Pharmacokinetics and Differential Regulation of Cytochrome P450 Enzymes in Type 1 Allergic Mice
“We investigated hepatic P450 metabolism and drug pharmacokinetics in type 1 allergic mice induced by ovalbumin (OVA) emulsified with aluminum and inactive Bordetella pertussis. To further propose a possible key factor in drug-allergic disease interactions, we examined the inhibitory effect of NO, a marker of allergic conditions on the activities of major P450 isoforms”.
VLA COMMENT-CD RE: FLUORIDE: There may be a miniscule amount of natural fluoride that exists in the soils and is released just like other minerals. I wonder FLUORIDE being less toxic in its natural state than the much more reactive state that is in the fluoride compounds added to water. I have only seen positive effects from people drinking Fiji water – the benefits of getting rid of the aluminum are so great, and I see it as a time/toxicity equation. That a 3-6 month intensive course of Fiji water to lower the body burden of aluminum is of such benefit, that it does not need to be consumed forever to reap benefits, and there are other likely ways to protect against any miniscule fluoride exposure (like taking vitamin c and other antioxidants) that it is worth consuming it if aluminum toxicity is suspected. Our studies show that ALL people with a level of greater than 1mcg/g of dry brain weight have pathology that is associated with Alzheimer’s, or autism (depending on the age) and no brains examined with these levels were healthy. All healthy brains had less than 1 mcg of aluminum per gram of dry brain weight. It is not debatable anymore.
In addition, people with the aggressive form of MS excreted far more aluminum in their urine than healthy people, and when their aluminum body burden was reduced by drinking silica rich mineral water, they did not have any progression of their disease. The study was not designed to measure improvement in their condition, but we would have likely seen improvement if the study was designed with that outcome. A facebook group has formed called Fiji Water Detox and Epilepsy support Group and parents are reporting that their children are stopping or drastically reducing the number of seizures per day when consuming Fiji water (sometimes the kids had hundreds of seizures a day which stopped overnight when they started drinking Fiji). The benefits far outweigh any risks, and getting the aluminum out should be the highest priority for anyone dealing with a chronic, complex, inflammatory health problem.
In a nutshell, scientists all over the world have learned the following about aluminum adjuvant, most of it since 2010 (not a single one of these new discoveries or published studies was considered in Dr. Mitkus’ paper).
From Canada, 2012: “Aluminum (Al) is highly neurotoxic and has been shown to impair both prenatal and postnatal brain development in humans and experimental animals.” From France, 2013: “However, continuously escalating doses of this poorly biodegradable adjuvant in the population may become insidiously unsafe, especially in the case of overimmunization or immature/altered blood brain barrier…” From France, 2015: “Thus alum and other poorly biodegradable materials taken up at the periphery by phagocytes circulate in the lymphatic and blood circulation and can enter the brain using a Trojan horse mechanism similar to that used by infectious particles. Previous experiments have shown that alum administration can cause CNS dysfunction and damage, casting doubts on the exact level of alum safety.” From France, 2016: “We conclude that Alhydrogel [aluminum adjuvant] injected at low dose in mouse muscle may selectively induce long-term Al cerebral accumulation and neurotoxic effects.” From England, 2017: “The amount of aluminum in the brain tissue was, I would say, extraordinarily high. Very high. My group has measured the aluminum content of probably more than one hundred human brains, and these brain tissues taken from the individuals with a diagnosis of autism were some of the highest we’ve measured bar none. The only ones we’ve seen that are similar were a recent study of familial Alzheimer’s. This in itself is a very important finding.”
So, versus ten years ago, scientists now know that aluminum adjuvant, when injected, can 1) impair brain development, 2) remain in the brain much longer than thought, 3) is brought into the brain by macrophages that grab the aluminum from the vaccine injection site and recirculate it, 4) may actually be worse when injected in small doses repeatedly (like it’s done during vaccination), and 4) there’s remarkably high levels of aluminum in the brains of people diagnosed with autism.Dr. Chris Exley, the author of this most recent study (#5, and the subject of my recent article) was so moved by the results of his study he said the following:
The total number of mcgs of Aluminum by 18 years old is 13,538 mcgs.
VLA Comment:These researchers and other moral saviors behind the scenes of public awareness (CD, CB, PK, GG, MDG, Cong B, Cong P…on and on) are the same dedicated persons who blew the whistle on Mercury in vaccines and dental fillings. Most mercury was taken out of vaccines in 2001. At one time mercury was in 16 vaccine doses, debilitating our children, causing them to be diagnosed as “mentally ill”, OCD, Bipolar, ADHD, Autism; prescribed psychiatric drugs as young a 0-1 years old.However, Mercury is still in vaccines today (see chart above).
Mercury and aluminum are both ” heavy metals”. Heavy Metals are causing malfunction; electrical malfunction, immune dysfunction, digestive disorder in every incoming generation of humanity. Metals do not belong in the human physiology. Adults are now spending thousands of dollars trying to get heavy metals out of their systems. Where do you think these deposits came from? If heavy metals negatively affect the outer environment it would be common sense to conclude that they would be harmful to the inner environment of man…and especially dangerous our young children and pregnant moms.
Link CDC Cover up: 4,250% increase in miscarriage reports from flu shots
According to IMS Health’s Vector One: National and Total Patient Tracker Database for 2013 these are the figures for 0-1-year-olds being prescribed psychiatric drugs:
249,669 0-1 year olds are on anti-anxiety drugs (such as Xanax, Klonopin, and Ativan).
26,406 0-1 year olds are on antidepressants (such as Prozac, Zoloft, and Paxil).
There are 1,422 0-1 year olds taking ADHD drugs (such as Ritalin, Adderall, and Concerta).
654 0-1 year olds are taking antipsychotics (such as Risperdal, Seroquel, and Zyprexa).
While the CDC was correct in issuing their report on the 10,000 2-3 year olds (toddlers) being prescribed ADHD drugs, the number of toddlers on anti-anxiety and antidepressants is staggering in comparison:
318,997 2-3 year olds are on anti-anxiety drugs.
46,102 2-3 year olds are on antidepressants.
3,760 2-3 year olds are taking antipsychotics.
And as for other age groups, the numbers start in the millions with 0-5 year olds:
The total number of 0-5 year olds currently prescribed psychiatric drugs is 1,080,168.
The number of 6-12 year olds on psychiatric drugs is 4,130,340.
The number of 13-17 year olds taking psychiatric drugs is 3,617,593.
Sep 1, 2017 – The group of most concern are known as the heavy metals and includes mercury, lead, cadmium, aluminium, and arsenic. The definition of what constitutes a heavy metal is vague and various criteria have been proposed based on density, atomic weight or atomic number, or various chemical properties and toxicity 1.
The results revealed that exposure to AlCl3 inhibited the microsomal CYP450 dependent enzyme system of liver. Our findings suggest that long term daily exposure of AlCl3 exerts the suppressive effects and thus may cause dysfunction of hepatic CYP450 dependent enzyme system of rat.
► AlCl3 exposure through drinking water gets close with actual chronic oral Al exposure. ► Effects of Al exposure on the hepatic microsomal protein, AND and ERND were studied. ► Metabolism of Al affected the hepatic microsomal cytochrome P450 enzyme system.
Oct 1, 2004 – Holt, shortly after, demonstrated that preformed aluminium phosphate, prepared from equimolar amounts of aluminium chloride and trisodium phosphate, acted as an adsorbant and was adjuvant active with diphtheria. Data on the use of alum-precipitated vaccines can be found in older literature, but in …
Apr 16, 2015 – Adjuvants such as the aluminum compounds (alum) have been dominantly used in many vaccines due to their immunopotentiation and safety records …. Aluminum compounds such as aluminum chloride, aluminum silicate, algammulin (gamma inulin plus AH), cesium alum (CA), Imject alum (IA) (AH plus ..
Using a transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminium content of brain tissue from donors with a diagnosis of autism. We have also used an aluminium-selective fluor to identify aluminium in brain tissue using fluorescence microscopy.
We recorded some of the highest values for brain aluminium content ever measured
in healthy or diseased tissues in these male ASDdonors including values of 17.10, 18.57 and 22.11 g/g dry wt. (Table 1)
Injecting Aluminum is now available in North America on DVD, Streaming and screening events from Cinema Libre Studio. More information on the film can be found at www.injectingaluminum.com. Don’t forget to join us on our Facebook page where a robust community has formed around the film and lively and informative discussions are taking place about vaccine safety. Daily news and resources about the risks of aluminum in vaccines are posted as well.
Injecting Aluminum, a new documentary by French journalist Marie-Ange Poyet, that investigates the history of aluminum in vaccines and its potentially devastating effects on the human body. Aluminum has been recognized as a neurotoxic ingredient by leading researchers and scientists across the globe. So why do babies in the U.S. receive up to 4,925 micrograms (mcg) of aluminum within the first 18 months, and an additional 170 to 625 mcg by the age of 6 through routine vaccinations? What are the possible side effects of aluminum on the human body when injected? Injecting Aluminum investiates how aluminum has been used as a vaccine adjuvant (a substance that enhances the body’s immune response) since the 1920’s but has only been tested one time, on two rabbits. Their remains have since disappeared.
Aluminum is a neurotoxin, yet infants and young children are repeatedly injected with aluminum adjuvants from multiple vaccines during critical periods of brain development. Numerous studies provide credible evidence that aluminum adversely affects important biological functions and may contribute to neurodegenerative and autoimmune disorders. It is impossible to predetermine which vaccinated babies will succumb to aluminum poisoning.
Conclusion: Toxic metals such as aluminum do not belong in prophylactic medications administered to children, teenagers, or adults. Parents, especially, should not be compelled to permit their loved ones to receive multiple injections of toxic metals that could increase their risk of neurodevelopmenta and autoimmune ailments.
Injectable Study Shows Injectable Aluminum Damages Children’s Circuitry
Dietary Aluminum vs. Injectable Aluminum – Dietary Aluminum is excreted fairly rapidly, where injectable Aluminum stays around damaging the bodies nervous system(circuitry)…at least that’s what one study is showing in an effort to counter the pro-vaccine argument that aluminum in humans isn’t a big deal. We are constantly bombarded with “aluminum is a natural part of our diets,” but after you watch the following video, you will soon see this sort of argument doesn’t hold water.