Category Archives: Pregnancy and birth

The Causes Mental Illness: A 61 Year History of Pharmacogenetics suppressed by Pharma

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Avram Goldstein: The Founder of Molecular Pharmacology
http://molpharm.aspetjournals.org/content/83/4/720

Summary:

As the Chair of the Department of Pharmacology with responsibility for training medical students in the use of drugs, he was fascinated by the kinetics of drug action. He and his wife Dody developed the plateau principle, which emerged from the recognition that the time to steady state for any drug administered continuously or repeatedly was dependent only on its rate of elimination. These developments drove his increasing desire to see the discipline of pharmacology, both in research and in medical and graduate education, as a science with a strong mechanistic and theoretical underpinning.

Avram was present in Moscow in 1961 when Marshall Nirenberg described his elucidation of the genetic code. With these seminal developments, Avram concluded that the time was ripe for the establishment of a journal devoted to mechanistic aspects of drug action at a molecular level.

Avram was able to persuade ASPET to publish the new journal, which would be called Molecular Pharmacology. “Suitable papers are those which describe applications of the methods of biochemistry, biophysics, genetics and molecular biology to pharmacologic or toxicologic problems…”

Avram, together with his Stanford faculty colleagues Lew Aronow and Sumner Kalman, were working on Principles of Drug Action (Goldstein et al., 1968), a pharmacology textbook that was new for its time in focusing only on basic principles underlying drug action and the longer-term responses of the body to the presence of drugs.

DRUG METABOLISM RESEARCH HAS A 61 YEAR HISTORY

VLA Comment: The field of Pharmacogenomics, Pharmacogenetics, Pharmacogenomics has a 61 YEAR HISTORY  well accepted research concerning drug metabolism.  Education in this field of research has been actively suppressed by Pharma. Anonymous sources in the field of education for medical students tells us that this information is actively suppressed as the pharmacuetical industry would loose billions and billions of dollars if the public knew.  Moreso  medical students and hospital psychiatrists and doctors in general from Pediatricians ot Oconologists  have virtually no knowledge or education of drug metabolism, yet they all provide prescriptions that are contraindicated, causing Medication (drug) induced psychosis.   90% of drugs need an active and mature liver system of Cytochrome P450 enzymes to metabolize and eliminate them from an individual’s body. A substantial percentage of Caucasians, Asians, Blacks have no activity to metabolize these modern drugs.  The results – increased (apparent) psychosis.

INCREASE IN PSYCHOSIS DIAGNOSES

The increase in psychosis diagnosis is actually the agressive poisoning of humanity by uneducated doctors from the cradle to the grave.  The increase in (apparent) mental illness and special needs is due to the inability of many individuals to eliminate, from the body, modern drugs (and streets drugs) such as SSRIs vaccine excipients.

VACCINES, THE BASIS OF MENTAL ILLNESS DIAGNOSES

Vaccines contain excipients that need a mature superfamily of Cytochrome P450 in order to be metabolize and successfully eliminated from the body of infants and children. The damage done to the physiology of a one hour old infant, injected with Aluminum (which interferes in Cyp 450 metabolism in the Hep B and Vitamin K shots),  and other vaccine excipients testifies to the basic underpinnings of the epidemic in Autism, ADHD, ADD, OCD, BiPolar,neurological, mitachondrial issues, depression, anxiety, panic attacks.   The misdiagnosis of mental illness by uneducated medical professionals who extensively prescribe psychiatric drugs and the push to vaccinate, to eliminate parental choice, to eliminate vaccine waivers appears to be an organized effort to debilite the entire emerging generations of humanity through the suppression of this Pharmacogenomic knowedge.  Note: There is no mandated continuing education in drug metabolism for practicing physicans; virtually no education for medical students; yet the prescrbing of medications and the push for vaccine compliance, school shootings, homicides and suicides, special needs education, is at an all time high.

CCHR Newsletter: Overview and layman understanding of Cyp 450, Pharmacogenetics, vaccines, psyche drugs,homicide, suicide.

Below, the American Society for Pharmacology and Experimental Therapeutics chronicled the discoveries and provided communications to advance the science of drug metabolism.

The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 2, 1959–1983
Patrick J. Murphy College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana Received February 18, 2008; accepted February 27, 2008

ABSTRACT (2008):
In 25 years, (now 35 years) drug metabolism research went from using subcellular
particles of undefined content to an understanding of metabolism
at the molecular level. The discoveries of cytochrome P450, en-
zyme induction, reactive intermediates, and genetic polymor-
phisms were milestones in the field. New publications from the
American Society for Pharmacology and Experimental Therapeu-
tics chronicled the discoveries and provided communications to
advance the science of drug metabolism.

THE DISCOVERY OF CYTOCHROME P450 (1957)
The discovery of P450 and its function evolved from observations by Ryan and Engel that C-21 hydroxylations of progesterone and hydroxylated progesterones were catalyzed by a CO inhibitable en-zyme in the adrenal cortex (Ryan and Engel, 1957). They character-ized the reaction as belonging to the class of enzymes categorized by
Mason as “mixed-function oxidases” (Mason, 1957) and by Hayaishias “oxygenases” (Hayaishi, 1962).

THE ROLE OF GLUTATHIONE (depleted in AUTISM?)

The role of glutathione as a precursor of mercapturic acids was confirmed in 1959 (Bray et al., 1959a,b), 80 years after the discovery of these important elimination products by Baumann and Preuss (1879). In the following 25 years, there were over 150 papers in the ASPET journals referring to aspects of glutathione in metabolism. The role of glutathione as a scavenger of reactive intermediates was ofprimary interest, as exemplified by the finding of the glutathione conjugate of acetaminophen by Hinson et al. (1982) or the formation of mercapturic acids from cyclohexene epoxide in the rat (van Bla-deren et al., 1981).

Billionaire Vaccine Entrepreneur Buys LA Times & San Diego Tribune

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Big Pharma vaccine billionaire just bought the LA Times… yet another example of the media being run by pharma

(Natural News) The latest example of Big Pharma taking over the media is the purchase of the Los Angeles Times and the San Diego Tribune for $500 million by Big Pharma billionaire Dr. Patrick Soon-Shiong. Instead of paying for advertisements, pharma billionaires have decided to just buy the publications outright so they can control the entire publication. All the journalists here are now officially bought; these publications should officially be recognized as propaganda rags from now on.Big Pharma vaccine billionaire just bought the LA Times… yet another example of the media being run by pharma. READ MORE...

 

 

MAYO CLINIC: Anti-depressant and Pregnancy – and current protocol of Shock treatments

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According to Mayo Clinic “generally, these antidepressants are an option during pregnancy:”

VLA comment: The list below are the recommended options that however come with risks.  What is not listed are the rest of the pharma madness drugs given to women approaching child bearing age and therefore compelled to continue the regimen during pregancy.  Other drugs are not listed because they are so risky for birth defects that they are not even considered.  However, how many young women have been prescribed these medication since teenagers?

  • Certain selective serotonin reuptake inhibitors (SSRIs). SSRIs are generally considered an option during pregnancy, including citalopram (Celexa), fluoxetine (Prozac) and sertraline (Zoloft). Potential complications include an increased risk of heavy bleeding after giving birth (postpartum hemorrhage), premature birth and low birth weight. Most studies show that SSRIs aren’t associated with birth defects. However, paroxetine (Paxil) appears to be associated with a small increased risk of a fetal heart defect.
  • Serotonin and norepinephrine reuptake inhibitors (SNRIs). SNRIs also are considered an option during pregnancy, including duloxetine (Cymbalta) and venlafaxine (Effexor XR). However, research suggests that taking SNRIs at the end of pregnancy is associated with postpartum hemorrhage.
  • Bupropion (Wellbutrin). This medication is used for both depression and smoking cessation. Although bupropion isn’t generally considered a first line treatment for depression during pregnancy, it might be an option for women who haven’t responded to other medications. Research suggests taking bupropion during pregnancy might be associated with heart defects.
  • Tricyclic antidepressants. This class of medications includes nortriptyline (Pamelor). Although tricyclic antidepressants aren’t generally considered a first line or second line treatment, they might be an option for women who haven’t responded to other medications. The tricyclic antidepressant clomipramine might be associated with fetal birth defects, including heart defects. Use of these medications during the second or third trimester might also be linked with postpartum hemorrhage.     READMore

SHOCK TREATMENTS

Electroshock is also known by the euphemism electroconvulsive therapy or ECT. Many electroshock patients receive the treatment against their will. Psychiatrists also claim that electroshock is safe during pregnancy and give the treatment to pregnant women.

Pregnancy and Electroconvulsive Therapy: A Multidisciplinary Approach  

STUDY: SHOCK TREATMENTS PREGNANCY 786178

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877273/
by SL Ray-Griffith – ‎2016 – ‎Cited by 7 – ‎Related articles

Electroconvulsive therapy is a safe and effective treatment during pregnancy and of particular benefit in the acute treatment of suicidal ideation.

VLA COMMENT: Suicidal ideations are a result of anti depressants and other drugs not being metabolized properly.  These drugs need Cytochrome P450 to metabolize.  If the patient does not have the activity of this family of liver enzymes and are prescribed drugs that are contra-indicated, as per the package inserts, adverse reactions such as “compelling” suicideal ideations (and heinous ideations of homicide) are likely to occur.

As the statement above refers to “acute treatment of suicidal ideation” it signals that the pregnant patient may be on medication that cannot be metabolized by his/her system of liver enzymes. Hence…the apparent solution to pregnant women who have been on anti depressants and psyche drugs for years and must continue during pregancy, is to top it all off with SHOCK TREATMENTS.  This allows the women to remain on psyche drug medication during her pregnancy.  However as noted in our posting Glyphosate, Drugs and Vaccines....the Cytochrome P450 metabolism is also found in the placenta.

Washington University in St. Louis Shocks Pregnant Women

According to the Citizen’s Commission on Human Rights (CCHR), Approximately 150,000 people get ECT every year in the US, with 2,000 shock treatments being done every year by WUSTL psychiatrists at Barnes-Jewish Hospital. Complications after treatment usually increase with the age of the patient; small surprise there. WUSTL psychiatrists say that, “ECT is considered a safe treatment modality in pregnant women in whom a number of medications may be associated with risk to the fetus.” READ MORE…

Article: ELECTRO SHOCK THERAPY WHILE PREGNANT

 

 

Glyphosate , Psyche Drug and Vaccines: THE CONNECTION

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CCHR Newsletter: Overview of Cyp 450, Pharmacogenetics, Psyche Drugs, vaccines.

AGRICULTURE

Read Study glyphosate_rats_CYP_enzyme_suppression_2006

Syngenta Patent shows that the Genetic Engineering of our nations food supply is based on Cytochrome P450 technology whereby the genetically engineered seed is manipulated to be an ultra rapidmetabolizer while the “weeds” who are normal metabolizer dies in the presence of Glysophate.  Cytochrome P450 Gene Conferring herbicide resistance PATENT

MENTAL ILLNESS DIAGNOSIS –

PHARMA DRUGS, STREET DRUGS & MEDICATION AND METABOLIZING OPIOIDS

Plants and humans share the same detox mechanism involving Cytochrome P450.  In humans Cytocrome P450

90% of today’s modern drugs are metabolized by Cytochrome P450.

CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 enzymes metabolize 90 percent of drugs. these enzymes are predominantly expressed in the liver, but they also occur in the small intestine (reducing drug bioavailability), lungs, placenta, and kidneys.2

One out of every 15 white or black persons may have an exaggerated response to standard doses of beta blockers (e.g., metoprolol [Lopressor]), or no response to the analgesic tramadol (Ultram). This is because drug metabolism via CYP450 enzymes exhibits genetic variability (polymorphism) that influences a patient’s response to a particular drug.3

Every person inherits one genetic allele from each parent. Alleles are referred to as “wild type” or “variant,” with wild type occurring most commonly in the general population.

For example, 7 percent of white persons and 2 to 7 percent of black persons are poor metabolizers of drugs dependent on CYP2D6, which metabolizes many beta blockers, antidepressants, and opioids.7,8 One in five Asian persons is a poor metabolizer of drugs dependent on CYP2C19, which metabolizes phenytoin (Dilantin), phenobarbital, omeprazole (Prilosec), and other drugs.9 

The Effect of Cytochrome P450
Metabolism on Drug Response,
Interactions, and Adverse Effects READ STUDYCyp Study

VACCINES

Studies: Cytochrome P450 and failure of infants to metabolize vaccine excipients READ more…

Early Childhood Vaccines contain excipients that need Cytochrome P450 to metabolize.

VLA Comment: Cytochrome P450 is not mature in infants and children under the age of three years old yet we are giving vaccines with excipients that must be detoxed out of the body by Cytochrome P450 family of liver enzymes which infants do not have. These enzymes are predominantly expressed in the liver, but they also occur in the small intestine (reducing drug bioavailability), lungs, placenta, and kidneys.2 

Note in cases of Autism and vaccinating pregnant women:

Cyp 450 are found in the “Small intestines and placenta”

READ more…

Italy: School attendance: No need to prove vaccination

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Proof of Children’s Vaccinations? Italy Will Now Take Parents’ Word for It

Image
Dr. Roberto Ieraci vaccinating a child in Rome this year. Vaccination rates in Italy and elsewhere in Europe are lower than in the United States.CreditAlessandra Tarantino/Associated Press

By Gaia Pianigiani

 

ROME — Italian parents will no longer have to provide state-run schools with a doctor’s note to show that their children have been vaccinated, the country’s new populist government announced on Thursday — a move that raised alarm among experts who fear that compliance with vaccines will drop.

The new rule, announced at a news conference by Giulia Grillo, Italy’s health minister and a prominent member of the anti-establishment Five Star Movement, requires only the assurance of parents that their children are immunized to enroll in school this September.

The government said its aim was to simplify enrollment procedures and enable school participation for all, including children whose parents do not have their paperwork in order yet.

“We want to spur school inclusion and simplify rules for parents,” Ms. Grillo said.

But critics of the move say the Italian government is eroding faith in science and public norms.

RFK, jr. THE CDC IS A SUBSIDIARY OF THE PHARMACEUTICAL INDUSTRY

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“The CDC is a subsidiary of the pharmaceutical industry. The agency owns more than 20 vaccine patents and purchases and sells $4.1 billion in vaccines annually.” 

Date: July 2, 2018Author: Nwo Report 3 Comments

Robert F. Kennedy Jr. claims the CDC owns patents on at least 57 different vaccines, and profits $4.1 billion per year in vaccination sales. 

According to RFK Jr., the CDC is not an independent government agency but is actually a subsidiary of Big Pharma.

“Upon cursory review of the patents, I found that one did not seem applicable to vaccination, but merely referenced an article on vaccination.  That leaves us with 56 CDC patents to scrutinize.  Here is what I found.

There are CDC patents applicable to vaccines for Flu, Rotavirus, Hepatitis A, HIV, Anthrax, Rabies, Dengue fever, West Nile virus, Group A Strep, Pneumococcal disease, Meningococcal disease, RSV, Gastroenteritis, Japanese encephalitis, SARS, Rift Valley Fever, and chlamydophila pneumoniae.

Sudden Infant Death Syndrome….Leading cause of death…

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VLA Comment:  Here is the truth about SIDS.  The establishment LIES, LIES, LIES…never put baby on back, only on tummy, could be because you smoked during pregnancy, age of the father….everything but the vaccine assault!

Sudden Infant Death Syndrome: The term strikes fear into new parents, and for good reason. More than 2000 infants die of SIDS each year, and it’s the leading cause of death for babies between 1 month and 1 year of age. The loss is devastating to families who have experienced it, and the problem is compounded by the fact that there seems to be no way to predict when or who it will strike.

Sudden Infant Death is a diagnosis of exclusion, meaning that it strikes a once-healthy baby whose death can’t be explained by any type of illness, defect, accident or injury. There is simply no identifiable reason for these deaths. People often confuse SIDS with infant suffocation, because of public campaigns to remove blankets, padding, pillows and crib bumpers in an effort to lower the rate of infant deaths—but it should be noted that SIDS is not the same as suffocation and is not caused by suffocation. If a child has suffocated, their death is not recorded as being related to SIDS.

What does cause SIDS, if it’s not suffocation or an undiagnosed underlying health problem? One potential culprit is vaccines.A disproportionate number of infants die of SIDS in the days and weeks after receiving scheduled vaccines.

“Prior to contemporary vaccination programs, ‘Crib death’ was so infrequent that it was not mentioned in infant mortality statistics,” a 2011 study published in Human and Experimental Toxicology states. In the 1960s, mandatory vaccination schedules were introduced and “Shortly thereafter, in 1969, medical certifiers presented a new medical term—sudden infant death syndrome. In 1973, the National Center for Health Statistics added a new cause-of-death category—for SIDS—to the ICD.”

That’s right—SIDS was not only the most common cause of infant death before the introduction of vaccines…it was practically unheard of!

A separate study found that babies die at a rate 8 times higher than usual in the 3 days after being immunized with the DPT vaccine.

The United States continues to have a high infant mortality rate and continues to lead the world in the number of vaccines required by the age of five. Could there be a connection? The graph below shows the relationship between the number of vaccines given and the rate of sudden infant death—and the data is shocking.

By the tender age of 12 months, American children have had three times the number of vaccines that are recommended in Sweden, Japan, Iceland, and Norway. These countries rank 2ed, 3ed, 4th, and 7th respectively in their infant mortality rates, while the US comes in a dismal 34th—our babies dying at over twice the rate of those in less vaccinated countries.

Japan took action in the 1970s when they saw that cases of death and severe injury were occurring after the DPT shot. Between 1975 and 1980, they raised the age of vaccination with DPT from 3 months to 2 years—and saw an immediate 80-90 percent decrease in injury and death.
How can we continue to put our children at risk, knowing that there is a real association between the rising number of inoculations we’re bombarding them with and Sudden Infant Death?

The only people benefitting from the inflated number of recommended vaccines are the big pharmaceutical companies. Our communities are less healthy, our people suffer from higher rates of autoimmune disease, our children are experiencing neurological problems at high rates, and our infants are dying.

It’s time to take action and follow the lead of countries whose health, infant mortality rate, and life-span all beat our own. Our children are paying a very high price for Big Pharma’s greed.

Jeff Hays

Jeff Hays Films

“Movies that Make Movements”

References:

Image Source

Human and Experimental Toxicology 2011 Study

Diphtheria-tetanus-pertussis

 

THE CAUSE of the epidemic of “apparent” mental illness: BIG PHARMA SECRET

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Psychiatric Drugs, School Violence, and Big Pharma Cover-Up   by the Citizen’s Commission on Human Rights (CCHR)

DOWNLOAD PDFCCHR Newsletter-Psychiatric Drugs, School Violence, and Big Pharma Cover-Up

 VLA Comment: The powerful activist organization Citizen’s Commission on Human Rights  (CCHR), considered the most successful worldwide organization holding the reins for decades on the misuse of psychiatric drugs, appear to be having a mind melt with our powerful Vaccine Movement.  

Our Vaccine movement has also been concerned with, and focused on, the rampant misdiagnosis of mental illness foisted on  on our infants,  children and youths not only by psychiatrists but all doctors, such as pediatricians and family physians,   The resultant issuing of psyche drugs and other medications to mitigate what is, in actuality, a physiological assault of 49 vaccine doses by the age of six has been disastrous to our culture.  It is causing the disabling of the entire emerging generations of humanity.  All Drugs (prescription,  vaccine excipient, street drugs) need a mature Cytochrome P450 superfamily of liver enzymes to metabolize. This information has been known by pharmacuetical manufacturers for over 20 years.  This field is called PHARMACOGENOMICS, PHARMACOGENETICS, PHARMACOKINETICS.

It is becoming evident from the research in this field,  that the early poisoning of generations of children with vaccines containing mercury, aluminum and other vaccine excipients such as formaldehyde, ethanol, polysorbate 80 (never mind dog kidney cells, fetal tissue, contaminants, bovine serum, etc) is physiologically damaging every vaccinated child,  leading to a heirarchal range of neurological damage, depression, aggression, etc.  In an effort to mitigate generations of depressed and ill-functioning humans, the further use of psychiatric drugs is causing medication induced psychosis (DSM-5), suicidal and homicidal ideations.

The assault of vaccines; the practice of misdiagnosing generations of children as mentally ill; the prescribing of antidepressants and psyche drugs to those who do not have the cytochrome enzymes (by demographic genetics) resulting in this modern day rash of suicides, homicides, depression;  labeling such as ADD, ADHD, OCD, special needs education, has resulted in a health crisis from cradle to grave and an epidemic of school shootings by young males.

See www.SSRIStories.net   – Wake up call – read snapshots of Thousands and Thousands of personal stories of suicide and homicide of children as young as 7 years old on psychotropic drugs hanging themselves by their belt in their closet. One must remember that the suicidal and homicidal ideations are HEINOUS and compelling, unlike decisions to commit suicide by considerable reasoning.

Cyp 450 superfamilies in infants and children.

STUDY DOWNLOAD

Synopsis:  Infants do not have a mature liver or liver enzyme function such as Cytochrome P450 and its various metabolites until the age of three years old. Hence upwards of 36 vaccine doses by 18 months old containing the above excipients are poisoning the world’s emerging humanity.:

Study #2:  Immaturity of Cyp 450 in Neonate boys (book)

Our mutual focus is on PHARMACOGENETICS and the failed ability to metabolize drugs and vaccine excipients.   I am so pleased and heartened, at last, to see that CCHR and our the incredibly potent Vaccine Movement are finally on the same page.

WHAT NEXT?

Our mutual mission would be well served if CCHR and our vaccine leaders, researchers, MDs, PhDs, etc. unite regarding the evidence presented by  Pharmacogenomics.  Media has pointed out the all these mass shooters are mentally ill and are on medication. What they are not aware of is that for example, 10% of Caucasians do not have the enzyme to metabolize the medications and have  “medication induced  psychosis and “heinous” ideation.

Taking a quantum leap together at this critical time in history where Donald Trump has articulated his concern about Opioids and Vaccines,  I suggest that we soon create a joint conference with CCHR and the Vaccine leaders and have conversation with experts in the field of pharmacogenetics with the goal of increasing exponentially, in harmony , our mutual momentum.

It is to be noted that several large organizations are now being vocal on the issue of Pharmacogenetics and individualized medicine such as the Mayo Clinic, St. Jude’s Hospital for Children, University of Chicago, etc. Mayo Clinic will be having a conference on Pharmacogenetics Sept. 11, 2018 in Minnesota.  I suggest many of us attend.

The easy test for your individual metabolism is available at Genesight, Genelex, etc. or at Healthscope in Australia for $250.00  The cytochrome P450 you need to look at is:

CYP 450 2D6, 2C9 and 2C19, 3A4

Or feel free to contact me at NCOWmail@gmail.com

 

Donald Trump on Vaccines: https://youtu.be/iP3nK0AdSHY

 

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