Thiol-modulating mechanisms affecting the cytotoxicity of Thimerosal (TM) have been identified. Importantly, the emergence of Autism Spectrum Disorder (ASD) symptoms post-6 months of age temporally follows the administration of many childhood vaccines. Worldwide, particularly in developing countries, TM is still present at preservative levels in many of the childhood vaccines such as HepB, Hib, DTP, DTwP-HepB-Hib vaccine, and various influenza vaccines [33,34,35]. Many infants, particularly those in the developing world, immunized according to the recommended childhood vaccine schedule, receive about 200 μg of Mercury (Hg) from TM-containing vaccines during the first 6 months of life.
Thimerosal exposure and the role of sulfation chemistry and thiol availability in Autism.
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