severe adverse drug reactions in individual patients by testing for important DNA polymorphisms (genotyping) in genes related to the metabolic pathway (pharmacokinetics) or single transduction pathway (pharmacodynamics) of the drug. Potentially, test results could be used to optimize drug choice and/or dose for more effective therapy, avoid serious adverse effects and decrease medical costs.

Some CYP450 enzyme genes are highly polymorphic, resulting in some enzyme variants that have variable metabolic capacities among individuals, and some with little to no impact on activity.

Individuals with a lack of function activity in these enzymes (CYP2C19, CYP2D6, CYP2C9, etc.) can be classified according to how fast they metabolize medications:

  • Poor metabolizers (PMs): lack active enzyme gene alleles, they will process a certain drug more slowly than normal because of the missing enzyme(s), the medication can build up in their system which can increase the likelihood that it will cause side effects. The individual might still be able to benefit from the medication, but at lower dosages.
  • Intermediate metabolizers (IMs): have one active and one inactive enzyme gene allele, these individuals have a reduced enzyme function in processing drugs, they may not process some medications as well as a normal metabolizer would. This can increase risk of side effects and drug interactions.
  • Normal metabolizers (extensive metabolizers Ems): these individuals have 2 copies (alleles) of the most common (wild type) DNA sequence of a particular CYP450 enzyme gene resulting in an active molecule and are termed extensive metabolizers. Medications are processed normally, these individuals are more likely to benefit from treatment and have fewer side effects than people who don’t process the same medication(s) as well.
  • Ultra-rapid metabolizers (UMs): individuals with more than 2 alleles of an active enzyme gene, which cause the medications to leave the body too quickly and often before they have had a chance to work properly. These individuals will likely need a higher than usual dose of medications.

Pharmagedon: Big Coverup: What is 2D6? Making our kids & soldiers psychotic!

The epidemic of  ADHD, ADD, OCD, Bipolar, Autism, encephalitis, narcolepsy is caused by the inordinate amount of vaccinations that are forced on children by our government in order to get into school.   To compensate or mitigate the effects of the vaccine injury, mis-nomered as “mental illness” psyche drugs are given out like candy.  25 % of all American children are on psyche drugs.

Suicide is the third leading cause of deaths for youths…Read more…

SSRIStories.org is a collection of over 5,000 stories that have appeared in the media (newspapers, TV, scientific journals) in which prescription drugs were mentioned and in which the drugs may be linked to a variety of adverse outcomes including violence.5000 Suicides & Murders. Access list

Bogus pharma establishment  Study studies 37,000 kids newly prescribed medication and suicide rates.  Clearly none of these kids were tested for Cytochrome P450 2D6 metabolic rates, although the opportunity is still there for the ones who did not complete the suicide attempt. Testing for Cytochrome P450 2D6 can be a little as $175.00 but it is not “standard of care”.

The National Coalition of Organized Women uncovered one of the most egregious Pharmacuetical cover-ups in modern psyche history. The information that would have averted the school shootings, the homicides, the overdoses, the bizarre epidemic of mentally ill in recent years has been available for circa 15 years since gene mapping.   Cytochrome P450 2D6 was discovered as the major metabolic pathway that detoxifies 50% of all psyche drugs and street drugs.  However, 7-10% of Caucasians, for example, due to genetic variation do not have sufficient activity of this gene to detoxify their bodies from these modern drugs. They are labeled poor or non-metabolizers due to a deletion or non-activity of the 2D6 pathway. There are a percentage of Asians, African Americans and Hispanics who are also poor metabolizers.  When certain drugs (list on link) are prescribed to these individuals, due to their inability to metabolize, these people become psychotic, homicidal, suicidal, a danger to themselves and society.

There are other pathways on Cytochrome P459 such as Cyt 3A4 implicated in the psychosis reports of soldiers on Larium, a malaria drug.  Another example:  Marijuana (Cannibals) is a powerful inhibitor of cytochrome P450 isozymes 3A4, 2C19, and 2D6. This is not a defect.  It is a genetic variation, that’s all.  Ethiopians and Tanzanian Afrikans who traditional have had poor soil to grow food have been consuming a lot of weeds (medicine weeds), they have evolved generational to multiply their Cytochrome 2D6.  These people are “rapid metabolizers”.

It is a very simple test: Swap the mouth, teeth and gums with 2 sterile swabs (looks like q-tips) and send to our lab contact in Australia.  Contact: Ncowmail@gmail.com for lab details. Price: $175.00.  Bottom line, perhaps these kids who are most affected by vaccines are poor metabolizers and can’t rid themselves of the toxins in vaccines.  Perhaps 45 shots by the time the kid is six years old is asking too much!  Contact us for cytochrome testing: Ncowmail@gmail.com

Links below:

You know those kids who are shooting each other and mothers who drown their kids in the bath tub? Check out this most egregious cover up in the history of modern psychiatry. Dr. Lucire elucidates –  Dr. Yolande Lucire’s recently published study. Her study  published in the summer of 2011 is not only a academic victory but the perpetrators speak of their experiences  on how they were moved to kill their loved ones while on or coming off of psyche drugs.

This information, now highlighted by Dr. Lucire has been heretofore suppressed by the stakeholder.  The justice system in the USA has not realized the implication in law. (See personalized Justice/Personalize Medicine).  These drugs force the patient who is a poor or non-metabolizer into heinous acts against themselves and society. And who and what  is really complicit when a crime is committed?  The manufacturer who “failed to warn”?; the physician who “failed to warn” and who did not do the simple genetic test?  Read Dr. Lucire’s study.  She removed her subjects from the drugs and they  regained their normal mental function.  It was the drugs. There is a test to prove it! However, the attorneys of several high profile cases such as Adam Lanza, Jerod Loughner, James Holmes were contacted and did not respond.

Dr. Yolande Lucire’s recently published study

list of the drugs that need 2D6 pathway to metabolize

Laymen’s Synopis

Mayo Clinic Report on 2D6

Psychosis reports of soldiers on Malaria Drugs

Comprehensive Article by Brandon Turberville

Dr. Mercola on Cytochrome P450 2D6

Autism is associated with precocious puberty.  Boys are 4X more likely to get Autism. Guess what else is regulated by Cytochrome P450 besides glutathione?

Personalized Justice/Personalize Medicine

Do you want the simple 2D6 gene test?  Contact us at NCOWmail@gmail.com