Human Exposure to Aluminium Exley
https://www.ncbi.nlm.nih.gov/pubmed/23059508
On May 17, 2017, we learned that Chris Cornell of Soundgarden had reportedly committed suicide by hanging. His family reports knowing a different Chris than one who would make this fatal decision, and suspect his anti-anxiety prescription in the altered state he was witnessed to be in the night he died. Perhaps an “addict turned psychiatric patient”, like so many, Chris Cornell seemed to have left the frying pan of substance abuse for the fire of psychiatric medication risks.
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FDA regulations require safety testing of constituent ingredients in drugs (21 CFR 610.15). With the exception of extraneous proteins, no component safety testing is required for vaccines or vaccine schedules. The dosing of aluminum in vaccines is based on the production of antibody titers, not safety science. Here we estimate a Pediatric Dose Limit that considers body weight. We identify several serious historical missteps in past analyses of provisional safe levels of aluminum in vaccines, and provide updates relevant to infant aluminum exposure in the pediatric schedule considering pediatric body weight
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VLA comment: Apparently it is okay with the CDC and Paul Offit at the Philadelphia Children’s Hospital that…and I quote and excerpt…the process which a small infant has to deal with excreting this poison or the consequences of retain the metal in the bones or the brains is inconsequental:
“We investigated hepatic P450 metabolism and drug pharmacokinetics in type 1 allergic mice induced by ovalbumin (OVA) emulsified with aluminum and inactive Bordetella pertussis. To further propose a possible key factor in drug-allergic disease interactions, we examined the inhibitory effect of NO, a marker of allergic conditions on the activities of major P450 isoforms”.
Magic Mushrooms: Some individuals are not able to metabolize-causing psychosis, albeit temporary and not to be confused with “mental illness”.
Increased knowledge in this area may advance our understanding of individual vulnerability to and/or protection from illicit drugs of abuse (15). This review, therefore, aims to describe our current understanding of the metabolism READ STUDY…
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The various factors that impact pharmacokinetics
and pharmacodynamics mature towards adult values at different rates, thus requiring continual modification of drug dose regimens in neonates, infants, and children.
Read Study Pediatric Population study Cyp 450.
The results revealed that exposure to AlCl3 inhibited the microsomal CYP450 dependent enzyme system of liver. Our findings suggest that long term daily exposure of AlCl3 exerts the suppressive effects and thus may cause dysfunction of hepatic CYP450 dependent enzyme system of rat.
► AlCl3 exposure through drinking water gets close with actual chronic oral Al exposure. ► Effects of Al exposure on the hepatic microsomal protein, AND and ERND were studied. ► Metabolism of Al affected the hepatic microsomal cytochrome P450 enzyme system.
Oct 1, 2004 – Holt, shortly after, demonstrated that preformed aluminium phosphate, prepared from equimolar amounts of aluminium chloride and trisodium phosphate, acted as an adsorbant and was adjuvant active with diphtheria. Data on the use of alum
Apr 16, 2015 – Adjuvants such as the aluminum compounds (alum) have been dominantly used in many vaccines due to their immunopotentiation and safety records …. Aluminum compounds such as aluminum chloride, aluminum silicate, algammulin (gamma inulin plus AH), cesium alum (CA), Imject alum (IA) (AH plus
The field of pharmacogenomics and pharmacogenetics provides a promising science base for vaccine research and development. A broad range of phenotype/genotype data combined with high-throughput genetic sequencing and bioinformatics are increasingly being integrated into this emerging field of vaccinomics. This paper discusses the hypothesis of the ‘immune response gene network’ and genetic (and bioinformatic) strategies to study associations between immune response gene polymorphisms and variations in humoral and cellular immune responses to prophylactic viral vaccines, such as measles–mumps–rubella, influenza, HIV, hepatitis B and smallpox. Immunogenetic studies reveal promising new vaccine targets by providing a better understanding of the mechanisms by which gene polymorphisms may influence innate and adaptive immune responses to vaccines, including vaccine failure and vaccine-associated adverse events. Additional benefits from vaccinomic studies include the development of personalized vaccines, the development of novel vaccines and the development of novel vaccine adjuvants.
As one clinician noted, ‘…vaccines licensed in the USA are safe and effective. However, not every vaccine is equally safe or equally effective in every person’ [2].
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Above chart click below for Cytochrome P450 maturation. Children do not have mature cytochrome P450 families and cannot metabolize the excipients in vaccines as neonates.Read…age of maturity of Cytochrome P450 For example:
Hep B (aluminum hydroxide, yeast protein, phosphate buffers, sodium dihydrogen phosphate dihydrate)
Vitamin K shot are given at birth