The various factors that impact pharmacokinetics and pharmacodynamics mature towards adult values at different rates, thus requiring continual modification of drug dose regimens in neonates, infants, and children.
Philippines prepared for ‘worst-case scenario’ after 733,000 given dengue vaccine that could worsen disease
ANILA – A public health expert on Friday called for legal action on the government’s recently suspended dengue immunization program, after a vaccine maker said the drug poses risks to individuals not previously infected with dengue. Read more
Phillipine President Duterte suspends program…says drug company found ‘direct link’ between vaccines and Autism.
President Duterte vows to protect his citizens from the dangers of vaccines
President Duterte has suspended all vaccination programs in Philipines, vowing to protect his people from the dangers of vaccines after finding a “direct link” with Autism.
The results revealed that exposure to AlCl3 inhibited the microsomal CYP450 dependent enzyme system of liver. Our findings suggest that long term daily exposure of AlCl3 exerts the suppressive effects and thus may cause dysfunction of hepatic CYP450 dependent enzyme system of rat.
Highlights
► AlCl3 exposure through drinking water gets close with actual chronic oral Al exposure. ► Effects of Al exposure on the hepatic microsomal protein, AND and ERND were studied. ► Metabolism of Al affected the hepatic microsomal cytochrome P450 enzyme system.
Oct 1, 2004 – Holt, shortly after, demonstrated that preformed aluminium phosphate, prepared from equimolar amounts of aluminium chloride and trisodium phosphate, acted as an adsorbant and was adjuvant active with diphtheria. Data on the use of alum-precipitated vaccines can be found in older literature, but in …
Apr 16, 2015 – Adjuvants such as the aluminum compounds (alum) have been dominantly used in many vaccines due to their immunopotentiation and safety records …. Aluminum compounds such as aluminum chloride, aluminum silicate, algammulin (gamma inulin plus AH), cesium alum (CA), Imject alum (IA) (AH plus ..
Excerpts: In a Florida case described by Dr. Lyons-Weiler, a mother was still under the effects of medication following birth by cesarean section, when a nurse entered her room asking if she was ready for the shots for the new baby. The mother was confused. Ready now? Ready in general? She didn’t understand and she told that to the nurse.
Without any response to her confusion, the nurse proceeded to call Child Protective Services and the baby was seized by the state.
Hospitals need to be called out on this, says Dr. Lyons-Weiler. He recommends that, if a parent is threatened with CPS for refusing a vaccine, the parent should call the medical director of the facility and tell that person that they intend to seek damages.
[Note: in many of the stories that we have covered, we have seen that such threats, including any threats to sue or file malpractice charges, almost always result in the prompt removal of the child by CPS within 24 hours, and false allegations made by hospital staff that the mother has Munchausen Syndrome by Proxy/Factious Disorder.]
The doctor addresses a situation that more and more parents are finding themselves in – the refusal of the hospital staff to allow the parents and their baby to leave the hospital. Dr. Lyons-Weiler doesn’t mince words.
The field of pharmacogenomics and pharmacogenetics provides a promising science base for vaccine research and development. A broad range of phenotype/genotype data combined with high-throughput genetic sequencing and bioinformatics are increasingly being integrated into this emerging field of vaccinomics. This paper discusses the hypothesis of the ‘immune response gene network’ and genetic (and bioinformatic) strategies to study associations between immune response gene polymorphisms and variations in humoral and cellular immune responses to prophylactic viral vaccines, such as measles–mumps–rubella, influenza, HIV, hepatitis B and smallpox. Immunogenetic studies reveal promising new vaccine targets by providing a better understanding of the mechanisms by which gene polymorphisms may influence innate and adaptive immune responses to vaccines, including vaccine failure and vaccine-associated adverse events. Additional benefits from vaccinomic studies include the development of personalized vaccines, the development of novel vaccines and the development of novel vaccine adjuvants.
As one clinician noted, ‘…vaccines licensed in the USA are safe and effective. However, not every vaccine is equally safe or equally effective in every person’ [2].
Welcome to the Australian state of Victoria, where the minister of health, Jill Hennessy, has just put all doctors under the gun. There are currently 41 vaccinations administered to children in Australia between birth and 4 years of age – more if you are of Aboriginal or Torres-Strait Islander descent.
Vaccinating every child has become so important to Hennessey, she’s declared that a doctor who writes an exemption will be ignored. In fact, that doctor, by implication, will be considered “rogue.”
He could have his license to practice stripped. He could be prosecuted. He could be denied a way to earn a living.
Instead, in order to allow a child an exemption from taking vaccines, evidence must be shown from some sort of medical registry. How this system will work is not clear.
Using a transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminium content of brain tissue from donors with a diagnosis of autism. We have also used an aluminium-selective fluor to identify aluminium in brain tissue using fluorescence microscopy.
We recorded some of the highest values for brain aluminium content ever measured
in healthy or diseased tissues in these male ASDdonors including values of 17.10, 18.57 and 22.11 g/g dry wt. (Table 1)
Developmental Pharmacokinetics in Pediatric Populations
Hong Lu, PhD and Sara Rosenbaum, PhD
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island
Information on drug absorption and disposition in infants and children has increased considerably over the past 2 decades. However, the impact of specific age-related effects on pharmacokinetics, pharmacodynamics, and dose requirements remains poorly understood. Absorption can be affected by the differences in gastric pH and stomach emptying time that have been observed in the pediatric population. Low plasma protein
concentrations and a higher body water composition can change drug distribution. Metabolic processes are often immature at birth, which can lead to a reduced clearance and a prolonged half-life for those drugs for which metabolism is a significant mechanism for elimination. Renal excretion is also reduced in neonates due to immature glomerular filtration, tubular secretion, and reabsorption. Limited data are available on the pharmacodynamic behavior of drugs in the pediatric population.Pediatric Population study Cyp 450.
VLA Comment: Remember children under 3 years old have “immature” cytochrome P450 and 10% of Caucasians for example, are “non-metabolizers”…they cannot metablize many drugs all their lives and become psychotic when given drugs after being diagnosed as ADHD, Autism, etc which are vaccine injuries caused by inability to metabolize the ingredients in vaccines.
Some more books (see recommended books in our list to the right)
RECOMMENDED BOOKS
“Vaccination Policy and the U.K. Government:
the Untold Truth” by England & Tomljenovich
“Vaccination Voodoo: What YOU Don’t Know
About Vaccines” by Frompovich & King
“The Book On Greatness: How to Keep Shining
Your Light by Mary Pulles Cavanaugh
“Eat to Beat Disease: Foods Medicinal
Qualities” by Catherine J. Frompovich
“No Vaccines for Me!”, a family friendly
book by Kathleen Dunkelberger
“Save My Species” by Freddie the Chihuahua
(due to be published by the end of 2017)