Category Archives: Pharmacogenetics

Study: Cytochrome P450 2D6 & 3A4 Potential for drug interactions involving cytochromes P450 2D6 and 3A4 on general adult psychiatric & functional elderly psychiatric wards

Our findings confirm extensive polypharmacy on general adult psychiatric and functional elderly psychiatric wards. A substantial proportion of patients were receiving combinations of drugs that interact with CYP2D6 and/or CYP3A4, many of which are known to produce clinically important interactions. Doctors practising in old age psychiatry should be aware that patients on functional elderly wards are at increased risk of clinically important CYP3A4 interactions. Psychiatrists should consider the pharmacokinetic implications of drugs prescribed for use ‘as needed’, because of the potential for unpredictable interactions. Read (2003) Study…

Fatal Intoxication: Soldiers dying in their sleep from psyche drugs

Such deaths have been occurring for years, but they were recently brought to light by a West Virginia couple who shared the story of their son, Andrew White, with ABC News. Andrew died in 2008 of fatal drug intoxication. The Whites blame the prescriptions their son was on for his death. According to a report by ABC11x:

“”We call it the lethal cocktail. It’s antidepressants, antipsychotics and analgesics. It’s just overloading, and your body can’t take it,” Stan [White] explained. The Whites said Andrew was taking Seroquel, Klonopin, and Paxil. They still have the pills prescribed by Veteran’s Administration doctors to treat Andrew’s post-traumatic stress disorder… “He made that choice to trust the VA and that trust cost him his life,” [Mrs. White] continued.”

The twist to the story is that within weeks of Andrew’s death, three other war veterans—all of whom were taking the same drugs Andrew was on—also died in their sleep. Read more… Comment by VLA founder: “Did the physician test for Cytochrome P450 2D6?

Read some stats:

Soldiers: Lariam (Malaria Drug) Drug induced Psychosis-Cytochrome P450

An anti-malarial drug that has been withdrawn from routine use by the U.S. military because of concerns about potentially dangerous side-effects continues to be prescribed to Canadian troops serving in malaria-prone regions.The drug, called mefloquine or Lariam, has been associated with psychiatric and physical side-effects that prompted the U.S. military to withdraw it from general use in 2009, but the Canadian Forces continue to prescribe it to soldiers. Side-effects can range from anxiety, vivid nightmares and depression, to hallucinations and psychotic episodes, and the drug has also been blamed for suicides and long-term health problems.  Read more…

PHARMACOGENETICS: The media has not yet become aware that a percentage of the population are poor or non-metablolizers due to an evolutionary deletion in CYTOCHROME P450.  If this drugs is taken by those who have this genetic deletion there is an inability to metabolize causing psychosis, homicidal and suicidal ideations.

Lariam (Mefloquine) Manufacturer’s InsertRead some stats:
At Fort Hood, where 48,000 troops and their families are stationed, 6,000 soldiers were on antidepressants, and 1,400 were on antipsychotic drugs in 2009, reported USA Today. At Fort Bragg, where 50,000 are stationed, 4,994 troops were on antidepressants, and 664 were on antipsychotics in 2010, reported the Fayetteville Observer, adding that “many soldiers take more than one type of medication. Read more…

Cytochrome P450 information including drug list…a synopsis of the issue.

Pharmagedon: Big Coverup: What is 2D6? Making our kids & soldiers psychotic!

The epidemic of  ADHD, ADD, OCD, Bipolar, Autism, encephalitis, narcolepsy is caused by the inordinate amount of vaccinations that are forced on children by our government in order to get into school.   To compensate or mitigate the effects of the vaccine injury, mis-nomered as “mental illness” psyche drugs are given out like candy.  25 % of all American children are on psyche drugs.

Suicide is the third leading cause of deaths for youths…Read more…

SSRIStories.org is a collection of over 5,000 stories that have appeared in the media (newspapers, TV, scientific journals) in which prescription drugs were mentioned and in which the drugs may be linked to a variety of adverse outcomes including violence.5000 Suicides & Murders. Access list

Bogus pharma establishment  Study studies 37,000 kids newly prescribed medication and suicide rates.  Clearly none of these kids were tested for Cytochrome P450 2D6 metabolic rates, although the opportunity is still there for the ones who did not complete the suicide attempt. Testing for Cytochrome P450 2D6 can be a little as $175.00 but it is not “standard of care”.

The National Coalition of Organized Women uncovered one of the most egregious Pharmacuetical cover-ups in modern psyche history. The information that would have averted the school shootings, the homicides, the overdoses, the bizarre epidemic of mentally ill in recent years has been available for circa 15 years since gene mapping.   Cytochrome P450 2D6 was discovered as the major metabolic pathway that detoxifies 50% of all psyche drugs and street drugs.  However, 7-10% of Caucasians, for example, due to genetic variation do not have sufficient activity of this gene to detoxify their bodies from these modern drugs. They are labeled poor or non-metabolizers due to a deletion or non-activity of the 2D6 pathway. There are a percentage of Asians, African Americans and Hispanics who are also poor metabolizers.  When certain drugs (list on link) are prescribed to these individuals, due to their inability to metabolize, these people become psychotic, homicidal, suicidal, a danger to themselves and society.

There are other pathways on Cytochrome P459 such as Cyt 3A4 implicated in the psychosis reports of soldiers on Larium, a malaria drug.  Another example:  Marijuana (Cannibals) is a powerful inhibitor of cytochrome P450 isozymes 3A4, 2C19, and 2D6. This is not a defect.  It is a genetic variation, that’s all.  Ethiopians and Tanzanian Afrikans who traditional have had poor soil to grow food have been consuming a lot of weeds (medicine weeds), they have evolved generational to multiply their Cytochrome 2D6.  These people are “rapid metabolizers”.

It is a very simple test: Swap the mouth, teeth and gums with 2 sterile swabs (looks like q-tips) and send to our lab contact in Australia.  Contact: Ncowmail@gmail.com for lab details. Price: $175.00.  Bottom line, perhaps these kids who are most affected by vaccines are poor metabolizers and can’t rid themselves of the toxins in vaccines.  Perhaps 45 shots by the time the kid is six years old is asking too much!  Contact us for cytochrome testing: Ncowmail@gmail.com

Links below:

You know those kids who are shooting each other and mothers who drown their kids in the bath tub? Check out this most egregious cover up in the history of modern psychiatry. Dr. Lucire elucidates –  Dr. Yolande Lucire’s recently published study. Her study  published in the summer of 2011 is not only a academic victory but the perpetrators speak of their experiences  on how they were moved to kill their loved ones while on or coming off of psyche drugs.

This information, now highlighted by Dr. Lucire has been heretofore suppressed by the stakeholder.  The justice system in the USA has not realized the implication in law. (See personalized Justice/Personalize Medicine).  These drugs force the patient who is a poor or non-metabolizer into heinous acts against themselves and society. And who and what  is really complicit when a crime is committed?  The manufacturer who “failed to warn”?; the physician who “failed to warn” and who did not do the simple genetic test?  Read Dr. Lucire’s study.  She removed her subjects from the drugs and they  regained their normal mental function.  It was the drugs. There is a test to prove it! However, the attorneys of several high profile cases such as Adam Lanza, Jerod Loughner, James Holmes were contacted and did not respond.

Dr. Yolande Lucire’s recently published study

list of the drugs that need 2D6 pathway to metabolize

Laymen’s Synopis

Mayo Clinic Report on 2D6

Psychosis reports of soldiers on Malaria Drugs

Comprehensive Article by Brandon Turberville

Dr. Mercola on Cytochrome P450 2D6

Autism is associated with precocious puberty.  Boys are 4X more likely to get Autism. Guess what else is regulated by Cytochrome P450 besides glutathione?

Personalized Justice/Personalize Medicine

Do you want the simple 2D6 gene test?  Contact us at NCOWmail@gmail.com