Inflammation is associated with down regulations of hepatic and extrahepatic CYP enzymes drug metabolism.
The CYP represent a superfamily of enzymes with a key role in the activation or inactivation of a plethora of therapeutic agents. CYP enzymes are involved in the metabolism of xenobiotic substances. Cytochromes present intra- or interindividual and intra- or interethnic genetic polymorphisms. Variations in the pharmacokinetic drug profile are linked to the rising toxicity following a declining metabolism, reduced efficacy of the drug, adverse drug interaction, and increasing production of toxic metabolites. The high-metabolic rate of the intestinal microbiota is due to its many enzymes which catalyze reactions in phase I and II drug metabolism. In case of a compromised intestinal barrier, there may be an increase in paracellular passive absorption.
It is evident that high-microbial abundance following intestinal disturbances, environment, aging, or food-associated diseases promotes the microbial metabolism of a drug before absorption.
During the “Health in Buildings Roundtable” sponsored by the NIH & co-organized by the US CDC and several other organizations, Dr. Martin Pall from the Washington State University (WSU) concluded that the “5G rollout is absolutely insane”
The study found that flu carriers exhale significant quantities of infectious influenza virus, and that counter intuitively, sneezing is rare and not important for influenza virus aerosolization; nor is coughing required to transmit these particles. Simply breathing will do. Additionally, the study found that males shed influenza viruses in greater quantity than females through fine aerosols, and women cough more frequently. READ MORE..
When my first child, Lily, was born 16 years ago, I had just gotten out of graduate school for organic chemistry. I had a top position as a medicinal chemist for Big Pharma. Every medical and chemistry journal ever published was at my fingertips…
A More Humane (sure) Livestock Industry, Brought to You by Crispr
(Crispr…a genetic engineering tool that uses a CRISPR sequence of DNA and its associated protein to edit the base pairs of a gene.)
Cow 401 and her herdmates were the product of two and a half years of research, Van Eenennaam’s attempt to create a strain of gene-edited cattle specially suited to the needs of the beef industry. Had everything gone as planned, all the calves in this experiment would have been born male—physiologically, at least. Like humans, cattle carry two sex chromosomes; those born XX are female, and those born XY are male. But it isn’t the Y that makes the man.
VLA Comment: Note this as the world accepts gender dysphoria.…It’s a single gene, called SRY, that briefly flickers to life as an embryo grows and instructs it to develop male traits. Using Crispr, Van Eenennaam’s team added a copy of SRY to the X chromosome too. That way, even if a cow was born genetically female, she’d be expected to appear male all the same.
It took 20 years, but a group of scientists south of the border has found a cure for the most prevalent infection that is found “south of the border.” Eva Ramon Gallegos and colleagues at the National School of Biological Sciences in Mexico City have found a way to kill human papillomavirus (HPV) (1) the most common sexually transmitted infection (STI) using light. Depending on the severity of infection and the presence or absence of skin lesions, the therapy eliminated between 57.2% and 100% of the virus in