Category Archives: Pharmacogenetics

PSYCHOTROPIC DRUGS-Stories of Suicides & Homicides

Lawyer Impulsively Jumps In Front of Train: Effexor, like All A/D’s, Can Cause Impulsivness
Suicide Med For Depression 2011-11-11 England Physician Kills Himself Shortly After Starting an A/D
Personality Drained Away/Huge Weight Gain Med For Depression 2011-11-10 England After Many Years on A/D’s, Man Felt Like His Personaity Was Drained Away & He Became Obese
Violence Med For Depression 2011-11-10 Canada Man Strikes an Ax at a Neighbor
Death Antidepressant 2011-11-10 England 23 Year Old Woman Dies of Cardio-Respiratory Arrest: High Level of A/D’s in Body: No Alcohol or Drug
Suicide Celexa Antidepressant 2011-11-10 England Woman, 73, Kills Herself While on Celexa
Murder-Suicide Prozac 2011-11-09 California Man Kills Two Police Officers & Himself
Heart Disease Med For Depression 2011-11-09 Global ++Depression Meds Are More Likely to Cause Heart Disease
Murder Attempt Med For Depression 2011-11-08 Malta/Mediterranean Man Attempts to Murder Uncle With Hammer: Confused & Agitated
Bizarre Behavior Lexapro & Desyrel Antidepressants 2011-11-08 California +Famous Actress Kim Richards Exhibits Bizarre Behavior on TV
Dulled Mind/Numbed Body Zoloft 2011-11-07 Georgia Woman Physician Quits Zoloft: Tells How She Recovered From Depression
Suicide Med For Depression 2011-11-07 Texas Woman Drives Her Car Into Lake
Suicide Antidepressants 2011-11-05 Ohio Soldier, 22, Kills Himself: Black Box Warning on Suicidality for This Age Group

Go to website…read more…

Pharmacogenetics: Cytochrome P450 in Pediatric Population

The various factors that impact pharmacokinetics
and pharmacodynamics mature towards adult values at different rates, thus requiring continual modification of drug dose regimens in neonates, infants, and children.

Read Study Pediatric Population study Cyp 450.

Aluminum & Cytochrome P450

Suppressive effect of accumulated aluminum trichloride on the hepatic microsomal cytochrome P450 enzyme system in rats.

The results revealed that exposure to AlCl3 inhibited the microsomal CYP450 dependent enzyme system of liver. Our findings suggest that long term daily exposure of AlCl3 exerts the suppressive effects and thus may cause dysfunction of hepatic CYP450 dependent enzyme system of rat.


► AlCl3 exposure through drinking water gets close with actual chronic oral Al exposure. ► Effects of Al exposure on the hepatic microsomal protein, AND and ERND were studied. ► Metabolism of Al affected the hepatic microsomal cytochrome P450 enzyme system.

Read Abstract

Aluminium compounds for use in vaccines | Immunology & Cell Biology
by EB Lindblad – ‎2004 – ‎Cited by 397 – ‎Related articles

Oct 1, 2004 – Holt, shortly after, demonstrated that preformed aluminium phosphate, prepared from equimolar amounts of aluminium chloride and trisodium phosphate, acted as an adsorbant and was adjuvant active with diphtheria. Data on the use of alum-precipitated vaccines can be found in older literature, but in …

The mechanisms of action of vaccines containing aluminum adjuvants …
by TR Ghimire – ‎2015 – ‎Cited by 20 – ‎Related articles

Apr 16, 2015 – Adjuvants such as the aluminum compounds (alum) have been dominantly used in many vaccines due to their immunopotentiation and safety records …. Aluminum compounds such as aluminum chloride, aluminum silicate, algammulin (gamma inulin plus AH), cesium alum (CA), Imject alum (IA) (AH plus ..


The New Science of Vaccinomics: Pharmacogenetics and Vaccines


The field of pharmacogenomics and pharmacogenetics provides a promising science base for vaccine research and development. A broad range of phenotype/genotype data combined with high-throughput genetic sequencing and bioinformatics are increasingly being integrated into this emerging field of vaccinomics. This paper discusses the hypothesis of the ‘immune response gene network’ and genetic (and bioinformatic) strategies to study associations between immune response gene polymorphisms and variations in humoral and cellular immune responses to prophylactic viral vaccines, such as measles–mumps–rubella, influenza, HIV, hepatitis B and smallpox. Immunogenetic studies reveal promising new vaccine targets by providing a better understanding of the mechanisms by which gene polymorphisms may influence innate and adaptive immune responses to vaccines, including vaccine failure and vaccine-associated adverse events. Additional benefits from vaccinomic studies include the development of personalized vaccines, the development of novel vaccines and the development of novel vaccine adjuvants.

As one clinician noted, ‘…vaccines licensed in the USA are safe and effective. However, not every vaccine is equally safe or equally effective in every person’ [].

Read Study…

Cytochrome P450 maturity in Neonate Boys


Above chart click below for Cytochrome P450 maturation.  Children do not have mature cytochrome P450 families and cannot metabolize the excipients in vaccines as neonates.Read…age of maturity of Cytochrome P450  For example:

Hep B (aluminum hydroxide, yeast protein, phosphate buffers, sodium dihydrogen phosphate dihydrate)

Vitamin K shot are given at birth

Phenol (carbolic acid – a poisonous substance derived from coal tar)
Benzyl alcohol (preservative)
Propylene glycol (better known as “edible” antifreeze)
– Acetic acid (astringent, antimicrobial agent)
– Hydrochloric acid
– Lecithin
– Castor oil


Mainstream Media: Ben Swan BLACK BOYS & AUTISM


At 14:00 Ben Swan shows that black boys under “36 months” (3 years) had higher autism. This goes along with the new study that shows that children under 3 do not have a mature detox mechanism (Cytochrome P450) in order to detox the excipients in vaccines such such as phenol, alcohol, polysorbate 80, formaldahyde. Aluminum & mercury inhibit Cytochrome p450. See INABILITY OF INFANTS TO METABOLIZE VACCINE EXCIPIENTS 


Mass Shootings, homicides, suicides and Pharmacogenomics (WHAT’S THAT?)



Posted on by Brandon Turbeville

In January, 2013, I wrote an article entitled, “Psychiatric Drugs, School Violence, And The Big Pharma Cover-up,” where I discussed the importance of the CYP450 enzymes on the metabolism of pharmaceutical drugs and the potential for adverse effects of those drugs if the CYP450 enzyme was not functioning properly. 

Studies conducted over the last decade have clearly demonstrated the link between adverse reactions to Psycho-Pharmaceutical medications and underactive or underperforming CYP450 enzymes. This has caused some to wonder whether or not the recent uptick in mass shootings and the obvious link to many of the perpetrators and prescription drugs could be related to the performance of the CYP450 enzymes. Additional research, however, is now causing more questions to be asked in reference to the connections that chemicals like Glyphosate may have in the inhibition of proper CYP450 performance and, thus, in the uptick in mass shootings.

For those unfamiliar with the functions of the CYP450 enzymes, CYP450 stands for the Cytochrome P450 enzymes. Scientists understand these enzymes to be responsible for metabolizing almost half of all drugs currently on the market. P450 gene variants (polymorphisms) are implicated in the variability in drug response among a wide range of individuals.  READ MORE…

Pharmacogenomics & the metabolism of drugs


Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects.

Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. The convergence of pharmacogenetics and human genomics in recent years has dramatically accelerated the discovery of new genetic variations that potentially underlie variability in drug response, giving birth to pharmacogenomics. Read ABSRACT

VLA comment:  10 % of Caucasians, for example, are unable to metabolize these modern drugs.  Hence, the epidemic of suicides and homicides.  Early clinical examples of genetic influence on drug response involved variations in single genes (i.e., monogenic inheritance) in which polymorphisms (no metabolic ability) of a single gene encoding a drug-metabolizing enzyme responsible for the metabolism and disposition of a substrate drug caused aberrant response to the drug. The phenotypic variation can be dramatic, especially when no alternate pathway exists to perform the same function.

Involuntary Intoxication and Automatism Homicide Defense (prescription drugs)




Effexor and a multiple of other psyche drugs, can cause people to commit murder and proposes how an nontraditional but commonly recognized criminal defense should be applied to such people. Effexor is labeled for homicidal ideations.  The rest are black box warned for suicidal ideations.  But the reality is that there are two sides to the same coin.  Suicide is committed by those who blame themselves.  Homicide is committed by those who blame “others”.  If the pharmaceuticals put homicidal ideations on each drug, as Effexor did) the public would connect the heinous murders such as school shootings with the drug.  Suicides and the homicides are committed by those persons (10% of Causcasians and 7 % of African Americans) who are “non metabolizers”.  These demographics, simply by genetic variations, do not have the Cytochrome P450 2D6 physiological mechanics to metabolize today’s modern psyche drugs.  The drugs therefore accumulatesin the body in such a toxic manner that the distressed person either kills himself or another.  Today suicides in veterans who are given drugs for PST is at an epidemic proportion.

Part III analyzes two defenses,
involuntary intoxication and automatism, which a criminal
defendant taking antidepressants could raise to avoid being
unjustly convicted.

After a comparison of these two defenses –

Part IV proposes that courts accept automatism as a viable defense for criminal defendants who take Effexor and then commit homicide. Automatism could function as either a complete defense (absolute exoneration) or as a partial defense (sentence mitigation). In giving life to the automatism defense, courts should consider the latest scientific findings about the link between genetic mutations and one’s inability to process drugs and the resulting toxic effect.

Genetic testing for mutations on the CYP450 gene can prevent future homicides by identifying people who are predisposed to side effects from these drugs.

Read more…


(click here for studies on infant metabolism of vaccine ingredients)

More and more  research in the area of pharmacogenetics is being funded by pharmacuetical companies in order to give physicians better guidelines for dosages.

Cytochrome P450, the major detox mechanism in the body (plants, animals and humans), varies among individuals.  Individuals can be rapid metabolizers, normal metabolizers and poor or non metabolizers.

Other than the fact that 10% of Caucasians and 7% of African Americans are straight out “non-metabolizers” and have the tendency to suicidal and/or homicidal ideations when given prescription drugs, cytochrome P450 is “maturing” and all infants do not have full mature activity this  important detox mechanism until the age of 3.

Ped cyp enzymes  (see graph)  (very important study of the immaturity of cyp 450 superfamilies in infants and children.

At birth and one hour old, all infants, except those whose parents have declined, will received a Vitamin K shot and Heb B vaccination.  With this they will be injected at birth with 450 mcgs. of aluminum and an amount of formaldehyde…we are talking an hour old.

According to Dr. Sherri Tenpenny:

Dr. Sherri J. Tenpenny’s Integrative Medical Center, by the time a child has reached 5 years of age, he or she has been injected with a total of 1,795 micrograms (mcg), or 1.795 milligrams of formaldehyde, as follows  Read more…

  • Hepatitis b – 3 doses x 15 mcg each
  • DTaP – 5 doses x 100 mcg each
  • Polio (IPV) – 5 doses x 200 mcg each
  • Influenza – 6 doses x 25 mcg each
  • Hepatitis A – 1 dose x 100 mcg each

              Total:  1,795 mcgs of fomaldehyde by age five

Included in the list of vaccine excipients is not only formaldehyde but ethanol, phenol, polysorbate 80, benzethonium chloride,  glutaraldehyde, acetone, thimerosal, aluminum. All needing mature cytochrome P450 enzymes to metabolize.

VLA Comment: Finally we have proof that our infants and children are being directly injected with poisons (toxins) that cannot be metabolized at such a young age.